4 Vitamin B Nootropic Peptides

August 16, 2024

The Brain-Boosting Vitamins

The B vitamin complex is a group of vitamins that contribute to various bodily functions, including cardiovascular and cell health. B vitamins are generally obtained through a balanced diet and serve as key components in a healthy body, directly affecting energy levels, brain function, and cellular metabolism. Nootropics that contain or are structurally similar to B vitamins, in particular, may help to enhance cognitive performance, improve mental clarity, and support overall brain health.

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Vitamin B complex is composed of eight B vitamins:

  • B1 (thiamine)

  • B2 (riboflavin)

  • B3 (niacin)

  • B5 (pantothenic acid)

  • B6 (pyridoxine)

  • B7 (biotin)

  • B9 (folic acid)

  • B12 (cobalamin)

Vitamin B1

Thiamine (B1) supports various bodily functions, including the nervous system, heart, and brain, by aiding in the production of adenosine triphosphate (ATP), which transports energy within cells. This energy supports muscle contractions and brain signaling.

Sulbutiamine (Enerion) is modified thiamine (vitamin B1) that crosses the blood-brain barrier and eventually produces both GABA and acetylcholine, thus affecting adaptability, mood, and focus.

Sulbutiamine is used to address fatigue, thiamine deficiency, and poor concentration. As a powerful cholinergic anxiolytic, it’s popular among nootropic users for boosting memory, focus, mood, and motivation, and it may be used by athletes to enhance performance.

Vitamin B5

Vitamin B5, also known as pantothenic acid, aids in blood cell production and helps convert food into energy. A deficiency in this vitamin can cause fatigue, headaches, and numbness in the hands and feet.

Hopantenic acid (Pantogam) is a nootropic that is structurally similar to vitamin B5 (pantothenic acid). It offers nootropic, anxiolytic, and anticonvulsant benefits. Pantogam is used to enhance physical performance and improve memory and attention by interacting with GABA-A, GABA-B, and dopamine D2 receptors, and stimulating acetylcholine production.

Vitamin B6

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that the body does not store and excretes excess amounts through urine, so it needs to be consumed daily. It supports over 100 enzyme reactions, aids in metabolizing proteins, fats, and carbohydrates for energy, and is involved in immune function, brain development during pregnancy and infancy, neurotransmitter production (including serotonin and dopamine), and the creation of hemoglobin in red blood cells.

Magne B6® is a supplement that combines magnesium and vitamin B6. Magnesium, the eleventh most abundant element in the body, is crucial for the function of about 300 enzymes and interacts with ATP, DNA, and RNA. It is vital for nerve impulse transmission, muscle contraction, and maintaining heart and nervous system health. Magne B6® is used to address magnesium deficiency, which can cause symptoms like irritability, sleep disturbances, stomach cramps, palpitations, fatigue, muscle cramps, and tingling.

Vitamin B12

Vitamin B12 (cobalamin) is crucial for nerve tissue health, brain function, and red blood cell production. Deficiency can cause headaches and fatigue. It also plays a role in the synthesis of neurotransmitters, such as serotonin and dopamine, which are involved in mood regulation and motivation. It is the largest and most complex of all vitamins.

Neurobion is a supplement that combines B vitamins—B1, B6, and B12. These water-soluble vitamins are crucial for neurological processes in the central nervous system (CNS). It is used to address conditions like neuritis and neuralgia (including trigeminal, facial nerve, and intercostal neuralgia) as well as pain syndromes related to spinal disorders, such as lumbosciatica, plexopathy, and radicular syndrome from degenerative spinal changes.

Conclusion

Vitamin B nootropics may significantly enhance cognitive function and brain health. When used alongside a healthy lifestyle, they help improve cognitive performance and reduce the risk of neurological disorders. It’s important to use these supplements responsibly and seek advice from a healthcare professional before starting any new regimen.

Bibliograpgy

  1. Sevim et al (2017) Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis https://www.ncbi.nlm.nih.gov/pubmed/28755683
  2. Starling-Soares et al (2020) Role of the Synthetic B1 Vitamin Sulbutiamine on Health https://pubmed.ncbi.nlm.nih.gov/32399290/
  3. Y Bykov, R Bekker (2022) [On the specific treatment of asthenic states: focus on sulbutiamine] https://pubmed.ncbi.nlm.nih.gov/36286970/
  4. O Ostroumova (2018) Possible applications of rac-hopantenic acid in the treatment of cognitive, anxiety and depressive disorders in patients with essential arterial hypertension https://www.ncbi.nlm.nih.gov/pubmed/30499507
  5. Zavadenko et al (2019) [Pharmacotherapy of psychomotor developmental delay in 6-12 months preterm infants with hypoxic-ischemic encephalopathy (the double-blind comparative multicenter placebo-controlled study)] https://pubmed.ncbi.nlm.nih.gov/31793540/
  6. V Zykov (2020) [Tics and Tourette’s syndrome in children] https://pubmed.ncbi.nlm.nih.gov/32621477/
  7. Noah et al (2021) Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial https://pubmed.ncbi.nlm.nih.gov/33864354/
  8. Barbagallo et al (2021) Magnesium in Aging, Health and Diseases https://pubmed.ncbi.nlm.nih.gov/33573164/
  9. Durrani et al (2022) Vitamin B6: A new approach to lowering anxiety, and depression? https://pubmed.ncbi.nlm.nih.gov/36268413/
  10. S Baltrusch (2021) The Role of Neurotropic B Vitamins in Nerve Regeneration https://pubmed.ncbi.nlm.nih.gov/34337067/
  11. H Nguyen, M-S Kim (2022) The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved https://pubmed.ncbi.nlm.nih.gov/35714552/
  12. Paez-Hurtado et al (2023) Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review https://pubmed.ncbi.nlm.nih.gov/35156556/

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