What Does Selank Peptide Do?
August 9, 2024
What is Selank
Selank is a peptide anxiolytic drug with nootropic properties that comes in drops. Its main effects include anti-anxiety, antidepressant, and antiasthenic. Selank is structurally derived from the endogenous tetrapeptide Tuftsin, which plays a crucial role in the immune system. Typically found in small concentrations, Tuftsin acts as an immunomodulator, enhancing human immunity. It crosses into the brain when synthesized in higher concentrations, for example during stressful conditions, effectively triggering biochemical anti-stress mechanisms.
As Tuftsin’s natural life is short, only a few minutes, the creators of Selank added glyproline to the formula, to slow down the breakdown of the peptide and prolong its effects. To learn more, check out our full Selank review.
Mechanism of Action
Selank, based on 7 natural amino acids present in the body, restores normal nervous system function by regulating the synthesis of neurotransmitters (serotonin, noradrenaline, dopamine) and enkephalins in the brain.
Selank acts through multiple mechanisms:
Anxiolytic: stops noradrenaline and serotonin from increasing in emotional areas of the brain and keeps enkephalins at the right level to counteract anxiety.
Antidepressant: normalizes enkephalins and serotonin in emotional areas of the brain.
Stress-Protective: reduces negative emotional stress, restores motivation and adaptive behaviors to achieve positive outcomes. It also corrects stress induced somatic disorders.
Nootropic: stimulates learning, memory retention, information analysis, and recall processes.
Antiasthenic: increases dopamine in cortex and diencephalon areas to reduce non-exhaustive asthenic symptoms.
Therapeutic Benefits
Selank has a broad range of pharmacological effects. Its main uses are:
Anxiety and adjustment disorders
Neurasthenia and emotional lability
Sleep disorders
Stress related disorders
It also helps to reduce somatic symptoms of anxiety like headaches and muscle pain.
The anxiolytic mechanism of action aims to regulate levels and metabolism of norepinephrine, serotonin, and enkephalins in the brain. There is also a mechanism of inhibition of enkephalin-degrading enzymes which increases the activity of the endogenous opioid system and explains Selank’s mild analgesic effects.
Conclusion
Selank peptide is a promising treatment option for anxiety disorders due to its unique mechanism of action. As a synthetic peptide, Selank may represents a new approach to managing anxiety and related conditions, offering potential advantages over conventional medications.
Bibliography
- Verbenko VA, Phedorov VN (2016). The using a new anxiolytic peptide “Selank” in the therapy of psychogenic binge eating disorder. https://cyberleninka.ru/article/n/vozmozhnosti-primeneniya-novogo-anksiolitika-peptidnoy-prirody-Selank-v-terapii-psihogennogo-pereedaniya
- Fomenko EV et al (2017). Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress. https://pubmed.ncbi.nlm.nih.gov/28853100/
- Verbenko VA, Shakina TA (2017). Effectiveness of new synthesized analogue of endogenous peptide taftcin – Selank in therapy of adjustment and posttraumatic stress disorders. https://www.med-alphabet.com/jour/article/view/344
- Siebert A et al (2017). Tuftsin – Properties and Analogs. https://pubmed.ncbi.nlm.nih.gov/28745220/
- Starikov P, Fedorov V (2019). The use of Selank in the treatment of vegetative and psycho-emotional disorders in climacteric syndrome in women. https://Selank.ru/provereno/publikatsii/
- Verbenko VA, Shakina TA (2019). New opportunities to potentiate the action of selective serotonin reuptake inhibitors by Selank regulatory peptide in the therapy of anxious-depressive disorders. https://Selank.ru/provereno/publikatsii/
- Yasenyavskaya AL et al (2020). The Influence of Selank on the Level of Cytokines Under the Conditions of Social Stress. https://pubmed.ncbi.nlm.nih.gov/32621722/