December 13, 2018

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Christmas schedule

Attention! Christmas Schedule. From December 25 to January 15 shipments from Russia will not be dispatched daily. We will be shipping new orders every 3-4 days. United States domestic orders will be shipped out daily, as usual. View full article →
December 03, 2018

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Doctor review of Tabex: administration, the return of cravings, dependency, side effects

Doctor review of Tabex: administration, the return of cravings, dependency, side effects

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November 29, 2018

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How people in different countries try to improve their cognitive abilities?

A global study on substance use with more than 100,000 participants: what do people from different countries prefer to use in order to improve their cognitive abilities and why this is not the best way. View full article →
September 24, 2018

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We are looking for partners from the US 🇺🇸

How to get a 50+% discount on original nootropic products from Russia? Looking for partners


If you are a passionate nootropic enthusiast living in the US, have placed several orders with us previously, and want to help the nootropic community, you have a chance to get the products with more than 50% discount.

We are looking for partners, to help with filling our warehouse in the USA.

It will not take much of your time, but will greatly help nootropic enthusiasts in the US.

Just email us (support@cosmicnootropic.com) or contact us via Messenger and we will get back to you.

 

September 04, 2018

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Nootropics for students

One of the major purposes of nootropics is to stimulate and improve cognitive abilities of the user. How nootropics can be used by students? There are several main rules to remember.

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September 01, 2018

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Monthly report: August

Ah, the last day of summer… The perfect time for our August monthly report.

Here are some interesting data from our store:

  • 30 orders were dispatched from our US warehouse and the average transit time is even lower this month - only 2.8 days on average. Some of our clients even reported that they got their parcel on the next day! Which makes it the fastest delivery of brand-name nootropics on the market!
  • Good news from the Russian post! There were no delays this month and average shipping time went down from 20 days to 12.6 days with the regular international mail.
  • Reshipments share went down to 0%. We did not need to do any reshipments at all this month and hope this trend will continue.
  • EMS shipping times are going down as well. On average our US clients get their EMS parcels in 8 days. Really fast!
  • New popular product is Picamilon - pretty much “universal” nootropic that we have posted video about recently https://www.youtube.com/watch?v=2KyUTKVb17Q Try it out yourself in our store: https://cosmicnootropic.com/collections/nootropics/products/picamilon
  • We are happy that our clients share their thoughts about us! We’ve received over 15 useful reviews on our website this month and will be  happy if you could recommend us on facebook as well!

Thank you for the continued support and we will continue to provide best service and brand name nootropics to our customers all over the world.

August 07, 2018

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We now have an Android App!

Fair share of traffic on our website comes from the mobile devices. Buy nootropics easily from mobile! View full article →
August 06, 2018

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GABAergic Drugs as an Alternative to Benzodiazepines for the Treatment of Anxiety Disorders

As of today, anxiety disorders are one of the most common psychological disorders in the world. According to statistics, about 18% of the population in the United States suffer from anxiety disorders, and most of such people do not receive the needed treatment.

The typical treatment for anxiety is Benzodiazepine tranquilizers. They usually act by binding to the benzodiazepine receptor site on the GABA-A receptors. Benzodiazepines have a pronounced anti-anxiety effect, but they also have significant side effects e.g. drowsiness, muscle relaxation, cognitive impairments, addiction potential.

The following article is a review of the GABAergic drugs that are mostly used in the former Soviet Union and might be a good alternative to benzodiazepines.

Pantogam (Hopantenic acid) is a Vitamin B5 derivative with anxiolytic activity. It is used since 1970’s n several countries as a treatment for epilepsy, developmental delays, anxiety disorders and chronic fatigue. Hopanthenic acid acts by interacting with D2 dopamine, GABA-A, and GABA-B receptors. Moreover, it does have pronounced cholinergic action, thus having a positive effect on cognitive functions.

Pantogam has a novel racemic modification called “Pantogam Active”, which is marketed since 2008. The modified version has more pronounced anxiolytic and anticonvulsant effect because of the different racemic mixture.

 

Afobazole (Fabomotizole) is a Russian anxiolytic drug developed in the 2000’s, which was primarily designed and used for anxiety management. Afobazole has a unique mechanism of action. It is not habit-forming since it has no affinity with GABA receptors. However, Fabomotizole restores the sensitivity of GABA receptors to endogenous ligands. Fabomotizole interacts with Melatonin MT1/MT3 receptors, sigma-1 receptors and has been shown to possess neurotrophic properties.

 

Adaptol (Mebicar) is a urea derivative with anxiolytic and nootropic action that is used in medicine since 1979. The mechanism of action of Mebicar is complex; it appears to have an influence on all major monoamine systems in the brain with moderate cholinergic and anti-excitotoxic effects.

One of the most important properties of Adaptol is its low toxicity. Russian medical journal “Psychiatry” reported a case when a patient with schizophrenia took 80 pills of Adaptol (24 grams) daily for two months in his attempt to self-medicate. His subjective well-being remained unchanged and he showed no symptoms of intoxication after a medical examination.

 

Grandaxin (Tofisopam) is a benzodiazepine tranquilizer with unique pharmacological atypical for commonly used benzodiazepines. It is used since 1970’s as anxiolytic drug in several countries, mostly Russia and Hungary.  

Tofisopam is a 2,3-benzodiazepine derivative, while most widely used BZDs like Lorazepam are 1,4 benzodiazepine derivatives. Because of such structural differences, it has a different mechanism of action. One of the most important benefits of Grandaxin over typical Benzos is the lack of addictive potential.

Rather than causing sedation and impairment of cognition, Tofisopam was shown to produce a subtle stimulant effect by increasing the sensitivity of dopamine receptors. It does not bind to benzodiazepine receptors but is able to potentiate the effect of other BZDs.

  

Phenibut (Beta-Phenyl-GABA) was designed in the 1960’s by Soviet scientist as a non-sedating anxiolytic drug.

Initially, it was used by astronauts; as of today, Phenibut is widely prescribed by Russian doctors for the treatment of anxiety disorders, chronic fatigue, insomnia and alcohol withdrawal syndrome.

Phenibut acts as a GABA-B receptors agonist and is able to increase dopamine levels in the brain. This drug is highly effective for anxiety, however, it may be habit-forming if used irresponsible and is known for its abuse potential.

  

Picamilon (nicotinoyl GABA) is a derivative of GABA and niacin (Vitamin B3) developed for the needs of Soviet psychiatry.

Unlike GABA itself, Picamilon is able to penetrate the blood-brain-barrier and produce an anxiolytic effect. Besides that, the drug does have nootropic properties and is shown to improve cerebral blood flow and glucose/oxygen uptake by the brain.

 

Mexidol (emoxypine succinate) is a Russian antioxidant drug with pronounced nootropic and anxiolytic activity. It is close to pyridoxine (Vitamin B6) by its chemical structure. Since its invention in the 1980’s, Emoxypine is widely used in Russian medicine as a treatment for cerebrovascular disorders, traumatic brain injuries, chronic fatigue, anxiety disorders and alcohol withdrawals. Mexidol is often used recreationally to protect the brain from the toxic effect of alcohol consumption and prevent hangovers.

Although this drug does not bind to GABA receptors, it does increase their sensitivity, thus providing the anxiolytic effect. According to studies, a coadministration of Mexidol with Phenazepam in low therapeutic doses provides the same anxiolytic response as Phenazepam alone in 10x higher dose.

  

Stresam (Etifoxine) is a benzoxazine derivative with anxiolytic action developed in 1966 in Germany. Currently, it is manufactured in France and is used in over 42 countries across the world, mostly in Russia and South Africa.

Etifoxine provides anxiolytic effect comparable to that of Lorazepam and Diazepam, without causing adverse effects that are typical for benzodiazepines.

Stresam acts by interacting with GABA-A receptors on a different binding site than benzodiazepines. It also stimulates the synthesis of endogenous neurosteroids with anxiolytic activity and does have neurotrophic properties. Etifoxine should be taken with caution as it may cause allergic reactions and can be hepatotoxic.

Phenazepam is a benzodiazepine tranquilizer developed in the 1974 in Soviet Union.

The drug is widely used in post-soviet states. Its pharmacological action, side effects and indications for use are similar to that of other benzodiazepine drugs. Just as other 1,4-BZDs, Phenazepam has addictive potential.

Currently, Phenazepam, Gidazepam, and Tofisopam are the only benzodiazepine derivatives that are not considered as narcotic drugs in Russia.

Gidazepam is a benzodiazepine tranquilizer that is currently used as a mild anxiolytic in Ukraine. It appears to have mild antidepressant effect and less severe side effect compared to other benzodiazepines; thus, Gidazepam the official indications for use include neurasthenia which is uncommon for BZDs.

August 06, 2018

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Mexidol - nootropic effect of the antioxidant

Mexidol as a way to protect yourself from sterss - indications, dosage, side effects View full article →
August 06, 2018

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Domestic (US) shipping of our bestsellers

Our nootropics are now shipped from LA warehouse View full article →