February 13, 2018

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New drug sheets transmission 📡

Hey there, cosmonauts 🚀

We've received a new data transmission form the command center with a bunch of official drug sheets for our products. 🛰️

They are all now uploaded 📡 to our 'Instructions' page.  Come check them out! 

 We've added instructions for the following products this time

Please, be responsible and check instructions on our website before taking any nootropic supplement.  

We want to remind you that following official information is the only way to safely perform any kind of therapy with any kind of medication. Don't take a chance following recommendations from the random people on the internet. Just visit our 'Instructions' page and consider all necessary precautions.

Best regards,
CosmicNootropic Team 🚀
January 09, 2018

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New SkQ1 products: key to eternal youth or not?

We all are afraid of ageing and, at least subconsciously, we all would want to slow it down. That's why we use cosmetics and plastic surgery. That's also why we eat healthy, do sports, take vitamins and dietary supplements.

For centuries scientists have been racking their brains over the possibility to control the mechanisms underlying the ageing process. How many examples of "elixirs of youth" and "elixirs of immortality" can we count throughout our history? But unfortunately until now all this was just an invention of charlatans or incorrigible romantics.

Today, the science has made a huge step up with regards to lengevity. Although no one talks about immortality and eternal youth these days, but the postulate, that ageing is a fatal process that cannot be prevented is no longer an axiom. More and more researchers agree that, in fact, a human body is designed for 120-150 years of life, and aging is nothing more than an integral complex of disorders and specific age-related diseases that can and should be fought off. One of the scientists that have devoted his carrier to ageing was Vladimir Skulachev, an outstanding Russian biochemist, who have been working on the creation of a tool, which would improve the life quality and life expectancy. It is he, who proved the existence of so-called mitochondrial electricity in the 70's and he, who is, by far, one of the most quoted biochemists in the world press.

Academician Skulachev supports the hypothesis that one of the main causes of aging is nothing more than a slow self-poisoning of the body. The fact is that the mitochondria in our cells produce free radicals that cause a lot of damage to these cells and, as time goes,  these free radicals activate the cell self-destruction program. Thus, if one neutralizes free radicals within the mitochondria, the aging program can be slowed down. Years-long investigations allowed the Skulachev`s research group to develop a mitochondrial antioxidant SkQ, Skulachev's Quinone, based on plastoquinone (a substance extracted from the most oxygenated place in the wild - chloroplast of the plants). SkQ accumulates in mitochondria, captures and neutralizes free radicals right at the site of their formation. Due to these unique properties the effectiveness of the SkQ antioxidant is 1000 times greater than that of the other well-known antioxidants, including famous coenzyme Q10. As a result, SkQ is able to prevent, slow down or even reverse the development of many aging signs, including age-related diseases. No one promises to double life expectancy, but certain things are already real, some of which are an approximately 10% life extension (mainly due to the reduction in middle-age mortality), improvement of life quality and an escape from the age-related conditions of body organs.  

 

 

More than 300 people from 40 organizations around the world have been taking part in the Skulachev Project, including Academicians, Nobel Prize winners and Ph.Ds from the leading scientific and medical centers in Russia, Germany, Sweden, Holland, Austria, Israel, USA, Canada and Australia. The products are approved for use in Russia and also passed a number of clinical trials before the US FDA, which is very hard for a non-US company. Their work has already resulted in 4 products based on SkQ molecules: eye drops "Visomitin", rejuvenating serum "Mitovitan", anti-aging concentrate "MitoVitan Active" and regenerating cream-gel "Exomitin". The pills for oral administration "Plastomitin" with a system-wide action are under development.

The official website of the SkQ-project is here.  We are happy to be one of the first cross-border vendors of this product line. Want to try? 

 

 

 

 

Visomitin® (eye-drops)

Exomitin® (regenerating antioxidant hydrogel)  MitoVitan Active® (mitochondrial antioxidant concentrate) MitoVitan®  (anti-aging serum)

 

So, who knows, maybe age is just a number printed in the ID card, nothing more?  And what do you think? :)

Live long! 

CosmicNootropic Team

 

 

January 02, 2018

1 comment


Original Drug Sheets For Nootropics And Why They Matter

The wrong choice or administration of the medicine will not have the desired effect (as a minimum), or can lead to sad results (as a maximum).

Unfortunately, it is not uncommon that a person picks up a drug only from the perspective of Internet articles and customer reviews, and completely forgets about the main source of information - the official instruction. 
Different indications for use, contraindications, side effects, interaction with other drugs, dosage regimen...
View full article →
January 01, 2018

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Good news from Australian Customs! 🇦🇺

Happy New Year everyone! 

Good news for our mates in Australia!

One of our customers contacted us with some valuable info from the Australian Border Force. In short, one of our parcels has been opened for a random check and the Border Force didn't find anything suspicious. This is official confirmation that nootropics can be imported to Australia without any problems or risks.

See the message for yourself! 

The opened parcel contained variety of nootropics, including liquid supplement and different pills. Here is the  full list:

  • Noopept
  • Grandaxin
  • Phenotropil
  • Afobazole
  • Selank
  • Nootropil
  • Picamilon
  • Stresam
  • Phenibut
  • Nooclerin
  • Neurobion

 

We also now have exactly same shipping rates to Australia and New Zeland as to the rest of the world! So come check our products out! Cheers! 

Sincerely yours,

CosmicNootropic Team 🛰️

December 25, 2017

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🎄 Winter Holidays at CosmicNootropic 🎅

Dear nootropic enthusiasts,

Our team wanted to wish you a merry Christmas and express words of gratitude for your continued support. We value your business,  and will need it in the future in order to implement some of our projects for the benefit of the nootropic community and all people who are indifferent about appropriate usage of nootropics and pharmaceuticals in general.  

Please note that our last shipment in this year will be on the 26th of December.

The next shipment will be on the 4th of January. (All orders paid after the 26th of December will be shipped on this day) 

After the 8th of January, the normal shipping schedule will be resumed.

In the meantime you can still pay for your orders.

Happy Holidays!

 

December 17, 2017

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🌿 🌷Herbal Adaptogens: Aralia Mandshurica, Siberian Ginseng, Leuzea, Ginseng, Rhodiola Rosea, and Schisandra Chinensis 🎄 🌷

In making your choice between natural and laboratory-synthesized supplements what will you take into account above all? For sure you will try to find balance between healing effect and possible risks. Any drug in practice has the potential to cause unwanted effects, but still natural compounds typically pose a much lower risk. Except reduced risk of side effects, natural remedies could be even more effective in dealing with protracted chronic conditions and have a positive influence on the entire organism, which means that the body’s natural healing process for treating various diseases will be activated.

The same is applicable to nootropics: if you’re interested in the idea of “smart drugs” but want (or have a reason) to avoid synthetic products, there are many outstanding all-natural options to enhance physical&mental work capacity, increase resistance to stress and improve memory without disturbing normal biological functions.

Many herbs we now recognize as natural nootropics date back millennia. They have not only withstood the test of time but also the competition from pharmaceutical products. Researchers still continue to learn the unique mechanisms of phytoremedies action that enable those herbs to be effectively used as cognitive enhancers. A lot of such healing plants grow in the area of majestic Siberia and especially the Altay Region, known for its abundant plant diversity and centuries-long traditional herbalism practices. By the way, cognitive enhancement properties of most of the nootropic herbs were clinically-proved: reportedly in 1960s soviet cosmonauts were prescribed brain herb extract as a mood-enhancer to help them withstand their physically and mentally demanding missions. Since that time natural supplements have been gaining in popularity among sportsmen all over the world as their usage helps to enhance physical work capacity and maintain general health during long, draining training sessions. These remedies can act just as effective as their lab-produced equivalents but they don`t harm the health and aren`t considered to be dope.

Although each phytonootropic can improve mental & physical performance and serve as a powerful source of natural health, different herbs have slightly different benefits and action emphases. Thus, it is possible to choose the one (or a set) that matches your symptoms and goals the best. Another helpful aspect is a variety of accessible dosage forms: pills, capsules, liquid extracts, tinctures (it’s no secret that correct selection of dosage form is already halfway to success).

All the pharmaceutical-grade herbal nootropics and adaptogen tinctures are 100% natural, organic, non-GMO, and have track records of reliability for a broad audience:

                          
                           

 

Below is the picture of Altai region, from which some of these products have been sourced.

 Altai Herbs

Please note that some of the herbal nootropics sold in Russian market are considered supplements, while others considered pharmaceutical drugs. Here you will find only products that are regulated as a drugs and are tested for the presence of an active ingredient, unlike supplements. The products here are also come in the form of tinctures, which means that they are likely to have higher bioavailability due to ethanol presence.

 

December 16, 2017

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How to Buy Nootropics in the UK 🇬🇧

We have all heard about the UK nootropics ban. There are many posts and questions on Reddit r/nootropics about getting these products in the UK and whether they are still legal. In this post I wanted to share a few insights about how to get these products when living in the Great Britain.

First of all, it is necessary to point out that it is absolutely legal to import nootropics to the UK for personal use. They are not scheduled substances and as such they can be safely imported. Nootropics are not allowed for sale in the territory of the UK but this is another story.

Another question about importing nootropics in the UK is the UK import duty and whether people have to pay it. When I lived in the UK, I also imported some staff for personal consumption and had to pay this very weird duty and very much disliked it. That is why we now mark all our parcels to the UK as gifts with the value less than 30 GBP so that you can receive your order hassle-free and not worry about paying the duty.

Last but not the least, our parcels to the UK are going very smoothly and standard delivery (Regular Airmail) for 5 USD is a great option for those whose shipping destination is the UK. 

 

 Thank you for choosing CosmicNootropic as your supplier of quality nootropics and food supplements. 

 

 

 

 

 

December 09, 2017

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Monthly Raffles

Hey there Nootropic Cosmonauts! 🚀

In the beginning of September this year we've decided to start rewarding our contributors for the reviews left on our site. And the way of doing that, is holding a raffle on 15th of each month. Each time we give out two 100 USD coupons on everything in our store.

All our raffles are streamed (and then saved) on our YouTube channel. You can check all the past broadcasts whenever you want! Over the last three months we had 24 participants and we will be happy to see this number growing in the following months. 

Why are the reviews  so important? 

Your opinion about our store is really important, both for us and for all nootropics enthusiasts. Listening to you helps us to improve our service and product range, so we can deliver even better experience to everyone.

Your feedback also gives valuable information to other customers, who are interested in nootropics. Information on nootropics and their usage is rather limited, so each personal experience may help someone else to chose the right supplement for them. 

All reviewed are welcome. Positive or negative - it is your experience and we value it.

So, you might be thinking, how do I participate in the raffle? The whole process is really simple:

  1. Make a purchase in our store.
  2. Leave your general feedback or feedback on a certain product. We don't have any specific format for the reviews, so just share your thoughts! 
  3. Be sure to specify your e-mail. We won't disclose it, but it is needed to contact you before and after the raffle.

You are in! Now you have to wait till the date of the raffle. We usually send the exact time of the broadcast to all the participants several days prior. 

Hope to see you in our next raffle and good luck! 

Sincerely yours,

CosmicNootropic Team 🛰️

P.S. You should totally subscribe to our YouTube channel. We have a lot of useful stuff coming up in the 2018! 😉

 

November 20, 2017

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November Shipping Issues and How We Have Handled Them

Soyuz 1 Cargo Spacecraft

Hey there Nootropic Cosmonauts! 

November has been rather challenging for us. Apart from managing many ongoing improvements of the store, we were also struck by Russian Post issues. And, unfortunately, some of you experienced this yourself. Although the postal service is outside of our reach, please accept our apologies for not meeting your expectations. 

So, what has happened and how we addressed this?

Around mid October we found that shipping time for many orders has increased a lot because several parcels were stuck in Russia. For instance, the one on the picture was traveling in circles, visiting same sorting centers over and over again. 

We reshipped all stuck orders or made refunds in BTC, as it is our policy. We also decided to dig deeper and contacted both Russian Post and the Customs. The problem was the unclear regulations regarding export shipping on behalf of the business. As this is sorted out now, we hope that it will not happen again. 

By now, all stuck orders have been reshipped. In total, we've reshipped 35 parcels and most of them have already reached our clients. Several of the orders were reshipped even twice. More on our delivery and reship or refund policy here.

We also want to inform you that right now it may (or may not) take several extra days for a parcel to reach you, as Russian post is undergoing reorganisation. We also had to increase our shipping time for the time being. In case you think that your parcel is stuck, don't hesitate to contact us.

We will be happy to sort out this problem with you by either reshipping or  refunding your order in full. Please know that we value our customers and try to meet their expectations the way we can.

Sincerely yours,

CosmicNootropic Team

October 04, 2017

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GABAergic Drugs as an Alternative to Benzodiazepines for the Treatment of Anxiety Disorders

As of today, anxiety disorders are one of the most common psychological disorders in the world. According to statistics, about 18% of the population in the United States suffer from anxiety disorders, and most of such people do not receive the needed treatment.

The typical treatment for anxiety is Benzodiazepine tranquilizers. They usually act by binding to the benzodiazepine receptor site on the GABA-A receptors. Benzodiazepines have a pronounced anti-anxiety effect, but they also have significant side effects e.g. drowsiness, muscle relaxation, cognitive impairments, addiction potential.

The following article is a review of the GABAergic drugs that are mostly used in the former Soviet Union and might be a good alternative to benzodiazepines.

Pantogam (Hopantenic acid) is a Vitamin B5 derivative with anxiolytic activity. It is used since 1970’s n several countries as a treatment for epilepsy, developmental delays, anxiety disorders and chronic fatigue. Hopanthenic acid acts by interacting with D2 dopamine, GABA-A, and GABA-B receptors. Moreover, it does have pronounced cholinergic action, thus having a positive effect on cognitive functions.

Pantogam has a novel racemic modification called “Pantogam Active”, which is marketed since 2008. The modified version has more pronounced anxiolytic and anticonvulsant effect because of the different racemic mixture.

 

Afobazole (Fabomotizole) is a Russian anxiolytic drug developed in the 2000’s, which was primarily designed and used for anxiety management. Afobazole has a unique mechanism of action. It is not habit-forming since it has no affinity with GABA receptors. However, Fabomotizole restores the sensitivity of GABA receptors to endogenous ligands. Fabomotizole interacts with Melatonin MT1/MT3 receptors, sigma-1 receptors and has been shown to possess neurotrophic properties.

 

Adaptol (Mebicar) is a urea derivative with anxiolytic and nootropic action that is used in medicine since 1979. The mechanism of action of Mebicar is complex; it appears to have an influence on all major monoamine systems in the brain with moderate cholinergic and anti-excitotoxic effects.

One of the most important properties of Adaptol is its low toxicity. Russian medical journal “Psychiatry” reported a case when a patient with schizophrenia took 80 pills of Adaptol (24 grams) daily for two months in his attempt to self-medicate. His subjective well-being remained unchanged and he showed no symptoms of intoxication after a medical examination.

 

Grandaxin (Tofisopam) is a benzodiazepine tranquilizer with unique pharmacological atypical for commonly used benzodiazepines. It is used since 1970’s as anxiolytic drug in several countries, mostly Russia and Hungary.  

Tofisopam is a 2,3-benzodiazepine derivative, while most widely used BZDs like Lorazepam are 1,4 benzodiazepine derivatives. Because of such structural differences, it has a different mechanism of action. One of the most important benefits of Grandaxin over typical Benzos is the lack of addictive potential.

Rather than causing sedation and impairment of cognition, Tofisopam was shown to produce a subtle stimulant effect by increasing the sensitivity of dopamine receptors. It does not bind to benzodiazepine receptors but is able to potentiate the effect of other BZDs.

  

Phenibut (Beta-Phenyl-GABA) was designed in the 1960’s by Soviet scientist as a non-sedating anxiolytic drug.

Initially, it was used by astronauts; as of today, Phenibut is widely prescribed by Russian doctors for the treatment of anxiety disorders, chronic fatigue, insomnia and alcohol withdrawal syndrome.

Phenibut acts as a GABA-B receptors agonist and is able to increase dopamine levels in the brain. This drug is highly effective for anxiety, however, it may be habit-forming if used irresponsible and is known for its abuse potential.

  

Picamilon (nicotinoyl GABA) is a derivative of GABA and niacin (Vitamin B3) developed for the needs of Soviet psychiatry.

Unlike GABA itself, Picamilon is able to penetrate the blood-brain-barrier and produce an anxiolytic effect. Besides that, the drug does have nootropic properties and is shown to improve cerebral blood flow and glucose/oxygen uptake by the brain.

 

Mexidol (emoxypine succinate) is a Russian antioxidant drug with pronounced nootropic and anxiolytic activity. It is close to pyridoxine (Vitamin B6) by its chemical structure. Since its invention in the 1980’s, Emoxypine is widely used in Russian medicine as a treatment for cerebrovascular disorders, traumatic brain injuries, chronic fatigue, anxiety disorders and alcohol withdrawals. Mexidol is often used recreationally to protect the brain from the toxic effect of alcohol consumption and prevent hangovers.

Although this drug does not bind to GABA receptors, it does increase their sensitivity, thus providing the anxiolytic effect. According to studies, a coadministration of Mexidol with Phenazepam in low therapeutic doses provides the same anxiolytic response as Phenazepam alone in 10x higher dose.

  

Stresam (Etifoxine) is a benzoxazine derivative with anxiolytic action developed in 1966 in Germany. Currently, it is manufactured in France and is used in over 42 countries across the world, mostly in Russia and South Africa.

Etifoxine provides anxiolytic effect comparable to that of Lorazepam and Diazepam, without causing adverse effects that are typical for benzodiazepines.

Stresam acts by interacting with GABA-A receptors on a different binding site than benzodiazepines. It also stimulates the synthesis of endogenous neurosteroids with anxiolytic activity and does have neurotrophic properties. Etifoxine should be taken with caution as it may cause allergic reactions and can be hepatotoxic.

Phenazepam is a benzodiazepine tranquilizer developed in the 1974 in Soviet Union.

The drug is widely used in post-soviet states. Its pharmacological action, side effects and indications for use are similar to that of other benzodiazepine drugs. Just as other 1,4-BZDs, Phenazepam has addictive potential.

Currently, Phenazepam, Gidazepam, and Tofisopam are the only benzodiazepine derivatives that are not considered as narcotic drugs in Russia.

Gidazepam is a benzodiazepine tranquilizer that is currently used as a mild anxiolytic in Ukraine. It appears to have mild antidepressant effect and less severe side effect compared to other benzodiazepines; thus, Gidazepam the official indications for use include neurasthenia which is uncommon for BZDs.