Cortexin In Details

What is Cortexin

Cortexin is a mixture of neuropeptide fractions, amino acids, vitamins and minerals, all of which have a pronounced but subtle positive effect on the brain. Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. However, there is a difference: Cortexin has significantly more peptide fractions and less amino acids.

Cortexin® has the following effects:

Nootropic effect: Improves higher cerebral functions, processes of learning and memory, concentration, attention and tolerance to mental and physical stress;

Neuroprotective effect: protects neurones against different endogenous neurotoxic factors (glutamate, calcium ions and free radicals) and reduces toxic impact of psychotropic agents;

Antioxidant effect: inhibits lipid peroxidation, increases survival of neurones under oxidative stress and hypoxia;

Tissue-specific effect: activates metabolism of neurones of central and peripheral nervous system as well as reparative processes; also, promotes stimulation of cortical function and general improvement of the nervous system.

Cortexin Compatibility with Other Drugs  

When considering any medicine, we are always concerned about how it will interact with other drugs. Whether a drug may be used in a complex therapy and whether it is possible to treat a person with several separate conditions depends on it.

Cortexin is a nootropic, which is a drug used for the treatment of nervous system diseases. It contains polypeptides extracted from the bovine or porcine cerebral cortex. Once in the body, Cortexin activates the peptides of our own neurons, thus balancing excitatory and inhibitory mediators. This explains the nootropic, neuroprotective and antioxidant effects of Cortexin. The list of indications for its use is extended and includes many conditions:

  • Impaired development of speech and learning skills;
  • Epilepsy;
  • Myocardial infarction and its consequences;
  • Encephalopathy;
  • Cerebral palsy;
  • Encephalitis, myelitis, and encephalomyelitis;
  • Cognitive impairment (impaired memory or thought process);
  • Traumatic injuries of the nervous system;
  • Asthenic conditions.

A single drug is rarely used for the effective treatment of the above-mentioned disorders; complex therapy is much more effective. Let's take a closer look at which drugs Cortexin is most often used with.

The drugs Cortexin is most often used with

Combinations of these specific drugs are commonly used in the complex treatment of nervous system disorders. Let’s examine the possible interaction of Cortexin with each of these drugs separately.

Can Cortexin, Mexidol and Fezam be used at the same time?

Mexidol is an antioxidant; it has membrane stabilizing, antihypoxic, nootropic as well as anticonvulsant effects, and also reduces the formation of free radicals. In addition to the treatment of neurological disorders, it is used for many pathological conditions. Its action mechanism is aimed at increasing the body's resistance to damaging factors.

Fezam is a combination of two drugs: piracetam and cinnarizine. 

Piracetam is a nootropic structurally derived from GABA (gamma-aminobutyric acid). GABA is a biological mediator of the central nervous system, through which nerve cells transmit impulses to each other. Piracetam improves the interaction of neurons, which causes the processes of thinking and reasoning to be more effective, and positively affects intellectual abilities.

Cinnarizine does not affect the nervous system directly. This drug has a specific effect on the brain vessels – it dilates them. This leads to an improvement in the blood supply to the brain, which positively affects the functioning of neurons and contributes to a faster recovery from various nervous system disorders.

As we found out, Cortexin, Mexidol and Fezam use completely different approaches but have one common goal. Therefore, their simultaneous use enhances their mutual positive effect.

Can Cortexin and Cavinton be used at the same time?

Cavinton is also a nootropic and has several indications for use. Firstly, this drug improves blood supply to the brain by reducing blood viscosity and accelerating the process of oxygen transfer to the nerve cells. Secondly, Cavinton reduces the damaging action of excitatory amino acids on nerve cells, providing a neuroprotective effect. The simultaneous administration of Cortexin and Cavinton will have a more pronounced positive effect than their separate use.

Can Cortexin and Cerebrolysin be used at the same time?

Cerebrolysin is a nootropic and, like Cortexin, contains animal brain peptides. However, with a deeper analysis, it becomes apparent that the ratio and composition of the peptides that make up Cerebrolysin and Cortexin are different.

Experts do not consider it rational to combine these drugs, but quite often recommend to use them in succession or alternate the courses.

Can Cortexin and Ceraxon be used at the same time?

Ceraxon, like many of the above-mentioned drugs, is a nootropic. However, its action mechanism is completely different. Ceraxon is a precursor of lipids from which the cell membranes, including nerve cell ones, are built. Due to this property, the use of this drug reduces the damaging influences on nerve cells and helps to accelerate their recovery. The simultaneous administration of Cortexin and Ceraxon provides an increase in the overall positive effect. 

Recently, many analogs of Ceraxon appeared, including one called Recognan, which has the same effect but is more affordable. When it is combined with Cortexin, the positive effect also intensifies.

Can Cortexin and Pantogam be used at the same time?

Pantogam is a drug that contains hopantenic acid. This acid is a nootropic with a mild stimulating effect, which is typically manifested by an acceleration of processes in brain cells. This ensures normalization of cognitive processes occurring in the brain and contributes to a rapid restoration of nerve structures if they are damaged.

With a simultaneous administration of Cortexin and Pantogam, the therapeutic effect will be more pronounced.

Can Cortexin and Lidocaine be used at the same time?

It is worth noting that Cortexin should be diluted before being injected: for that purpose, one may use anesthetic solutions, water for injections or physiological saline solution (0.9% NaCl solution).

Water for injections and saline solution are not considered drugs but are usually used for diluting the main medicine. Their goal is to create the necessary concentration of an active substance. However, local anesthetics themselves are drugs and usually have a number of other effects besides the anesthetic one. Therefore, it is worth considering the interaction of Cortexin with them (we will take lidocaine as an example).

Lidocaine has an anesthetic effect due to its capacity to reduce the excitability of nerve cell membranes. However, this ability also causes the antiarrhythmic effect of this drug. When using lidocaine, one may develop such side effect as a decrease in heart rate and a change in blood pressure. In addition, allergic reactions frequently develop upon the injection of this drug. It was discovered that the use of local anesthetic lidocaine as a solvent for the preparation of a solution is associated with an increase in the severity of undesirable reactions, and therefore its simultaneous use with Cortexin is not recommended. But at the same time, there is a local anesthetic that can be safely used together with Cortexin as a suitable solvent - it is procaine (novocaine).

The simultaneous use of several drugs is a complex issue. It is necessary to take into account the chemical structure of the drugs, their action mechanisms and the general condition of the patient. An optimal option is to use drugs strictly as prescribed by your doctor, having previously read the official instructions for the use of each one.

Doctor's Review

We've also prepared the video of doctor's review of Cortexin! In this video, you can find more information about the directions for use, speech development, side-effects, dosage and duration of treatment. The review is given by the doctor-psychotherapist of the highest category with the years of practice, Candidate of Medical Sciences: Galushchak Alexander Vasilievich.


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