Ah, the last day of summer… The perfect time for our August monthly report.
Here are some interesting data from our store:
- 30 orders were dispatched from our US warehouse and the average transit time is even lower this month - only 2.8 days on average. Some of our clients even reported that they got their parcel on the next day! Which makes it the fastest delivery of brand-name nootropics on the market!
- Good news from the Russian post! There were no delays this month and average shipping time went down from 20 days to 12.6 days with the regular international mail.
- Reshipments share went down to 0%. We did not need to do any reshipments at all this month and hope this trend will continue.
- EMS shipping times are going down as well. On average our US clients get their EMS parcels in 8 days. Really fast!
- New popular product is Picamilon - pretty much “universal” nootropic that we have posted video about recently https://www.youtube.com/watch?v=2KyUTKVb17Q Try it out yourself in our store: https://cosmicnootropic.com/collections/nootropics/products/picamilon
- We are happy that our clients share their thoughts about us! We’ve received over 15 useful reviews on our website this month and will be happy if you could recommend us on facebook as well!
Thank you for the continued support and we will continue to provide best service and brand name nootropics to our customers all over the world.
As of today, anxiety disorders are one of the most common psychological disorders in the world. According to statistics, about 18% of the population in the United States suffer from anxiety disorders, and most of such people do not receive the needed treatment.
The typical treatment for anxiety is Benzodiazepine tranquilizers. They usually act by binding to the benzodiazepine receptor site on the GABA-A receptors. Benzodiazepines have a pronounced anti-anxiety effect, but they also have significant side effects e.g. drowsiness, muscle relaxation, cognitive impairments, addiction potential.
The following article is a review of the GABAergic drugs that are mostly used in the former Soviet Union and might be a good alternative to benzodiazepines.
Pantogam (Hopantenic acid) is a Vitamin B5 derivative with anxiolytic activity. It is used since 1970’s n several countries as a treatment for epilepsy, developmental delays, anxiety disorders and chronic fatigue. Hopanthenic acid acts by interacting with D2 dopamine, GABA-A, and GABA-B receptors. Moreover, it does have pronounced cholinergic action, thus having a positive effect on cognitive functions.
Pantogam has a novel racemic modification called “Pantogam Active”, which is marketed since 2008. The modified version has more pronounced anxiolytic and anticonvulsant effect because of the different racemic mixture.
Afobazole (Fabomotizole) is a Russian anxiolytic drug developed in the 2000’s, which was primarily designed and used for anxiety management. Afobazole has a unique mechanism of action. It is not habit-forming since it has no affinity with GABA receptors. However, Fabomotizole restores the sensitivity of GABA receptors to endogenous ligands. Fabomotizole interacts with Melatonin MT1/MT3 receptors, sigma-1 receptors and has been shown to possess neurotrophic properties.
Adaptol (Mebicar) is a urea derivative with anxiolytic and nootropic action that is used in medicine since 1979. The mechanism of action of Mebicar is complex; it appears to have an influence on all major monoamine systems in the brain with moderate cholinergic and anti-excitotoxic effects.
One of the most important properties of Adaptol is its low toxicity. Russian medical journal “Psychiatry” reported a case when a patient with schizophrenia took 80 pills of Adaptol (24 grams) daily for two months in his attempt to self-medicate. His subjective well-being remained unchanged and he showed no symptoms of intoxication after a medical examination.
Grandaxin (Tofisopam) is a benzodiazepine tranquilizer with unique pharmacological atypical for commonly used benzodiazepines. It is used since 1970’s as anxiolytic drug in several countries, mostly Russia and Hungary.
Tofisopam is a 2,3-benzodiazepine derivative, while most widely used BZDs like Lorazepam are 1,4 benzodiazepine derivatives. Because of such structural differences, it has a different mechanism of action. One of the most important benefits of Grandaxin over typical Benzos is the lack of addictive potential.
Rather than causing sedation and impairment of cognition, Tofisopam was shown to produce a subtle stimulant effect by increasing the sensitivity of dopamine receptors. It does not bind to benzodiazepine receptors but is able to potentiate the effect of other BZDs.
Phenibut (Beta-Phenyl-GABA) was designed in the 1960’s by Soviet scientist as a non-sedating anxiolytic drug.
Initially, it was used by astronauts; as of today, Phenibut is widely prescribed by Russian doctors for the treatment of anxiety disorders, chronic fatigue, insomnia and alcohol withdrawal syndrome.
Phenibut acts as a GABA-B receptors agonist and is able to increase dopamine levels in the brain. This drug is highly effective for anxiety, however, it may be habit-forming if used irresponsible and is known for its abuse potential.
Picamilon (nicotinoyl GABA) is a derivative of GABA and niacin (Vitamin B3) developed for the needs of Soviet psychiatry.
Unlike GABA itself, Picamilon is able to penetrate the blood-brain-barrier and produce an anxiolytic effect. Besides that, the drug does have nootropic properties and is shown to improve cerebral blood flow and glucose/oxygen uptake by the brain.
Mexidol (emoxypine succinate) is a Russian antioxidant drug with pronounced nootropic and anxiolytic activity. It is close to pyridoxine (Vitamin B6) by its chemical structure. Since its invention in the 1980’s, Emoxypine is widely used in Russian medicine as a treatment for cerebrovascular disorders, traumatic brain injuries, chronic fatigue, anxiety disorders and alcohol withdrawals. Mexidol is often used recreationally to protect the brain from the toxic effect of alcohol consumption and prevent hangovers.
Although this drug does not bind to GABA receptors, it does increase their sensitivity, thus providing the anxiolytic effect. According to studies, a coadministration of Mexidol with Phenazepam in low therapeutic doses provides the same anxiolytic response as Phenazepam alone in 10x higher dose.
Stresam (Etifoxine) is a benzoxazine derivative with anxiolytic action developed in 1966 in Germany. Currently, it is manufactured in France and is used in over 42 countries across the world, mostly in Russia and South Africa.
Etifoxine provides anxiolytic effect comparable to that of Lorazepam and Diazepam, without causing adverse effects that are typical for benzodiazepines.
Stresam acts by interacting with GABA-A receptors on a different binding site than benzodiazepines. It also stimulates the synthesis of endogenous neurosteroids with anxiolytic activity and does have neurotrophic properties. Etifoxine should be taken with caution as it may cause allergic reactions and can be hepatotoxic.
Phenazepam is a benzodiazepine tranquilizer developed in the 1974 in Soviet Union.
The drug is widely used in post-soviet states. Its pharmacological action, side effects and indications for use are similar to that of other benzodiazepine drugs. Just as other 1,4-BZDs, Phenazepam has addictive potential.
Currently, Phenazepam, Gidazepam, and Tofisopam are the only benzodiazepine derivatives that are not considered as narcotic drugs in Russia.
Gidazepam is a benzodiazepine tranquilizer that is currently used as a mild anxiolytic in Ukraine. It appears to have mild antidepressant effect and less severe side effect compared to other benzodiazepines; thus, Gidazepam the official indications for use include neurasthenia which is uncommon for BZDs.
Here some reasons why several brain supplements are no longer available in our store.
Significant share of popular factory-produced nootropics and brain supplements has disappeared from the market over the past months. Those include Ladasten (Bromantane), Phenilpiracetam (Phenotropil), Encepahbol (Pyritinol), Bemitil (Metaprot).View full article →
We all are afraid of ageing and, at least subconsciously, we all would want to slow it down. That's why we use cosmetics and plastic surgery. That's also why we eat healthy, do sports, take vitamins and dietary supplements.
For centuries scientists have been racking their brains over the possibility to control the mechanisms underlying the ageing process. How many examples of "elixirs of youth" and "elixirs of immortality" can we count throughout our history? But unfortunately until now all this was just an invention of charlatans or incorrigible romantics.
Today, the science has made a huge step up with regards to lengevity. Although no one talks about immortality and eternal youth these days, but the postulate, that ageing is a fatal process that cannot be prevented is no longer an axiom. More and more researchers agree that, in fact, a human body is designed for 120-150 years of life, and aging is nothing more than an integral complex of disorders and specific age-related diseases that can and should be fought off. One of the scientists that have devoted his carrier to ageing was Vladimir Skulachev, an outstanding Russian biochemist, who have been working on the creation of a tool, which would improve the life quality and life expectancy. It is he, who proved the existence of so-called mitochondrial electricity in the 70's and he, who is, by far, one of the most quoted biochemists in the world press.
Academician Skulachev supports the hypothesis that one of the main causes of aging is nothing more than a slow self-poisoning of the body. The fact is that the mitochondria in our cells produce free radicals that cause a lot of damage to these cells and, as time goes, these free radicals activate the cell self-destruction program. Thus, if one neutralizes free radicals within the mitochondria, the aging program can be slowed down. Years-long investigations allowed the Skulachev`s research group to develop a mitochondrial antioxidant SkQ, Skulachev's Quinone, based on plastoquinone (a substance extracted from the most oxygenated place in the wild - chloroplast of the plants). SkQ accumulates in mitochondria, captures and neutralizes free radicals right at the site of their formation. Due to these unique properties the effectiveness of the SkQ antioxidant is 1000 times greater than that of the other well-known antioxidants, including famous coenzyme Q10. As a result, SkQ is able to prevent, slow down or even reverse the development of many aging signs, including age-related diseases. No one promises to double life expectancy, but certain things are already real, some of which are an approximately 10% life extension (mainly due to the reduction in middle-age mortality), improvement of life quality and an escape from the age-related conditions of body organs.
More than 300 people from 40 organizations around the world have been taking part in the Skulachev Project, including Academicians, Nobel Prize winners and Ph.Ds from the leading scientific and medical centers in Russia, Germany, Sweden, Holland, Austria, Israel, USA, Canada and Australia. The products are approved for use in Russia and also passed a number of clinical trials before the US FDA, which is very hard for a non-US company. Their work has already resulted in 4 products based on SkQ molecules: eye drops "Visomitin", rejuvenating serum "Mitovitan", anti-aging concentrate "MitoVitan Active" and regenerating cream-gel "Exomitin". The pills for oral administration "Plastomitin" with a system-wide action are under development.
The official website of the SkQ-project is here. We are happy to be one of the first cross-border vendors of this product line. Want to try?
|Exomitin® (regenerating antioxidant hydrogel)||MitoVitan Active® (mitochondrial antioxidant concentrate)||MitoVitan® (anti-aging serum)|
So, who knows, maybe age is just a number printed in the ID card, nothing more? And what do you think? :)
The wrong choice or administration of the medicine will not have the desired effect (as a minimum), or can lead to sad results (as a maximum).