Dosage and administration
Orally, after a meal.
For adults with body mass below 80kg – two capsules in the morning, one capsule in the daytime (3 capsules a day).
For adults with body mass above 80kg – two capsules in the morning, two capsules in the daytime (4 capsules a day).
The drug should be taken by a 5-days course. To avoid accumulation, another 5-day days course is suggested after a two days break.
To increase working performance in extreme conditions the drug should be taken 40-60 minutes prior to work at the 500-750mg dosage. The maximum number of courses – two 5-day courses with two days break.
The frequency of side effects: very often (above 10%), often (1-10%), infrequent (0.1-1%), rare (0.01-0.1%), very rare (<0.01%, including isolated cases with undefined frequency).
Central nervous system: very often – headaches, facial hyperemia, sleep disturbances, anxiety; very rare – paresthesia, spasms.
Cardiovascular system: very rare – hypertension, tachycardia.
Digestive system: rare – nausea, vomiting, liver and stomach discomfort.
Allergic reaction: often – hives, allergic conjunctivitis, allergic rhinitis If the side effects occur, including those that were not listed in this instruction, you should cease using the drug and seek a medical advice.
ContraindicationsHypersensitivity to any ingredients of the medication, hypoglycemia, pronounced liver dysfunctions, epilepsy, psychomotor agitation, arterial hypertension, glaucoma, ischemic heart disease, arrhythmia, lactase deficiency, lactose intolerance, glucose-galactose malabsorption, pregnancy, lactation and age below 18 years.
Symptoms: agitation and sleep disturbances.
If the signs of the overdose occur, the dosage should be reduced or the treatment ceased. Overdose treatment: gastric lavage, administration of activated charcoal, if necessary, symptomatic therapy.
Do not take in the evening time (may cause sleep disturbances). While taking this drug, a constant monitoring of arterial pressure is necessary. The usage of drug Bemitil is not recommended for people with suicidal behavior and for those who experienced suicidal thoughts before treatment. In case of behavior alteration or appearance of suicidal thoughts, patients should inform their doctor immediately.
Country of Manufacture: Belarus
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Developed in the Soviet Union for the needs of the military, Bemitil (also known as Metaprot and AntiHot) has a long history of usage in clinical practice and in sport. It was developed in the 1970s and was successfully used during Afghanistan war, Chernobyl catastrophe and Olympic games in Moscow.
The drug has nootropic, regenerative, antihypoxic, antioxidant and immunomodulatory action.
The main purpose of Bemitil is increasing the physical and mental performance in people exposed to stressful conditions, and accelerating the recovery process after physical exertion. That makes it useful for athletes, especially for bodybuilders and runners. What is important is that Bemitil can be taken by healthy individuals.
But sport is not its only off-label usage. Bemitil works synergistically with other nootropics and can potentiate their effect, which makes this drug a possible part of a nootropic stack. According to clinical studies, the combination of Metaprot with the standard nootropic therapy is significantly more effective in the treatment of chronic fatigue, than a standard therapy alone.
Bemitil has quite a wide field of application in the clinical practice, too. In Russian medicine, this drug is used in the complex treatment of:
- Asthenic conditions (chronic fatigue)
- Traumatic brain injuries
- Meningitis, encephalitis
- Cerebrovascular and cognitive disorders
Mechanism of action
The chemical structure of Bemitil is similar to that of nucleobases adenine and guanine, which can explain its pharmacological effects.
Bemitil does increase the expression of RNA and proteins in the skeletal muscle, brain cells, liver, and kidneys. It also stimulates ATP formation and gluconeogenesis. Gluconeogenesis is the process of formation of glucose from non-carbohydrate substrates, such as lactate, fats and glucogenic amino acids, which plays an important role in the energy supply during exercise. Fasting, physical exercises and a low-carb diet rich in proteins and fats have also shown to stimulate gluconeogenesis.
Country of Manufacture: Belarus
Here you can read more Review and clinical trials of Metaprot