ACTOVEGIN ®

Dosage and administration

Pills:

Take 1-2 tablets 3 times per day prior to meals. Do not chew the tablet. Drink some water after the administration. The course of treatment is 4-6 weeks.

Injections:

Inject 5-10 Ml intramuscularly or intravenously 3-4 times per week. (In case of mild metabolic disturbances the dose is 5 Ml; In case of severe metabolic disturbances, injuries and strokes the recommended dose is10 Ml)

Side effects

As a rule, the compounds of Actovegin are very well tolerated. However, depending on the ROA and the dose, the drug can cause allergy reactions.

Overdose

Overdose cases have not been reported.

Country of Manufacture: Norway

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Many decades ago shepherds in Switzerland noticed that young calves are able to heal their injuries and regenerate their tissue much faster than older calves. However, it was only in 1957, when Swiss scientists obtained a highly purified extract from blood of young calves and developed the drug.

Actovegin enhances aerobic oxidation, absorption of glucose and oxygen uptake in tissue. For this reason Actovegin has been used by athletes who wanted to speed up the recovery process and enhance physical performance and stamina. It is also a great drug to treat various sport injuries.

From a medical viewpoint, Actovegin has the following treatment applications::

  • Malfunction of the blood circulation and trophic disturbances in the brain;
  • Impairment of peripheral blood circulation and associated diseases;
  • Dermal transplants and acute and chronic wounds.

The drug is a combination of various physiologically active ingredients:

  • Amino acids, e.g. ornithine, leucine, alanine, glutamate, proline, glycine, taurine, etc;
  • Oligopeptides;
  • Lipids;
  • Oligosaccharides;
  • Nucleosides, e.g. adenosine, uridine;
  • Antioxidants;
  • Electrolytes, e.g. Na, Cl, K, Mg, Ca, F, Fe;
  • Microelements, e.g. Cu, Si, Se, Zn.

The organic compounds account for 30% of the extract. As a starting material the blood of young calves less than 3 months is used. The extract is obtained by ultrafiltration method, which insures that there are no prion.

As of 2015, Actovegin has been approved in 17 countries including Russia, China, South Korea, Latvia and some others.

Country of Manufacture: Norway

Legal Disclaimer

This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.

This product is not intended to diagnose, treat, cure, or prevent any disease.

  1. A Fomin, D Pershakov (2015) Actovegin in treatment of critical limb ischemia https://www.ncbi.nlm.nih.gov/pubmed/26356060
  2. Guekht et al (2013) A Randomised, Double-Blind, Placebo-Controlled Trial of Actovegin in Patients with Post-Stroke Cognitive Impairment: ARTEMIDA Study Design https://www.ncbi.nlm.nih.gov/pubmed/24516413
  3. Brock et al (2018) Update on the Role of Actovegin in Musculoskeletal Medicine: A Review of the Past 10 Years https://www.ncbi.nlm.nih.gov/pubmed/29337720
  4. Melin et al (2014) Treatment with Actovegin improves spatial learning and memory in rats following transient forebrain ischaemia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190908/
  5. Guekht et al (2017) ARTEMIDA Trial (A Randomized Trial of Efficacy, 12 Months International Double-Blind Actovegin): A Randomized Controlled Trial to Assess the Efficacy of Actovegin in Poststroke Cognitive Impairment https://www.ncbi.nlm.nih.gov/pubmed/28432265
  6. Ziegler et al (2009) Treatment of Symptomatic Polyneuropathy With Actovegin in Type 2 Diabetic Patients https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713653/
  7. Trofimova et al (2016) An experimental in vitro study of antioxidant and antiradical properties of cytoflavin, vinpocetine, actovegin and ethylmethylhydroxypyridine succinate https://www.ncbi.nlm.nih.gov/pubmed/27500876
  8. Y Vakhrushev, M Lyapina (2017) Correction of small bowel function as a new direction for treating patients with metabolic syndrome https://www.ncbi.nlm.nih.gov/pubmed/28914850
  9. Elmlinger (2011) Neuroprotective and Anti-Oxidative Effects of the Hemodialysate Actovegin on Primary Rat Neurons in Vitro https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220826/
  10. Ziegler et al (2017) Predictors of response to treatment with actovegin for 6 months in patients with type 2 diabetes and symptomatic polyneuropathy https://www.ncbi.nlm.nih.gov/pubmed/28438471
  11. Ziegler et al (2009) Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients https://www.ncbi.nlm.nih.gov/pubmed/19470838
  12. Machicao et al (2012) Pleiotropic neuroprotective and metabolic effects of Actovegin's mode of action https://www.ncbi.nlm.nih.gov/pubmed/22910148
  13. Dieckmann et al (2012) Treatment with Actovegin® improves sensory nerve function and pathology in streptozotocin-diabetic rats via mechanisms involving inhibition of PARP activation https://www.ncbi.nlm.nih.gov/pubmed/22020669
  14. Baiandin et al (1992) The effect of trental and actovegin on the organs of vision when administered into the end periorbital branches of the ophthalmic artery (experimental research) https://www.ncbi.nlm.nih.gov/pubmed/1295186
  15. Safarova et al (2018) Methods of augmentation of antidepressant therapy (on the model of complex therapy with the inclusion of actovegin) in gerontopsychiatric hospital https://www.ncbi.nlm.nih.gov/pubmed/30346435
  16. Elmlinger et al (2011) Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro https://www.ncbi.nlm.nih.gov/pubmed/21983748


Type: Peptides




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