Magne B6

Formulation and Packaging

Coated tablets. Active ingredients: magnesium lactate dihydrate 470 mg (equal to 48 mg of Mg2+, or magnesium ion) and pyridoxine hydrochloride 5 mg.

Inactive ingredients: sucrose, heavy kaolin, acacia gum, carbomer 934, talc and magnesium stearate.

Solution for oral administration in ampoules of 10 ml. Active ingredients: magnesium lactate dihydrate 186 mg and magnesium pidolate 936 mg (in aggregate equal to 100 mg of Mg2+) and pyridoxine hydrochloride 10 mg.

Inactive ingredients: sodium disulfite, sodium saccharin, cherry-caramel flavoring and purified water.

Application and Dosage

Coated tablets: Daily dose is 6-8 tablets for adults and 4-6 tablets for children from 6 years of age. It is recommended to divide the daily dose into 2-3 administrations. Take the tablets with meals washed down by a glass of water.

Average length of treatment course is one month.

Once the amount of magnesium stabilises, it is recommended to discontinue treatment.

How to open an ampoule: Take the ampoule’s narrow section, cover it with a piece of cloth and remove it.


  • acute kidney failure;
  • phenylketonuria;
  • children under 6 years (for tablets) or under 1 year (for solution);
  • fructose intolerance;
  • glucose or galactose malabsorption;
  • sucrase-isomaltase deficiency;
  • hypersensitivity to the components of the drug.

It is recommended to use the drug with caution in patients with chronic kidney disease in stages other than acute as it may cause hypermagnesemia.

Drug Interaction

Co-administration with drugs containing phosphates and calcium salts reduces magnesium absorption from the digestive system.

Magne B6 reduces absorption of tetracycline and iron.

It also lowers the effect of clot-busting drugs.

Pyridoxine inhibits the activity of levodopa.

Side Effects

Abdominal pains, nausea, vomiting, flatulence, constipation or allergic response.


Magnesium overdose does not cause intoxication in patients with normal kidney function. Though it may occur in patients with chronic kidney disease. 

The symptoms include low blood pressure, nausea, vomiting, depressive disorder, slowing reflexes, respiratory depression, coma, cardiac arrest, heart paralysis and anuria.

Recommended treatment: rehydration and forced diuresis. In case of chronic kidney disease hemodialysis or peritoneal dialysis may be required.

Storage Conditions and Shelf Life

Tablets: store in a dark place at a temperature not higher than 25°C. Shelf life is 2 years.

Solution for oral administration: store in a dark place at a temperature not higher than 25°C. Shelf life is 3 years.

Keep out of the reach of children.

Magne B6 is a drug intended to restore the amount of magnesium in the body. Magnesium is the eleventh most abundant element by mass in the human body and is essential to all cells and some 300 enzymes. Magnesium ions interact with polyphosphate compounds such as ATP, DNA, and RNA. Hundreds of enzymes require magnesium ions to function. It is engaged in transmission of nerve impulses and muscle contraction. Normal levels of magnesium are important for the maintenance of heart and nervous system function.

The body consumes magnesium with food. Its deficiency may occur as a result of eating disorders (including reduction diets) and an increased need for magnesium in case of intense physical or mental activity, stress, pregnancy or the use of diuretics. Losses of magnesium from the kidneys also become a common cause of magnesium deficit.

Pyridoxine (vitamin B6), one of the drug’s main ingredients, participates in various metabolic processes, and in regulating metabolism of the nervous system, in particular. It improves magnesium absorption from the digestive system into the body’s cells.

The normal adult value for magnesium is 1.5-2.5 mEq/L. Lesser amounts are the evidence of magnesium deficiency, also known as hypomagnesemia. It may cause fatigue or muscle weakness, mental numbness and lack of emotion. Scientists have suggested that deficiency may also cause anxiety and raise blood pressure.


Magnesium deficiency (might be in combination with other deficiencies) with increased irritability, sleep disorders, stomach cramps, palpitations, fatigue, pain and muscle cramps or tingling sensation.

  1. Martineau et al (1985) Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism
  2. J Eisinger, J Dagorn (1986) Vitamin B6 and magnesium
  3. Kalinin et al (2004) A use of Magne-B6 in the treatment of anxiety-depressive states in patients with epilepsy
  4. O Nogovitsina, E Levitina (2006) Effect of MAGNE-B6 on the clinical and biochemical manifestations of the syndrome of attention deficit and hyperactivity in children
  5. Fathizadeh et al (2010) Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome
  6. Ebrahimi et al (2012) Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms
  7. Pouteau et al (2018) Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial

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