Leuzea-P (Rhaponticum carthamoides or Maral root)

Dosage and administration: 2-3 Leuzea (Rhaponticum) pills should be taken 3 times a day with food during 2-3 weeks.

Side effects (rarely): headache, sleep disturbance, allergic reactions, hypertension and indigestion.

Contraindications: hyperexcitability, insomnia, hypertension, pregnancy and lactation, apparent atherosclerosis, cardiac disturbance, epilepsy, hypersensitivity, age below 12 years.

Special instructions: the supplement contains vitamin C.

Country of manufacture: Russia.

To be used as a food supplement.

Leuzea (Rhaponticum) has been used in traditional Siberian medicine to bolster both physical and mental performance (especially after illness). The major requirement associated with Leuzea is the enhancement of physical strength and muscle protein synthesis. The other indications for use include mental and physical fatigue, asthenia, exhaustion, decreased mental and physical capacity, irritability, headache, chronic alcoholism, erectile dysfunction.

Leuzea regulates the nervous, sensory, hormonal, cardiovascular and digestive systems, metabolism and energy, immunity and reproduction. In case of deviations and failures in the system of homeostasis, the mechanisms of self-regulation and restoration of the vital functions of the body to the optimum values ÔÇőÔÇőare activated; regulates the production, utilization and balance of specific products of metabolism, corrects the immunodeficiency and maladaptive states.

Leuzea has a tonic, adaptogenic, and antioxidant effect; reduces allergic reactions, dermatitis, asthmatic and autoimmune conditions, normalizes the activity of the endocrine system of the body; restores humoral and cellular immunity, has a nootropic and psycho-energizing action.

Many users report that Leuzea promotes clarity of mind and gives energy like coffee, but does not overstimulate your nervous system. So you can stay awake and productive not worrying about agitation and headache.

Leuzea P is recommended for use for:

  • adaptation of the body to increased physical and mental stress,
  • performance enhancement,
  • cheerfulness,
  • recovery after serious illness and exhaustion,
  • reduction of fatigue, irritability,
  • libido stimulation (due to the high content of ecdysten).

Leuzea P is recommended for athletes to prepare for competitions, because it:

  • increases the amplitude of the heartbeat,
  • expands peripheral blood vessels and increases blood flow,
  • removes lactic acid from the muscles
  • increases endurance, reduces fatigue.

  1. Bespalov et al (1992) The inhibiting effect of phytoadaptogenic preparations from bioginseng, Eleutherococcus senticosus and Rhaponticum carthamoides on the development of nervous system tumors in rats induced by N-nitrosoethylurea https://www.ncbi.nlm.nih.gov/pubmed/1300820
  2. Plotnikov et al (2005) Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia https://www.ncbi.nlm.nih.gov/pubmed/16193651
  3. Gaube et al (2008) Effects of Leuzea carthamoides on human breast adenocarcinoma MCF-7 cells determined by gene expression profiling and functional assays https://www.ncbi.nlm.nih.gov/pubmed/18975255
  4. L Kokoska, D Janovska (2009) Chemistry and pharmacology of Rhaponticum carthamoides: a review https://www.ncbi.nlm.nih.gov/pubmed/19457517
  5. Borrione et al (2012) Consumption and biochemical impact of commercially available plant-derived nutritional supplements. An observational pilot-study on recreational athletes https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407721/
  6. Dushkin et al (2014) Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905158/
  7. Skala et al (2015) Establishment of Hairy Root Cultures of Rhaponticum carthamoides (Willd.) Iljin for the Production of Biomass and Caffeic Acid Derivatives https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354965/
  8. Skala et al (2016) Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells https://www.ncbi.nlm.nih.gov/pubmed/27034736
  9. Skala et al (2016) The Essential Oils of Rhaponticum carthamoides Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities https://www.ncbi.nlm.nih.gov/pubmed/27034736
  10. Skala et al (2016) Inhibition of human glioma cell proliferation by altered Bax/Bcl-2-p53 expression and apoptosis induction by Rhaponticum carthamoides extracts from transformed and normal roots https://www.ncbi.nlm.nih.gov/pubmed/27696406
  11. Wu et al (2017) Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats https://www.ncbi.nlm.nih.gov/pubmed/28373010
  12. Skala et al (2018) Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines https://www.ncbi.nlm.nih.gov/pubmed/30622675
  13. Skala et al (2018) Rhaponticum carthamoides transformed root extract inhibits human glioma cells viability, induces double strand DNA damage, H2A.X phosphorylation, and PARP1 cleavage https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269353/
  14. Glazowska et al (2018) Chromatographic separation, determination and identification of ecdysteroids: Focus on Maral root (Rhaponticum carthamoides, Leuzea carthamoides) https://www.ncbi.nlm.nih.gov/pubmed/30303602





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