STRESAM ® [Etifoxine]

Side Effects

Rare allergic reactions and sleepness.


Overdose effects have not been observed, even when increasing the active doses over 100-fold.


When not treated, emotional stress tends to have physical manifestations.

Country of Manufacture: France

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Developed in the 1960s, Etofoxine was one of several anxiolytics with enough potential to replace benzodiazepine drugs. It has anxiolytic properties and can relieve various psychosomatic disorders, while not having negative effects on psychomotor and cognitive domains. From 1995 untill 2007, Etofoxine was used to treat more than 11.3 mln patients. It is approved in more than 40 countries. It also does not cause addiction, tolerance or withdrawal syndroms.

One interesting property of Etofoxine that was discovered only recently is its possible use as a neuroprotector. Etofoxine was shown to promote neuron growth; in particular, Etofoxine accelerates axonal regeneration and might be a treatment for polyneuropathy. Furthermore, Etofoxine was also proven to have the ability to alleviate mild depressions.

Overall, etofoxine is a safe drug with few side effects that has the potential to alleviate a wide range of symptoms:

  • Anxiety-asthenic disorders
  • Various psychosomatic disorders
  • Mild depressions
  • Chronic pain syndrome
  • Alcohol withdrawal syndrome
  • Country of Manufacture: France

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    This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.

    This product is not intended to diagnose, treat, cure, or prevent any disease.

    1. Micallef et al (2001) A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected]
    2. Hamon et al (2003) The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit
    3. Nhuyen et al (2006) Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice
    4. Ugale et al (2007) Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats
    5. Girard et al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery
    6. Verleye et al (2011) Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits?
    7. Zhou et al (2013) Etifoxine promotes glial derived neurotrophic factor induced neurite outgrowth in PC12 cells
    8. Aouad et al (2014) Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy
    9. Choi et al (2015) Etifoxine for pain patients with anxiety
    10. Y Choi, K Kim (2015) Etifoxine for Pain Patients with Anxiety
    11. Rego et al (2015) The Non-Benzodiazepine Anxiolytic Drug Etifoxine Causes a Rapid, Receptor-Independent Stimulation of Neurosteroid Biosynthesis
    12. D Stein (2015) Etifoxine Versus Alprazolam for the Treatment of Adjustment Disorder with Anxiety: a Randomized Controlled Trial
    13. Simon-O’Brien et al (2016) Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury
    14. Ravikumar et al (2016) Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of Multiple Sclerosis
    15. Bouillot et al (2016) A microPET comparison of the effects of etifoxine and diazepam on [(11)C]flumazenil uptake in rat brains
    16. Costa et al (2017) The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity
    17. Poisbeau et al (2018) Anxiolytics targeting GABAA receptors: Insights on etifoxine
    18. Deplanque et al (2018) Etifoxine impairs neither alertness nor cognitive functions of the elderly: A randomized, double-blind, placebo-controlled crossover study

    Type: Nootropics