Stimol®
Stimol® Instruction
International Non-Proprietary Name (INN) | Citrulline malate |
Dosage form | Oral solution 100 mg/1 ml: sachets 10 ml, 18 pcs. |
Structure | Active ingredient: citrulline malate. Excipients: natural sangria orange flavor – 0.1 g, 30% sodium hydroxide solution – 0.1886 g, purified water – up to 10 ml. 10 ml – sachets made from a paper-polyethylene-aluminum complex (18) – cardboard boxes. |
Description | Oral solution in the form of a colorless or yellowish liquid with an orange scent |
Pharmacological classification | General tonic |
ATC code | A13A |
Pharmacological action | A medication used for asthenic conditions |
Pharmacological Action
It has an anti-asthenic effect and promotes liver detoxification.
Citrulline is an amino acid involved in the liver’s process of neutralizing ammonia, which is produced from the breakdown of nitrogen-containing compounds. In the liver, ammonia is converted into urea. Citrulline is incorporated into the urea cycle, enhancing the elimination of ammonium ions.
Malate participates in the Krebs cycle and gluconeogenesis, reducing blood lactate levels, supporting metabolic normalization, and activating the body’s non-specific defense mechanisms.
Pharmacokinetics
Absorption
After oral administration, the medication is rapidly absorbed from the gastrointestinal tract. The maximum plasma concentration (Cmax) is reached approximately 50 minutes after ingestion. It is quickly cleared from plasma, with plasma concentrations approaching physiological levels within 6 hours.
Metabolism and Excretion
Since the active component is incorporated into cellular metabolic processes, only small amounts are found in the urine.
Intended uses
Symptomatic treatment of functional asthenia:
– Asthenic syndrome
– Overwork
– Increased fatigue
– During recovery after illness
Dosage and Administration
Stimol® should be taken during meals by mixing the contents of the sachet with approximately 100 ml of plain or sweetened water.
– For adults and elderly individuals: 3.0 g (contents of 3 sachets) per day.
– For children aged 5 and older: 2.0 g (contents of 2 sachets) per day.
The course of treatment is 10-12 days. Repeat courses are possible after a break (1-3 months) or as recommended by a physician.
Side Effects
Possible: in some cases, transient abdominal pain and allergic reactions may occur at the beginning of treatment.
Contraindications
– Increased sensitivity to the medication
– Peptic ulcer disease in the acute stage
– Age under 5 years
Use During Pregnancy and Breastfeeding
The use of Stimol® during pregnancy and lactation is justified when the expected benefits outweigh the potential risks.
Use in Children
The use in children under 5 years of age is contraindicated.
Special Precautions
Each sachet contains approximately 30 mg of sodium. This should be taken into account for patients on a sodium-restricted diet.
As the formulation does not contain sugar, the medication can be prescribed to patients with diabetes mellitus.
Overdose
Data on the overdose of Stimol® are not available.
Drug Interactions
Data regarding any drug interactions with Stimol® are not available.
Storage Conditions
The medication should be stored out of reach of children at a temperature between 15°C and 25°C.
Shelf Life
The shelf life is 3 years. The medication should not be used after the expiration date indicated on the packaging.
Dispensing Conditions
The medication is available without a prescription.
Manufacturer
Biocodex, France.