National Health Commission of the People’s Republic of China has selected Umifenovir (ARBIDOL®) as a medication to treat coronavirus 2019-nCoV. There are also a number of studies showing it’s effectiveness against ARVI and influenza.

Read more in these blog posts:

You will find a bunch of useful information and links about Arbidol there. 

Arbidol is a broad-spectrum antiviral drug used in the treatment of influenza A and B infections (including swine and avian) and other ARVI and rotavirus pathogens. The drug inhibits fusion between the viral capsid and the cell membrane of the target cell. This prevents viral entry to the target cell, and therefore protects it from infection.

Arbidol was developed in the USSR by a team of scientists from All-Union Scientific Research Chemical-Pharmaceutical Institute, Institute of Medical Radiology of USSR Academy of Medical Sciences and Leningrad Bacteriological and Diagnostic Institute. The international nonproprietary name is Umifenovir. The tests conducted in the USSR and later in Russia showed that the drug has significant antiviaral effects; for instance, in a direct comparison with Tamiflu, Arbidol was shown to achieve a similar efficiency both in vitro and in a clinical setting.

Arbidol reduces the severity of influenza and ARVI and minimizes the incidence of complications. Prophylactic administration significantly reduces the risk of infection in case of contact with a patient with influenza or ARVI. Arbidol exhibits modulatory effects on the immune system. The drug stimulates a humoral immune response (the growth of T-cells, T-helpers and NK cells), induces interferon-production, and stimulates the phagocytic function of macrophages. The drug has also been investigated as a candidate drug for the treatment of hepatitis C.

Arbidol is a low-toxic drug. It is quickly absorbed and distributed to the organs and tissues of the body. Then, it is metabolized in the liver.

Indications (off-label):

 

  • Prevention and treatment of influenza A and B infections and ARVI;
  • As part of complex therapy of recurrent herpetic infection;
  • Prevention of postoperative infectious complications;
  • As a part of complex therapy of rotavirus infections.