Ethoxidol is a combination drug that inhibits free radical processes and has antioxidant, membrane-protective, anti-hypoxic, nootropic, anti-convulsant, anxiolytic and stress-protective effect. It contains ethylme-thylhydroxypyridine malate, which is a compound that is very closely related to another drug Mexidol. Ethoxidol was shown to be more effective than Mexidol in cardiac antiarhythmic effects, while other effects were very similar.

Apart from that it should be noted that Ethoxidol contains other active ingredients such as dimethylethanolamine (DMAE), N-Acetyl-DL-glutamic acid and glycine.

Ethoxidol can be used in anti-ischemic therapy as it stimulates blood flow in the penumbra. It also reduces total cholesterol and low-density lipoproteins.

The drug increases resistance towards various damaging factors, as well as pathological conditions such as shock, hypoxia, ischemia, cerebrovascular ac-cidents and intoxication with alcohol and antipsychotics (neuroleptics).

Ethoxidol improves brain metabolism, brain blood supply, microcirculation and blood’s rheological properties and reduces platelet aggregation. It stabilizes membrane structures of erythrocytes and platelets that are involved in hemolysis.

Pharmacodynamic properties

Ethoxidol’s effect is driven by its antioxidant, anti-hypoxic and membrane-protective properties. It inhibits lipid peroxidation, increases the lipid-protein ratio, stabilizes the membrane fluidity and stimulates the membrane-bound enzymes and receptors.

Pharmacokinetic properties

After ingestion, the drug is absorbed from the gastrointestinal tract and gets distributed to the organs and tissues of the body. It stays in the blood plasma for 7-10 hours. Then Ethoxidol is extensively metabolized in the liver.



  • as part of complex therapy of coronary heart disease;
  • as part of complex therapy of ischemic stroke;
  • encephalopathy;
  • mild to moderate cognitive impairment.


Hypersensitivity to the components of the drug, lactose intolerance, lactose deficiency, glucose galactose malabsorption, acute kidney injury, acute liver failure, children under 18 years of age, pregnancy and lactation.