Heptor is a drug based on ademetionine (S-Adenosyl methionine), which is currently considered one of the most powerful hepatoprotectors. Ademetionine takes part in transmethylation and is a biosynthetic precursor of cysteine, taurine and glutathione. Apart from its hepatoprotective properties, ademetionine also has anti-inflammatory, painkiller and antidepressant effects. Heptor is a choleretic and cholekinetic drug.

The use of drug in patients with osteoarthritis helps relieve pain and stimulates proteoglycan synthesis and cartilage tissue regeneration.

Heptor also has detoxifying, regenerating, antioxidant, antifibrotic and neuroprotective properties.

The drug was shown to be effective in patients with hepatopathy caused by hepatotoxic drugs.

Pharmacodynamic properties

As a hepatoprotector, Heptor replenishes ademetionine deficiency and stimulates its production in brain and liver. As a part of transmethylation, it elevates glutamine levels in the liver and increases plasma cysteine and taurine concentration. It also lowers the concentration of methionine in serum; this helps stabilize the metabolic functions of the liver. Heptor acts as a precursor of polyamines: putrescine which stimulates cell regeneration, spermidine and spermine that are compounds of ribosomes and living tissues.

Choleretic effect of the drug is driven by synthesis of phosphatidylcholine in hepatocyte membranes which increases their mobility. This enhances the function of biliary system. The drug is effective in case of bile secretion disorders, including cholestasis.

The use of Heptor in patients with opioid addiction accompanied by liver damage helps reduce manifestations of withdrawal symptoms and improves the functional state of the liver.

Antidepressant effects of the drug increase gradually starting from the 2nd week of the treatment course. Heptor treatment is recommended in case of recurrent endogenous and neurotic depressions. Research demonstrated that the drug is effective in treating depression relapse.

Indications (on-label uses)

 

  • hepatitis of various origins: toxic, viral, drug-induced (caused by antibiotics, anticancer drugs, anti-tuberculosis and antiviral drugs, tricyclic antidepressants and oral contraceptives);
  • intrahepatic cholestasis;
  • cirrhosis;
  • secondary metabolic encephalopathy;
  • depressive disorder;
  • alcohol withdrawal syndrome.

 

Counterindications

 

  • genetic disorders affecting the methionine cycle and/or causing homocystinuria/hyperhomocysteinemia;
  • children under 18 years of age;
  • hypersensitivity to the components of the drug.