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Noben is a modern neuroprotector with a universal mechanism of action. The active substance of the drug is idebenone. This is the only synthesized coenzyme responsible for the generation of energy in nerve cells. The active component of Noben was first synthesized in Japan, at the Asian pharmaceutical company Takeda Pharmaceutical, with the goal of treating Alzheimer’s disease (memory loss). Then the research was continued by European pharmacists.
A number of researchers recommend idebenone (Noben®) therapy for the treatment of various neurological disorders due its nootropic pharmacology. Indeed, as a structural analogue of CoQ10, the drug was shown to improve cerebral blood flow and oxygen delivery to human brain. It improves metabolic processes; in particular, synthesis of glucose and adenosine triphosphate (ATP) and lactate elimination. Also, idebenone slows down the process of lipid peroxidation and protects membranes of neurons and mitochondria from damage.
The drug is effective in the treatment of the following conditions:
- Multi-infarct dementia;
- Complex therapy after a stroke;
- Alzheimer’s disease;
- Cerebrovascular disease;
- In the treatment of the consequences of a traumatic brain injury;
- Comprehensive treatment of migraine.
In 2007, idebenone was described as an orphan drug for the treatment of Leber’s hereditary optic neuropathy (LHON) and later approved by the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) for the treatment of certain rare conditions.