Nooclerin ® (Deanol aceglumate) is one of the oldest nootropic drugs. It is also known as DMAE, a widely used cognitive-enhancing and anti-aging supplement.

Deanol has a history of medicinal use since 1950s; back then, it was marketed in the North America under the trade name “Deaner” as a treatment for learning disabilities, ADHD for children, chronic fatigue, and depression.

Later, the drug was discontinued by the FDA; however, it is still being used in Russian medical practice.

Indications for use are:

  • Asthenia (chronic fatigue);
  • Depression;
  • Recovery from traumatic brain injuries;
  • Alcohol abstinence syndrome;
  • Decreased mental capacity in children above 10 years of age;
  • Neurasthenia and organic brain syndrome.

According to numerous clinical trials, Deanol appears to be highly effective in patients with chronic fatigue, depression, and ADHD and has a moderate efficacy in the treatment of Tardive Dyskinesia.

Nooclerin has fewer side effects compared to amphetamine derivatives that are often used in the ADHD treatment, so it might be used as a safer alternative to Adderall. (Link)

The exact mechanism of action is still unclear. Initially, it was proposed that, DMAE as a choline precursor, is able to increase brain acetylcholine levels, thus producing a cholinergic effect. However, the results of research on the drug’s pharmacology are controversial and put into question the fact that Deanol’s primary mechanism of action is cholinergic.

More recent studies suggest that DMAE acts as a potent free radical scavenger and antioxidant, which may be responsible for its anti-aging and nootropic effects.