Stimol is a tonic drug used to treat asthenia, which may occur as a result of ageing or stress. It stabilizes metabolic processes and provides for liver detoxification. Stimol helps stimulate recovery after surgery and severe illnesses.
Stimol combines medicinal properties of malate and L-citrulline. Citrulline is an α-amino acid which participates in neutralization of ammonia in liver produced as a result of decomposition of nitrogen-containing compounds. Ammonia is then transformed into urea. Circulating citrulline concentration is a biomarker of intestinal functionality.
Malate is an important intermediate in various metabolic pathways including the Krebs cycle. In guard cells, malate concentration plays a crucial role for stomata movement. It also reduces the amount of lactate in the blood.
Citrulline malate is widely used for the treatment of patients suffering from asthenia to mitigate recovery time following physical activity. Moreover, the consistent search by athletes to obtain a competitive advantage has led to the use of it as a potential ergogenic aid. Citrulline malate has been purported to improve performance in both aerobic and anaerobic exercise modalities via a variety of mechanisms including: improved ammonia and lactic acid metabolism, increased oxygen delivery capacity via increased vasodilation and increased adenosine triphosphate production via increases in Krebs cycle intermediates.
The drug is rapidly absorbed in the intestine, and is excreted by the kidneys within 5-6 hours.
Since Stimol does not contain sugar, the drug can be used in patients with diabetes mellitus.
- hypotension and dysautonomia;
- asthenia during the recovery period after infectious diseases;
- physical or mental asthenia;
- alcohol abstinence;
- in order to improve physical performance in athletes;
- asthenic syndrome;
- recovery after surgery;
- as a tonic in ageing patients.