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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product, consulting a qualified MD is mandatory. See more

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5-Hydroxytryptophan (5-HTP) is a serotonin-producing supplement. It has antidepressant, appetite suppressant, and sleep aid properties. It is a natural amino acid extracted from the seeds of an African shrub Griffonia simplicifolia

Synonyms 5-Hydroxytryptophan / 5-HTP / Oxitriptan
Form: 30 pills
Ingredients: One pill: valerenic acid – 0.4 (±20 %) mg, magnesium – no less than 30 mg, vitamin B6 – 2 (±20 %) mg,  5-hydroxytryptophan  – 100 (±15 %) mg. Separate ingredients: Griffonia extract – 102 mg, valerian root extract – 50 mg.
Category: Food supplement
Shelf life: 2 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: OOO Kvadrat-S


What is 5-HTP?

5-HTP, or 5-hydroxytryptophan, is a natural substance that can normalize sleep, improve mood, and increase resistance to stress.

5-HTP comes from the seeds of an African shrub known as Griffonia simplicifolia. This amino acid is an intermediate product in the metabolism of tryptophan, one of the essential amino acids.

It is not produced in the human body, so it must be supplied with food. Tryptophan can be found in protein-rich foods, such as dairy products, poultry, meat, chocolate, nuts, legumes, caviar, and certain types of fish. Often this amount of amino acid is not enough and it can be provided with 5-HTP dietary supplements.

5-HTP is a chemical precursor of serotonin and melatonin. Low serotonin levels are associated with depression, anxiety, sleep disorders, weight gain, and other health problems. Thus increasing your body’s production of serotonin has various benefits.

What are the Benefits and Effects of 5-HTP?

  • 5-HTP helps with depression by increasing serotonin levels. Serotonin imbalance may lead to depression. 5-HTP supplements are thought to act as antidepressants and treat depression by increasing serotonin levels. 5-HTP helps to get rid of irritability, aggressiveness, and lethargy and can reduce anxiety and nervous tension.
  • It relieves symptoms of fibromyalgia. Supplementing with 5-HTP may improve symptoms of fibromyalgia such as general weakness and muscle and bone pain. Low serotonin levels are associated with the disorder.
  • It can help reduce migraine frequency. 5-HTP is said to help with migraines which are often accompanied by nausea or disturbed vision. While their exact cause is debated, some researchers believe migraines are also triggered by low serotonin levels.
  • 5-HTP can improve sleep by increasing melatonin production. Serotonin is converted into the hormone melatonin that regulates sleep.
  • 5-HTP can aid weight loss by increasing the feeling of fullness. 5-HTP may counteract hunger-inducing hormones, working to suppress appetite and help you lose weight. 5-HTP may also reduce excessive food intake due to stress or depression.

What is 5-HTP Used For?

The main indications for the use of the drug are:

  • depression;
  • sleep disorders;
  • chronic fatigue;
  • migraine;
  • alcoholism and drug addiction;
  • excess weight.

In addition, the 5-hydroxytryptophan will be useful during stressful periods of life that require efficiency and concentration.

Where Can I Order 5-HTP Online?

You can buy 5-HTP online from different vendors. CosmicNootropic offers 5-HTP in packs of 30 pills. We offer worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order 5-HTP and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

What is 5-HTP Dosage, How to Take It?

For adults 2 tablets in the afternoon with meals. The duration of administration – 1 month. If necessary, the course can be repeated.

What are 5-HTP Side Effects?

The side effects of 5-HTP are very weakly expressed.

They might include headache, nausea, abdominal pain, vomiting, and diarrhea. Usually, such reactions occur in the first days of treatment and gradually disappear.

Side effects may also include drowsiness and slow reactions. If they occur, reduce the dosage and consult with your doctor.

5-HTP Contraindications

Individual intolerance to the drug components; pregnancy, lactation; schizophrenia.

5-HTP Interactions

Simultaneous use of 5-HTP and antidepressants that suppress or delay the breakdown of serotonin can lead to an increase in its level and the occurrence of life-threatening side effects. If, when taking the drug, a person experiences convulsions, muscle tremors, nausea, or frustration, then the treatment shall be carefully analyzed. And, if possible, serotonin precursors shall be abandoned.

In all other cases, dietary supplements can be taken without special precautions.

  1. Benedittis and Marssei (1985) Serotonin precursors in chronic primary headache. A double-blind cross-over study with L-5-hydroxytryptophan vs. placebo 
  2. Titus et al (1986) 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial 
  3. Caruso et al (1990) Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome 
  4. Pöldinger et al (1991) A functional-dimensional approach to depression: serotonin deficiency as a target syndrome in a comparison of 5-hydroxytryptophan and fluvoxamine 
  5. Puttini and Caruso (1992) Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study 
  6. Birdsall T C (1998) 5-Hydroxytryptophan: a clinically-effective serotonin precursor 
  7. Cangiano et al (1998) Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients 
  8. Shaw et al (2002) Tryptophan and 5-hydroxytryptophan for depression 
  9. Turner et al (2006) Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan
  10. Shell et al (2010) A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep 
  11. Jangid et al (2013) Comparative study of efficacy of l-5-hydroxytryptophan and fluoxetine in patients presenting with first depressive episode 
  12. Hong et al (2016) Sleep-promoting effects of a GABA/5-HTP mixture: Behavioral changes and neuromodulation in an invertebrate model 
  13. Kious et al (2017) An Open-Label Pilot Study of Combined Augmentation With Creatine Monohydrate and 5-Hydroxytryptophan for Selective Serotonin Reuptake Inhibitor- or Serotonin-Norepinephrine Reuptake Inhibitor-Resistant Depression in Adult Women 
  14. Sharma et al (2019) 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology 
  15. Javelle et al (2020) Effects of 5-hydroxytryptophan on distinct types of depression: a systematic review and meta-analysis  
  16. Kayacan et al (2020) Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity 
  17. Yousefzadeh et al (2020) 5-Hydroxytryptophan as adjuvant therapy in treatment of moderate to severe obsessive-compulsive disorder: a double-blind randomized trial with placebo control  
  18. Zamoscik et at (2021) Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level
  19. Meloni et al (2022) Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson’s disease 
  20. Wu et al (2022) Oral Administration of 5-Hydroxytryptophan Restores Gut Microbiota Dysbiosis in a Mouse Model of Depression 
  21. Truyens et al (2022) Effect of 5-Hydroxytryptophan on Fatigue in Quiescent Inflammatory Bowel Disease: A Randomized Controlled Trial
  22. Evans et al (2022) The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT


Based on 1 Reviews








chelsea b.

chelsea b.

 Verified Buyer


5htp is helpful

i will be honest and say i ordered this because of its affects on serotonin and oxytocin, so i had an expectation, to feel something if anything .."better".. so incase that is anyones intended use, it doesnt do that. but i will say it does positively affect mood for a few weeks (hince: the serotonin aspect of the supplement) very subtle.


Hi Chelsea! Thank you for your feedback on 5-HTP. We're pleased to hear it positively affected your mood. While it may not deliver immediate, noticeable effects, its subtle mood enhancement over time aligns with its serotonin influence. We're committed to providing quality supplements for your well-being!

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