Buy Afobazole Fabomotizole

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AFOBAZOLE ® (Fabomotizole)

12 Reviews

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Buy Afobazole® (Fabomotizole) Online!

Afobazole, also known as Fabomotizole, is a selective non-benzodiazepine anxiolytic launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.

Chemical name Fabomotizole
Form: 30 pills of 10mg / 60 pills of 10mg
Form description: Bevel-edged pills of flat-cylindrical shape in white or light cream color.
Active substance: Fabomotizole 10mg
Excipients: Potato starch, microcrystalline cellulose, lactose, povidone, magnesium stearate.
СAS Number: 173352-21-1
ATC code: N05BX
Pharmacological action: Anxiolytic
Shelf life: 2 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep in a safe place out of reach of children.
Terms of release: Over-the-counter
Manufacturer: OTCPharm / PharmStandard

What is Afobazole?

Fabomotizole (brand name Afobazole) is a novel anxiolytic drug with nootropic properties used to treat anxiety and some cardiac disorders. One of the most important advantages of Fabomotizole over benzodiazepines is that it does not form dependence and has fewer side effects.

Afobazole was discovered at the beginning of the 2000s in Russia at the Zakusov Institute of Pharmacology. This institute is also known for its discovery of Noopept, Ladasten (Bromantane), and Selank. Afobazole is a popular anxiolytic that it can be bought over the counter in almost every Russian pharmacy.

What makes Afobazole so special among other anti-anxiety medications? – Afobazole does not have sedative, hypnotic, or muscle relaxant action. Along with that, it does not form dependence in any dosage. Besides that, Afobazole studies in models of local and global ischemia have revealed the neuroprotective effects of the drug.

 

What is the Afobazole Mechanism of Action?

Afobazole’s mechanism of action is different from that of benzodiazepines. It is not a benzodiazepine receptor site agonist; at the same time, it prevents stress-induced changes in the GABA-benzodiazepine receptor complex and restores its sensitivity to endogenous inhibitory mediators. The drug acts on σ1 receptors, melatonin MT1 and MT3 receptors, and was shown to reversibly inhibit MAO-A.

Afobazole also increases the bioenergetic potential of neurons, and restores and protects nerve cells. Besides, it has some neurotrophic properties, although they are not as pronounced as in Stresam another non-sedative anxiolytic. In studies on rats, Afobazole prevented stress-induced BDNF decrease and it increased NGF and BDNF content in hippocampal HT22 cells culture.

What are Afobazole’s Benefits and Effects?

The benefits of the drug are achieved mostly through the combination of its anxiolytic and light-stimulating effects.

Afobazole reduces:

  • anxiety, bad foreboding, and fears;
  • irritability, tension (fearfulness, tearfulness, anxiety, inability to relax, insomnia, and fear);
  • depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory, and gastrointestinal symptoms);
  • autonomic disorders (dry mouth, sweating, and dizziness);
  • cognitive disorders (difficulty concentrating and poor memory), including those arising from stress.

The treatment is usually well-tolerated by the patients. The drug is not habit-forming and does not cause withdrawal after cessation.

What is Afobazole Used for?

Afobazole (Fabomotizole) is used to treat the following symptoms:

  • Generalized anxiety disorder symptoms, e.g. bad feelings, tensions in the body, irritability, tearfulness, fearfulness, etc.;
  • Adjustment disorders;
  • Various somatic (psychophysiological) disorders, e.g. asthma, irritable bowel syndrome, systemic lupus erythematosus, ischemic heart diseases, etc.;
  • Sleep disorders caused by anxiety;
  • Premenstrual syndrome;
  • Alcohol withdrawal and nicotine withdrawal syndrome;
  • Neurocirculatory dystonia;
  • Neurasthenia;
  • Premenstrual syndrome.

Where Can I Order Afobazole Online?

You can order Afobazole online from different vendors. CosmicNootropic offers Afobazole in packs of 30x10mg and 60x10mg pills with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Afobazole and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

Check other products from the ANTI-ANXIETY category.

What is Afobazole Dosage?

Afobazole shall be taken after meals. The normal daily dose is 30 mg: 10 mg 3 times a day (morning, afternoon, and evening). The duration of one course of treatment is 2–4 weeks. If needed, the daily dose can be raised up to 60 mg and the course duration extended to 3 months.

What are the Side Effects of Afobazole?

Allergic reactions, occasional headaches. The treatment is usually well-tolerated by the patients.

The drug is not habit-forming and does not cause withdrawal after cessation.

Can One Overdose on Afobazole?

In case of overdose, the sedative effect and sleepiness are possible. They can be treated with caffeine.

 

OFFICIAL INSTRUCTION

  1. Neznamov et al (2001) Clinical study of the selective anxiolytic agent afobazol https://www.ncbi.nlm.nih.gov/pubmed/11548440
  2. VS Kudrin (2006) A comparative study of the effect of afobazole on brain monoamine systems in BALB/C and C57BL/6 mice https://www.ncbi.nlm.nih.gov/pubmed/17153957
  3. A Uyanaev, V Fisenko (2006) Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis https://link.springer.com/article/10.1007/s10517-006-0327-5
  4. Davydova et al (2010) Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015 https://www.ncbi.nlm.nih.gov/pubmed/20408420
  5. Reutova et al (2010) Anxiolytic afobazole action self-evaluated by patients with anxiety-asthenic disorders https://www.ncbi.nlm.nih.gov/pubmed/21086645
  6. Volkova et al (2010) Comparative study of the interoceptive effects of afobazole and diazepam https://www.ncbi.nlm.nih.gov/pubmed/21254504
  7. Kryzhanovskyi et al (2011) Study of anti-ischemic effect of afobazole in experimental myocardial infarction https://www.ncbi.nlm.nih.gov/pubmed/21240343
  8. Cuevas et al (2011) Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors https://www.ncbi.nlm.nih.gov/pubmed/21715561
  9. Seredenin et al (2013) On the mechanism of anti-ischemic effects of afobazole https://www.ncbi.nlm.nih.gov/pubmed/24288760
  10. Behensky et al (2013) Afobazole activation of σ-1 receptors modulates neuronal responses to amyloid-β25-35 https://www.ncbi.nlm.nih.gov/pubmed/24006338
  11. Kadnikov et al (2015) Cytoprotective Effect of Afobazole and Its Main Metabolite M-11 https://www.ncbi.nlm.nih.gov/pubmed/26033588
  12. TS Syunyakov, GG Neznamov (2016) Evaluation of the therapeutic efficacy and safety of the selective anxiolytic afobazole in generalized anxiety disorder and adjustment disorders: Results of a multicenter randomized comparative study of diazepam https://www.ncbi.nlm.nih.gov/pubmed/27636931
  13. Kryzhanovkii et al (2018) On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole) https://www.ncbi.nlm.nih.gov/pubmed/30225699
  14. Ostrovkaya et al (2018) Antidiabetic Activity of Afobazole in Wistar Rats https://www.ncbi.nlm.nih.gov/pubmed/30225697
  15. Kapitsa et al (2019) Afobazole Alleviates Cognitive Rigidity in Experimental Model of Autism Spectrum Disorders https://pubmed.ncbi.nlm.nih.gov/31776949/ 
  16. Ivanov et al (2020) Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes https://pubmed.ncbi.nlm.nih.gov/33098515/
  17. Kryzhanovskii et (2021) Angiogenic Effects of Anxiolytic Fabomotizole https://pubmed.ncbi.nlm.nih.gov/33895918/

4.8

Based on 12 Reviews

(10)

(2)

(0)

(0)

(0)

 

05/23/2024

Steve

Steve

US

US

Great option for SAD

This has been great for my seasonal depression. The tablets are small and easy to take. It begins working in a few days. It\'s helped to reduce my anxiety and get back into my normal routines. There have been no side effects and no withdrawal symptoms. I have been on Paxil, which works well, but has some side effects and I was concerned about long-term use. Only downside with Afobazole is remembering to take it three times a day, but I just take it with meals. There is a 30mg, extended release version, but I haven\'t been able to find that for sale anywhere online.

05/24/2024

Hi Steve! Thank you for your review! We are glad to hear that Afobazole has been helpful for you.

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07/01/2022

Pettclan

Pettclan

 Verified Buyer
US

US

Cheap quick and easy

AFOBAZOLE is the go-to generic anti-anxiety. It will only take the edge off the hard stuff. But for everyday things it can't be beat. If you need the edge taken off the knife of anxiety, this is it. It's not going to deal with major stuff, but sometimes a little is alot. For me it allows me to deal with anxiety instead of removing it. Anxiety is still there, but so much easier to deal with. People say I'm not as "on edge" while on it. The price can't be beat, and the shipping is fast. For cheap quick easy stuff, this is it. If you need something stronger, there are other things out there.

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10/31/2021

Mr P.

Mr P.

 Verified Buyer
US

US

Better than I thought it would be

Since this was one of the least expensive anti-anxiety meds, I figured it would just work just a little bit. I was pleasantly surprised. Bought it for my daughter who has BAD anxiety. For her she says it feels like her anxiety is both there and not there at the same time. So it does help her in a way, which is good. I don't have anxiety, but I do have a lot of stress and worries. For me it makes me just forget I'm stressed or worried about things. I can get things done and deal with things much easier. I'll definitely be ordering again. It doesn't make either of us tired or "spacey" which is nice.

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0

06/11/2020

Tony L.

Tony L.

 Verified Buyer
US

US

Awesome again..,

Every aspect of dealing with these guys is easy and professional.

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0

07/11/2019

DL

David L.

 Verified Buyer

Responsible Merchant

Prompt and transparent shipping. Products are authentic and as described. Packaging is discrete and appropriate.

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0

09/14/2018

LG

Lane G.

 Verified Buyer

Afobazole x120 Tabs, Emoxypine x50

Great Communication, Fast shipping. Reliable. Would buy again

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0

08/01/2018

EB

Emiel B.

 Verified Buyer

Staple of my anxiolytic stack

One of the best additions to my anti anxiety stack. No side effects whatsoever, non sedating, but very active at reducing anxiety. Can absolutely recommend this product!

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0

08/01/2018

EB

Emiel B.

 Verified Buyer

Staple of my anxiolytic stack

One of the best additions to my anti anxiety stack. No side effects whatsoever, non sedating, but very active at reducing anxiety. Can absolutely recommend this product!

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0

02/20/2017

JO

Jeff O.

 Verified Buyer

Reset My Emotional State

After years of being kicked around by life, I was in a sorry place mentally - sad, lacking confidence, and quick to hostility. I ordered Afobazole and began taking it 3x per day. I didn't notice any specific feeling from it, but after one week I could tell it was working. I was becoming less emotional than before. I finished the box (20 days total) and I must say that I am very impressed with the results. Afobazole "fixed" me and I feel like a new man.

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02/08/2017

R

Robert

 Verified Buyer

Overall very nice experience

I personally don't feel very incapacitated when I use it but I much prefer taking this after a long day's work because it puts me in the mood to relax and sleep. For me this supplement pretty much kills any effects from stimulants I'm taking (which I sadly found out yesterday morning when I had work to do). My recommendation would be to try this supplement at night after you have all your work done, then consider the effects it has on you and implement it into a non-busy workday. That being said, I'm a laidback guy. If you have serious anxiety this might calm you down to a regular level.

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0

10/31/2016

M

Mattikus

 Verified Buyer

Mild but side effect free

Noticed a slight calming effect, and may have slept a little better while using. Hard to say as I generally have no problem with anxiety. Never had any negative effects at all, and never felt sedated like some anxiolitics can cause.

01/01/1970

Hi Mattikus, thank you for the feedback! Most if our products are intended to normalize brain functions, not to improve them greatly of you are already healthy. Best regards, Andrey

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04/12/2016

R

Roi

 Verified Buyer

Anxiolytic, maybe a little sedating, works good with stimulants.

First of all, I want to mention that there is a high probability this drug works on Melatonin receptors. When I take Melatonin I notice nightmares as a side effect and wake up groggier than usual (I always wake up groggy no matter how much I sleep). I have been taking Afobazole for around 2 weeks. I didn't take it at the recommended dosage of 3 tablets per day because I never felt a clear acute effect and read online that people managed with 2 tablets per day. I have finished 27 tablets. There are days I only took 1 and a day I tried 3. Never felt diminished or increased effects, except maybe when I took the dosage with some stimulants like Ritalin and coffee (no heart issues or anxiety). I can say it works for social anxiety, but nothing like Phenibut, which is also stimulating. Today at class I could keep a prolonged eye contact with a girl, something I find normally very hard since childhood. To be honest, I actually have a problem to keep an eye contact with males too (I'm 27 soon). I'm going to stop the medication in about a week and see what happens. Then, I will use what I got left. I will update if there is anything interesting.

01/01/1970

Thank you, Roi! Another great and deep review from you! We are happy that you enjoy our products. Best regards, Andrey

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< 1 >

6 years ago

Review

Emiel B. Verified Buyer

Staple of my anxiolytic stack

One of the best additions to my anti anxiety stack. No side effects whatsoever, non sedating, but very active at reducing anxiety. Can absolutely recommend this product!

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