Buy Afobazole Fabomotizole


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AFOBAZOLE ® (Fabomotizole)

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Buy Afobazole® (Fabomotizole) Online!

Afobazole, also known as Fabomotizole, is a selective non-benzodiazepine anxiolytic launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.

Chemical name Fabomotizole
Form: 30 pills of 10mg / 60 pills of 10mg
Form description: Bevel-edged pills of flat-cylindrical shape in white or light cream color.
Active substance: Fabomotizole 10mg
Excipients: Potato starch, microcrystalline cellulose, lactose, povidone, magnesium stearate.
СAS Number: 173352-21-1
ATC code: N05BX
Pharmacological action: Anxiolytic
Shelf life: 2 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep in a safe place out of reach of children.
Terms of release: Over-the-counter
Manufacturer: OTCPharm / PharmStandard

What is Afobazole?

Fabomotizole (brand name Afobazole) is a novel anxiolytic drug with nootropic properties used to treat anxiety and some cardiac disorders. One of the most important advantages of Fabomotizole over benzodiazepines is that it does not form dependence and has fewer side effects.

Afobazole was discovered at the beginning of the 2000s in Russia at the Zakusov Institute of Pharmacology. This institute is also known for its discovery of Noopept, Ladasten (Bromantane), and Selank. Afobazole is a popular anxiolytic that it can be bought over the counter in almost every Russian pharmacy.

What makes Afobazole so special among other anti-anxiety medications? – Afobazole does not have sedative, hypnotic, and muscle relaxant action. Along with that, it does not form dependence in any dosage. Besides that, Afobazole studies in models of local and global ischemia have revealed the neuroprotective effects of the drug.


What is Afobazole Mechanism of Action?

Afobazole’s mechanism of action is different from that of benzodiazepines. It is not a benzodiazepine receptor site agonist; at the same time, it prevents stress-induced changes of GABA-benzodiazepine receptor complex and restores its sensitivity to endogenous inhibitory mediators. The drug acts on σ1 receptors, melatonin MT1 and MT3 receptors, and was shown to reversibly inhibit MAO-A.

Afobazole also increases the bioenergetic potential of neurons, restores and protects nerve cells. Besides, it has some neurotrophic properties, although they are not as pronounced as in Stresam another non-sedative anxiolytic. In studies on rats, Afobazole prevented stress-induced BDNF decrease and it increased NGF and BDNF content in hippocampal HT22 cells culture.

What are Afobazole Benefits and Effects?

The benefits of the drug are achieved mostly through the combination of its anxiolytic and light stimulating effects.

Afobazole reduces:

  • anxiety, bad foreboding, and fears;
  • irritability, tension (fearfulness, tearfulness, anxiety, inability to relax, insomnia, and fear);
  • depressive mood, somatic manifestations of anxiety (muscular, sensory, cardiovascular, respiratory and gastrointestinal symptoms);
  • autonomic disorders (dry mouth, sweating, and dizziness);
  • cognitive disorders (difficulty concentrating and poor memory), including those arising from stress.

The treatment is usually well-tolerated by the patients. The drug is not habit-forming and does not cause withdrawal after cessation.

What is Afobazole Used for?

Afobazole (Fabomotizole) is used to treat the following symptoms:

  • Generalized anxiety disorder symptoms, e.g. bad feelings, tensions in the body, irritability, tearfulness, fearfulness, etc.;
  • Adjustment disorders;
  • Various somatic (psychophysiological) disorders, e.g. asthma, irritable bowel syndrome, systemic lupus erythematosus, ischemic heart diseases, etc.;
  • Sleep disorders caused by anxiety;
  • Premenstrual syndrome;
  • Alcohol withdrawal and nicotine withdrawal syndrome;
  • Neurocirculatory dystonia;
  • Neurasthenia;
  • Premenstrual syndrome.

Where Can I Order Afobazole Online?

You can order Afobazole online from different vendors. CosmicNootropic offers Afobazole in packs of 30x10mg and 60x10mg pills with fast US delivery and worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Afobazole and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

Check other products from the ANTI-ANXIETY category.

Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Afobazole Dosage?

Afobazole shall be taken after meals. The normal daily dose is 30 mg: 10 mg 3 times a day (morning, afternoon, and evening). The duration of one course of treatment is 2–4 weeks. If needed, the daily dose can be raised up to 60 mg and the course duration extended to 3 months.

What are the Side Effects of Afobazole?

Allergic reactions, occasional headaches. The treatment is usually well-tolerated by the patients. The drug is not habit-forming and does not cause withdrawal after cessation.

Can One Overdose on Afobazole?

In case of overdose, the sedative effect and sleepiness are possible. They can be treated with caffeine.  


  1. Neznamov et al (2001) Clinical study of the selective anxiolytic agent afobazol
  2. VS Kudrin (2006) A comparative study of the effect of afobazole on brain monoamine systems in BALB/C and C57BL/6 mice
  3. A Uyanaev, V Fisenko (2006) Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis
  4. Davydova et al (2010) Neurochemical study of effects of the new anxiolytic drugs afobazol and ladasten on the synthesis and metabolism of monoamines and their metabolites in the brain structures of Wistar rat on the model of monoamine synthesis blockade induced by aromatic amino acid decarboxylase inhibitor NSD-1015
  5. Reutova et al (2010) Anxiolytic afobazole action self-evaluated by patients with anxiety-asthenic disorders
  6. Volkova et al (2010) Comparative study of the interoceptive effects of afobazole and diazepam
  7. Kryzhanovskyi et al (2011) Study of anti-ischemic effect of afobazole in experimental myocardial infarction
  8. Cuevas et al (2011) Afobazole modulates microglial function via activation of both sigma-1 and sigma-2 receptors
  9. Seredenin et al (2013) On the mechanism of anti-ischemic effects of afobazole
  10. Behensky et al (2013) Afobazole activation of σ-1 receptors modulates neuronal responses to amyloid-β25-35
  11. Kadnikov et al (2015) Cytoprotective Effect of Afobazole and Its Main Metabolite M-11
  12. TS Syunyakov, GG Neznamov (2016) Evaluation of the therapeutic efficacy and safety of the selective anxiolytic afobazole in generalized anxiety disorder and adjustment disorders: Results of a multicenter randomized comparative study of diazepam
  13. Kryzhanovkii et al (2018) On the Mechanism of the Cardioprotective Action of σ1 Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole)
  14. Ostrovkaya et al (2018) Antidiabetic Activity of Afobazole in Wistar Rats
  15. Kapitsa et al (2019) Afobazole Alleviates Cognitive Rigidity in Experimental Model of Autism Spectrum Disorders 
  16. Ivanov et al (2020) Analysis of Cytoprotective Properties of Afobazole in Streptozotocin Model of Diabetes
  17. Kryzhanovskii et (2021) Angiogenic Effects of Anxiolytic Fabomotizole

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