alpha-gpc

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Cereton® (Alpha-GPC)

1 Reviews

This product has not been approved by the US FDA to treat, cure, or prevent any disease. The statements made within this website have not been evaluated by the US Food and Drug Administration. For research and development use only.

 

Pharmacological Profile

Synonyms L-Alpha glycerylphosphorylcholine / choline alfoscerate / α-GPC
Form: 3 vials of 4ml /  28 capsules of 400mg
Form description: Clear, colorless liquid / Soft, gelatine, oval capsules of yellow or brownish color with oily, clear, colorless or slightly colored liquid.
Active ingredient: Choline alphoscerate polyhydrate – 1000 mg / choline alphoscerate – 400 mg
Excipients for vials: Water for injections
Excipients for pills: Glycerol, purified water;
Capsules composition: gelatine, sorbitol, glycerol, methylparahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide, iron oxide yellow, purified water.
СAS Number: 28319-77-9
ATC code: N07AX02
Pharmacological action: Nootropic
Shelf life: 5 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Sotex, Russia 

What is Cereton?

Cereton (Alpha-GPC)  is one of the most effective sources of choline, first discovered in 1864. Alpha-GPC is a natural choline compound found in the brain. Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier.

It is routinely prescribed by doctors in Europe as a treatment for Alzheimer’s disease and other degenerative conditions. Alpha-GPC is frequently compared to CDP-choline, another effective source of choline.

What is Cereton Used For?

In medical practice, Cereton has been proven to be useful for treating:

  • Strokes and post-stroke complications;
  • Alzheimer’s disease and other types of dementia;
  • Traumatic brain injuries;
  • Psychoorganic syndrome;
  • Various cognitive disorders e.g. disorientation, low motivation, concentration difficulties, etc.

More detailed information about the studies on the application can be found in the Dosage tab.

What are the Benefits and Effects of Cereton?

  • Alpha-GPC increases choline levels and treats choline deficiency;
  • Intake of Alpha-GPC has a positive effect on the cognitive and behavioral responses of patients with cerebrovascular diseases (discirculatory encephalopathy and residual effects of cerebral circulation disorders);
  • This medication provides a preventive and corrective effect on the pathogenetic factors of the involutional psycho-organic syndrome;
  • Alpha-GPC changes the phospholipid composition of neuronal membranes and participates in the synthesis of phosphotidylcholine – a membrane phospholipid – and improves the plasticity of neuronal membranes;
  • Alpha-GPC stimulates dose-dependent ejection of acetylcholine under physiological conditions, it can increase synaptic transmission and improve receptor function;
  • Alpha-GPC does not affect the reproductive cycle and does not have teratogenic and mutagenic effects.

Is Cereton Safe to Take?

Cereton has several contraindications:

  • Increased sensitivity to choline alfoscerate and/or any excipient of the drug
  • Pregnancy
  • Breastfeeding period
  • Children under 11 years of age when used for the indication: mild to moderate cognitive impairment caused by traumatic brain injury or hemorrhagic stroke
  • Children under 18 years of age when used for other indications

FAQ

What is Alpha-GPC?

Alpha-GPC (Alpha-Glyceryl Phosphoryl Choline) is a highly bioavailable source of choline, naturally present in the human brain and in certain foods. It helps the body produce acetylcholine — a neurotransmitter that regulates memory, concentration, and muscle control. Because of its strong effect on cognitive and physical function, Alpha-GPC is widely used as a nootropic supplement. Research suggests it can support brain health, enhance focus and mental performance, and even boost physical strength by stimulating growth hormone production. It’s one of the most efficient forms of choline for both cognitive and athletic benefits.

How long does Alpha-GPC last?

Alpha-GPC usually stays active in the body for about 4 to 6 hours. The onset of effects may begin within 30–60 minutes, providing enhanced focus, mental clarity, and energy during that time. Because its half-life is moderate, some people prefer splitting the daily dose to sustain benefits throughout the day. Duration can vary based on dosage, individual metabolism, and diet.

Is Alpha-GPC a stimulant?

No, Alpha-GPC isn’t a stimulant. It doesn’t increase heart rate or act on the central nervous system like caffeine or amphetamines. Instead, Alpha-GPC provides choline, a nutrient used by the brain to make acetylcholine, a neurotransmitter important for learning, memory, and concentration. The result is smoother, more natural cognitive support without the overstimulation or energy crashes often associated with traditional stimulants.

How does Alpha-GPC work?

Alpha-GPC easily crosses the blood-brain barrier. In the brain, it is metabolized into choline and glycerophosphate. Choline enhances the synthesis of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerophosphate is said to support cell membranes. It improves blood flow and enhances metabolic processes in the central nervous system.

Alpha-GPC can naturally boost brain functions, including memory retention, focus, and neuroplasticity.

Alpha-GPC can promote the normalization of spatiotemporal characteristics of spontaneous bioelectric activity of the brain, regression of local neurological symptoms, and restoration of consciousness.

 

  1. Lopez et al (1991) Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain, PubMed
  2. Schettini et al (1992) Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats, PubMed
  3. N Maslova, A Pysina (2008) The use of cereton in ischemic stroke, PubMed
  4. Shmyrev et al (2008) The domestic drug cereton in the treatment of patients in the acute period of ischemic stroke, PubMed
  5. Builova et al (2009) The use of cereton in the rehabilitation of patients with hemorrhagic stroke, PubMed
  6. Levin et al (2009) Efficacy and tolerability of choline alphoscerate (cereton) in patients with Parkinson’s disease with cognitive disorders, PubMed
  7. Stulin et al (2009) Choline alphoscerate (ceretone) in the treatment of patients with chronic cerebral ischemia, PubMed
  8. Ismagilov et al (2009) Efficacy of cereton in the acute period of ischemic stroke, PubMed
  9. N Pizova (2014) The use of cereton in patients with chronic brain ischemia and moderate cognitive impairment, PubMed
  10. Bellar et al (2015) The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength, NIH
  11. Parker et al (2015) The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility, NIH
  12. Stifler et al (2016) Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine, NIH
  13. Marcus et al (2017) Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance, NIH
  14. Alesenko et al (2017) Detection of effective treatment of amnestic mild cognitive impairement with cereton by testing of lipids markers, PubMed
  15. Alesenko et al (2017) Detection of effective treatment of amnestic mild cognitive impairement with cereton by testing of lipids markers, PubMed
  16. Lee et al (2017) Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment, PubMed
  17. Gavrilova et al (2018) Clinical efficacy and safety of choline alfoscerate in the treatment of late-onset cognitive impairment, PubMed
  18. Barringer et al (2018) Impact of a purported nootropic supplementation on measures of mood, stress, and marksmanship performance in U.S. active duty soldiers, NIH
  19. Tamura et al (2021) Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study, NIH
  20. S-H Han, Y C Youn (2022) Quantitative electroencephalography changes in patients with mild cognitive impairment after choline alphoscerate administration, NIH
  21. Barzanjeh et al (2022) The Effects of Alpha-Glycerylphosphorylcholine on Heart Rate Variability and Hemodynamic Variables Following Sprint Interval Exercise in Overweight and Obese Women, NIH
  22. Kim et al (2022) Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study, NIH

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Based on 1 Reviews

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11/01/2024

D

Donald

 Verified Buyer
US

US

It\'s alpha-gpc

It\'s alpha GPC! solid addition along with any other nootropic that interacts with other Neurotransmitters. Caffeine included. from my experience, it doesn\'t do a whole lot. price is a bit steep for what it is.

11/04/2024

CosmicNootropic

Dear Donald, thank you for your feedback! We’re glad you found Alpha-GPC a solid addition to your nootropic stack. We understand that pricing is an important factor, but we aim for them to reflect our commitment to providing the highest quality and safest products. Your safety and satisfaction are our top priorities.

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To \ FromInternational Warehouse 
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If your order exceeds this timeframe, it becomes eligible for compensation at your choice. See below for more details.

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Customs rules, restrictions, and enforcement practices vary significantly between countries and may change without notice.
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Upon your request, we can offer either a refund to your BTC wallet or give you a store credit, or we can reship your order.

  • Refunds are offered in BTC only. We do so to simplify international transfer and save on fees both for you and us. Refunds are issued within 1-3 business days.
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