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ALPHA-GPC (Cereton ®)
Buy Alpha-GPC (Cereton®) Online!
Alpha-GPC (Cereton®) is a cholinergic compound that helps to improve brain health. It is said to support cell membranes and may help prevent cognitive decline.
Order Alpha-GPC capsules and injections with fast US delivery.
One pack of Alpha-GPC capsules is sufficient for a course treatment of 9–14 days. The drug can be taken for up to 6 months. Save with the volume discount!
|Synonyms||L-Alpha glycerylphosphorylcholine / choline alfoscerate / α-GPC|
|Form:||3 vials of 4ml / 28 capsules of 400mg|
|Form description:||Clear, colorless liquid / Soft, gelatine, oval capsules of yellow or brownish color with oily, clear, colorless or slightly colored liquid.|
|Active ingredient:||Choline alphoscerate polyhydrate – 1000 mg / choline alphoscerate – 400 mg|
|Excipients for vials:||Water for injections|
|Excipients for pills:||Glycerol, purified water;
Capsules composition: gelatine, sorbitol, glycerol, methylparahydroxybenzoate, propyl parahydroxybenzoate, titanium dioxide, iron oxide yellow, purified water.
|Shelf life:||5 years. Do not use it beyond the expiration date printed on the package.|
|Storage conditions:||Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.|
|Terms of release:||Over-the-counter|
|Manufacturer:||Sotex, Russia https://www.sotex.ru/|
What is Alpha-GPC?
Alpha-GPC is one of the most effective sources of choline, first discovered in 1864. Alpha-GPC is a natural choline compound found in the brain. Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier.
It is routinely prescribed by doctors in Europe as a treatment for Alzheimer’s disease and other degenerative conditions. Alpha-GPC is frequently compared to CDP-choline, another effective source of choline.
What is the Mechanism of Action of Alpha-GPC?
Alpha-GPC easily crosses the blood-brain barrier. In the brain, it is metabolized into choline and glycerophosphate. Choline enhances the synthesis of acetylcholine, a neurotransmitter involved in memory, attention, and skeletal muscle contraction. Glycerophosphate is said to support cell membranes. It improves blood flow and enhances metabolic processes in the central nervous system.
Alpha-GPC can naturally boost brain functions, including memory retention, focus, and neuroplasticity.
Alpha-GPC can promote the normalization of spatiotemporal characteristics of spontaneous bioelectric activity of the brain, regression of local neurological symptoms, and restoration of consciousness.
What are the Benefits and Effects of Alpha-GPC?
- Alpha-GPC increases choline levels and treats choline deficiency;
- Intake of Alpha-GPC has a positive effect on the cognitive and behavioral responses of patients with cerebrovascular diseases (discirculatory encephalopathy and residual effects of cerebral circulation disorders);
- This medication provides a preventive and corrective effect on the pathogenetic factors of the involutional psycho-organic syndrome;
- Alpha-GPC changes the phospholipid composition of neuronal membranes and participates in the synthesis of phosphotidylcholine – a membrane phospholipid – and improves the plasticity of neuronal membranes;
- Alpha-GPC stimulates dose-dependent ejection of acetylcholine under physiological conditions, it can increase synaptic transmission and improve receptor function;
- Alpha-GPC does not affect the reproductive cycle and does not have teratogenic and mutagenic effects.
What is Alpha-GPC Used For?
In medical practice, Alpha-GPC has been proven to be useful for treating:
- Strokes and post-stroke complications;
- Alzheimer’s disease and other types of dementia;
- Traumatic brain injuries;
- Psychoorganic syndrome;
- Various cognitive disorders e.g. disorientation, low motivation, concentration difficulties, etc.
Where Can I Order Alpha-GPC Online?
You can purchase Alpha-GPC online from different vendors. CosmicNootropic offers Alpha-GPC under the brand name Cereton in packs of 3x4ml vials and 28x400mg pills. We offer fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
You can order Alpha-GPC capsules and injections and get them delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more
What is Alpha-GPC Dosage, How to Use It?
In acute conditions, the recommended course treatment is 1000 mg (1 ampoule) per day for 10–15 days.
The medicine is slowly administered intravenously or intramuscularly.
Alpha-GPC in capsules has indication-specific dosing. Usually, the recommended dosage is 400 mg (1 capsule) three times a day after meals.
In the recovery period of craniocerebral injury, ischemic or hemorrhagic stroke, the recommended dosage is 800 mg in the morning and 400 mg in the afternoon for 6 months.
In chronic cerebrovascular insufficiency and dementia, the recommended dosage is 400 mg 3 times a day after meals, for 3–6 months.
What are the Side Effects of Alpha-GPC?
Possible side effects of Alpha-GPC include allergy reactions, constipation, diarrhea, dry mouth, pharyngitis, headache, drowsiness, insomnia, agitation, anxiety, aggression, brain ischemia, dizziness, convulsions, rashes, urticaria, pain in the area of injection, increased urination.
In case of nausea due to dopaminergic activation, the dose shall be decreased.
Note: Alpha-GPC works particularly well with racetams, like Piracetam and Aniracetam. These racetams boost acetylcholine receptors in the brain, which means your brain needs to produce more acetylcholine. Alpha-GPC gives your brain the acetylcholine it needs by delivering high amounts of choline.
- Lopez et al (1991) Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain https://www.ncbi.nlm.nih.gov/pubmed/1662399
- Schettini et al (1992) Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition-enhancing drug, on behavioral and biochemical parameters in young and aged rats https://www.ncbi.nlm.nih.gov/pubmed/1409797
- N Maslova, A Pysina (2008) The use of cereton in ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/19431273
- Shmyrev et al (2008) The domestic drug cereton in the treatment of patients in the acute period of ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/19253468
- Builova et al (2009) The use of cereton in the rehabilitation of patients with hemorrhagic stroke https://www.ncbi.nlm.nih.gov/pubmed/19894302
- Levin et al (2009) Efficacy and tolerability of choline alphoscerate (cereton) in patients with Parkinson’s disease with cognitive disorders https://www.ncbi.nlm.nih.gov/pubmed/20032953
- Stulin et al (2009) Choline alphoscerate (ceretone) in the treatment of patients with chronic cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/19708279
- Ismagilov et al (2009) Efficacy of cereton in the acute period of ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/19365389
- N Pizova (2014) The use of cereton in patients with chronic brain ischemia and moderate cognitive impairment https://www.ncbi.nlm.nih.gov/pubmed/25726784
- Bellar et al (2015) The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/
- Parker et al (2015) The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595381/
- Stifler et al (2016) Targeting Mitochondrial Dysfunction with L-Alpha Glycerylphosphorylcholine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115775/
- Marcus et al (2017) Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629791/
- Alesenko et al (2017) Detection of effective treatment of amnestic mild cognitive impairement with cereton by testing of lipids markers https://www.ncbi.nlm.nih.gov/m/pubmed/28745666/
- Alesenko et al (2017) Detection of effective treatment of amnestic mild cognitive impairement with cereton by testing of lipids markers https://www.ncbi.nlm.nih.gov/pubmed/28745666
- Lee et al (2017) Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment https://www.ncbi.nlm.nih.gov/pubmed/27765578
- Gavrilova et al (2018) Clinical efficacy and safety of choline alfoscerate in the treatment of late-onset cognitive impairment https://www.ncbi.nlm.nih.gov/pubmed/29927403
- Barringer et al (2018) Impact of a purported nootropic supplementation on measures of mood, stress, and marksmanship performance in U.S. active duty soldiers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984413/
- Tamura et al (2021) Alpha-Glycerylphosphorylcholine Increases Motivation in Healthy Volunteers: A Single-Blind, Randomized, Placebo-Controlled Human Study https://pubmed.ncbi.nlm.nih.gov/34207484/
- S-H Han, Y C Youn (2022) Quantitative electroencephalography changes in patients with mild cognitive impairment after choline alphoscerate administration https://pubmed.ncbi.nlm.nih.gov/35714391/
- Barzanjeh et al (2022) The Effects of Alpha-Glycerylphosphorylcholine on Heart Rate Variability and Hemodynamic Variables Following Sprint Interval Exercise in Overweight and Obese Women https://pubmed.ncbi.nlm.nih.gov/36235623/
- Kim et al (2022) Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study https://pubmed.ncbi.nlm.nih.gov/36294373/
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