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CORTEXIN ®

45 Reviews

All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product, consulting a qualified MD is mandatory. See more

Buy Cortexin® Online!

Cortexin is a complex of low molecular weight neuropeptides, amino acids, and vitamins derived from the cerebral cortex of cattle. Cortexin is similar to Cerebrolysin, but it has a significantly larger amount of peptide fractions and fewer amino acids.

One Course is 1 pack x 10 ml vials for 10 days.  The course can be repeated in 3-6 months.

Chemical name Cortexin
Form: 10 vials of 5mg / 10 vials of 10mg
Form description: Lyophilized powder or porous mass of white or white-yellowish color
Active ingredient: Cortexin® (complex of water-soluble polypeptide fractions): 5 mg in a 3 ml vial, and 10 mg in a 5 ml vial
Excipients: Glycine (stabilizer) – 6 mg in a 3 ml vial and 12 mg in a 5 ml vial.
СAS Number: 83270-84-2
ATC code: N06BX
Pharmacological action: Neuroprotective, nootropic, antioxidant, tissue-specific
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep in a safe place out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Gerofarm, Russia https://geropharm.com/

What is Cortexin?

Cortexin is a mixture of neuropeptide fractions, amino acids, vitamins, and minerals, all of which have a mild positive effect on the brain. Similar to Cerebrolysin, Cortexin is based on neuropeptides and amino acids. While the former is produced from pig brains only, the latter is extracted mostly from young horned cattle cerebral cortex by acetic acid extraction. For more information on the comparison of the two compounds please read our blog post

Cortexin comes in injection form only: 10 mg – for adults, and 5 mg – for children. 

What are the Benefits and Effects of Cortexin?

Cortexin has the following effects:

  • Nootropic effect: it improves higher cerebral functions, processes of learning and memory, concentration, attention, and tolerance to mental and physical stress;
  • Neuroprotective effect: Cortexin protects neurons against different endogenous neurotoxic factors (glutamate, calcium ions, and free radicals) and reduces the toxic impact of psychotropic agents;
  • Antioxidant effect: Cortexin inhibits lipid peroxidation, and increases the survival of neurons under oxidative stress and hypoxia;
  • Tissue-specific effect: this drug activates the metabolism of neurons of the central and peripheral nervous system as well as reparative processes; also, it promotes stimulation of cortical function and general improvement of the nervous system.

Wonder what the difference is between Cortexin and Cerebrolysin?

The answer is in the Cortexin video review via the link below

What is Cortexin Used for?

Intended uses of Cortexin are defined by its correction of impaired molecular and cellular processes. Cortexin injections are prescribed in the following cases:

  • cerebral circulation disorders;
  • encephalopathy of various genesis;
  • acute and chronic encephalitis and encephalomyelitis;
  • epilepsy;
  • traumatic brain injury and its consequences;
  • asthenia;
  • infantile cerebral palsy;
  • psychomotor and speech retardation in children;
  • cognitive disorders (dysfunction of memory and ideation);
  • reduced learning ability.

There is evidence that Cortexin may relieve post-COVID syndrome. [19]

What is Cortexin Composition?

Amino acids: Aspartic acid 446 nmol/mg; Glycine 298 nmol/mg; Threonine 212 nmol/mg; Serine 268 nmol/mg; Glutamic acid 581 nmol/mg; Proline 187 nmol/mg; Alanine 246 nmol/mg; Isoleucine 356 nmol/mg; Tyrosine 109 nmol/mg; Phenylalanine 162 nmol/mg; Histidine 116 nmol/mg; Lysine 253 nmol/mg; Arginine and other amino acids 202 nmol/mg.

Vitamins: Lysine 253 nmol/mg; Thiamine (Vitamin B1) 0.08 mcg/10mg; Riboflavin (Vitamin B2) 0.03 mcg/10 mg; Niacin (Vitamin B3, Vitamin PP) 0.05 mcg/10 mg; Retinol (Vitamin A) 0.011 mcg/10mg; Alfa-tokoferol (vitamin E) 0.007 mcg/10mg.

Minerals: (Cu) 0.2129 mcg/10 mg; (Fe) 2.26 mcg/10 mg; (Ca) 22.93 mcg/10 mg; (Mg) 8.5 mcg/10 mg; (K) 19.83 mcg/10 mg; (Na) 643.2 mcg/10 mg; (S) 152.65 mcg/10 mg; (P) 91.95 mcg/10 mg; (Zn) 4.73 mcg/10 mg; (Mb) 0.0203 mcg/10 mg; (Co) 0.0044 mcg/10 mg; (Mn) 0.0061 mcg/10 mg; (Se) 0.0745 mcg/10 mg; (Al) 0.3104 mcg/10 mg; (Li) 0,0340 mcg/10 mg.

Where Can I Order Cortexin Online?

You can order Cortexin online from different vendors. CosmicNootropic offers Cortexin in packs of 10x5mg and 10x10mg vials with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Cortexin and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

What is Cortexin Dosage, How To Use?

Cortexin has indication-specific dosing. The most common regime is intramuscular injections once daily: 10 mg per day for a period of 10 days for adults. For pediatric dosage please refer to the official instruction. If necessary, the course can be repeated after 3–6 months of discontinuation. 

Cortexin shall be taken in the first part of the day, before 3 p.m.

Please use sterile needles, sterilize the administration site, wear sterile plastic gloves, and administer as soon as you open the vial. Before injection dissolve the content of the vial in 1-2 ml of 0.5% procaine (Novocain) solution, water for injection, or 0.9% sodium chloride solution. Relax your muscles and inject slowly.

What are the Side Effects of Cortexin?

No adverse reactions were observed during administration when taken as indicated. Individual hypersensitivity to the product components is possible. Please pay close attention to your body response when you administer the drug for the first time.

 

OFFICIAL INSTRUCTION

  1. Coulter et al (1993) Identification of cortexin: a novel, neuron-specific, 82-residue membrane protein enriched in rodent cerebral cortex https://www.ncbi.nlm.nih.gov/pubmed/8336151
  2. Khavinson et al (1999) Cortexin effectiveness in circulatory encephalopathy https://www.ncbi.nlm.nih.gov/pubmed/10356917
  3. Shabanov et al (2007) Comparison of behavioral effects of cortexin and cerebrolysin injected into brain ventricles https://www.ncbi.nlm.nih.gov/pubmed/18214294
  4. Shabanov et al (2007) Comparative study of behavioral effects of cortexin and cerebrolysine upon intraventricular and intraperitoneal administration in rats https://www.ncbi.nlm.nih.gov/pubmed/17650626
  5. Nurguzhaev et al (2009) Use of cortexin in the early rehabilitation period of ischemic stroke of moderate severity https://www.ncbi.nlm.nih.gov/pubmed/19672239
  6. B Gafurov, Sh Gafurov (2010) Cortexin in the complex treatment of post stroke epilepsy https://www.ncbi.nlm.nih.gov/pubmed/20873481
  7. A Solov’ev, T Elistratova (2010) Effectiveness of cortexin in the complex treatment of patients with chronic alcohol encephalopathy and polyneuropathy https://www.ncbi.nlm.nih.gov/pubmed/20517210
  8. Mendzheritsky et al (2015) Pinealon and Cortexin influence on behavior and neurochemical processes in 18-month aged rats within hypoxia and hypothermia https://www.ncbi.nlm.nih.gov/pubmed/28509493
  9. Belova et al (2016) Efficacy of cortexin in acute and recovery periodes of hemispheric ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/27845314
  10. Yakovlev et al (2017) Peptide drug cortexin inhibits brain caspase-8 https://www.ncbi.nlm.nih.gov/pubmed/28251948
  11. A Yakovlev, N. Gulyaeva (2017) Molecular partners of Cortexin in the brain https://link.springer.com/article/10.1134/S1819712416040164
  12. Zukov et al (2018) Results of a multicenter study on the efficacy of cortexin in treatment of cognitive dysfunction in children ttps://www.ncbi.nlm.nih.gov/pubmed/29652302h
  13. N Gulyaeva (2018) Molecular mechanisms of brain peptide-containing drugs: cortexin https://www.ncbi.nlm.nih.gov/pubmed/30499504
  14. A Fedin (2018) The efficacy of cortexin and memantinol (memantine) in the treatment of cognitive impairment in patients with chronic cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/29460902
  15. Belova et al (2018) Efficacy of Korteksin in acute period of hemispheric ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/30132453
  16. Fedin et al (2018) Dose-dependent effects of cortexin in chronic cerebral ischemia (results of a multicenter randomized controlled study) https://www.ncbi.nlm.nih.gov/pubmed/30335070
  17. Gulyaeva (2019) Molecular Mechanisms of the Actions of Brain Peptide-Containing Drugs: Cortexin https://link.springer.com/article/10.1007/s11055-019-00839-4
  18. Mashin et al (2019) [Evaluation of the efficacy and safety of application of the drug cortexin in the complex rehabilitation of verticalization in patients with ischemic stroke in the acute period] https://pubmed.ncbi.nlm.nih.gov/31626220/
  19. Putilina et al (2022) [Determination of the prevalence of postcovid syndrome and assessment of the effectiveness of the drug Cortexin in the treatment of neurological disorders in patients with postcovid syndrome. Results of the multicenter clinical and epidemiological observational program CORTEX] https://pubmed.ncbi.nlm.nih.gov/35175707/

4.5

Based on 45 Reviews

(37)

(2)

(1)

(0)

(5)

 

09/22/2024

Brandon

Brandon

 Verified Buyer
US

US

Cortexin

Has anyone tried injecting this IV instead of IM? I am doing this and have great results I also adminiter IV with Cerebrolysin and it\'s the best result.

10/07/2024

Cosmic Nootropic

Thanks for sharing your experience with Cortexin and Cerebrolysin! It's great to hear that you’re achieving such positive results with IV administration. However, it is important to note that according to the official instructions, Cortexin is meant for IM administration only. Everyone's body responds differently, so it’s always interesting to hear about different methods. Just a reminder to consult with a healthcare professional when experimenting with any treatments. If you have any more insights or questions, feel free to share!

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09/18/2024

Ivan W.

Ivan W.

 Verified Buyer
US

US

Helps reverse methamphetamine brain damage

Was ****** and abused methamphetamine that my parents BOUGHT ME. Got severe brain damage visible on a PET scan. Also pill mill doctors overprescribing me Adderall saying it'll help me (it did nothing good) Reduced my persistent anxiety from the damage and more motivation. Very expensive. It was like about $6000 to cause the damage it'll take half that amount to reverse repair it.

09/20/2024

Cosmic Nootropic

Hi Ivan! Thank you for sharing your experience. It's clear that you've been through a lot, and we appreciate your openness. It’s important to mention that individual experiences can vary greatly, and what works for one person may not work for another. We always recommend consulting with a qualified healthcare professional before making any decisions about treatment or medication. Your journey is unique, and it's vital to seek personalized advice tailored to your needs. Wishing you the best on your path to recovery.

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09/10/2024

Brandy P.

Brandy P.

 Verified Buyer
US

US

Amazing

My husband and I both love this product. We stack it with Cerebro and I swear we have super powers, lol. Super sharp recall , fog lifted, feel amazing.

09/11/2024

Cosmic Nootropic

Hi Brandy! Thank you so much for your enthusiastic review! We're thrilled to hear that Cortexin and Cerebrolysin are working wonders for you and your husband. It's fantastic to know that this product worked for you :)

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08/13/2024

Kevin

Kevin

 Verified Buyer
FR

FR

It works long after

It doesn\'t give me super brain, but it gives me an appreciable cognitive boost, especially for my memory. And best of all, the effect lasts a long time after the 10 dose course ends. For 2 months after I did my first course, I never forgot where I parked! It\'s my favorite nootropic.

08/14/2024

Cosmic Nootropic

Hi Kevin! Thank you so much for your feedback! We’re thrilled to hear that our nootropic has had a positive impact on your memory and that you’ve experienced lasting benefits. It’s fantastic to know it’s become your favorite!

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08/06/2024

Lina R.

Lina R.

 Verified Buyer
US

US

Reliable brain support

I found both cerebrolysin and cortexin being reliably helpful for my brain function recovering from mold toxicity, lyme, other toxicities that has left me foggy, costant headaches, reduced executive functions, etc These two, I can say with certainty, have been vital in supporting my mind in finding it's way back to myself. Thank you for making this easily available and your awesome customer service with a prompt responses to my enquiries.

08/06/2024

Cosmic Nootropic

Hi Lina! Thank you so much for your thoughtful review! We’re delighted to hear that both Cerebrolysin and Cortexin have been instrumental in supporting your recovery. It’s incredibly rewarding to know our products and customer service have made a positive impact on your journey back to better health. If you have any questions or need further assistance, we’re always here to help. Wishing you continued progress and wellness!

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07/28/2024

Jayc

Jayc

 Verified Buyer
US

US

For me Cortagen was more effective

I did a round of cortagen before this and it had a solid reduction effect on my palinopsia. It was super expensive so I decided to take cortexin because it was cheaper. Even though I took 4x as much cortexin than cortagen it almost didn\'t have any affect at all. I didn\'t know if that\'s because I reaped all the benefits from cortagen, if the cortexin was degraded in transport as it took a long time in transport, or if the cortagen is just that more potent.

08/02/2024

Cosmic Nootropic

Hi Jayc! Thank you for sharing your experience. We understand that cost considerations are important, and we’re sorry to hear that Cortexin didn’t meet your expectations. The effectiveness of the products can vary, and such factors as personal conditions and dosage can play a role.

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07/25/2024

Jessica H.

Jessica H.

 Verified Buyer
US

US

Helped husband with TBI symptoms

Definitely was able to start thinking more clearly and make better decisions. Cognitive function improved greatly. Mood and temper improved as well.

07/26/2024

Cosmic Nootropic

Hi Jessica! Thank you so much for sharing your experience! We're delighted to hear that our product could make such a positive impact on your husband's life!

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0

07/06/2024

corey r.

corey r.

 Verified Buyer
AU

AU

Fantastic service

Great. Super helpful when I contacted with a shipping question.

07/08/2024

Cosmic Nootropic

Hi Corey! Thank you for your wonderful feedback! We're delighted to hear that you found our service fantastic and our team helpful. Ensuring a seamless experience, from inquiries to delivery, is our goal.

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05/23/2024

Sanije B.

Sanije B.

 Verified Buyer
DK

DK

terrible

It was terrible. I have not recieved my shipment and not refund! The policies of refundment are just terrible.

05/23/2024

Cosmic Nootropic

Hi Sanije! We are so sorry to hear this, thank you for reaching out. We have emailed you to see what can be done in this situation.

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0

01/04/2024

Kevin

Kevin

PK

PK

Appreciable and lasting benefit

This is one of my top 3 nootropics. This stuff makes a noticeable difference in my focus and memory. And one 10-day course leaves a benefit that lasts a few weeks. After the first time I tried it, I never forgot where I parked for like 2 months. Normally that\'s always a problem for me. Of course it helps in other ways too besides parking.

01/04/2024

Cosmic Nootropic

Dear Kevin, we are happy to hear that you are satisfied with this product :) Thank you for leaving the review!

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0

12/22/2023

Joshua

Joshua

Great Product

After 10 years of brain fog from Lyme disease I\'m finally seeing light at the end of the tunnel. I find that cortexin gives me more mental energy and clarity. I\'m suddenly remembering the words to songs I didn\'t know I knew lol. It is also helping with my anxiety. It seems to make my brain sharper than cerebrolisyn. In 6 months I would like to do another course of cortexin with cerebrolisyn.

12/22/2023

Cosmic Nootropic

Hi Joshua! Thank you for finding a moment to leave a review. We're beyond happy to know that this product helped you with such a serious issue.

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0

12/05/2023

Jeff D.

Jeff D.

US

US

Bait and switched me

It boggles my mind that I paid for 10 vials, and they gave me a tracking # that had no cortexin in it at all. It\'s super infuriating. Only now, 11 days after paying for it, am I seeing the banner running saying you\'re out of stock. This is beyond unacceptable! People count on these meds and your company, with our lives and health depending on it, and this is what you let happen? Forcing me to source it elsewhere.

12/06/2023

Cosmic Nootropic

Dear Jeff, We understand your frustration with the temporary delays in our warehouse and we deeply apologize. Now your order is on its way and will be delivered shortly. Please check your email.

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12/05/2023

Jeff D.

Jeff D.

US

US

Never got what I paid for!!!

Paid for 10 vials of cortexin and never got them!!

12/06/2023

Cosmic Nootropic

Dear Jeff, your order is on its way and will be delivered shortly. Please check your email.

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0

12/03/2023

Kyle B.

Kyle B.

 Verified Buyer
US

US

Never received

I would have like the product if I ever receive it.

12/15/2023

Cosmic Nootropic

Dear Kyle, we apologize for the recent delays at our US warehouse. We see now that you received your order on the Dec 11th and hope you're satisfied with the product.

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11/17/2023

Joseph L.

Joseph L.

 Verified Buyer
US

US

The best Noot out there

Saw immediate effects and cerebral enhancements. Loved it. Reordering every 3-4 months

12/14/2023

Cosmic Nootropic

Dear Joseph, we're thrilled to know Cortexin is working for you. Thanks for being our loyal customer!

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0

11/02/2023

Kai N.

Kai N.

 Verified Buyer
GB

GB

It’s very good product. I feel clearly mind and have more concentration.

11/03/2023

Cosmic Nootropic

Hi Kai! We are glad that the product worked for you!

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0

10/02/2023

henry b.

henry b.

 Verified Buyer
CA

CA

cortexin

cortexin really did help with my thinking.i will start another course in Nov.loved it

10/03/2023

Cosmic Nootropic

Dear Henry, thank you for sharing your experience with our product. We are glad that it helps you!

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08/02/2023

Kandace M.

Kandace M.

 Verified Buyer
US

US

Amazing product

I love using Cortexin. It relieves my stress and anxiety almost immediately and it helps with concentration and focus. I keep this in my arsenal of peptides and bioregulators.

08/02/2023

Cosmic Nootropic

Hi Kandace, thank you for the review! We're glad that you're satisfied with the product. :)

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0

06/05/2023

Dmitri S.

Dmitri S.

 Verified Buyer
US

US

Great service

All expectations satisfied!

06/07/2023

Cosmic Nootropic

Hi Dmitri, thank you for your feedback! We're happy to hear that we met your expectations! :)

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05/16/2023

Jennifer M.

Jennifer M.

 Verified Buyer
US

US

Great Product Like Always

I really liked cortexin. Definitely something I will be alternating with Cerebro from here on.

05/19/2023

Cosmic Nootropic

Hi Jennifer, thank you for your feedback! We're thrilled to hear that you had a great experience with Cortexin.

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