ENERION ® (Sulbutiamine)


Buy Sulbutiamine 200 mg with 3–7 day fast domestic delivery within the US ($5) – just choose “Ships from: US (+15%)”

Synthesized first by Japanese researchers, Sulbutiamine is modified thiamine (vitamin B1), that can easily cross the blood-brain barrier. In the brain it eventually produces both GABA and acetylcholine, thus affecting adaptability, mood and focus.

Official indications for Sulbutiamine use include:

  • Symptomatic treatment of asthenic disorders;
  • Hypo- and avitaminoses;
  • Lingering illnesses;
  • After surgical interventions.


One pack of Enerion contains 20 or 60 pills, each containing 200 mg of Sulbutiamine, which is sufficient for an average of 10 days of supplementation.

Produced by Servier, France.

Buy Sulbutiamine from CosmicNootropic!

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

Dosage and administration

Enerion should be taken following meals. The normal daily dose is 400–600 mg: 200–400 mg twice daily (morning and afternoon).

Side effects

Side effects occur very rarely, with the most common being increased irritability and hyperkinesia (excessive abnormal movements).


Transient agitation and tremor.


Servier, France.


  1. Micheau et al (1985) Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation https://www.ncbi.nlm.nih.gov/pubmed/4059305
  2. Tiev et al (1999) Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo https://www.ncbi.nlm.nih.gov/pubmed/10573727
  3. O Van Reeth (1999) Pharmacologic and therapeutic features of sulbutiamine https://www.ncbi.nlm.nih.gov/pubmed/12973384
  4. Trovero et al (2000) Evidence for a modulatory effect of sulbutiamine on glutamatergic and dopaminergic cortical transmissions in the rat brain https://www.ncbi.nlm.nih.gov/pubmed/10996447
  5. Loo et al (2000) Effects of sulbutiamine (Arcalion 200) on psycho-behavioral inhibition in major depressive episodes https://www.ncbi.nlm.nih.gov/pubmed/10858919
  6. Kiew et al (2002) Effects of Sulbutiamine on Diabetic Polyneuropathy: An Open Randomised Controlled Study in Type 2 Diabetics https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436103/
  7. Vein et al (2003) Use of enerion in psychovegetative syndrome with pronounced asthenia https://www.ncbi.nlm.nih.gov/pubmed/14628585
  8. S Shah (2003) Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia https://www.ncbi.nlm.nih.gov/pubmed/14710977
  9. Bizot et al (2005) Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task https://www.ncbi.nlm.nih.gov/pubmed/15951087
  10. Dmitriev et al (2005) Clinical efficacy of the drug enerion in the treatment of patients with psychogenic (functional) erectile dysfunction https://www.ncbi.nlm.nih.gov/pubmed/15776829
  11. Litvinovich et al (2006) The use of sulbuthiamine (enerion) in the combined therapy of patients with symptomatic focal epilepsy https://www.ncbi.nlm.nih.gov/pubmed/17274400
  12. Ollat et al (2007) Effects of the association of sulbutiamine with an acetylcholinesterase inhibitor in early stage and moderate Alzheimer disease https://www.ncbi.nlm.nih.gov/pubmed/17675917
  13. O Levin, L Slizakova (2007) The use of enerion in the treatment of asthenic disorders in patients after mild cranio-cerebral trauma https://www.ncbi.nlm.nih.gov/pubmed/18379496
  14. T Sobolevsky, G Rodchenkov (2010) Sulbutiamine in sports https://www.ncbi.nlm.nih.gov/pubmed/21204296
  15. Kang et al (2010) Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells https://www.ncbi.nlm.nih.gov/pubmed/20809085
  16. Kwag et al (2011) Evidence for neuroprotective effect of sulbutiamine against oxygen-glucose deprivation in rat hippocampal CA1 pyramidal neurons https://www.ncbi.nlm.nih.gov/pubmed/22040892
  17. Farid et al (2016) Stability-Indicating HPTLC Method for Studying Stress Degradation Behavior of Sulbutiamine HCl https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4885403/
  18. Sevim et al (2017) Sulbutiamine shows promising results in reducing fatigue in patients with multiple sclerosis https://www.ncbi.nlm.nih.gov/pubmed/28755683

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