Two tablets (the recommended daily dose) of Glycine Forte contain 300 mg of glycine, B vitamins: B1- 5 mg, B6- 6 mg, B12- 9 mcg. One pack contains a month’s supply of 60 tablets.
Pharmacokinetics and pharmacodynamics
Glycine quickly enters tissue and bodily fluids in the human body. It also passes the blood brain barrier. In the liver, it is converted rapidly to carbon dioxide and water.
Administration and dose
Adult patients are to take one tablet twice a day. The patient must hold the tablet in their mouth until it dissolves. As a rule, the course of treatment is one month, but it can be lengthened according to the patient’s needs.
Glycine lowers toxicity of antidepressants, antipsychotics, and anticonvulsive medications. When taken along with tranquilisers, sleeping pills, and neuroleptics, it adds to the suppression of the central nervous system.
This drug should not be mixed with alcohol, as it is intended to reduce alcohol cravings and diminish the effects of alcohol on the body.
Attention! Extended courses of Glycine Forte Evalar do not cause dependency in patients because the drug only contains substances naturally occuring in the human body. People with arterial hypotension should take a lower dose of Glycine Forte and monitor blood pressure. The patient should stop taking the medication if blood pressure drops to lower levels than usual.
Glycine is a nootropic medication which improves metabolic function in the brain. Due to its safety, it is one of the most popular and commonly sold nootropic supplements in territories and countries of the former soviet union. This product includes B vitamins which increase its nootropic effect.
Glycine is an organic compound with the chemical formula NH2CH2COOH. It is industrially produced by processing chloroacetic acid with ammonia: ClCH2COOH + 2 NH3 → H2NCH2COOH + NH4Cl. It is unique among proteinogenic amino acids in that achiral. It can be hydrophilic or hydrophobic because it only has a single carbon atom at its side chain position.
Henri Braconnot discovered glycine in 1820 by evaporating gelatine with sulfuric acid. To this day, doctors continue to use glycine as a non-narcotic solution for treating stress and mental fatigue.
Indications for use (as a dietary supplement or additional treatment):
The active substance in the drug is an amino acid which the human body produces to regulate metabolism and central nervous system functions. Under its influence, the body experiences lowered feelings of aggression and psychoemotional stress, as well as increased productivity. When consuming the medication, the patient will notice better sleep quality and improved mood. The drug alleviates vegetovascular disorders, particularly during menopause. It improves the patient’s condition following stroke or traumatic brain injury. The drug also lowers the toxicity of alcohol on the human body.
A higher dose of glycine in combination with a maximum dose of B vitamins widens the scope of the drug's effects. As a result, it can work as a sedative in addition to being a nootropic and metabolic aid.
Vitamin B1 acts to normalise the state of the nervous system and stimulate thought and mental productivity.
Vitamin B6 accelerates the functional processes of the brain and helps to overcome irritability and fatigue.
Vitamin B12 speeds nerve tissue regeneration and improves concentration and memory. It plays a part in acetylcholine production, a neurotransmitter that affects learning and memory.
The product is produced according to GMP standards.
One pack contains a month’s supply of 60 tablets.
- Smith et al (2008) Effect of glycine propionyl-L-carnitine on aerobic and anaerobic performance https://www.researchgate.net/publication/5579075_Effect_of_glycine_propionyl-L-carnitine_on_aerobic_and_anaerobic_performance
- Kawai et al (2015) The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397399/
- Shen et al (2016) Glycine Transporter 1 is a Target for the Treatment of Epilepsy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655139/
- Cornelison et al (2016) Identification and characterization of heptapeptide modulators of the glycine receptor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851912/
- Perez-Torres et al (2017) Beneficial Effects of the Amino Acid Glycine https://www.ncbi.nlm.nih.gov/pubmed/27292783
- Razak et al (2017) Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350494/