Buy Grandaxin (Tofisopam) tablets online with 3–7 day fast domestic delivery within the US ($5) – just choose “Ships from: US (+15%)”
Grandaxin (Tofisopam) is a non-sedating anxiolytic drug with unique pharmacological action. Tofisopam was first synthesized in 1966 in Hungary and is successfully used for anxiety management since the 1970s.
As of today, Grandaxin is used in 15 countries across the world, including Russia, Japan, Hungary, and the Czech Republic. Although this drug is not approved for use in North America, its R-enantiomer is in stage II clinical trials for the treatment of irritable bowel syndrome.
Grandaxin is a benzodiazepine tranquilizer; however, its pharmacological action differs from that of typical benzodiazepine derivatives. Tofisopam belongs to the 2,3-benzodiazepines family, a unique class of psychoactive substances also known as homophthalazines. Unlike 1,4- benzodiazepine derivatives (e.g Diazepam), Tofisopam does not have sedative and anticonvulsant properties and is not habit-forming.
Grandaxin (Tofisopam) does not impair cognitive functions, you can buy it for its mild stimulant action and the ability to potentiate the effect of dopaminergic stimulants.
Tofisopam has a complicated mechanism of action. It does not bind to benzodiazepine receptors and has a limited affinity to the peripheral benzodiazepine receptors, but shown to improve the binding of 1,4-benzodiazepines to their receptors.
The drug acts as a PDE inhibitor with the highest affinity to PDE-4A1, PDE-10A1, PDE-3, and PDE-2A3 which can be responsible for its moderate antipsychotic action.
Several studies suggest that the behavioral effects of Grandaxin are likely to be mediated through its effect on dopaminergic and opioid neurotransmission. Tofisopam appears to increase the sensitivity of dopamine receptors and modulate opioid signal transduction in the brain without the danger of addiction.
Produced by EGIS Pharmaceuticals, Hungary.
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more