grandaxin

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Grandaxin® (Tofisopam)

47 Reviews

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$60.80 /item
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$59.52 /item
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$58.24 /item
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Please note that Grandaxin (Tofisopam) is not a dietary supplement. Read the information below carefully and consult your doctor before purchasing Grandaxin. Tofisopam is not approved for use in North America. Its R-enantiomer is in Phase II clinical trials for the treatment of irritable bowel syndrome.

Synonyms Grandaxin, Emandaxin, Sériel
Form: 20 pills of 50mg / 60 pills of 50mg
Form description: Round, flat tablets of white or greyish-white color in the form of a disc, with a facet and a break line on one side and the engraving “GRANDAX” on the other side, without or with almost no smell.
Active ingredient: Tofisopam—50 mg
Excipients: Stearic acid, magnesium stearate, gelatin, talc, potato starch, lactose monohydrate, microcrystalline cellulose.
CAS Number: 22345-47-7
ATC code: N05BA23
Pharmacological action: Anxiolytic
Shelf life: 5 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store at temperatures no higher than 15-25°C (59-77°F). Keep in a safe place out of reach of children.
Terms of release: Over-the-counter
Manufacturer: EGIS Pharmaceuticals, Hungary

What is Grandaxin (Tofisopam)?

Tofisopam (Grandaxin) is a non-sedating daytime anxiolytic. It belongs to the 2,3-benzodiazepines family (also known as homophthalazines) and differs from typical benzodiazepine derivatives in its mechanism of action.

What is Grandaxin (Tofisopam) Used For?

Tofisopam can be used for the following conditions (according to the manufacturer):

  • Neurosis, psychopathy, and other conditions accompanied by a feeling of emotional stress, anxiety, and fear;
  • Reactive depression with mild psychopathic symptoms;
  • Premenstrual syndrome, climacteric syndrome;
  • Cardialgia (in the form of monotherapy or in combination with other drugs);
  • Myasthenia gravis, myopathies, neurogenic muscular atrophies, and other pathological conditions with secondary neurotic symptoms when anxiolytics with a pronounced muscle relaxant effect are contraindicated; alcohol withdrawal syndrome;
  • Alcohol withdrawal.

More detailed information about the studies on the application can be found in the Research tab.

What Are the Benefits and Effects of Grandaxin (Tofisopam)?

Tofisopam provides anxiolytic effects without addiction risk or withdrawal syndrome. It has a mild stimulant action, does not impair cognitive function, and can enhance the effects of dopaminergic stimulants. Tofisopam does not have sedative, skeletal muscle relaxant, motor skill-impairing, anticonvulsant, or amnestic properties.

Is Grandaxin (Tofisopam) Safe to Take?

Tofisopam has the following contraindications:

    • hypersensitivity to the active or any other ingredient of the medicine or to any other benzodiazepines;
    • conditions accompanied by severe psychomotor agitation, aggressiveness or severe depression;
    • decompensated respiratory failure;
    • 1 trimester of pregnancy and breastfeeding;
    • sleep apnea (in the anamnesis);
    • simultaneous taking of tacrolimus, sirolimus, and cyclosporin;
    • intolerance to galactose, congenital lactase insufficiency, or glucose and galactose malabsorption syndrome (the medicine contains lactose monohydrate).

With caution: decompensated chronic respiratory distress, acute respiratory failure in the anamnesis, angle-closure glaucoma, epilepsy, organic brain lesions (such as atherosclerosis).

Grandaxin review by Boost Your Biology Expert – Lucas Aoun!

FAQ

No schema found.

 

 

What is the Dosage of Grandaxin (Tofisopam)?

Standard dose: 1–2 tablets, 1–3 times per day.

Maximum dose: 300 mg per day.

Occasional use: 1–2 tablets as needed.

Geriatric or renal impairment: use half the dose.

Alcohol withdrawal treatment: duration may vary from several days to 3-6 weeks.

Note: To avoid sleep disturbance, avoid taking it after 3-4 p.m.
Always follow a doctor’s recommendation for proper dosing.

Please consult your healthcare provider before use.

What are the Side Effects of Grandaxin (Tofisopam)?

Tofisopam (Grandaxin) has rare but possible side effects, such as:

  • Allergic reactions;
  • Decreased appetite;
  • Constipation;
  • Flatulence;
  • Nausea;
  • Dry mouth;
  • Headache;
  • Insomnia;
  • Irritability;
  • Agitation;
  • May provoke seizures in patients with epilepsy;
  • Skin rash, itching;
  • Muscle tension.

To prevent sleep disorders, the drug should be taken no later than 3-4 p.m.

For more information on Tofisopam (Grandaxin) dosages and side effects, please refer to the translated official drug sheets linked below.

Grandaxin Official Instruction

 

  1. Varady et al. (1975). The clinical evaluation of Grandaxin used in the treatment of outpatients (a multicentric study).
  2. Sladka et al. (1978). Placebo-controlled study with tofisopam in anxious neurosis.
  3. Bond A.,  Lader M. (1982). A comparison of the psychotropic profiles of tofisopam and diazepam.
  4. Banki C. (1983). Comparative study with Grandaxin and diazepam in alcohol withdrawal syndrome and gerontopsychiatric diseases.
  5. Szego et al. (1993). Excerpts from the clinical-pharmacologic and clinical studies of Grandaxin.
  6. Klebovich et al. (1993). Pharmacokinetics and metabolism of tofizopam (Grandaxin).
  7. Kalashnikov et al. (2002). Immunomodulating effects of tofizopam (Grandaxin) and diazepam in vitro.
  8. Baek et al. (2002). Analysis of tofisopam in human serum by column-switching semi-micro high-performance liquid chromatography and evaluation of tofisopam bioequivalency.
  9. Eros et al. (2002). A population-based case-control teratologic study of nitrazepam, medazepam, tofisopam, alprazolam, and clonazepam treatment during pregnancy.
  10. Kato et al. (2003). A case in which tofisopam was effective for treatment of paroxysmal supraventricular tachycardia.
  11. Arushanian et al. (2004). Peculiarities in the effect of tofisopam and valerian extract on short-term memory and anxiety states in healthy humans.
  12. Plotnikova E., Beloborodova E. (2005). Use of grandaxin in hypermotor dysfunction of the biliary ducts in young people.
  13. Rundfeldt et al. (2010). The atypical anxiolytic drug, tofisopam, selectively blocks phosphodiesterase isoenzymes and is active in the mouse model of negative symptoms of psychosis.
  14. Srivastava et al. (2014). Current Update on Evidence-Based Literature of Tofisopam.
  15. Hatayama et al. (2015). Acute Effects of Oral Tofisopam on Plasma Concentration and Urinary Excretion of Uric Acid and Oxypurinol “Preliminary Communication.”
  16. Agamamedova and Nikitina (2016). Tofisopam: Anxiety Therapy in Neurologic Profile Patients.
  17. Pattnaik et al. (2021). Role of Tofisopam in Post-COVID Neuropsychiatric Sequelae: A Case Series.

 

4.2

Based on 47 Reviews

(32)

(4)

(4)

(3)

(4)

 

08/17/2025

RW

Ralph W

 Verified Buyer
US

US

Works great for my anxiety

I ordered this to deal with stress related anxiety. I put my expectations on hold after reading reviews that were positive and somewhat negative here on Cosmic Nootropic. I feel very fortunate that when taking Grandaxin it completely removes my anxiety, without any sedation. It\'s such a shame that this is not available in the USA, but I\'m not surprised anymore, as our medical system is indeed broken. Imagine how many people could be saved from benzodiazepine addiction and abuse here in the USA. It\'s brilliant that scientists managed to take out just the bad stuff while leaving the good stuff in a benzodiazepine medication. Thank You Cosmic Nootropics!

08/18/2025

CosmicNootropic

We’re so glad to hear Grandaxin has been helping you manage anxiety without the unwanted sedation and that’s exactly what makes it unique. You’re absolutely right that it offers a gentler alternative compared to traditional benzodiazepines. Thank you for trusting Cosmic Nootropic and sharing your experience! Feedback like yours helps others who are searching for effective, safer options.

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08/09/2025

RW

Ralph W

 Verified Buyer
US

US

Sanctuary

Amazingly great experience. I had bought and tried Phenibut from C.N. but that didn\'t do much for me. Over the past6 months and for various reasons I developed severe anxiety, complete with blood pressure that spiked very high. I\'m working with my doctor on that but man, this is the worst anxiety I\'ve experienced in over 30 years. I received my order a few days ago. I tried one pill a couple times and then yesterday, when anxiety was still extreme, I took 1 pill 2 times and 2 pills at a time 1 times. This literally and finally, broke the back of my anxiety, with last BP reading about 150/82. Not great but way better than before, and I went from horrible anxiety, with related elevated BP, to feeling mostly back to my normal self and BP decreasing. I\'ll be going back to doctor in couple weeks, as I just started on baby dose of Losartan, which they doubled 2 days ago. I think they might have to increase it another time but man, so glad I found some sanctuary from the anxiety storm! Thank You Cosmic Nootropic!

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0

08/02/2025

AS

Alexander S.

 Verified Buyer
US

US

Great alternative to other benzos

Grandaxin has a calming effect without sedation and habit-forming side effects of other benzodiazepines, so I can stay mentally alert to do my work without feeling stressed. That's exactly what I needed.

08/03/2025

CosmicNootropic

Dear Alexander, Thank you so much for your review! We're glad to hear that Grandaxin is helping you.

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06/19/2025

JS

Jan S.

 Verified Buyer
US

US

Some effect initially but goes away

I had very high hopes regarding tofisopam, but it didn’t work too well for me. The first dose at evening put me to sleep, but I was never able to replicate this effect regardless of dosing. I have tolerance to benzodiazepines, so it may work for someone without benzo tolerance!

06/20/2025

CosmicNootropic

Thank you for sharing your experience! Responses to products can vary a lot from person to person, and your insight might be helpful to others.

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03/29/2025

AG

Alan G.

 Verified Buyer
US

US

Tofisopam- A Aspirin alternative

This Medicine might work for a weak Aspirin, but wouldn't recommend it for anything else. Save Your money and something else

03/30/2025

CosmicNootropic

Thanks for sharing your thoughts! Tofisopam isn’t actually an aspirin alternative — it’s a different type of product with its own unique effects. If you were looking for something specific, feel free to reach out, and we’d be happy to help!

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0

02/11/2025

A

Alex

 Verified Buyer
US

US

Exceeded expectations

Feels very simular to a low dose of xanax without any noticably intoxicating/addicting qualities, exactly what i was hoping for if not a little better than expected. It was nicely sedating to me with my nightly cannabis dose, very anxiolytic. I have access to xanax but these seem to be a much safer alternative and give me all the same benifets without all the negative effects of benzos. Highly reccomend grandaxin!

02/12/2025

CosmicNootropic

Dear Alex, thank you for your thoughtful review! We're so glad to hear that Grandaxin is providing the benefits you're looking for and that it’s been a safe and effective alternative for you. We truly appreciate your recommendation!

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0

01/19/2025

FL

Fred L.

 Verified Buyer
US

US

Great Product

Great product. Helps with anxiety.

01/19/2025

CosmicNootropic

Thank you for your feedback! We're glad to hear that this product is helping you.

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01/16/2025

JF

Justin F.

 Verified Buyer
US

US

Decent relief for anxiety

As someone who suffers from a genetic neurological condition finally after a brain scan and MRI doctor agreed I suffer from a form of a seizure disorder, causing my brain to misfire at rapid succession as well as PTSD and at times debilitating/crippling panic attack attacks with panic disorder, and have been on Clonazepam for a very, very long time and being forced to wean/taper off of .. even though I am medication compliant with random pill counts and through my drug screen and urine analysis nonetheless and understandably so..I seek relief, and I believe the Grandaxin (Tofizopam) usually 100 mg three times a day, other times 200 mg 2x a day I believe this medication is very helpful at bringing gentle relief, or sort of a gentler landing if you well I almost see it as the tramadol of benzodiazepines, now this review is entirely subjective specific to just my personal genetic make up neurological condition and by no means is this medical advice but simply my personal/subjective review, and in all honesty “GABAergic” wise, if I had to rate them in order from most effective to least I would say 1) Pantogam Active 2) Grandaxin 3)Picamilon and 4th because I see this one is comparing apples to oranges not that it is the least effective by any means perhaps the most effective..but the Selank, start out with the 0.15% nasal drops as prescribed, directed by Cosmic Nootropics and would like to encourage other customers to please check out the YouTube channel as well!! if you are under the care of a medical doctor consult with them being your own advocate, do some research and stay well, blessings and Best of Regards to all!! -Justin F

01/16/2025

CosmicNootropic

Dear Justin, thank you so much for sharing your detailed and thoughtful review! We're really glad to hear that Grandaxin has been helpful for you, and we truly appreciate you outlining your personal experience. We also appreciate your support for our YouTube channel and your encouragement to others. Wishing you continued health and well-being—take care!

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0

11/30/2024

SS

Scott S.

 Verified Buyer
CA

CA

We never received it

It’s been stuck at USA customs for two months and it’s not looking like we will ever receive the pills

12/01/2024

CosmicNootropic

Dear Scott, Unfortunately, customs can be unpredictable, and we're sorry there's an issue with the delivery. We can see that our customer support team have already prepared a reshipment order for you. They're currently waiting for your reply to confirm that all the details are correct so that we can proceed with the shipment. Please check your inbox!

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0

11/23/2024

RW

Ryan W.

 Verified Buyer
US

US

Cool name, interesting to have an OTC benzodiazepine product, albeit I am not certain it works all that well or noticeably.

I'm not sure how I feel about this product. I do believe that, at a dose around 100-200 mg it very gently and subtly tempers anxiety, although it is so subtle as to almost be homeopathic (i.e. I am not even sure if it is the tofisopam or something else). A few times, I woke up groggy with sleep intertia and feel I may have a "hangover" from tofisopam, but I can't tell. In any case, it's worth a shot, but this is not an anxiolytic in the sense that even a lesser-potent benzodiazepine like diazepam or chlordiazepoxide will be. Give it a try!

11/25/2024

CosmicNootropic

Thank you for sharing your detailed feedback, Ryan! We appreciate you giving the product a try and sharing your experience — everyone’s response can be a bit different. If you have any questions or need assistance, feel free to reach out our support team!

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0

11/14/2024

CH

Christopher H.

 Verified Buyer

Gradaxin

Not very good didn't feel anything really maybe you need to take it for a longer period of time

11/15/2024

CosmicNootropic

Hi Christopher! Thank you for your feedback. The effects of nootropics can vary, and some may require longer use for noticeable results. Rest assured, our products are original, certified, and sourced from trusted manufacturers. Feel free to reach out if you have any questions—we’re here to help!

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11/11/2024

CG

Carlos G.

 Verified Buyer
US

US

Excellent grandaxin

Excellent and exceptional

11/11/2024

CosmicNootropic

Hi Carlos! Thank you for the great review and the photos! We’re thrilled to hear you’re enjoying your experience with Grandaxin. Your feedback means a lot to us, and we’re here anytime you need. Enjoy!

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0

11/05/2024

CG

Carlos G.

 Verified Buyer
US

US

Excellent resultd

A plus for two months now. Cosmic delivers

11/08/2024

CosmicNootropic

Hi Carlos! Thank you for your great review! We're so pleased to hear that you’ve had excellent results over the past two months and that our service has met your expectations. Your satisfaction is our top priority, and we're excited to keep delivering the quality you can count on. Here's to continued success!

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10/19/2024

RW

Ryan W.

 Verified Buyer
US

US

Decent quality, brand name, more subtle than benzodiazepines and does not work in minutes, BUT does work within hours.

Among Cosmic Nootropics' selection of anxiolytics, tofisopam (Grandaxin) is a good product; It does not work instantly in the sense that it can stop a panic attack in the moment (at least not in my experience), but it does work quickly in the sense that I felt a calming, sedated effect within an hour or so, and this sensation increases as you increase the dose from 50 mg to the upper threshold of 300 mg. This is a decent product, but the effects are subtle. That said, I concur this does in fact qualify as a daytime anxiolytic....which I specify because some of the other anxiolytic products offered by CN are very sedating, specifically Mebicar. All around, CN is a reputable, legitimate business with quality products and I would recommend. Start off with the 20-count packs if you are going for Grandaxin. For what it's worth, if you are addicted to nicotine (vapes, cigar/ettes, lozenges, patches, etc.) and are interested in stopping, look into the product cytisine (TABEX), which is also sold on this marketplace and is a "banger" among products offered by CN.

10/20/2024

CosmicNootropic

Thanks a lot for the awesome review! We're happy to hear that Grandaxin worked well for you and great you shared how it compares to other options like Mebicar, too. Also, glad to hear Tabex has been helpful for you — definitely a hidden gem! We appreciate you recommending us and trusting our products!

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10/16/2024

N

Nlm

 Verified Buyer
US

US

Incredible

This place is the real deal. I am so happy I found this product as well. It has been an absolute life saver. I would recommend this product to anyone that struggles with anxiety.

10/17/2024

CosmicNootropic

Thank you for your amazing review! We’re so glad to hear that our product has been a lifesaver for you. Your recommendation means the world to us, and we’re committed to helping others find relief as well.

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0

09/21/2024

S

Sam

 Verified Buyer
US

US

Not what I thought it was. But can’t complain about the great service

I thought since tofisopam binds to benzodiazepine receptors it would be at least somewhat sedating but the product description that Cosmic Nootropics gave is very accurate. It is NOT a sedative in any way. Just because it binds to benzo receptors doesn’t mean it enhances GABA-a activity. Just thought I would put that out there if anyone else thought this would be a similar substitute to traditional benzodiazepines but it’s not. I do get anxiety relief from it but in a more social and outgoing way rather than a sedated and calm way.

09/23/2024

CosmicNootropic

Thank you for your honest feedback, Sam! We're glad to hear you had a positive experience with our service and we appreciate your insights on tofisopam — it’s important for customers to know what to expect.

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0

09/12/2024

AW

Al. W

 Verified Buyer
US

US

I enjoy this

Take note everyone is different and will have different experiences. For me, this drug is quite fascinating. It assists with my prescribed ADHD medication on the days I take breaks and increases efficacy. It has slight effects on lessening chronic pains, nothing very pronounced but noticeable. It can causes some anxiety if the dose is too high. I used to be prescribed benzodiazepines & this is very different. Increases sentence fluency & thought clarity. I recommend cycling. Thank you for a great product!

09/12/2024

CosmicNootropic

Hi Al! Thank you for your feedback! We're glad our product helps with your ADHD medication and enhances thought clarity. We noticed your 4-star rating and would love to understand if there's anything specific we could improve. Your insights are important to us as we aim to provide the best experience. Thanks for choosing CosmicNootropic, and feel free to reach out if you need any assistance!

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08/25/2024

alex k.

alex k.

 Verified Buyer
US

US

weird

makes you feel weird

08/29/2024

CosmicNootropic

Hi Alex! Thank you for your feedback. We're sorry to hear that you’re feeling weird with the product. We’d like to understand more about your experience to help address the issue. We’ve sent you an email asking for more details. Please check your inbox and let us know more about what you’ve encountered.

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0

07/28/2024

B

Brad

 Verified Buyer
US

US

Very effective replacement for benzodiazapines!

This medicine got me off of benzodiazapines!

07/28/2024

CosmicNootropic

Dear Benjamin, Thanks for sharing your experience. We're thrilled to hear that Grandaxin has helped you replace benzodiazepines and it's great to know you found a solution that works for you!

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0

07/13/2024

DM

Deron M.

 Verified Buyer
US

US

Making a reasonable difference

I am currently on my second box, and notice a subtle but a difference nonetheless with my anxiety, along with a bit of a energy boost. I've lived with GAD for most of my life, and I highly recommend this product for anyone experiencing anxiety to give it a shot as you may be surprised! And I would be remiss to not mention Cosmic Nootropics as they continued to provide a phenomenal service with incredibly quick delivery. I'm so glad Cosmic Nootropics exists as they are a top notch company providing products that are absolutely hard to find with beautiful employees and first rate customer service! �����

07/31/2024

CosmicNootropic

Hi Deron! Thank you for sharing your experience with Tofisopam! We're glad to hear that you've noticed a subtle but noticeable difference in managing your anxiety, along with a slight boost in energy. We greatly appreciate your recommendation of Tofisopam for others who may be experiencing anxiety. At CosmicNootropic, we are committed to providing top-notch products and excellent customer service. It's fantastic to hear that our service has met your expectations, from quick delivery to helpful support.

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0
< 1 2 3 >

10 months ago

Review

Justin F. Verified Buyer

Decent relief for anxiety

As someone who suffers from a genetic neurological condition finally after a brain scan and MRI doctor agreed I suffer from a form of a seizure disorder, causing my brain to misfire at rapid succession as well as PTSD and at times debilitating/crippling panic attack attacks with panic disorder, and have been on Clonazepam for a very, very long time and being forced to wean/taper off of .. even though I am medication compliant with random pill counts and through my drug screen and urine analysis nonetheless and understandably so..I seek relief, and I believe the Grandaxin (Tofizopam) usually 100 mg three times a day, other times 200 mg 2x a day I believe this medication is very helpful at bringing gentle relief, or sort of a gentler landing if you well I almost see it as the tramadol of benzodiazepines, now this review is entirely subjective specific to just my personal genetic make up neurological condition and by no means is this medical advice but simply my personal/subjective review, and in all honesty “GABAergic” wise, if I had to rate them in order from most effective to least I would say 1) Pantogam Active 2) Grandaxin 3)Picamilon and 4th because I see this one is comparing apples to oranges not that it is the least effective by any means perhaps the most effective..but the Selank, start out with the 0.15% nasal drops as prescribed, directed by Cosmic Nootropics and would like to encourage other customers to please check out the YouTube channel as well!! if you are under the care of a medical doctor consult with them being your own advocate, do some research and stay well, blessings and Best of Regards to all!! -Justin F

Reply:

Dear Justin, thank you so much for sharing your detailed and thoughtful review! We're really glad to hear that Grandaxin has been helpful for you, and we truly appreciate you outlining your personal experience. We also appreciate your support for our YouTube channel and your encouragement to others. Wishing you continued health and well-being—take care!

Response

1 year ago

Review

Carlos G. Verified Buyer

Excellent grandaxin

Excellent and exceptional

Reply:

Hi Carlos! Thank you for the great review and the photos! We’re thrilled to hear you’re enjoying your experience with Grandaxin. Your feedback means a lot to us, and we’re here anytime you need. Enjoy!

Response

1 year ago

Review

Carlos G. Verified Buyer

Excellent grandaxin

Excellent and exceptional

Reply:

Hi Carlos! Thank you for the great review and the photos! We’re thrilled to hear you’re enjoying your experience with Grandaxin. Your feedback means a lot to us, and we’re here anytime you need. Enjoy!

Response

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