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INTERFERON GAMMA (Ingaron ®)

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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product, consulting a qualified MD is mandatory. See more

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Buy Interferon Gamma at the best price!

Ingaron belongs to a gamma class of interferons and is the first and only Russian interferon-gamma medication at this point. Unlike other interferons, interferon-gamma has a combined effect: broad-spectrum antiviral (more than 200 viruses) and immunomodulating activity. Interferon-gamma blocks the penetration and reproduction of viruses and also kills virus-infected cells, which is the second line of defense if a severe infection breaks through the first level of protection.

Soviet scientists began developing Ingaron back in 1989, but because of the reformation period in the country, the research has only been recently completed. In 2006, the drug Ingaron received a license for production and sale.

It is important to note that there is no drug addiction to Ingaron, and side effects are not observed during its use. The convenient form of administration (nasal) and storage makes this antiviral and immunomodulatory agent optimal for use. Before dilution, the solution can be stored at temperatures up to 25°C (77°F). After dilution, it must be stored in the refrigerator for no longer than 10 days.

The potential of the combined use of the two main classes of IFN (alpha and gamma) in the treatment of influenza is demonstrated as well. Clinical studies have shown that the combined use of these types of IFN drugs reduces the severity of the infection process, shortens the duration of the disease, and prevents the development of severe complications.

Produced by Pharmaclon, Russia.

Contents

Ingaron package contains 1 vial of 100 000 IU of Interferon Gamma. In the box, you will find a vial with lyophilisate and a dissolvent. After the dilution, you should use the nasal dropper.

Dosage and administration

The drug is usually used for the treatment of flu, H5N1, and H1N1. 

At the first signs of disease, Ingaron is prescribed for 5–7 days. The usual dose is 2 drops in each nasal passage 5 times a day. As a prophylactic of ARVI, after contact with a sick person and in case of hypothermia use 2-3 drops in each nasal passage 30 minutes prior to breakfast for a period of 10 days. 

Contraindications 

  • Individual intolerance to interferon-gamma or other components of the drug;
  • Pregnancy;
  • Age below 7 y.o.

 

Side effects

Side effects were not observed.

Overdose

The information on the overdose is not available.

Storage conditions

Keep out of the reach of children. Store at a temperature below 20°C (35–46 °F).
Shelf life is 2 years. An open bottle is to be stored in the fridge for no more than 10 days.

Manufacturer

Pharmaclon, Russia.

  1. A Billiau (1983) [Interferons: physiology, pharmacology and pharmacotherapeutic perspectives] https://pubmed.ncbi.nlm.nih.gov/6200731/ 
  2. K Leslie (1994) Gamma-interferon in the treatment of fibrocontractive disorders of the skin https://pubmed.ncbi.nlm.nih.gov/7972477/ 
  3. Metz et al (2001) Interferon-gamma in healthy subjects: selective modulation of inflammatory mediators https://pubmed.ncbi.nlm.nih.gov/11422404/ 
  4. S Mahmutović, E Beslagić (2004) Significance of the interferon (IFN) in the therapy https://pubmed.ncbi.nlm.nih.gov/15628995/ 
  5. Hoxumi et al (2008) Protective effects of interferon-gamma against methamphetamine-induced neurotoxicity https://pubmed.ncbi.nlm.nih.gov/18282668/ 
  6. Mata-Espinosa et al (2008) Interferon-gamma administration after abdominal surgery rescues antigen-specific helper T cell immune reactivity https://pubmed.ncbi.nlm.nih.gov/19227440/ 
  7. S Chevaliez, J-M Pawlotsky (2009) Interferons and their use in persistent viral infections https://pubmed.ncbi.nlm.nih.gov/19048202/ 
  8. A Khryanin, O Reshetinikov (2016) Interferon-Gamma: Treatment Horizons https://pubmed.ncbi.nlm.nih.gov/29874451/ 
  9. M Rakhmatulina, N Bolshenko (2016) [Interferon in combined therapy of human papillomavirus infections associated with sexually transmitted infections. linical observation] https://pubmed.ncbi.nlm.nih.gov/28248030/ 
  10. Rakityanskaya et al (2019) [Influence of ingaron on the dynamics of interferon-α and -γ production and on the manifestation of clinical symptoms in patients with chronic virus Eрsthtein-Barr infection] https://pubmed.ncbi.nlm.nih.gov/30893526/ 
  11. Harada et al (2021) Subcutaneous injection of interferon gamma therapy could be useful for anti-IFN-γ autoantibody associated disseminated nontuberculous mycobacterial infection https://pubmed.ncbi.nlm.nih.gov/33071037/

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10/31/2021

Cy L.

Cy L.

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BE

BE

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all went as expected, arrived in time.

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