melarena-package
melarena-package-2
melarena-instruction
melarena-package
melarena-package-2
melarena-instruction

Melarena [Melatonin]

Clear
Bulk deal
Quantity Discount Discounted price
2 5% -
3 10% -
4 15% -
5 + - -
Bulk pricing will be applied to package:

Buy Melatonin with the fastest delivery!

Description

Melarena (Melatonin) is an adaptogen, sedative and hypnotic drug based on a synthetic analogue of pineal hormone melatonin. It is used in case of jet lag, adjusts sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and helps blind people establish a day and night cycle. It stabilises circadian rhythms.

It increases levels of gamma-Aminobutyric acid and serotonin in the midbrain and hypothalamus as it regulates the pyridoxal kinase which influences the synthesis of these compounds. The drug inhibits the secretion of gonadotropins and other pituitary gland hormones (corticotropin, thyroid stimulating hormone and somatotropin). It normalizes daily changes in body activity and temperature, improves brain activity and reduces irritability. Melarena has a positive effect on night sleep. It helps fall asleep, reduces night time awakenings and facilitates morning awakening.

The drug has also been proven effective in adapting to rapid change of time zones while travelling. Buy Melatonin (Melatonin) to reduce stress and weather sensitivity and stabilize the neuroendocrine system. Melarena has immunomodulating and antioxidant properties. The drug is non-addictive. It has been shown that the natural production of melatonin declines with age, so it is better to use melatonin at an older age.

Indications

Prevention and treatment of:

• desynchronosis (alterations to the body’s circadian rhythms caused by rapid long-distance trans-meridian (east–west or west–east) travel or working shifts and jet lag);
• weather sensitivity;
• fatigue and sleep disorders;
• depression

Check out others adaptogens.

Formulation and Packaging Coated tablets, dosage 0.3 mg and 3 mg Active ingredient: synthetic melatonin 0.3/3 mg Inactive ingredients: calcium hydrophosphate dihydrate 67.37 mg, microcrystalline cellulose 25 mg, sodium croscarmellose 2 mg, povidone K25 3.33 mg, fumed silica 0.5 mg, talc 1 mg and calcium stearate 0.5 mg. Application and Dosage To be administered orally. The dosage is 1 tablet daily 30-40 minutes before sleep. Duration of treatment course is to be prescribed by a doctor (6-8 weeks). If necessary, the treatment courses can be repeated. The dose of 0.3 mg is sufficient in most cases. Side Effects Allergic response, headache, nausea, vomiting, diarrhea, morning sleepiness or edema. Counterindications Hypersensitivity to melatonin and other components of the drug, autoimmune diseases, lymphogranulomatosis, leukemia, lymphoma, myeloma, epilepsy, diabetes mellitus, chronic kidney failure and other kidney diseases, pregnancy, lactation and children under 18 years of age. Overdose Cases of overdose are not registered. Drug Interaction Melarena is incompatible with monoamine oxidase inhibitors, glucocorticoids and cyclosporine. It enhances the effect of CNS depressants and beta blockers. It is not recommended to co-administer Melarena with nonsteroidal anti-inflammatory and hormonal drugs. Storage Conditions Keep out of the reach of children. Store in a dark place at a temperature not higher than 25°C (77°F). Shelf life is 2 years.
  1. P Pevet (2002) Melatonin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181670/
  2. Malhotra et al (2004) The Therapeutic Potential of Melatonin: A Review of the Science https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395802/
  3. Buscemi et al (2004) Melatonin for Treatment of Sleep Disorders: Summary
  4. https://www.ncbi.nlm.nih.gov/books/NBK11941/
  5. Pandi-Perumal et al (2006) Melatonin: Nature's most versatile biological signal? https://www.ncbi.nlm.nih.gov/pubmed/16817850
  6. Ferracioli-Oda et al (2013) Meta-analysis: melatonin for the treatment of primary sleep disorders https://www.ncbi.nlm.nih.gov/pubmed/23691095
  7. I Kostoglou-Athanassiou (2013) Therapeutic applications of melatonin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593297/
  8. Costello et al (2014) The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273450/
  9. B Claustrat, J Leston (2015) Melatonin: Physiological effects in humans https://www.ncbi.nlm.nih.gov/pubmed/25908646
  10. Masters et al (2015) Melatonin, the Hormone of Darkness: From Sleep Promotion to Ebola Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334454/
  11. Tordjman et al (2017) Melatonin: Pharmacology, Functions and Therapeutic Benefits https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405617/
  12. Xie et al (2017) A review of sleep disorders and melatonin https://www.ncbi.nlm.nih.gov/pubmed/28460563
  13. Meng et al (2017) Dietary Sources and Bioactivities of Melatonin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409706/
  14. N Zisapel (2018) New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057895/
  15. Zwart et al (2018) Long-Term Melatonin Therapy for Adolescents and Young Adults with Chronic Sleep Onset Insomnia and Late Melatonin Onset: Evaluation of Sleep Quality, Chronotype, and Lifestyle Factors Compared to Age-Related Randomly Selected Population Cohorts https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872230/

Related products

CORTEXIN ®

$ 35.00$ 63.25

Cortexin® is a mixture of neuropeptide fractions, amino acids, vitamins and minerals. Cortexin® was shown to provide a normalizing effect on many functions of the brain. It has been used in children and adults alike for a wide variety of indications including ADHD, TBI and minor cerebral problems.

Cerebrum compositum is a multi-component homeopathic medicine intended to improve brain metabolism. It is useful as part of complex therapy of different types of encephalopathy as it stimulates immunity and cell regeneration. It helps enhance brain function and improve the overall body tone, performance and mood. The medicine is built up of more than 20В homeopathic animal, herbal and mineral components.

Biotredin is a nootropic medication which improves metabolism and boosts cellular energy. The drug is comprised of L-threonine and pyridoxine hydrochloride (vitamin B6). Together, threonine and vitamin B6 interact to form:В The amino acid glycine, Acetaldehyde.The resulting substance promotes active stimulation of inhibitory processes, oxidation-reduction, and supports respiratory function, and synthesis of adenosine triphosphate in the cells.

BEMITIL [Metaprot]

$ 24.50$ 25.00

Bemitil has a long history of usage in clinical practice and in sport. It is the reference drug of actoprotectors class. Actoprotectors are the substances that are intended to improve physical performance of people exposed to stressful conditions, such as high physical loads, heat exposure, and hypoxia. It is often used recreationally to improve cognitive functions and physical performance.

A perfect alternative for the discontinued Ladasten (Bromantane)