buy melatonin

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MELATONIN (Melarena ®, Good Sleep ®)

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Melatonin is an adaptogen, sedative and hypnotic drug based on a synthetic analog of the pineal hormone melatonin. It is used to normalize the sleep-wake cycle and stabilize circadian rhythms in case of jet lag, sleeping disorders or shift work. It can helpful in case of weather sensitivity.

Buy Melatonin (Melarena ®, Good Sleep ®) with fast US delivery. Save with the volume discount!


Synonyms 5-Methoxy-N-acetyltryptamine / N-Acetyl-5-methoxytryptamine / NSC-113928
Form: 30 pills of 0.3mg /  30 pills of 3mg / spray 30ml
Form description: Round biconvex film-coated tablets of light brown color.
Active ingredient for pills: Synthetic melatonin
Excipients for pills: Calcium hydrophosphate dihydrate, microcrystalline cellulose, sodium croscarmellose, povidone K25, fumed silica, talc, calcium stearate.
Shell composition: hypromellose, macrogol 400, triethyl citrate, titanium dioxide, aluminum varnish FD&C blue No. 2, aluminum varnish FD&C blue No. 1, quinoline yellow, iron dye black oxide.
Active ingredients for spray: 20 mg of Passiflora incamata liquid extract and 1.95 mg of Melatonin per dose
Excipients for spray: Distilled water
СAS Number: 73-31-4
ATC code: N05CH01
Pharmacological action: Adaptogen
Shelf life: 2 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Stada / Nizhfarm, Russia

What is Melatonin?

Melatonin is a natural compound found in plants and animals, first discovered in 1958. It is primarily known as a hormone released by the pineal gland in the brain at night, and has long been associated with control of the sleep-wake cycle. Melatonin is involved in synchronizing circadian rhythms, including sleep-wake cycle and blood pressure regulation. It is also responsible for seasonal rhythmicity including reproduction, fattening, and hibernation.

As a dietary supplement, Melatonin is used in the treatment of sleep and circadian rhythm disorders.

What is the Mechanism of Action of Melatonin?

Intake of Melatonin increases levels of gamma-Aminobutyric acid and serotonin in the midbrain and hypothalamus as melatonin is responsible for regulating the pyridoxal kinase and higher Melatonin levels influence the synthesis of these compounds. The drug inhibits the secretion of gonadotropins and other pituitary gland hormones (corticotropin, thyroid-stimulating hormone, and somatotropin). It normalizes daily changes in body activity and temperature, improves brain activity, and reduces irritability.

What are the Benefits and Effects of Melatonin?

Melatonin has a positive effect on night sleep. It helps fall asleep, reduces nighttime awakenings, and facilitates morning awakening.

The drug has also been proven effective in adapting to the rapid change of time zones while traveling. Melatonin can be used to reduce stress and weather sensitivity and stabilize the neuroendocrine system. Melatonin has immunomodulating and antioxidant properties. The drug is non-addictive. It has been shown that the natural production of melatonin declines with age, so it is better to use melatonin at an older age.

What is Melatonin Used For?

Melatonin is used in the prevention and treatment of:

  • Desynchronosis (alterations to the body’s circadian rhythms caused by rapid long-distance trans-meridian (east-west or west-east) travel or working shifts and jet lag);
  • Weather sensitivity;
  • Fatigue and sleep disorders;
  • Depression.

Melatonin also helps blind people establish a day and night cycle.

Read our review on using Melatonin in the treatment of COVID-19 and cancer.

Where Can I Order Melatonin Online?

You can buy Melatonin online at different vendors. CosmicNootropic offers Melatonin (Melarena) in packs of 30×0.3mg pills and 30x3mg pills and Melatonin (Good Sleep) in the spray 30 ml. Melatonin spray contains passionflower extract with natural sedative properties – it reduces stress and promotes healthy sleep.

We offer fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Melatonin (Melarena, Good Sleep) and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

 

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Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Melatonin Dosage, How to Use It?

Tablets

To be administered orally. The dosage is 1 tablet daily 30–40 minutes before sleep. Duration of treatment course is to be prescribed by a doctor (6–8 weeks). If necessary, the treatment courses can be repeated.

The dose of 0.3 mg is sufficient in most cases.

Good Sleep spray

To be administered sublingually. Remove the spray cap. Spray the aerosol once under the tongue. This way one dose or 150 mg of preparation is administered. The recommended dosage is one dose once a day, 20 minutes before bedtime. Shake well before use.

30 ml of the preparation contains 200 doses.

Sublingual administration of the spray provides absorption that is 4 times faster than using melatonin tablets.

What are the Side Effects of Melatonin?

Possible side effects include allergic response, headache, nausea, vomiting, diarrhea, morning sleepiness, or edema.

Contraindications

Hypersensitivity to melatonin and other components of the drug, autoimmune diseases, lymphogranulomatosis, leukemia, lymphoma, myeloma, epilepsy, diabetes mellitus, chronic kidney failure and other kidney diseases, pregnancy, lactation, and children under 18 years of age.

Overdose

Cases of overdose are not registered.

Drug interaction

Melarena is incompatible with monoamine oxidase inhibitors, glucocorticoids, and cyclosporine.

It enhances the effect of CNS depressants and beta-blockers.

It is not recommended to co-administer Melarena with nonsteroidal anti-inflammatory and hormonal drugs.

  1. P Pevet (2002) Melatonin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181670/
  2. Malhotra et al (2004) The Therapeutic Potential of Melatonin: A Review of the Science https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1395802/
  3. Buscemi et al (2004) Melatonin for Treatment of Sleep Disorders: Summary
  4. https://www.ncbi.nlm.nih.gov/books/NBK11941/
  5. Pandi-Perumal et al (2006) Melatonin: Nature’s most versatile biological signal? https://www.ncbi.nlm.nih.gov/pubmed/16817850
  6. Ferracioli-Oda et al (2013) Meta-analysis: melatonin for the treatment of primary sleep disorders https://www.ncbi.nlm.nih.gov/pubmed/23691095
  7. I Kostoglou-Athanassiou (2013) Therapeutic applications of melatonin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3593297/
  8. Costello et al (2014) The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4273450/
  9. B Claustrat, J Leston (2015) Melatonin: Physiological effects in humans https://www.ncbi.nlm.nih.gov/pubmed/25908646
  10. Masters et al (2015) Melatonin, the Hormone of Darkness: From Sleep Promotion to Ebola Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334454/
  11. Tordjman et al (2017) Melatonin: Pharmacology, Functions and Therapeutic Benefits https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405617/
  12. Xie et al (2017) A review of sleep disorders and melatonin https://www.ncbi.nlm.nih.gov/pubmed/28460563
  13. Meng et al (2017) Dietary Sources and Bioactivities of Melatonin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409706/
  14. N Zisapel (2018) New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057895/
  15. Zwart et al (2018) Long-Term Melatonin Therapy for Adolescents and Young Adults with Chronic Sleep Onset Insomnia and Late Melatonin Onset: Evaluation of Sleep Quality, Chronotype, and Lifestyle Factors Compared to Age-Related Randomly Selected Population Cohorts https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872230/
  16. Delpino et al (2021) Melatonin supplementation and anthropometric indicators of obesity: A systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/34626955/ 
  17. Park et al (2022) Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs https://pubmed.ncbi.nlm.nih.gov/36401340/ 
  18. Mansilla-Roselló et al (2022) A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in surgical patients with severe sepsis admitted to the intensive care unit https://pubmed.ncbi.nlm.nih.gov/36428216/ 
  19. Faridzadeh et al (2022) The role of melatonin as an adjuvant in the treatment of COVID-19: A systematic review https://pubmed.ncbi.nlm.nih.gov/36254292/
  20. Puliappadamb et al (2022) Efficacy and Safety of Melatonin as Prophylaxis for Migraine in Adults: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/36445912/

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