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MEMANTINE (Memantale ®)

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Buy Memantine (Memantale®) Online!

Memantale® (Memantine) is a anti-Alzheimer medication. It reduces the actions of chemicals in the brain that may contribute to the symptoms of memory loss. Memantine can also treat epilepsy, multiple sclerosis, Parkinson’s and Huntington’s diseases. It is said to be effective for improving cognitive processes and reversing tolerance for caffeine, nicotine, and opioids.


Synonyms Memantine / Memantale / Namenda
Form: 60 pills of 10mg
Active ingredient: Memantine hydrochloride – 10mg
Excipients: Lactose monohydrate – 149.75 mg, microcrystalline cellulose – 27.10 mg, talc – 11.15 mg, colloidal silicon dioxide – 1.25 mg, magnesium stearate – 0.75 mg.
Film coating: opadry white (lactose monohydrate – 2.16 mg, hypromellose – 1.68 mg, titanium dioxide – 1.56 mg, macrogol-4000 0.60 mg) – 6.00 mg.
СAS Number: 19982-08-2
ATC code: N06DX01
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Sotex, Russia

 

What is Memantine?

Memantine hydrochloride (HCl), also known as Memantale, is a cognitive-enhancing medication used to treat moderate-to-severe Alzheimer’s disease. Memantine is approved by the FDA and is a legal prescription drug in the United States. Memantine HCl helps keep the nerve cells in the brain working properly.

It works by blocking NMDA receptors, which are responsible for memory loss, dementia, and confusion in patients with Alzheimer’s disease. Memantine HCl is also used to treat Parkinson’s disease since it works as an antipsychotic drug.

Off-label Memantine hydrochloride can be used for reversing tolerance for caffeine, nicotine, and opioids and as a treatment for generalized anxiety disorder (GAD).

How Does Memantine Work?

Memantine HCl is an adamantane derivative and a non-competitive NMDA receptor antagonist. Memantine HCl has a modulatory effect on the glutamatergic system. Memantine (Memantale) reduces certain types of brain activity by NMDA receptor binding and blocking the activity of glutamate.

It regulates ion transport, blocks calcium channels, normalizes membrane potential, and improves nerve impulse transmission. As a result, it can have a cognitive-enhancing effect.

What are the Benefits of Memantine?

There are many benefits to Memantine HCl:

  • It is an approved medication for Alzheimer’s symptoms. Memantine HCl is reported to improve cognition in patients with dementia of Alzheimer’s type.
  • Memantine HCl can improve cognitive processes and health state, thus increasing daily activity.
  • Memantine HCl is also a valuable drug for people struggling with addictions.
  • Besides, Memantine HCl can be helpful in treating agitation and hallucinations.

Where Can I Order Memantine Online?

You can order Memantine (Memantale) online from different vendors. CosmicNootropic offers it in packs of 60x10mg pills. We have fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Memantine and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.

 

Check out other nootropics for brain health!

 


Legal Disclaimer
This form might not be approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Memantine Dosage?

The starting dosage of Memantine HCl pills is 5 mg daily. It can slowly be tapered up to 10-20 mg, depending on the indication.

Please note that Memantine half-life is 60–100 hours. Therefore caution shall be taken when tapering up after the first days of use.

Below are some guidelines on how to take this medication:

  • Dosage is based on medical condition and response to treatment.
  • Memantine will bring the best results when taken at the same time of the day regularly.
  • Always follow the directions given by your doctor.

It can take up to four weeks for Memantine HCl to manifest its effects.

Memantine Side Effects

Some people may experience diarrhea, dizziness, pain, and headache. Memantine side effects also include allergies, confusion, agitation, and hallucinations. In case of side effects, it is recommended to consult with a doctor immediately.

Caution

Driving shall be avoided when taking Memantale.

Memantine Interactions

It is generally safe for patients to take Memantine HCl with most foods. But some interactions can occur with other medications.

Concomitant use with antidepressants, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAOIs) requires close monitoring. Memantine HCl may not be safe to take with amantadine, dextromethorphan, ketamine, and phenytoin.

This page does not contain all possible drug interactions. Discuss with your doctor any drugs you may be taking before the treatment with Memantine.

Is Memantine Compatible with Alcohol?

Alcohol shall be avoided when taking Memantine nootropic as it can interfere with the medication’s effectiveness.

Memantine Trustworthy Reviews

To read about Memantine experiences check the ‘Review’ tab above or user anecdotal reports on the Memantine Reddit page.

  1. M Rogawski, G Wenk (2003) The neuropharmacological basis for the use of memantine in the treatment of Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/14530799
  2. Reisberg et al (2003) Memantine in moderate-to-severe Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/12672860
  3. Mobius et al (2004) Memantine hydrochloride: pharmacological and clinical profile https://www.ncbi.nlm.nih.gov/pubmed/15510240
  4. Unger et al (2005) Effect of memantine on the a7 neuronal nicotinic receptors, synaptophysin- and low molecular weight MAP-2 levels in the brain of transgenic mice over-expressing human acetylcholinesterase https://pubmed.ncbi.nlm.nih.gov/15372325/
  5. R Tampi, C van Dyck (2007) Memantine: efficacy and safety in mild-to-severe Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654628/
  6. Charles et al (2007) Memantine for prevention of migraine: a retrospective study of 60 cases https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3451671/
  7. H Kavirajan, L Schneider (2007) Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials https://www.ncbi.nlm.nih.gov/pubmed/17689146
  8. Farlow et al (2008) Memantine for the treatment of Alzheimer’s disease: tolerability and safety data from clinical trials https://www.ncbi.nlm.nih.gov/pubmed/18558791
  9. Porsteinsson et al (2008) Memantine treatment in patients with mild to moderate Alzheimer’s disease already receiving a cholinesterase inhibitor: a randomized, double-blind, placebo-controlled trial https://www.ncbi.nlm.nih.gov/pubmed/18288936
  10. S Thomas, G Grossberg (2009) Memantine: a review of studies into its safety and efficacy in treating Alzheimer’s disease and other dementias https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762361/
  11. Howard et al (2012) Donepezil and memantine for moderate-to-severe Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/22397651
  12. Yang et al (2013) Effectiveness and safety of memantine treatment for Alzheimer’s disease https://www.ncbi.nlm.nih.gov/pubmed/23635410
  13. Dysken et al (2014) Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease The TEAM-AD VA Cooperative Randomized Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109898/
  14. Nakamura et al (2014) Efficacy and safety of memantine in patients with moderate-to-severe Alzheimer’s disease: results of a pooled analysis of two randomized, double-blind, placebo-controlled trials in Japan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4025599/
  15. Matsunaga et al (2015) Memantine monotherapy for Alzheimer’s disease: a systematic review and meta-analysis https://www.ncbi.nlm.nih.gov/pubmed/25860130
  16. Atri et al (2015) Cumulative, additive benefits of memantine-donepezil combination over component monotherapies in moderate to severe Alzheimer’s dementia: a pooled area under the curve analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436119/
  17. Hager et al (2016) Effect of concomitant use of memantine on mortality and efficacy outcomes of galantamine-treated patients with Alzheimer’s disease: post-hoc analysis of a randomized placebo-controlled study https://www.ncbi.nlm.nih.gov/pubmed/27846868
  18. Marimuthu et al (2016) Evaluating the efficacy of memantine on improving cognitive functions in epileptic patients receiving anti-epileptic drugs: A double-blind placebo-controlled clinical trial (Phase IIIb pilot study) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980957/
  19. Kishi et al (2017) Memantine for Alzheimer’s Disease: An Updated Systematic Review and Meta-analysis https://www.ncbi.nlm.nih.gov/pubmed/28922160
  20. Karahmadi et al (2017) Study of the effect of Memantine therapy on the treatment of dyslexia in children https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767814/
  21. N Titova et al (2017) Memantine: from the original brand to generics https://www.ncbi.nlm.nih.gov/pubmed/29171502
  22. Folch et al (2018) Memantine for the Treatment of Dementia: A Review on its Current and Future Applications https://www.ncbi.nlm.nih.gov/pubmed/29254093
  23. Tavakoli-Ardakani et al (2018) Study of the Effect of Memantine on Negative Sign in Patients with Schizophrenia and Schizoaffective Disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958331/
  24. Balázs et al (2021) Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias https://pubmed.ncbi.nlm.nih.gov/34856086/ 
  25. Holland et al (2021) Effect of Memantine on Prolonging Safe Driving in Early AD: a Pilot Study https://pubmed.ncbi.nlm.nih.gov/34912482/ 
  26. Schiller et al (2022) Randomized placebo-controlled crossover trial of memantine in children with epileptic encephalopathy https://pubmed.ncbi.nlm.nih.gov/36256600/
  27. Niemeyer et al (2022) Memantine as treatment for compulsivity in child and adolescent psychiatry: Descriptive findings from an incompleted randomized, double-blind, placebo-controlled trial https://pubmed.ncbi.nlm.nih.gov/36092975/
  28. Motamedi et al (2022) Memantine administration in patients with optic neuritis: a double blind randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/35781594/

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