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Mexidol® is a unique development of the Russian pharmaceutical industry. Due to the universal mechanism of action and a wide range of pharmacological effects, Mexidol® is effective in the treatment of acute and chronic diseases caused by ischemia and hypoxia of various origins. Nowadays the drug is widely used in neurology, therapy, cardiology, psychiatry, and narcology. Mexidol® is produced at leading pharmaceutical manufacturing sites in the Russian Federation, which operate in accordance with GMP (Good Manufacturing Practice) production and quality control standards.

The development of Mexidol® is closely associated with the name of the Soviet chemist N.N. Semenov, who was awarded the Nobel Prize in Chemistry for his piece of research on free radicals in 1956. Understanding the mechanisms of the free radical formation became the basis for creating the concept of combating tissue ischemia and for developing drugs with antioxidant and antihypoxic activity. The work on Mexidol® was continued by the students of N.N. Semenov in the 1980s. The drug has been in clinical practice since the middle 1990s.

We also sell a close analogue of Mexidol – Ethoxidol. Be sure to check it out, as it is more effective than Mexidol in some cases!

The presence of succinate in the structure of Mexidol® is of fundamental importance for the manifestation of its pharmacological effects since succinate is functionally significant for many processes in the body. In particular, it is a substrate for increasing the energy metabolism in the cell. Due to its properties, free radicals, which have a damaging effect on the cellular structures, are deactivated.

Mexidol® is known to treat the followings diseases:

  • Neurological problems: vegetovascular dystonia, acute cerebral circulation disorders, cognitive problems associated with cerebral arteriosclerosis (impaired memory, speech, loss of basic skills, etc.);
  • In psychiatry: withdrawal syndrome (alcohol or drug withdrawal), anxiety, neurosis, intoxication with drugs from the group of antipsychotics;
  • In surgery: for the complex treatment of acute purulent-inflammatory processes in the peritoneum.

Country of Manufacture: Russia. Produced by Pharmasoft.

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Dosage and Administration The drug is taken orally, 1-2 pills 3 times a day, maximum daily dose is 6 pills. The general period of therapy is 2-6 weeks. The duration of the therapy for the alcohol abstinence treatment is 5-7 days. The duration of treatment in case of ischemic heart disease is 1.5 - 2 months or more. Contraindications Hypersensitivity, acute kidney and liver diseases. Pregnancy and lactation. Side Effects & Overdose Allergic reactions are possible. The patient may feel drowsiness in case of an overdose. Hence special caution must be taken when driving vehicles and engaging in other potentially dangerous activities. Awards:
  • 2003 - award of the Government of the Russian Federation for the development and implementation of Mexidol® in clinical practice;
  • 2014 - Russian Pharma Awards in the nomination “The Drug of Choice in the Treatment of Ischemic Disorders Caused by Cerebral Spasm”;
  • 2016 - "Molecule of Life" award of the Russian Scientific Medical Community of Therapists.
  1. Ivanov et al (2002) Effectiveness of mexidol in acute pancreatitis
  2. Garazha et al (2006) Efficacy of the use of antioxidant preparation mexidol in comprehensive treatment of inflammatory diseases of parodontium
  3. Voronina et al (2007) Mexidol effects in extreme conditions (experiments with animals)
  4. Volchegorskii et al (2008) Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome
  5. L Abramenko et al (2011) The assessment of the clinical efficacy, vasoactive and metabolic effects of mexidol in elderly patients with discirculatory encephalopathy
  6. Volchegorkii et al (2011) Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients
  7. Tsublova et al (2012) Studies on actoprotective and antihypoxic properties of new succinate-containing benzothiazole derivatives
  8. Motin et al (2012) Electrophysiological study of the mechanism of mexidol action
  9. Shchul’kin et al (2014) A comparative study of mexidol and mexiprim pharmacokinetic parameters
  10. Androfagina et al (2015) Mexidol in the rehabilitation of patients in the acute ischemic stroke
  11. V Sergin, T Dronova (2015) The use of mexidol in the intensive treatment of acute severe ischemic stroke
  12. Chukanova et al (2015) The results of the study of the efficacy and safety of mexidol in patients with chronic cerebral ischemia
  13. Berezhnaya et al (2016) The efficacy of combination therapy with mexidol and cerebrolysin in chronic cerebral ischemia
  14. Povarnina et al (2017) Comparison of the Pharmacological Effects of Dimeric Dipeptide Nerve Growth Factor Mimetic GK-2 and Mexidol on the Model of Ischemic Stroke in Rats
  15. Stakhovskaya et al (2017) Results of a randomized double blind multicenter placebo-controlled, in parallel groups trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA)
  16. Volchegorskii et al (2017) Anxiolytic and antidepressant effects of emoxipine, reamberin and mexidol in experimental diabetes mellitus
  17. Gromova et al (2017) A study of the neuroprotective effect of mexidol on the cell model of glutamate stress
  18. N Kulai, E Kovalchuk (2018) Assessment of the efficacy of mexidol in the combination with hyperbaric oxygen in acute ischemic stroke
  19. Zamoshchina et al (2018) Effect of mexidol on physical working capacity and level of lactate in the blood of rats in conditions of light deprivation
  20. Gromova et al (2018) Experience with mexidol in neurological practice
  21. Yakusheva et al (2018) An effect of mexidol on the expression of the transcription factor Nrf2 in the rat cerebral cortex in ischemia
  22. Godunova et al (2018) An influence of submaximal (submineximal) doses of mexidol on oxidant stress and inflammation in the acute period of ischemic stroke
  23. E Dyakonova, V Makerova (2018) Mono- and combination therapy with the mexidol in young patients with cerebral angiodystonia
  24. E Polozova (2018) Preventive therapy with mexidol in toxic damage to the heart

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