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Mexidol® (Emoxypine)
25 Reviews
Synonyms | Emoxypine / 2-ethyl-6-methyl-3-hydroxypyridine / Mexifin |
Form: | 30 pills of 125mg / 10 vials of 2 ml |
Active ingredient: | Ethylmethylhydroxypyridine succinate (2-ethyl-6-methyl-3-hydroxypyridine) – 125 mg in pills or 50 mg/1 ml in vials |
Excipients for pills: | Lactose monohydrate – 97.5 mg, povidone – 25 mg, magnesium stearate – 2.5 mg. Film coat: opadrai II white 33G28435 – 7.5 mg (hypromellose 3 mg, titanium dioxide – 1.875 mg, lactose monohydrate – 1.575 mg, polyethylene glycol (macrogol) – 0.6 mg, triacetin – 0.45 mg). |
Excipients for vials: | Sodium metabisulfite – 0.4 mg, water for injection – up to 1 ml. |
СAS Number: | 2364-75-2 |
ATC code: | N07XX |
Pharmacological action: | Antioxidant, anxiolytic, anti-hypoxic, anticonvulsant, anti-ischemic, nootropic, neuroprotective, anti-inflammatory, and cardioprotective |
Shelf life: | 3 years. Do not use it beyond the expiration date printed on the package. |
Storage conditions: | Store in a dry, dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children. |
Terms of release: | Over-the-counter |
Manufacturer: | Pharmasoft |
What is Mexidol?
Mexidol is an antioxidant, an inhibitor of free-radical processes, and a membrane protector. In studies, it shows anti-hypoxic, stress-protective, nootropic, anticonvulsant, and anxiolytic action.
It was developed in the post-USSR and has been in clinical practice since the 1990s as a tool that can increase the body’s resistance to various damaging factors such as shock, hypoxia, ischemia, and cerebral circulation disorders. The chemical structure of thisstress-adaptogen resembles that of vitamin B6.
What is Mexidol Used For?
Mexidol has been researched for use in acute and chronic conditions caused by ischemia and hypoxia, such as:
- Cerebral circulation disorders;
- Cognitive disorders, such as impaired memory, speech, loss of basic skills, etc.
- Withdrawal syndrome from alcohol or drug abuse, intoxication;
- Anxiety disorders, neurosis.
More detailed information about the studies on the application can be found in the Research tab.
What are the Benefits and Effects of Mexidol?
Preliminary studies suggest that Mexidol may support cerebral blood flow, reduce oxidative stress, and enhance cognitive functions like memory and learning. It appears to show antistress and antitoxic effects, particularly in cases of alcohol withdrawal. Some evidence also points to cardioprotective properties. Studies show that it can also reduce platelet aggregation and lower the level of total cholesterol and low-density lipoproteins.
Additionally, Mexidol is thought to enhance the efficacy of other neuroactive drugs in nootropics stacks, potentially allowing for lower doses. However, many of these effects are based on limited or regional clinical research, so broader validation is still needed.
Is Mexidol Safe To Take?
Mexidol has certain contraindications, such as hypersensitivity, acute kidney and liver diseases, pregnancy, and lactation.
Always consult a doctor before starting new supplements, especially if you have any health issues.
FAQ:
What is Mexidol Pharmacology?
The pharmacology of Mexidol includes antioxidant, anti-hypoxic, and membrane-protective properties. The presence of succinate in the structure of Mexidol is of fundamental importance for the manifestation of its pharmacological effects, since succinate is functionally significant for many processes in the body.
What are Mexidol Dosage Forms?
Mexidol goes in packs of 30x125mg pills or 10x2ml vials.
Where Can I Order Mexidol Online?
You can order Mexidol (Emoxypine) online from different vendors. CosmicNootropic offers worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
What is the Dosage of Mexidol?
Mexidol Pills
Mexidol pills are taken orally, 1-2 pills 3 times a day. The maximum daily dose is 800 mg (6 pills). The common duration of the course is 2–6 weeks.
Mexidol Injections
Mexidol injections are administered intramuscularly or intravenously (stream or drip). The maximum daily dose should not exceed 1200 mg. Detailed dosages for injections depend on the person’s conditions and the doctor’s recommendations.
What are the Side Effects of Mexidol?
Side effects of Mexidol include nausea, dry mouth, allergic reactions, etc.
For more information on Mexidol dosages and side effects, please refer to the translated official drug sheets linked below.
Mexidol Pills Official Instruction
Mexidol Injections Official Instruction
- Ivanov et al. (2002). Effectiveness of Mexidol in acute pancreatitis.
- Garazha et al. (2006). Efficacy of the use of antioxidant preparation Mexidol in the comprehensive treatment of inflammatory diseases of the parodontium.
- Voronina et al. (2007). Mexidol effects in extreme conditions (experiments with animals).
- Volchegorskii et al. (2008). Effect of alpha-lipoic acid and mexidol on neuro- and affective status in patients at early stages of diabetic foot syndrome.
- Abramenko et al. (2011). The assessment of the clinical efficacy, vasoactive and metabolic effects of mexidol in elderly patients with discirculatory encephalopathy.
- Volchegorkii et al. (2011). Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions, and quality of life in diabetes mellitus patients.
- Tsublova et al. (2012). Studies on actoprotective and antihypoxic properties of new succinate-containing benzothiazole derivatives.
- Motin et al. (2012). Electrophysiological study of the mechanism of mexidol action.
- Shchul’kin et al. (2014). A comparative study of Mexidol and Mexiprim pharmacokinetic parameters.
- Androfagina et al. (2015). Mexidol in the rehabilitation of patients with acute ischemic stroke.
- Sergin, Dronova (2015). The use of Mexidol in the intensive treatment of acute severe ischemic stroke.
- Chukanova et al. (2015). The results of the study of the efficacy and safety of Mexidol in patients with chronic cerebral ischemia.
- Berezhnaya et al. (2016.) The efficacy of combination therapy with Mexidol and Cerebrolysin in chronic cerebral ischemia.
- Povarnina et al. (2017). Comparison of the Pharmacological Effects of Dimeric Dipeptide Nerve Growth Factor Mimetic GK-2 and Mexidol on the Model of Ischemic Stroke in Rats.
- Stakhovskaya et al. (2017). Results of a randomized, double-blind, multicenter, placebo-controlled, in parallel groups trial of the efficacy and safety of prolonged sequential therapy with mexidol in the acute and early recovery stages of hemispheric ischemic stroke (EPICA).
- Volchegorskii et al. (2017). Anxiolytic and antidepressant effects of emoxipine, reamberin, and mexidol in experimental diabetes mellitus.
- Gromova et al. (2017). A study of the neuroprotective effect of Mexidol on the cell model of glutamate stress.
- Kulai, Kovalchuk (2018). Assessment of the efficacy of Mexidol in combination with hyperbaric oxygen in acute ischemic stroke.
- Zamoshchina et al. (2018). Effect of Mexidol on physical working capacity and level of lactate in the blood of rats in conditions of light deprivation.
- Gromova et al. (2018). Experience with mexidol in neurological practice.
- Yakusheva et al. (2018). An effect of Mexidol on the expression of the transcription factor Nrf2 in the rat cerebral cortex in ischemia.
- Godunova et al. (2018). An influence of submaximal (submineximal) doses of mexidol on oxidant stress and inflammation in the acute period of ischemic stroke.
- Dyakonova, Makerova (2018). Mono- and combination therapy with Mexidol in young patients with cerebral angiodystonia.
- Polozova (2018). Preventive therapy with Mexidol in toxic damage to the heart.
- Kunelskaya et al. (2019). The Possibility of application of Mexidol for the treatment of patients suffering from sensorineural hearing loss and cerebrovascular insufficiency.
- Shamrey et al. (2020). Possibilities of using Mexidol in the complex therapy of mental disorders.
- Zavadenko et al. (2022). Results of a multicenter, double-blind, randomized, placebo-controlled clinical trial evaluating the efficacy and safety of Mexidol in the treatment of Attention Deficit Hyperactivity Disorder in Children (MEGA).
- Voronina et al. (2022). The role of oxidative stress in hemorrhagic stroke and restorative effects of Mexidol.
- Gupta et al. (2022). Promising effects of emoxypine and its succinate derivative in the management of various diseases-with insights on recent patent applications.
4.5
Based on 25 Reviews
(21)
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(2)
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(2)
03/24/2025
Kari B.
Verified BuyerUS
Helped with long Covid
Based on published studies I started taking this to help combat the brain fog and other effects of long Covid. It definitely helped, and so far I’ve not experienced any side effects.
03/26/2025
CosmicNootropic
Dear Kari, thank you for sharing your experience! We’re glad to hear that the product helped with the brain fog and other effects of long Covid. We appreciate your feedback and wish you continued well-being!
10/01/2024
Brandon
Verified BuyerUS
Migraines
The first two days I took it, it worked great. On the third I noticed a bad headache and the forth day was a full blown migraine. I only took a half tablet each day. So I waited a week and tried again. I took a quarter of a tablet and got a migraine. I had not had a migraine in months and this definitely triggers them. I imagine this might work really well for some people but that fact that it can trigger migraines is very troubling.
10/01/2024
CosmicNootropic
Dear Brandon, thank you for your honest feedback! We are sorry that the product was not useful for you. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.
09/23/2024
Mike S
Verified BuyerUS
Best Emoxypine around
We\'ve all tried multiple supplements. Emoxypine is something I respond very well too. Therefore I will keep it stocked in my medicine cabinet. If its a stressful day I can count on it to help calm me down and clear my head.
09/24/2024
CosmicNootropic
Hi Mike! Thank you for your fantastic review! We’re so glad to hear that Emoxypine works well for you and helps you manage stress. It’s always great to find a supplement that fits your needs!
09/12/2024
Nick B.
Verified BuyerUS
Effective
Subtle but effective and good as a hangover remedy
09/13/2024
CosmicNootropic
Hi Nick! Thank you for your feedback! We're glad to hear that Mexidol has been effective and useful as a hangover remedy. We noticed you rated it 3/5 stars. If there are specific aspects where you think we could improve or any additional feedback you'd like to share, we’d love to hear more. Your insights are important to us!
08/30/2024
David S.
Verified BuyerUS
Excellent product
Really worked great on mood
08/30/2024
CosmicNootropic
Hi David! Thank you for your feedback! We're thrilled to hear that it worked great for you.
07/22/2024
john t.
Verified BuyerUS
Top 3 Favorite Nootropic!
Mexidol is amazing! When I stack it Meldonium and a race tam it boosts me through my workouts and morning routine!
07/23/2024
CosmicNootropic
Hi John! Thank you for sharing your experience with these products! It's fantastic to hear how well it enhances your workouts and morning routine. Keep up the great work!
05/24/2024
Patrick J.
Verified BuyerUS
Mexidol
Very good work as promised
05/27/2024
CosmicNootropic
Hi Patrick! Thank you for leaving your review!
03/08/2024
Lance B.
Verified BuyerUS
very efective
my hopes and expectations were exceeded. It does everything they put in the product description and more
03/09/2024
CosmicNootropic
Hi Lance! Thank you for sharing. We are so happy to hear that this product is beneficial to you!
03/05/2024
Dan W.
Verified BuyerUS
Mexidol
Mexidol is working well with no side effects
03/07/2024
CosmicNootropic
Dear Dan, we're glad our product helps you! Thank you for your feedback :)
03/03/2024
nick a.
Verified BuyerUS
This is a great product.
Mexidol is a super product for memory improvement. I have noticed immense speed in recalling short term information.
03/03/2024
CosmicNootropic
Dear Nick, Your feedback on Mexidol is fantastic! It's wonderful to hear about the noticeable improvement in memory speed. Cheers to sharper memory!
03/02/2024
victor g.
Verified BuyerUS
Mexidol
I first purchased this product with a bundle, which is the best way to try products. This was my favorite of that bundle. It allows me greater focus when lifting. I use it currently on all heavy training days. It may cause a bit of an increase in aggression after working out. Don’t forget to eat.
03/03/2024
CosmicNootropic
Dear Victor, A big thank you for sharing your positive experience with Mexidol! It's fantastic to hear that it's your go-to for a heavy training sessions. And of course, your insights about potential effects and the reminder to fuel up are appreciated 🙌️
03/01/2024
MICHAEL U.
Verified BuyerUS
It works
Legit stuff. Huge help with anxiety and inflammation.
03/01/2024
CosmicNootropic
Dear Michael, thank you for your review!
09/25/2023
Linda A.
Verified BuyerUS
Didn't work for me
Product didn't work nor did phenibut and couldn't get a refund!!!
09/27/2023
CosmicNootropic
Dear Linda, we're sorry to hear that the product didn't work for you. If you are using any of the products without a prescription from a qualified MD, you assume all the risks associated with such a decision. This also includes cases when the product is not working for you, which may sometimes happen as metabolic processes can vary significantly in different individuals. Therefore, this case is not covered by our Reshipment and Refund Policy, this is stated on our website.
03/31/2023
Matija G.
Verified BuyerUS
Game changer
Felt drained for years, started getting agitation than anxiety first time in my life in 2020 after pain medication switch. Been put on Clonazepam to make me function which made me not get anxiety but made me feel numb and drowsy,memory issues. This after quarter tab made be get rush of happiness probably due to my dopamine being so depleted all these years. Than went to half tab and full tab once a day and energy levels coming back to where I was before all this. Makes me take less of my pain medication and anxiety medication. It makes both work better and I need less of them. My memory recall is getting much better, mood much more stable. Only 3 days with this at low dose and seeing amazing mood lift. Unlike anything before. I will stick with this for couple weeks than try SELANK and report back. But this on its own is already enough. Russian pharma is the best. Using vitamin analogues and more natural approach to fix people vs all else here in the West. Thank you for carrying this product and making it available for us. If you were closer I would kiss you and give you a hug the Slavic way! Pozdrav!
03/31/2023
CosmicNootropic
Dear Matija, thank you for your kind words! We are really happy that our product helps you. We wish you good health! 🧡
02/24/2023
John S
Verified BuyerUS
Definitely Sedates You
I see this being a moderate anxiolytic but on the very sedating side. The first day, I felt strange AF. It felt like my center of vision was changed and my head felt wierd. There's no euphoria, so it's not pleasant. It's designed to treat vascular disorders, so I'm not expecting this to be like NZT or anything lmao. I was on this stuff for 4 days and my mom asked me a question and then I snapped because I got easily irritated. I get pretty mad on this stuff, I don't know.
02/24/2023
CosmicNootropic
Hi John! We are sorry that the product didn't work for you properly. Sometimes a product really may not have the right effect because metabolic processes can vary greatly from person to person. That's why we always recommend consulting a doctor before taking a product so that you can find the right one for you.
01/31/2022
Simon J.
Verified BuyerGB
Effective
The full effects took about 2-3 days but the cardiovascular benefits could be felt within couple of hours. Very good product for heart regulations
09/10/2021
Mieszko S.
Verified BuyerPL
Super!!
Works great. It is worth using in a training cycle and as an anti-clotting protection. The drug works 100%. It's worth having it.
12/12/2019
Melinda M
Verified BuyerMexidol is my favorite nootropic
I purchased Mexidol to help with my benzodiazepine related issues. After 13 years on it, I wanted to completely discontinue my benzo because of the unpleasant head symptoms between doses and the worsening cognitive impairment. Mexidol gives you a nice, clean, clear headed feeling and eliminates head pressure and burning. Unfortunately I had to reinstate on 1 mg benzo, as the coordination and perception problems while completely off bzd left me non-functional for over 6 months after a way too fast taper. So I needed a new strategy. The good news is that now I have nootropics under my belt to combat interdose headaches and cog fog! :) With Mexidol, 1 mg benzo feels twice as much in terms of relaxation but without too heavy sedation and cognitive impairment. As for Cosmic Nootropic, these guys provide a top notch service. You are informed about every important step through the order process. They are quick to respond should you have any questions...unlike other nootropic vendors I've done business with. Those vendors might offer cheaper prices but the professional communication and fast shipping from Cosmic worth the extra cost. Thanks for your service and keep it up!
11/07/2019
Alex
Verified BuyerGreat with Cerebrolysin
Mexidol is commonly administered along with Cerebrolysin in clinical studies to (I suppose) enhance the efficacy of Cerebrolysin. The effects are mild but I am sure it has helped me, at least the Cerebrolysin cycle I am on is very effective. Good product!
04/30/2025
luke
good for depression?
06/27/2024
CosmicNootropic
Hi Luke! Unfortunately, we are not able to give any medical advice. The effect of most nootropics varies from person to person, depending on the personal conditions, so you should definitely consult a doctor before taking any medication.
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john t. Verified Buyer
Top 3 Favorite Nootropic!
Mexidol is amazing! When I stack it Meldonium and a race tam it boosts me through my workouts and morning routine!
Hi John! Thank you for sharing your experience with these products! It's fantastic to hear how well it enhances your workouts and morning routine. Keep up the great work!
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