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MELDONIUM (Mildronate ®)

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The information presented on the drug instruction pages is a translation of official instructions from the manufacturers and does not reflect the opinions or views of the CosmicNootropic team. This content is provided for informational purposes only and should not be interpreted as company endorsement or opinion.

Buy Meldonium (Mildronate) Online

Meldonium, trade name – Mildronate®, is a pharmaceutical that was developed in the 1970s as an anti-ischemia medication. Meldonium is now also used as a nootropic to restore energy and performance in case of physical and mental overload. Athletes are known to take it for better sports results.

Chemical name Meldonium / 3-(2,2,2-trimethylhydrazine)propionate / THP / MET-8 / Quaterine
Form: 40 pills of 250mg / 60 pills of 500mg / 10 ampoules of 5 ml
Form description: White gelatin capsules with a white crystalline powder inside / colorless solution in vials
Active ingredient: Meldonium dihydrate
Excipients for capsules: Potato starch, silicon dioxide, calcium stearate.
Shell of the capsules: titanium dioxide (E171), gelatin
Excipients for vials: Water for injections
СAS Number: 76144-81-5
dihydrate: 86426-17-7
ATC code: C01EB22 Other cardiac preparations
Pharmacological action: Metabolic agent
Bioavailability: 78% for capsules, 100% for injections
Shelf life: 4 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Grindex, Latvia https://grindeks.eu/

What is Meldonium?

Meldonium is the active substance of Mildronate. It is a synthetic analog of gamma-butyrobetaine, a compound found in every cell of the human body. According to the official drug sheet Meldonium has the ability to prevent the accumulation of activated forms of unoxidized fatty acids in cells and normalize myocardial metabolism [1].

How does Meldonium work in the body?

According to the manufacturer, in ischemia Meldonium restores the balance between the processes of oxygen delivery and its consumption in cells. Also it activates glycolysis without additional oxygen consumption. This reduces oxidative stress [2] and cellular damage and makes the body use energy in a more efficient way. Check out comprehensive Meldonium review.

What are the Mildronate Benefits?

Mildronate’s mechanism of action determines the variety of effects of the drug [5, 25]:

  • Increased efficiency, improved mood,
  • Reduced symptoms of mental and physical overload,
  • Activation of tissue and humoral immunity,
  • Cardioprotective effect.

Meldonium also shows a tonic effect on the central nervous system, and eliminates functional disorders of the somatic and autonomic nervous system in patients with chronic alcoholism and withdrawal syndrome. [3]

Meldonium in Sports

Among athletes, Meldonium is used to increase recovery rate, endurance, and exercise performance. It is said to improve muscle tissue oxygenation which helps muscles work better. [4]

Can Meldonium Be Used in Sports? – The substance is included in the WADA list as a hormone and metabolic modulator. For this reason it is not recommended to take it prior to serious competition. Meldonium can test positive in doping control tests.

Besides athletes, Meldonium is also used by those healthy individuals who just want to improve their work capacity during physical and mental overloads and cope with stress better. Please note that prior to taking any medication or supplement a proper consultation with the doctor is a must. 

Here is the video explanation of Mildronate’s effect in the cell ⬇️

Where to Buy Mildronate Online?

You can order Mildronate (Meldonium) online at different vendors in various forms: Mildronate powder, capsules and vials. Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

CosmicNootropic offers Mildronate with worldwide shipping and volume discounts. We sell original, pure nootropics of high quality with safety confirmed by years of research and clinical trials.

What is Mildronate Dosage?

Mildronate Pills

To increase tolerance to mental and physical overloads, the recommended dosage is 250 mg of Mildronate pills 2–4 times per day.

Before and during sports events, coaches often recommend athletes take 500–1000 mg before workouts, preferably in the morning. The standard duration of a course is between 14 and 21 days.

Mildronate injections

The compound can be taken IM or IV. The average dose for injections is 0.5-1.0 g (5–10 ml) per day. When the injection course is completed the attending physician may recommend continuing the treatment with the pill form depending on the patient’s condition.

For more information on the dosage refer to the official instructions section via the links below. The exact dosage and course duration shall be prescribed by your attending physician.

What are Mildronate’s Side Effects?

Mildronate is, in general, well-tolerated, and side effects are rare. They may include headaches, high blood pressure, agitation, and allergic reactions. Caution shall be taken by patients with kidney or liver disorders.

 

OFFICIAL INSTRUCTION – Capsules
OFFICIAL INSTRUCTION – Injections

  1. Shutenko et al (1995) Mildronate: mechanisms of action and prospects for correction of pathologic states https://link.springer.com/article/10.1007%2FBF02219376
  2. Georges et al (2000) Carnitine Transport into Muscular Cells. Inhibition of Transport and Cell Growth by Mildronate https://www.ncbi.nlm.nih.gov/pubmed/10751544
  3. Dambrova et al (2002) Mildronate: Cardioprotective Action through Carnitine-Lowering Effect https://www.ncbi.nlm.nih.gov/pubmed/12242052
  4. Sjakste et al (2004) Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate https://www.ncbi.nlm.nih.gov/pubmed/15219822
  5. Sjakste et al (2005) Mildronate: An Antiischemic Drug for Neurological Indications https://pubmed.ncbi.nlm.nih.gov/16007237/
  6. Peschechera et al (2005) Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life https://www.ncbi.nlm.nih.gov/pubmed/15979102
  7. Liepinch et al (2006) Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction https://www.ncbi.nlm.nih.gov/pubmed/17204911
  8. Sesti et al (2006) Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics https://www.ncbi.nlm.nih.gov/pubmed/16633095
  9. Liepnich et al (2008) Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart https://www.ncbi.nlm.nih.gov/pubmed/18801379
  10. _Mildronate_improves_carotid_baroreceptor_reflex_function_in_patients_with_chronic_heart_failure Vitols et al (2008) Mildronate improves carotid baroreceptor reflex function in patients with chronic heart failure https://www.researchgate.net/publication/228500027
  11. Liepnich et al (2009) Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats https://www.ncbi.nlm.nih.gov/pubmed/19594753
  12. Liepnich et al (2009) Effects of long-term mildronate treatment on cardiac and liver functions in rats https://www.ncbi.nlm.nih.gov/pubmed/19663820
  13. Trumbeckaite et al (2009) Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function https://www.ncbi.nlm.nih.gov/pubmed/19904009
  14. Vilskersts et al (2009) Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR –/– Mice https://www.ncbi.nlm.nih.gov/pubmed/19325254
  15. Jaudzems et al (2009) Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism https://www.ncbi.nlm.nih.gov/pubmed/19912061
  16. Zvejniece et al (2010) Mildronate exerts acute anticonvulsant and antihypnotic effects https://www.ncbi.nlm.nih.gov/pubmed/20661137
  17. Kuka et al (2011) The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine https://www.ncbi.nlm.nih.gov/pubmed/21903968
  18. Isajevs et al (2011) Mildronate as a Regulator of Protein Expression in a Rat Model of Parkinson’s Disease https://www.ncbi.nlm.nih.gov/pubmed/22186119
  19. V. Dzerve (2011) A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I” https://www.ncbi.nlm.nih.gov/pubmed/22186118
  20. Zhu et al (2013) Efficacy and Safety of Mildronate for Acute Ischemic Stroke: A Randomized, Double-Blind, Active-Controlled Phase II Multicenter Trial https://www.ncbi.nlm.nih.gov/pubmed/23949899
  21. Klusa et al (2013) Mildronate and its Neuroregulatory Mechanisms: Targeting the Mitochondria, Neuroinflammation, and Protein Expression https://www.ncbi.nlm.nih.gov/pubmed/24375241
  22. Klusa et al (2013) Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats https://www.ncbi.nlm.nih.gov/pubmed/23537732
  23. Beitnere et al (2014) Carnitine congener mildronate protects against stress and haloperidol-induced impairment in memory and brain protein expression in rats https://www.ncbi.nlm.nih.gov/pubmed/25446926
  24. Zhao et al (2015) Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection https://www.ncbi.nlm.nih.gov/pubmed/26697890
  25. Dambrova et al (2016) Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity https://pubmed.ncbi.nlm.nih.gov/26850121/
  26. Schobersberger et al (2016) Story behind meldonium-from pharmacology to performance enhancement: a narrative review https://pubmed.ncbi.nlm.nih.gov/27465696/
  27. Di Cristo et al (2019) Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression https://pubmed.ncbi.nlm.nih.gov/30362565/ 
  28. Gureev et al (2021) Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise https://pubmed.ncbi.nlm.nih.gov/33930377/
  29. Savic et al (2021) Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart https://pubmed.ncbi.nlm.nih.gov/33458907/
  30. Vilskersts et al (2021) Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 https://pubmed.ncbi.nlm.nih.gov/35008470/

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