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MELDONIUM (Mildronate ®)
64 Reviews
Buy Meldonium (Mildronate) Online
Meldonium, trade name – Mildronate®, is a pharmaceutical that was developed in the 1970s as an anti-ischemia medication. Meldonium is now also used as a nootropic to restore energy and performance in case of physical and mental overload. Athletes are known to take it for better sports results.
Chemical name | Meldonium / 3-(2,2,2-trimethylhydrazine)propionate / THP / MET-8 / Quaterine |
Form: | 40 pills of 250mg / 60 pills of 500mg / 10 ampoules of 5 ml |
Form description: | White gelatin capsules with a white crystalline powder inside / colorless solution in vials |
Active ingredient: | Meldonium dihydrate |
Excipients for capsules: | Potato starch, silicon dioxide, calcium stearate. Shell of the capsules: titanium dioxide (E171), gelatin |
Excipients for vials: | Water for injections |
СAS Number: | 76144-81-5 dihydrate: 86426-17-7 |
ATC code: | C01EB22 Other cardiac preparations |
Pharmacological action: | Metabolic agent |
Bioavailability: | 78% for capsules, 100% for injections |
Shelf life: | 4 years. Do not use it beyond the expiration date printed on the package. |
Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children. |
Terms of release: | Over-the-counter |
Manufacturer: | Grindex, Latvia https://grindeks.eu/ |
What is Meldonium?
Meldonium is the active substance of Mildronate. It is a synthetic analog of gamma-butyrobetaine, a compound found in every cell of the human body. According to the official drug sheet Meldonium has the ability to prevent the accumulation of activated forms of unoxidized fatty acids in cells and normalize myocardial metabolism [1].
How does Meldonium work in the body?
According to the manufacturer, in ischemia Meldonium restores the balance between the processes of oxygen delivery and its consumption in cells. Also it activates glycolysis without additional oxygen consumption. This reduces oxidative stress [2] and cellular damage and makes the body use energy in a more efficient way. Check out comprehensive Meldonium review.
What are the Mildronate Benefits?
Mildronate’s mechanism of action determines the variety of effects of the drug [5, 25]:
- Increased efficiency, improved mood,
- Reduced symptoms of mental and physical overload,
- Activation of tissue and humoral immunity,
- Cardioprotective effect.
Meldonium also shows a tonic effect on the central nervous system, and eliminates functional disorders of the somatic and autonomic nervous system in patients with chronic alcoholism and withdrawal syndrome. [3]
Meldonium in Sports
Among athletes, Meldonium is used to increase recovery rate, endurance, and exercise performance. It is said to improve muscle tissue oxygenation which helps muscles work better. [4]
Can Meldonium Be Used in Sports? – The substance is included in the WADA list as a hormone and metabolic modulator. For this reason it is not recommended to take it prior to serious competition. Meldonium can test positive in doping control tests.
Besides athletes, Meldonium is also used by those healthy individuals who just want to improve their work capacity during physical and mental overloads and cope with stress better. Please note that prior to taking any medication or supplement a proper consultation with the doctor is a must.
Here is the video explanation of Mildronate’s effect in the cell ⬇️
Where to Buy Mildronate Online?
You can order Mildronate (Meldonium) online at different vendors in various forms: Mildronate powder, capsules and vials. Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
CosmicNootropic offers Mildronate with worldwide shipping and volume discounts. We sell original, pure nootropics of high quality with safety confirmed by years of research and clinical trials.
What is Mildronate Dosage?
Mildronate Pills
To increase tolerance to mental and physical overloads, the recommended dosage is 250 mg of Mildronate pills 2–4 times per day.
Before and during sports events, coaches often recommend athletes take 500–1000 mg before workouts, preferably in the morning. The standard duration of a course is between 14 and 21 days.
Mildronate injections
The compound can be taken IM or IV. The average dose for injections is 0.5-1.0 g (5–10 ml) per day. When the injection course is completed the attending physician may recommend continuing the treatment with the pill form depending on the patient’s condition.
For more information on the dosage refer to the official instructions section via the links below. The exact dosage and course duration shall be prescribed by your attending physician.
What are Mildronate’s Side Effects?
Mildronate is, in general, well-tolerated, and side effects are rare. They may include headaches, high blood pressure, agitation, and allergic reactions. Caution shall be taken by patients with kidney or liver disorders.
OFFICIAL INSTRUCTION – Capsules
OFFICIAL INSTRUCTION – Injections
- Shutenko et al (1995) Mildronate: mechanisms of action and prospects for correction of pathologic states https://link.springer.com/article/10.1007%2FBF02219376
- Georges et al (2000) Carnitine Transport into Muscular Cells. Inhibition of Transport and Cell Growth by Mildronate https://www.ncbi.nlm.nih.gov/pubmed/10751544
- Dambrova et al (2002) Mildronate: Cardioprotective Action through Carnitine-Lowering Effect https://www.ncbi.nlm.nih.gov/pubmed/12242052
- Sjakste et al (2004) Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate https://www.ncbi.nlm.nih.gov/pubmed/15219822
- Sjakste et al (2005) Mildronate: An Antiischemic Drug for Neurological Indications https://pubmed.ncbi.nlm.nih.gov/16007237/
- Peschechera et al (2005) Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life https://www.ncbi.nlm.nih.gov/pubmed/15979102
- Liepinch et al (2006) Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction https://www.ncbi.nlm.nih.gov/pubmed/17204911
- Sesti et al (2006) Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics https://www.ncbi.nlm.nih.gov/pubmed/16633095
- Liepnich et al (2008) Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart https://www.ncbi.nlm.nih.gov/pubmed/18801379
- _Mildronate_improves_carotid_baroreceptor_reflex_function_in_patients_with_chronic_heart_failure Vitols et al (2008) Mildronate improves carotid baroreceptor reflex function in patients with chronic heart failure https://www.researchgate.net/publication/228500027
- Liepnich et al (2009) Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats https://www.ncbi.nlm.nih.gov/pubmed/19594753
- Liepnich et al (2009) Effects of long-term mildronate treatment on cardiac and liver functions in rats https://www.ncbi.nlm.nih.gov/pubmed/19663820
- Trumbeckaite et al (2009) Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function https://www.ncbi.nlm.nih.gov/pubmed/19904009
- Vilskersts et al (2009) Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR –/– Mice https://www.ncbi.nlm.nih.gov/pubmed/19325254
- Jaudzems et al (2009) Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism https://www.ncbi.nlm.nih.gov/pubmed/19912061
- Zvejniece et al (2010) Mildronate exerts acute anticonvulsant and antihypnotic effects https://www.ncbi.nlm.nih.gov/pubmed/20661137
- Kuka et al (2011) The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine https://www.ncbi.nlm.nih.gov/pubmed/21903968
- Isajevs et al (2011) Mildronate as a Regulator of Protein Expression in a Rat Model of Parkinson’s Disease https://www.ncbi.nlm.nih.gov/pubmed/22186119
- V. Dzerve (2011) A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I” https://www.ncbi.nlm.nih.gov/pubmed/22186118
- Zhu et al (2013) Efficacy and Safety of Mildronate for Acute Ischemic Stroke: A Randomized, Double-Blind, Active-Controlled Phase II Multicenter Trial https://www.ncbi.nlm.nih.gov/pubmed/23949899
- Klusa et al (2013) Mildronate and its Neuroregulatory Mechanisms: Targeting the Mitochondria, Neuroinflammation, and Protein Expression https://www.ncbi.nlm.nih.gov/pubmed/24375241
- Klusa et al (2013) Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats https://www.ncbi.nlm.nih.gov/pubmed/23537732
- Beitnere et al (2014) Carnitine congener mildronate protects against stress and haloperidol-induced impairment in memory and brain protein expression in rats https://www.ncbi.nlm.nih.gov/pubmed/25446926
- Zhao et al (2015) Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection https://www.ncbi.nlm.nih.gov/pubmed/26697890
- Dambrova et al (2016) Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity https://pubmed.ncbi.nlm.nih.gov/26850121/
- Schobersberger et al (2016) Story behind meldonium-from pharmacology to performance enhancement: a narrative review https://pubmed.ncbi.nlm.nih.gov/27465696/
- Di Cristo et al (2019) Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression https://pubmed.ncbi.nlm.nih.gov/30362565/
- Gureev et al (2021) Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise https://pubmed.ncbi.nlm.nih.gov/33930377/
- Savic et al (2021) Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart https://pubmed.ncbi.nlm.nih.gov/33458907/
- Vilskersts et al (2021) Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 https://pubmed.ncbi.nlm.nih.gov/35008470/
4.6
Based on 64 Reviews
(55)
(3)
(0)
(2)
(4)
11/01/2024
Donald
Verified BuyerUS
Unlimited energy
I will use this while coming towards the end of an AAS cycle, after dropping fats and increasing carbs. The result is more energy in the gym, and seemingly less lactic acid from hard leg days. If I was still a runner, this would be at the top of the list for PEDs. I have yet to utilize it\'s affects for the purpose of clarity. I might have to bump it up to a 5 stars if I\'m blown away, like I am with Noopept and cerbrolyosin.
11/04/2024
Cosmic Nootropic
Hi Donald! Thank you for sharing your experience! We're glad to hear this has boosted your energy and endurance during tough workouts. Looking forward to hopefully earning that 5-star rating from you!
10/29/2024
Ruth K.
Verified BuyerUS
Great product
Very good like all products
10/31/2024
Cosmic Nootropic
Hi Ruth! Thanks for the positive feedback! We're thrilled to hear you’re enjoying the product. If you have any questions or need assistance, feel free to reach out!
10/12/2024
Debra F.
Verified BuyerZA
Works like magic!
I purchased the Mildronate 500mg because at the time of ordering, the lower dose was sold out- and I’m SO glad I did, otherwise I might have missed out on this magical little capsule 😊 I’m busy recovering from very severe burnout, and this is exactly what the doctor ordered. Depression, exhaustion and mind-fog is lifting nicely. Mildronate does not give a stimulant-type of buzz you get from chemicals, it’s the type of natural energy and vitality you had when you were young and you could just play with your friends outside forever. My current stack is: Mildronate 500Mg with 300mg of picamilon and 40mg of Noopept. The products are great and the customer service is even better!
10/13/2024
Cosmic Nootropic
Dear Debra, Thanks for the amazing review! We're so glad to hear that Mildronate is helping you through your recovery. And it sounds like a great stack you’ve got there :) Wishing you all the best on your journey!
10/06/2024
Justin M.
Verified BuyerUS
Never received all products
Even though my products were never delivered to my home and the products that were supposed to be delivered got sent back to this company, they refuse to give my money back. So they get their products back and took my money. Not a trust worthy company.
10/07/2024
Cosmic Nootropic
Dear Justin, thank you for your feedback, and we're sorry to hear about your experience. We understand how frustrating it can be not to receive your order. I’d like to emphasize that we have communicated with you about this issue via email and have policies in place regarding refunds in such cases. Our goal is always to resolve issues fairly while adhering to our policies. We appreciate your understanding and encourage you to reach out if you have any further questions or concerns. Thank you for bringing this to our attention.
08/07/2024
Alyssa W.
Verified BuyerUS
Some positives but more negatives.
I really enjoyed this nootropic. It gave me a lot of energy and I felt like I could breathe better. HOWEVER, I did have a massive headache and neck ache the day after. I also noticed rapid weight gain after only a few days of use. I eat well and do stay active, but it still came on suddenly. Water weight or whatever it was, my clothes were tight. Really sucks because I really enjoyed how clear I felt mentally plus the extra boost in my lungs.
08/08/2024
Cosmic Nootropic
Hi Alyssa! Thank you for sharing your experience with our nootropic. We're glad to hear that you enjoyed the mental clarity and increased energy. However, we're sorry to learn about the headaches, neck aches, and weight gain you experienced. We believe that it might be helpful to review the dosage or consult a healthcare professional to address these issues. We appreciate your insights and are committed to ensuring a positive experience for all our customers.
06/24/2024
Ila J.
Verified BuyerUS
Works well
Worked extremely well. Improvement in endurance was noticeable and not insignificant.
06/25/2024
Cosmic Nootropic
Hi Ila! Thank you for sharing your experience with Mildronate! We're delighted to hear that our product has made a noticeable improvement in your endurance. We are committed to providing high-quality products that contribute positively to our customers' well-being.
06/17/2024
Robert B.
Verified BuyerUS
Mildronate, bemetil, hypoxen and mexidol
Dear Sir or Madame, I am honored that you would ask my opinion on your products. I am not only an athlete but a physician as well, So I do have some knowledge on these kind of products. First of all, your website is very well organized and very easy to navigate which is always a plus. All items were shipped to me promptly with no delay. And all four items that I ordered were pharmaceutical grade legitimate products. I am currently using Mildronate with mexidol, and then I will switch to bemetil with hypoxen. All these products markedly improved athletic performance, and especially endurance training. But where they shine the brightest as when you’re doing anaerobic activity like interval training. It almost becomes effortless. What’s even more amazing is all these products have multiple other beneficial effects on your health and well-being, and with no side effects !! This is the only website that I use to buy these kinds of products because I know they’re legitimate Sincerely Robert M.D
06/17/2024
Cosmic Nootropic
Dear Robert M.D., Thank you for your glowing review! We're thrilled to hear that our products have enhanced your athletic performance and endurance training without any side effects. Your feedback about our website and service is greatly appreciated. We're committed to providing pharmaceutical-grade products that meet your standards. Best regards, CosmicNootropic team
06/02/2024
Justin R.
Verified BuyerUS
Meldonium
My experience was great! Convenient way to pay and came in a timely manner!
06/03/2024
Cosmic Nootropic
Dear Justin, thank you so much for leaving your review! We are delighted to hear about your positive experience with our company!
03/06/2024
Ashley H.
Verified BuyerUS
Mildronate / Meldonium - product review
Couldn’t really tell one way or the other if it was producing results as the weren’t noticeable. In my opinion and based off my personal experience, not worth purchasing if you are looking for something similar to effects of piracetam, specifically Nootropil, as no other brand has proven effective for me for whatever reason.
03/08/2024
Cosmic Nootropic
Hi Ashley! Thank you for taking the time and leaving your review. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.
02/18/2024
John S.
Verified BuyerUS
Have zero faith in American Healthcare Cabal
(1)500mg cap each morning for 14 days. Starting my 2nd round in 3 days. I'm trying to improve my self diagnosed early stages of dementia. Hoping for improved recall and/or arrest progression. I'm 76 yo !
02/18/2024
Cosmic Nootropic
Dear John, Thank you for sharing your journey with our product! While we appreciate your commitment to your health improvement, we highly recommend consulting with a healthcare professional to ensure the most suitable approach for addressing concerns related to cognitive health, especially given your age.
02/11/2024
Adrian
Verified BuyerCA
I\'m sold
This is one of the best supplements I\'ve ever taken. While I\'m not sure I notice any cognitive effects, I\'m amazed at how quickly and effectively it increased my physical work capacity. Starting it after a couple months long period of bad habits (nights out, smoking), I didn\'t have to ease myself back into my exercise regime. Not only am I able to get right back into the more intense movements, in terms of reps or weight as the case may be, I can feel the energy in my body to provide the motivation to do the exercises. I will definitely be continuing to utilize it this year, with a longer duration, after taking a break.
02/15/2024
Cosmic Nootropic
Dear Adrian, thank you so much for sharing your experience! We're thrilled to hear about the positive impact of Meldonium on your physical work capacity. Appreciate your support and look forward to being part of your wellness journey!
02/05/2024
Carlos B.
Verified BuyerES
Does not pass customs control
They say that there are no shipping problems in Europe and that there are no problems at customs, but it is not true, they ship from Russia and the shipments are intercepted at customs.
02/06/2024
Cosmic Nootropic
Dear Carlos, we are very sorry to hear that your order was detained at customs. The destinations listed on our website are those that have a re-shipment and refund policy, other destinations are considered high risk and we try to warn our customers in advance. Most countries allow the individual import of supplements and nootropics. However, there are some countries, whose customs previously blocked parcels containing nootropics or countries with which we have little shipping experience. When making orders to these destinations you agree that we reserve the right not to be held accountable for the problems associated with the customs or local post in the receiving country.
12/20/2023
Joshua
Verified BuyerUS
Increases Exercise Performance
Great for exercise performance. I did a 10 day course hoping it would help with my chronic fatigue syndrome. The first day it made me more fatigued but by the second day I was feeling more energy. During the first few days I did have more mood swings but I would say for the increased stamina it was worth it. After ending the 10 day course I did notice a little bit of an energy crash. I would definitely use this product again to increase stamina for running or hiking but it\'s probably not something I would use every day.
12/22/2023
Cosmic Nootropic
Dear Joshua, thank you for sharing your experience, we really appreciate it!
11/02/2023
Jared S.
Verified BuyerCA
I love Meldonium
God tier nootropic to use for high intensity workouts, especially with a high carb meal. Wouldn't use it every day but it can definitely protect you from stress and muscle damage in my opinion. Clears up your brain too!
11/03/2023
Cosmic Nootropic
Hi Jared! Thank you for your feedback!
09/03/2023
Niamh M.
Verified BuyerAU
Good product
Great spur of energy during run without jitteriness
09/06/2023
Cosmic Nootropic
Dear Niamh, thank you for your feedback!
09/02/2023
James M.
Verified BuyerUS
definitely a pick-me-up in the gym
aids focus. I also feel a greater precision with my movement.
09/03/2023
Cosmic Nootropic
Thanks for the feedback, James. We're happy to know Meldonium works well for you!
08/29/2023
trevor d.
Verified BuyerAU
Mildronate
I have been using this product for many months. I cannot tell you how satisfied iam. I have more energy, higher endurance and overall health has improved.
08/30/2023
Cosmic Nootropic
Dear Trevor, Thank you for sharing your experience with our product. We are glad that Mildronate helped you!
08/23/2023
Brooke R.
Verified BuyerUS
Brain power !
I believe this have me results; a clear focus.
08/23/2023
Cosmic Nootropic
Dear Brooke, thank you for your review on this product as well :) Happy to hear it was helpful too!
08/09/2023
Brandon S.
Verified BuyerUS
Timely shiomwnt
Very prompt in delivery and will recommend to people in the future
08/09/2023
Cosmic Nootropic
Dear Brandon, thank you for your feedback, we really appreciate it!
08/02/2023
ERIC V.
Verified BuyerCA
ex endurance athlete turned handicapped
Excellent. Use it for my diaphragm palsy since I lost my phrenic nerve. Look it up. not a small feat.
08/04/2023
Cosmic Nootropic
Dear Eric, we are thrilled to hear that you find Meldonium effective for you!
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