buy meldonium

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MELDONIUM (Mildronate ®)

58 Reviews

Legal disclaimer

Mildronate (Meldonium) is an officially manufactured compound in Latvia. It is a non-prescription drug in countries like Russia, Ukraine, and some others with a dose of 250mg. Meldonium is not licensed by the FDA for medical use in the United States. Meldonium has been on the World Anti-Doping Agency (WADA) list of banned metabolic regulators since 2016. 

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Buy Meldonium (Mildronate) Online

Meldonium, trade name – Mildronate®, is a pharmaceutical that was developed in the 1970s as an anti-ischemia medication. Meldonium is now also used as a nootropic to restore energy and performance in case of physical and mental overload. Athletes are known to take it for better sports results.

Chemical name Meldonium / 3-(2,2,2-trimethylhydrazine)propionate / THP / MET-8 / Quaterine
Form: 40 pills of 250mg / 60 pills of 500mg / 10 ampoules of 5 ml
Form description: White gelatin capsules with a white crystalline powder inside / colorless solution in vials
Active ingredient: Meldonium dihydrate
Excipients for capsules: Potato starch, silicon dioxide, calcium stearate.
Shell of the capsules: titanium dioxide (E171), gelatin
Excipients for vials: Water for injections
СAS Number: 76144-81-5
dihydrate: 86426-17-7
ATC code: C01EB22 Other cardiac preparations
Pharmacological action: Metabolic agent
Bioavailability: 78% for capsules, 100% for injections
Shelf life: 4 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Grindex, Latvia https://grindeks.eu/

What is Meldonium?

Meldonium is the active substance of Mildronate. It is a synthetic analog of gamma-butyrobetaine, a compound found in every cell of the human body. According to the official drug sheet Meldonium has the ability to prevent the accumulation of activated forms of unoxidized fatty acids in cells and normalize myocardial metabolism [1].

How does Meldonium work in the body?

According to the manufacturer, in ischemia Meldonium restores the balance between the processes of oxygen delivery and its consumption in cells. Also it activates glycolysis without additional oxygen consumption. This reduces oxidative stress [2] and cellular damage and makes the body use energy in a more efficient way. Check out comprehensive Meldonium review.

What are the Mildronate Benefits?

Mildronate’s mechanism of action determines the variety of effects of the drug [525]:

  • Increased efficiency, improved mood,
  • Reduced symptoms of mental and physical overload,
  • Activation of tissue and humoral immunity,
  • Cardioprotective effect.

Meldonium also shows a tonic effect on the central nervous system, and eliminates functional disorders of the somatic and autonomic nervous system in patients with chronic alcoholism and withdrawal syndrome. [3]

Meldonium in Sports

Among athletes, Meldonium is used to increase recovery rate, endurance, and exercise performance. It is said to improve muscle tissue oxygenation which helps muscles work better. [4]

Can Meldonium Be Used in Sports? – The substance is included in the WADA list as a hormone and metabolic modulator. For this reason it is not recommended to take it prior to serious competition. Meldonium can test positive in doping control tests.

Besides athletes, Meldonium is also used by those healthy individuals who just want to improve their work capacity during physical and mental overloads and cope with stress better. Please note that prior to taking any medication or supplement a proper consultation with the doctor is a must. 

Here is the video explanation of Mildronate’s effect in the cell ⬇️

Where to Buy Mildronate Online?

You can order Mildronate (Meldonium) online at different vendors in various forms: Mildronate powder, capsules and vials. Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

CosmicNootropic offers Mildronate with worldwide shipping and volume discounts. We sell original, pure nootropics of high quality with safety confirmed by years of research and clinical trials.

What is Mildronate Dosage?

Mildronate Pills

To increase tolerance to mental and physical overloads, the recommended dosage is 250 mg of Mildronate pills 2–4 times per day.

Before and during sports events, coaches often recommend athletes take 500–1000 mg before workouts, preferably in the morning. The standard duration of a course is between 14 and 21 days.

Mildronate injections

The compound can be taken IM or IV. The average dose for injections is 0.5-1.0 g (5–10 ml) per day. When the injection course is completed the attending physician may recommend continuing the treatment with the pill form depending on the patient’s condition.

For more information on the dosage refer to the official instructions section via the links below. The exact dosage and course duration shall be prescribed by your attending physician.

What are Mildronate’s Side Effects?

Mildronate is, in general, well-tolerated, and side effects are rare. They may include headaches, high blood pressure, agitation, and allergic reactions. Caution shall be taken by patients with kidney or liver disorders.

 

OFFICIAL INSTRUCTION – Capsules
OFFICIAL INSTRUCTION – Injections

  1. Shutenko et al (1995) Mildronate: mechanisms of action and prospects for correction of pathologic states https://link.springer.com/article/10.1007%2FBF02219376
  2. Georges et al (2000) Carnitine Transport into Muscular Cells. Inhibition of Transport and Cell Growth by Mildronate https://www.ncbi.nlm.nih.gov/pubmed/10751544
  3. Dambrova et al (2002) Mildronate: Cardioprotective Action through Carnitine-Lowering Effect https://www.ncbi.nlm.nih.gov/pubmed/12242052
  4. Sjakste et al (2004) Endothelium- and nitric oxide-dependent vasorelaxing activities of gamma-butyrobetaine esters: possible link to the antiischemic activities of mildronate https://www.ncbi.nlm.nih.gov/pubmed/15219822
  5. Sjakste et al (2005) Mildronate: An Antiischemic Drug for Neurological Indications https://pubmed.ncbi.nlm.nih.gov/16007237/
  6. Peschechera et al (2005) Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life https://www.ncbi.nlm.nih.gov/pubmed/15979102
  7. Liepinch et al (2006) Mildronate, an Inhibitor of Carnitine Biosynthesis, Induces an Increase in Gamma-Butyrobetaine Contents and Cardioprotection in Isolated Rat Heart Infarction https://www.ncbi.nlm.nih.gov/pubmed/17204911
  8. Sesti et al (2006) Mildronate, a novel fatty acid oxidation inhibitor and antianginal agent, reduces myocardial infarct size without affecting hemodynamics https://www.ncbi.nlm.nih.gov/pubmed/16633095
  9. Liepnich et al (2008) Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart https://www.ncbi.nlm.nih.gov/pubmed/18801379
  10. _Mildronate_improves_carotid_baroreceptor_reflex_function_in_patients_with_chronic_heart_failure Vitols et al (2008) Mildronate improves carotid baroreceptor reflex function in patients with chronic heart failure https://www.researchgate.net/publication/228500027
  11. Liepnich et al (2009) Protective effects of mildronate in an experimental model of type 2 diabetes in Goto-Kakizaki rats https://www.ncbi.nlm.nih.gov/pubmed/19594753
  12. Liepnich et al (2009) Effects of long-term mildronate treatment on cardiac and liver functions in rats https://www.ncbi.nlm.nih.gov/pubmed/19663820
  13. Trumbeckaite et al (2009) Effects of ischemia-reperfusion and pretreatment with mildronate on rat liver mitochondrial function https://www.ncbi.nlm.nih.gov/pubmed/19904009
  14. Vilskersts et al (2009) Mildronate, a Regulator of Energy Metabolism, Reduces Atherosclerosis in apoE/LDLR –/– Mice https://www.ncbi.nlm.nih.gov/pubmed/19325254
  15. Jaudzems et al (2009) Inhibition of carnitine acetyltransferase by mildronate, a regulator of energy metabolism https://www.ncbi.nlm.nih.gov/pubmed/19912061
  16. Zvejniece et al (2010) Mildronate exerts acute anticonvulsant and antihypnotic effects https://www.ncbi.nlm.nih.gov/pubmed/20661137
  17. Kuka et al (2011) The Cardioprotective Effect of Mildronate is Diminished After Co-Treatment With l-Carnitine https://www.ncbi.nlm.nih.gov/pubmed/21903968
  18. Isajevs et al (2011) Mildronate as a Regulator of Protein Expression in a Rat Model of Parkinson’s Disease https://www.ncbi.nlm.nih.gov/pubmed/22186119
  19. V. Dzerve (2011) A Dose-Dependent Improvement in Exercise Tolerance in Patients With Stable Angina Treated With Mildronate: A Clinical Trial “MILSS I” https://www.ncbi.nlm.nih.gov/pubmed/22186118
  20. Zhu et al (2013) Efficacy and Safety of Mildronate for Acute Ischemic Stroke: A Randomized, Double-Blind, Active-Controlled Phase II Multicenter Trial https://www.ncbi.nlm.nih.gov/pubmed/23949899
  21. Klusa et al (2013) Mildronate and its Neuroregulatory Mechanisms: Targeting the Mitochondria, Neuroinflammation, and Protein Expression https://www.ncbi.nlm.nih.gov/pubmed/24375241
  22. Klusa et al (2013) Mildronate enhances learning/memory and changes hippocampal protein expression in trained rats https://www.ncbi.nlm.nih.gov/pubmed/23537732
  23. Beitnere et al (2014) Carnitine congener mildronate protects against stress and haloperidol-induced impairment in memory and brain protein expression in rats https://www.ncbi.nlm.nih.gov/pubmed/25446926
  24. Zhao et al (2015) Single- and Multiple-dose Pharmacokinetic, Safety and Tolerability Study of Mildronate Injection in Healthy Chinese Subjects Pharmacokinetic of Mildronate Injection https://www.ncbi.nlm.nih.gov/pubmed/26697890
  25. Dambrova et al (2016) Pharmacological effects of meldonium: Biochemical mechanisms and biomarkers of cardiometabolic activity https://pubmed.ncbi.nlm.nih.gov/26850121/
  26. Schobersberger et al (2016) Story behind meldonium-from pharmacology to performance enhancement: a narrative review https://pubmed.ncbi.nlm.nih.gov/27465696/
  27. Di Cristo et al (2019) Meldonium improves Huntington’s disease mitochondrial dysfunction by restoring peroxisome proliferator-activated receptor γ coactivator 1α expression https://pubmed.ncbi.nlm.nih.gov/30362565/ 
  28. Gureev et al (2021) Mildronate protects heart mtDNA from oxidative stress toxicity induced by exhaustive physical exercise https://pubmed.ncbi.nlm.nih.gov/33930377/
  29. Savic et al (2021) Hyperpolarized magnetic resonance shows that the anti-ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post-ischemic function in the diabetic heart https://pubmed.ncbi.nlm.nih.gov/33458907/
  30. Vilskersts et al (2021) Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19 https://pubmed.ncbi.nlm.nih.gov/35008470/

4.7

Based on 58 Reviews

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06/17/2024

Robert B.

Robert B.

 Verified Buyer
US

US

Mildronate, bemetil, hypoxen and mexidol

Dear Sir or Madame, I am honored that you would ask my opinion on your products. I am not only an athlete but a physician as well, So I do have some knowledge on these kind of products. First of all, your website is very well organized and very easy to navigate which is always a plus. All items were shipped to me promptly with no delay. And all four items that I ordered were pharmaceutical grade legitimate products. I am currently using Mildronate with mexidol, and then I will switch to bemetil with hypoxen. All these products markedly improved athletic performance, and especially endurance training. But where they shine the brightest as when you’re doing anaerobic activity like interval training. It almost becomes effortless. What’s even more amazing is all these products have multiple other beneficial effects on your health and well-being, and with no side effects !! This is the only website that I use to buy these kinds of products because I know they’re legitimate Sincerely Robert M.D

06/17/2024

Dear Robert M.D., Thank you for your glowing review! We're thrilled to hear that our products have enhanced your athletic performance and endurance training without any side effects. Your feedback about our website and service is greatly appreciated. We're committed to providing pharmaceutical-grade products that meet your standards. Best regards, CosmicNootropic team

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06/02/2024

Justin R.

Justin R.

 Verified Buyer
US

US

Meldonium

My experience was great! Convenient way to pay and came in a timely manner!

06/03/2024

Dear Justin, thank you so much for leaving your review! We are delighted to hear about your positive experience with our company!

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03/06/2024

Ashley H.

Ashley H.

 Verified Buyer
US

US

Mildronate / Meldonium - product review

Couldn’t really tell one way or the other if it was producing results as the weren’t noticeable. In my opinion and based off my personal experience, not worth purchasing if you are looking for something similar to effects of piracetam, specifically Nootropil, as no other brand has proven effective for me for whatever reason.

03/08/2024

Hi Ashley! Thank you for taking the time and leaving your review. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.

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02/18/2024

John S.

John S.

 Verified Buyer
US

US

Have zero faith in American Healthcare Cabal

(1)500mg cap each morning for 14 days. Starting my 2nd round in 3 days. I'm trying to improve my self diagnosed early stages of dementia. Hoping for improved recall and/or arrest progression. I'm 76 yo !

02/18/2024

Dear John, Thank you for sharing your journey with our product! While we appreciate your commitment to your health improvement, we highly recommend consulting with a healthcare professional to ensure the most suitable approach for addressing concerns related to cognitive health, especially given your age.

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02/11/2024

Adrian

Adrian

 Verified Buyer
CA

CA

I\'m sold

This is one of the best supplements I\'ve ever taken. While I\'m not sure I notice any cognitive effects, I\'m amazed at how quickly and effectively it increased my physical work capacity. Starting it after a couple months long period of bad habits (nights out, smoking), I didn\'t have to ease myself back into my exercise regime. Not only am I able to get right back into the more intense movements, in terms of reps or weight as the case may be, I can feel the energy in my body to provide the motivation to do the exercises. I will definitely be continuing to utilize it this year, with a longer duration, after taking a break.

02/15/2024

Dear Adrian, thank you so much for sharing your experience! We're thrilled to hear about the positive impact of Meldonium on your physical work capacity. Appreciate your support and look forward to being part of your wellness journey!

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02/05/2024

Carlos B.

Carlos B.

 Verified Buyer
ES

ES

Does not pass customs control

They say that there are no shipping problems in Europe and that there are no problems at customs, but it is not true, they ship from Russia and the shipments are intercepted at customs.

02/06/2024

Dear Carlos, we are very sorry to hear that your order was detained at customs. The destinations listed on our website are those that have a re-shipment and refund policy, other destinations are considered high risk and we try to warn our customers in advance. Most countries allow the individual import of supplements and nootropics. However, there are some countries, whose customs previously blocked parcels containing nootropics or countries with which we have little shipping experience. When making orders to these destinations you agree that we reserve the right not to be held accountable for the problems associated with the customs or local post in the receiving country.

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12/20/2023

Joshua

Joshua

 Verified Buyer
US

US

Increases Exercise Performance

Great for exercise performance. I did a 10 day course hoping it would help with my chronic fatigue syndrome. The first day it made me more fatigued but by the second day I was feeling more energy. During the first few days I did have more mood swings but I would say for the increased stamina it was worth it. After ending the 10 day course I did notice a little bit of an energy crash. I would definitely use this product again to increase stamina for running or hiking but it\'s probably not something I would use every day.

12/22/2023

Dear Joshua, thank you for sharing your experience, we really appreciate it!

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11/02/2023

Jared S.

Jared S.

 Verified Buyer
CA

CA

I love Meldonium

God tier nootropic to use for high intensity workouts, especially with a high carb meal. Wouldn't use it every day but it can definitely protect you from stress and muscle damage in my opinion. Clears up your brain too!

11/03/2023

Hi Jared! Thank you for your feedback!

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09/03/2023

Niamh M.

Niamh M.

 Verified Buyer
AU

AU

Good product

Great spur of energy during run without jitteriness

09/06/2023

Dear Niamh, thank you for your feedback!

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09/02/2023

James M.

James M.

 Verified Buyer
US

US

definitely a pick-me-up in the gym

aids focus. I also feel a greater precision with my movement.

09/03/2023

Thanks for the feedback, James. We're happy to know Meldonium works well for you!

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08/29/2023

trevor d.

trevor d.

 Verified Buyer
AU

AU

Mildronate

I have been using this product for many months. I cannot tell you how satisfied iam. I have more energy, higher endurance and overall health has improved.

08/30/2023

Dear Trevor, Thank you for sharing your experience with our product. We are glad that Mildronate helped you!

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08/23/2023

Brooke R.

Brooke R.

 Verified Buyer
US

US

Brain power !

I believe this have me results; a clear focus.

08/23/2023

Dear Brooke, thank you for your review on this product as well :) Happy to hear it was helpful too!

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08/09/2023

Brandon S.

Brandon S.

 Verified Buyer
US

US

Timely shiomwnt

Very prompt in delivery and will recommend to people in the future

08/09/2023

Dear Brandon, thank you for your feedback, we really appreciate it!

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0

08/02/2023

ERIC V.

ERIC V.

 Verified Buyer
CA

CA

ex endurance athlete turned handicapped

Excellent. Use it for my diaphragm palsy since I lost my phrenic nerve. Look it up. not a small feat.

08/04/2023

Dear Eric, we are thrilled to hear that you find Meldonium effective for you!

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07/20/2023

trevor d.

trevor d.

 Verified Buyer
AU

AU

Mildronate

This product definately improved energy levels.A feel of wellbeing was constant, with improved sleep and early rising. Would highly recomend this product.

07/21/2023

Hi Trevor! We are happy that the product worked for you :)

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07/03/2023

Niall C.

Niall C.

 Verified Buyer
GB

GB

Works for keeping my workout going for longer

Good experience - managed to increase stamina in workouts.

07/04/2023

Dear Niall, thank you for your feedback! We're happy to hear that you're satisfied with our product :)

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0

05/15/2023

William s.

William s.

Has helped a lot

I have been taking this now for about 4 months with a proper break. I'm a former high School athlete who hasn't really been able to get back in shape due to my physicality being lackluster having fallen away from my old training regiments. It had been 15 years since I had even remotely considered working out or doing any form of exercise. When I started back up with the exercise routines initially everything was beyond difficult and for the first two months with diet changes and a basic exercise routine I saw zero progress towards any sort of physical improvement whatsoever. My cardio was still the same I wasn't seeing any weight loss and my strength needless to say was not improving much. After doing some research I decided to give meldonium a try. After the first week I started to see improvements in my endurance and stamina. I went from only being able to do about three or four miles on a bike to being able to do 7-10 after just one week of use. Originally I thought it was placebo but I only continued to improve the longer I took this. I have since lost 35 lbs I am able to do 20 to 25 miles on a bicycle. For athletes trying to use this as a performance enhancer right away I'm sure you will see a benefit. People like myself though who just need that little extra edge to make progress and their fitness goals, give it time be patient the results will speak for themselves.

05/19/2023

Hi William, thank you so much for sharing your detailed experience with Meldonium! We're thrilled to hear how it has positively impacted your fitness journey and helped you achieve significant progress in endurance, stamina, and weight loss. We appreciate your trust in our product and wish you continued success in reaching your fitness goals. :)

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05/05/2023

PAUL R.

PAUL R.

Wow

Took this with an open mind, really not knowing what to expect. I'd read online how some individuals had seen more endurance, better recovery, etc. So it was really all over the place. First time I dosed 500mg half hour prior to my workout. Noticed nothing, during or after :(. Thought it might be a bust. Next and subsequent sessions I dosed at 1g 30 min prior. Focus was intense. Best thing i can compare it to was my first time working out after taking 30mg of Adderall. Session was fire. Didn't want to stop. Didn't see any of the other purported benefits (everyone reacts differently) but from a focus/intensity aspect this one is hands down my favorite. Maybe add some cheque drops to the mix for aggression. Can't wait to combine with the new turkesterone product to see how that complements the overall benefit.

05/12/2023

Dear Paul, Thank you for your feedback! We are very happy that the product is working well for you 🙌

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04/28/2023

James B.

James B.

 Verified Buyer
US

US

Works well

Data shows it may be able to treat diabetes and heart failure.

04/28/2023

Dear James , thank you for sharing your experience!

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03/14/2023

VASSILIS M.

VASSILIS M.

 Verified Buyer
GR

GR

Best supplier

Best Mildronate in the market. Safe and fast delivery. Many thanks!

03/15/2023

Hi Vassilis, thank you for your feedback! We are happy to hear that you are satisfied with the product and delivery! :)

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