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Buy Naltrexone with 37 day fast domestic delivery within the US ($5)  just choose “Ships from: US (+15%)”

Naltrexone has been classically used as an FDA-approved drug since the 1980s in a 50 mg dose for the purpose of helping heroin, tobacco, and opium addicts, by blocking the effect of such drugs. By blocking opioid receptors, Naltrexone also blocks the reception of the opioid hormones that our brain and adrenal glands produce.

In 1985, Bernard Bihari, MD, a physician with a clinical practice in New York City, discovered the effects of a much smaller dose of Naltrexone (3 to 4.5 mg once a day) on the body’s immune system. Naltrexone, blocking endorphins, sends a false signal to the hypothalamus that “there are no endorphins” and in response, the hypothalamus increases their production. Endorphins are a natural defense of the body against viruses and infections. In people with HIV, their quantity was less than 30% of the norm of healthy people. Therefore, Bihari then began to experiment with Naltrexone doses, which, on the one hand, would increase the number of endorphins, and on the other, would not block them for a long time. The effect began with a 1.5 mg dose and ceased to increase from doses above 4.5 mg. He found that this low-dose Naltrexone (LDN) was able to enhance a patient’s response to infection by HIV, the virus that causes AIDS. The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that is caused by taking LDN at bedtime is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production.

In the mid-1990s, Dr.Bihari found in his practice that patients with cancer (such as lymphoma or pancreatic cancer) could benefit, in some cases dramatically, from LDN. In addition, people who had an autoimmune disease (such as lupus) often showed prompt control of the disease activity while taking LDN.

In human cancer, research by Professor Ian S. Zagon of the Pennsylvania State University over many years has demonstrated inhibition of a number of different human tumors in laboratory studies by using endorphins and LDN. It is suggested that the increased endorphin and enkephalin levels, induced by LDN, work directly on the tumors’ opioid receptors and, perhaps, induce cancer cell death (apoptosis). In addition, it is believed that they act to increase natural killer cells and other healthy immune defenses against cancer.

In general, in people with diseases that are partially or largely triggered by a deficiency of endorphins (including cancer and autoimmune diseases), or are accelerated by a deficiency of endorphins (such as HIV/AIDS), restoration of the body’s normal production of endorphins is the major therapeutic action of LDN. You can buy Naltrexone to treat the following diseases: Cancer; Hepatitis C; Lupus; Ulcerative colitis; Autism; Chronic fatigue syndrome; HIV/AIDS; Irritable bowel syndrome (IBS); Diabetic neuropathies; Dermatomyositis (an inflammatory muscle disease); Multiple sclerosis; Crohn’s disease; Alzheimer’s disease; Hashimoto’s thyroiditis; Parkinson’s disease etc.

* In 2012 the Norwegian documentary program, called “Our Small Country”, aired the documentary about LDN that has helped many patients with a large number of autoimmune diseases and some cancers. By 2015, LDN users in Norway had increased from a mere 300 to about 15,000 people. It has also changed many doctors’ attitude towards LDN, turning a widespread skepticism towards this unfamiliar drug into a willingness to prescribe LDN at a patient’s request.

Produced by Mosfarma, Russia.

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This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

FDA-approved Naltrexone, in a low dose, can normalize the immune system – helping those with HIV/AIDS, cancer, autoimmune diseases, and central nervous system disorders.

Dosage and administration

The therapeutic dosage range for LDN is from 1.5 mg to 4.5 mg every night. The course is usually started with 1.5 mg at bedtime. After one week the dosage is increased to 3 mg, and after another week or two – to 4.5 mg. Because of the rhythms of the body’s production of master hormones, LDN is best taken between 9 pm and 3 am. Most patients take it at bedtime.

The drug comes in a dosage of 50 mg per pill. To make a solution with the right concentration one pill is dissolved in 50 ml of distilled water (i.e. 1 part of water and 1 part of medication). The solution is kept in a refrigerator. Shake it up prior to use. Then pull up the necessary amount of a solution using a measuring device and plunge it into the back of your mouth. Take a small glass of water after an intake.

Side effects

LDN has virtually no side effects. Occasionally, during the first week’s use of LDN, patients may complain of some difficulty sleeping. This rarely persists after the first week. Should it do so, the dosage can be reduced from 4.5 mg to 3 mg nightly.

Drug interaction

Naltrexone blocks the action of opioid drugs.


  1. LDN users who are planning to have a surgery performed generally discontinue taking LDN for one or two days prior to the scheduled procedure. They then are able to restart it promptly after the surgery, when they no longer need to take narcotics regularly.
  2. Those patients who are taking thyroid hormone replacement for a diagnosis of Hashimoto’s thyroiditis with hypothyroidism ought to begin LDN at the lowest range (1.5 mg for an adult). Be aware that LDN may lead to a prompt decrease in the autoimmune disorder, which then may require a rapid reduction in the dose of thyroid hormone replacement in order to avoid symptoms of hyperthyroidism.
  3. Full-dose Naltrexone (50 mg) carries a cautionary warning against its use in those with liver disease.
  4. People who have received organ transplants and who therefore are taking immunosuppressive medication on a permanent basis are cautioned against the use of LDN.


It is important to note that full-dose Naltrexone can potentiate the course of a disease rather than inhibit it!

Storage conditions

Store the pills in a dry place, at a temperature not exceeding 25°C (77°F). The solution should be kept in a refrigerator. Keep out of the reach of children.


Mosfarma (Moscow Pharmaceutical Factory), Russia.

  1. Bihari B (1995). Efficacy of low dose naltrexone as an immune stabilizing agent for the treatment of HIV/AIDS.
  2. Kolaric S et al (1999). Paradoxical effects of intracerebroventricular low-dose opioid antagonists in SHR with chronic pain.
  3. Kariv R et al (2006). Low-dose naltreoxone for the treatment of irritable bowel syndrome: a pilot study.
  4. Smith JP et al (2007). Low-dose naltrexone therapy improves active Crohn’s disease.
  5. Cree BA et al (2010). Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis.
  6. Younger J et al (2014). The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain.
  7. Ludwig MD et al (2016). Long-term treatment with low dose naltrexone maintains stable health in patients with multiple sclerosis.
  8. Strazzulla LC et al (2017). Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris.
  9. Wilding JP (2017). Combination therapy for obesity.
  10. Zagon ISMcLaughlin PJ (2018). Intermittent blockade of OGFr and treatment of autoimmune disorders.
  11. Toljan KVrooman B (2018). Low-Dose Naltrexone (LDN)-Review of Therapeutic Utilization. 30248938
  12. Bronfenbrener R (2019). Inexpensive compounding of low dose naltrexone (LDN) with orange juice. 30930087
  13. Wang R et al (2019). Interaction of opioid growth factor (OGF) and opioid antagonist and their significance in cancer therapy. 31404891
  14. Zappaterra M et al (2020). Low-Dose Naltrexone reduces symptoms in Stiff-Person Syndrome. 31954293 
  15. Bolton MJ et al (2020). Low-dose naltrexone as a treatment for chronic fatigue syndrome.

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