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Buy Hopantenic Acid (Pantogam) Online!

Hopantenic acid (Pantogam) is a nootropic structurally similar to vitamin B5 (pantothenic acid). It has nootropic, anxiolytic and anticonvulsant effects. Pantogam is used to boost physical performance and improve memory and attention.

Save with the volume discount!

Synonyms Hopantenic acid / Homopantothenic acid / N-pantoyl-GABA
Form: 50 pills of 250mg / 60 capsules of 300mg
Form description: White, flat-cylindrical tablets with a chamfer and a break line / Firm gelatine capsules of white color; the capsule’s content is powder of white or yellowish color
Active ingredient for pills: Calcium hopantenate – 250 mg
Excipients for pills: Methylcellulose, calcium stearate, magnesium hydroxycarbonate, talc.
Active ingredient for capsules: Rac-hopantenic acid (D-, L-hopantenic acid) – 300 mg
Excipients for capsules: Microcrystalline cellulose, magnesium stearate.
Capsule composition: gelatin, titanium dioxide.
СAS Number: 18679-90-8
ATC code: N06BX
Pharmacological action: Anticonvulsant, nootropic
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 30°C (86°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: PIQ-Pharma, Russia

What is Hopantenic Acid?

Pantogam (Hopantenic acid) is a nootropic drug with anxiolytic action.

The molecule of hopantenic acid is obtained by substituting the beta-alanine moiety of pantothenic acid (vitamin B5) for gamma-aminobutyric acid (GABA). Unlike GABA itself, Pantogam can cross the blood-brain barrier and produce a GABAergic effect.

Pantogam was first synthesized in the 1950s by Japanese scientists. Since 1977 in Russia and since 1978 in Japan, it is used in medicine to treat various neurological disorders in children and adults, including autism.

The drug has nootropic, anxiolytic and anticonvulsant effects. Pantogam interacts with GABA-A, GABA-B, and dopamine D2 receptors and stimulates acetylcholine synthesis.

What is the Difference Between Pantogam and Pantogam Active?

Pantogam Active (D-, L-Hopanthenic acid) is the racemic modification of the original drug; this modification was developed by the Russian pharmaceutical company “Piq-Pharma” in 2008. Its active substance Calcium hopantenate has two active isomers with different pharmacology, and Pantogam Active has a higher content of L-hopantenic acid than Pantogam. Because of the ratio of the different isomers in these two drugs, they differ in both effects and efficacy.

Pantogam Active exhibits more pronounced anxiolytic, anti-amnesic, and anticonvulsant effects and can be used long-term without forming an addiction.

What is Hopantenic Acid Used For?

Intended uses of Pantogam (Hopantenic acid) include:

  • Organic brain syndrome;
  • Cerebrovascular insufficiency;
  • Extrapyramidal symptoms;
  • Epilepsy;
  • Decreased mental and physical capacity;
  • Neurogenic bladder dysfunction;
  • Developmental delays.


You can also use Pantogam in healthy individuals to increase mental and physical capacity and relieve chronic fatigue. It also may improve memory and attention.

Where Can I Order Hopantenic Acid Online?

You can buy Hopantenic Acid online from different vendors. CosmicNootropic offers Hopantenic Acid (Pantogam / Pantogam Active) in packs of 50x250mg pills and 60x300mg capsules. We offer worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Hopantenic Acid (Pantogam / Pantogam Active) and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.


We also sell a similar product – Pantocalcin.

What is Hopantenic Acid Dosage?

Pantogam (Hopantenic Acid) is used orally, 15-20 minutes after meals, 2-3 times a day, preferably in the morning or afternoon.

The duration of treatment is 1-4 months, sometimes up to 6–12 months. After 3-6 months the treatment can be repeated.

For 250 mg pills: for adults, a single dose is 1-4 pills (0.25-1 g), the maximum daily dose is 3 g.

For 300 mg capsules: 1-3 capsules per one time (0.3-0.9 g). The maximum daily dose is 9 capsules (2.7 g).

What are the Side Effects of Hopantenic Acid?

In rare cases, allergic reactions are possible (rhinitis, conjunctivitis, skin rash). In these cases, a dose has to be decreased or treatment stopped. Sleeping impairments or somnolence, a noise in the head are short-lasting symptoms, the drug withdrawal is not necessary in these cases.


Hypersensitivity, acute severe diseases of kidneys, pregnancy (1st trimester), lactation, patient’s age under 18 years (there are no clinical data of the drug use for younger patients).


In case of overdose, the side effects can increase. Treatment: charcoal, gastric lavage, symptomatic treatment.

Drug interaction

Pantogam (Hopantenic Acid) prolongs the effects of barbiturates, increases anticonvulsants effects, and prevents side effects of phenobarbital, carbamazepine, and neuroleptics. The efficiency of Pantogam (Hopantenic Acid) is increased in combination with glycine, or ethydronic acid. The drug potentiates the effect of local anesthetics (procaine).



  1. Katunina et al (2010) Pantogam active in the complex treatment of dystonic hyperkineses
  2. Poverennova et al (2011) Efficacy and tolerability of pantogam activ in patients with partial epilepsy
  3. Kovalev et al (2012) Pantogam and pantogam active: qualitative and quantitative features of the interaction with neurotransmitter receptors in vitro
  4. Medvedev et al (2015) Augmented antipsychotic therapy with pantogam active in patients with schizophrenia
  5. Smulevich et al (2015) Pantogam activ (D-, L-hopantenic acid) in the treatment of cognitive and anxiety disorders in patients with arterial hypertension
  6. Gekht et al (2016) Possible applications of rac-hopantenic acid in the treatment of anxiety and depressive disorders in patients with chronic cerebral ischemia
  7. Baranov et al (2016) Effective treatment of patients with chronic heart failure and depressive disorders with nootropics drug pantogam activ
  8. T Voronina, S Litvinova (2017) Pharmacological effects and clinical application of pantogam and pantogam active
  9. Zavadenko et al (2017) Pharmacotherapy of attention deficit hyperactivity disorder in children: the results of a multicenter double-blind placebo-controlled study of hopantenic acid
  10. Tiganov et al (2017) A differential approach to the improvement of prevention and correction of neuroleptic side extrapyramidal disorders with pantogam activ in patients with schizophrenia
  11. O Ostroumova (2018) Possible applications of rac-hopantenic acid in the treatment of cognitive, anxiety and depressive disorders in patients with essential arterial hypertension
  12. Zavadenko et al (2019) [Pharmacotherapy of psychomotor developmental delay in 6-12 months preterm infants with hypoxic-ischemic encephalopathy (the double-blind comparative multicenter placebo-controlled study)]
  13. V Zykov (2020) [Tics and Tourette’s syndrome in children]


Based on 6 Reviews










 Verified Buyer


Impressed with service

I bought Pantogam for my Mom who recently moved from Russia to live with me. I did not think I was going to receive the order at all-did it more so to show my Mom we would have to find something else similar in the US. First, my order was shipped right away. Second, I got it before I knew it-less than 2 weeks. I was also notified by email when it was out for delivery. I am sorry I had little trust. You guys impressed me. Please do not stop being there for us here in the States. We need your company!


Hi Evelina! Thank you so much for your feedback! We are pleased to hear that you are satisfied with our service. Your kind words encourage us to continue to provide the quality products.

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 Verified Buyer


Beyond grateful

Hi there! It’s not easy to write review about Cosmic Nootropic because words such as “ good customer service” or “ they are doing a good job” just won’t cut it. I have been a customer for few years now and I will stay a customer for many more. Top notch service! Good chunk of US businesses maybe should send their stuff for training to Cosmic Nootropic as no one beats their service and how they treat clients. My gratitude goes beyond any words to the stuff. Thank you, everyone, especially Vlada and Ksenia 💖 Regarding Pantogam Active… couple of years ago when real estate market was on the rise, I have made a huge mistake when I decided to make all money in the world and started to take Adderall. The worst decision I have ever made. Those who went through this experience know how difficult it is to stop taking it because withdrawal is just unbearable. I completed and massive research on how to ease the withdrawal symptoms and one particular story seemed interesting and it was published on National Library website. One psychiatrist told about his patient who didn’t want to do a weaning schedule and just wanted to stop and Pantogam Active was the medicine that patient took to ease withdrawal symptoms. I went with this choice as well. Just felt like it was the right thing to do. Let me tell you this: I call Pantogam Active my healthy Adderall because it pretty much does the same thing just much softer and it feels natural. I still had a mild depression though, but Pantogam Active in a combo with Lithium Orotate and Noopept brought me back to normal in a matter of days. I am almost 40 years and still can’t believe that I was ****** enough to start taking Adderall, especially considering that I never in my life tried anything even **** lol No money was worth it. But I am very happy that I was able to get Pantogam Active and pretty much I got away with what I call “little shake up”. Lithium Orotate is a different story lol I think everyone need to take it. Not only because it’s healthy but also because “happy” pill does exist and it doesn’t have to be an addictive drug that requires prescription. It also works fast. I could tell in about half an hour how fast it’s working, Thank you Cosmic Nootropics stuff for making it possible and all your help. 💖


Thank you very much for your kind words, we really appreciate your feedback and try to do our best for our customers! We're really glad you found the product useful and helpful :)

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 Verified Buyer


Better than I was expecting.

I originally purchased this for my daughter who has anxiety. I don't have anxiety, but I also tried it to see how what effects it would have since it is for more than just anxiety. My daughter says that for her it gives her more focus, reduces brain-fog, and takes the edge off when dealing with stressful situations. She didn't have a response on the anti-anxiety effects since she already takes Etifoxine for that. For myself I found that it gives me a kind of motivational focus. When I take it, I find it's MUCH easier to get things accomplished throughout the day. Wakes me up, makes it easier to think and figure things out. Like I said, I don't have anxiety, but I do have stress. I found it helps with that also. When something stressful happens, instead of the stress response taking over, it seems to start up, then plateau at about 1/4 of normal. Which is a nice effect for me. I have been prescribed Dexedrine in the past (prescription amphetamine), and Pantogam seems to have a similar effect without the burnout that comes when the Dexedrine wears off. When the Pantogam wears off, I just feel calm and relaxed. I have found that if I take it too late in the afternoon though, it can make getting to sleep a bit hard for me. As with all things, everyone has different body chemistry. How a substance affects one person may not have the same affect on another. Best thing I can say is try it out. Works great for me!


Dear Pettclan, thank you for your detailed feedback!

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Alexandra P.

Alexandra P.

 Verified Buyer


Great Service!

Great product and nice shopping experience overall! Thank you!

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Magic stuff

I found this product to be key in managing PTSD and the anxiety, sleeplessness, anger and brain fog that comes with it. I feel more like myself when I take it and have a much easier time with life necessities and schoolwork. I also find a noticeable reduction in my chronic back pain. The only side effect I notice is that sometimes I get a little too hot, especially with exertion, when it's in my system. But it's barely noticeable and a miracle for me when nothing else really helped! I highly recommend this. My partner with narcolepsy feels benefits too - easier time with anxiety, managing emotions and cognitive function in general, as well as significant relief from some of the satellite symptoms he experiences. He also tends to get better nights of sleep and better results out of the baclofen and stimulants he needs to take to function. Can't live without it now!


Hi, May! Happy that it works for you!

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 Verified Buyer

Good aid for wide variety of problems.

Came suprisingly 11 days to United States, was happy with this nootropic, helped sooth muscles and work under less stress. Thanks again for your quality service.

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