phenibut instruction

PHENIBUT

139 Reviews

Phenibut is not approved for clinical use by the U.S. FDA and in most of Europe. According to the FDA Phenibut is a substance that does not meet the statutory definition of a dietary ingredient. Note that self-prescription of Phenibut, its prolonged use or recreational overdose can cause addiction, dependence, and severe withdrawal among other side effects. Phenibut is marketed for medical use as anxiolytic and sleep-aid in Russia, Ukraine, Belarus, Kazakhstan, and Latvia.

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Buy Phenibut Online and Use it Safely

Phenibut is a GABAergic drug with anxiolytic and nootropic effects. It is widely used in CIS countries as a mood elevator, a tranquilizer, and a nootropic for anxiety.

Please note that Phenibut is not a dietary supplement. The capsules are a medication with a complex effect, which may cause adverse reactions, including severe drug dependence [1] if misused.

Other names: Aminophenyl butyric hydrochloride acid, Phenibut HCL, Fenibut, Fenigam; Phenigam; Phenybut; Phenygam; Phenylgamma; Phenigama; PHG; PhGABA; β-Phenyl-γ-aminobutyric acid; β-Phenyl-GABA; Noophen/ Noofen; Anvifen
Form: Pills (250mg)
Active ingredient: Aminophenyl butyric acid hydrochloride
Excipients: Lactose, potato starch, calcium stearate
Formula: C10H13NO2 • HCl
Pharmacological classification: Nootropic, anxiolytic
ATC code: N06BX22 Other psychostimulants and nootropic agents
CAS Number: 1078-21-3
Pharmacological action: Nootropic, tranquilizing, anxiolytic, neuroprotective, antioxidant, antiplatelet
Elimination half-life: 5.3 hours (250 mg)
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C. Keep out of reach of children.
Shelf life: 5 years
Manufacturer: Usolye Pharm https://usolpharm.ru/

What Is Phenibut?

Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter Gamma-Aminobutyric Acid, or GABA. An extra phenyl ring makes Phenibut cross the blood-brain barrier much better than the original compound. [2]

Phenibut was synthesized in the USSR in the 1960s by the Soviet chemist and professor Dr Perekalin. Phenibut was recognized for its brain stimulation and anxiety-reducing effects.

What is Phenibut Used For?

According to the official Phenibut drug sheet and some human research papers mostly conducted in Russia as well as anecdotal Phenibut reviews, the nootropic is said to be beneficial in case of the following symptoms:

  • Emotionally labile disorders including post-traumatic stress disorder (PTSD) [3;4];
  • Asthenic disorders (lack of energy) [5];
  • ADHD [6,7];
  • Alcohol withdrawal [8];
  • Poor sleep quality [9];
  • Other conditions, characterized by reduced intellectual productivity.

What are Phenibut Benefits and Effects?

The ability of Phenibut to combine two opposite effects: tranquilizing and activating – makes it a limelight for those who look for a substance with a calming, yet nootropic action. 

Unlike benzodiazepine tranquilizers that have a depressing effect on the CNS and cause reduced performance and attention, Phenibut is said to be void of such side effects if used moderately and under the doctor’s strict supervision. That is one of the reasons why it is widely prescribed by doctors in former Soviet countries to treat ADHD, hyperactivity and lethargy.

Are Phenibut Capsules Safe to Take?

Phenibut can be a safe medication when used responsibly, in moderation and according to the doctor’s prescription. [10] When taking Phenibut, it is important to be aware of the potential side effects and contraindications.

Refrain from using Phenibut in these cases: individual intolerance to any components of the drug, age below 2 y.o., pregnancy and lactation, as well as history of severe drug abuse. It is also recommended to avoid Phenibut anxiolytic while driving.

FAQ:

Where to Buy Phenibut Online?

When looking for the best place to obtain Phenibut online, it is important to ensure that you are doing so safely. There are different versions available for purchase like Phenibut powder and Phenibut hcl capsules of different dosages.

CosmicNootropic sells original Phenibut only, with fast delivery. Phenibut nootropic capsules 250mg are tested and verified for product purity and identity by the official manufacturer. If you want to order Phenibut, buy nootropics at CosmicNootropic.

Note: Phenibut is produced by different official manufacturers. We reserve the right to ship Phenibut capsules of the same quality produced by different Russian manufacturers. The package might be different from the one presented on the website. The maximum order quantity is limited to 3 packs. Please note that due to regulations Phenibut can only be shipped to the US.

Can I order Phenibut to Australia?

We highly recommend refraining from purchasing Phenibut if you are from Australia. Phenibut is officially banned in Australia and will likely be stopped by local customs. In this case, we cannot be held accountable and will not be able to refund or reship your order. This may also concern countries such as Hungary, Lithuania, France or Italy.

Is Phenibut the Right Drug to Calm You Down?

Phenibut capsules may have a calming effect in small doses and can improve sleep quality along with other positive Phenibut effects. Phenibut was even used by Russian astronauts to decrease stress and maintain high performance levels. It is a known fact that the cosmonauts of the Soyuz-Apollo Space Project had Phenibut in their medical kits.

What Are Phenibut Alternatives?

Phenibut is a strong medication that should be only used when prescribed by the doctor. Remember that there are safer Phenibut alternatives to support the nervous system, for example: Selank, Afobazole, Mexidol, Stresam as well as other non-medicational methods to reduce stress.

What Are Phenibut Recreational Use Restrictions?

Phenibut is known to be used by some people for recreational purposes. However, such misuse poses serious health threats. If taken in large quantities for recreational purposes, it is likely to cause euphoria, hallucinations followed by tolerance and severe withdrawal symptoms.

Other side effects of taking Phenibut high doses include delirium, dissociative effects, and even coma. Therefore, we limit the maximum order quantity to 3 packs of 20 capsules.

What Are Phenibut Reviews?

You can check some Phenibut Reddit reviews. There are also Phenibut Russian reviews which you can read via google translate. Please note that individual reviews from customers and Phenibut users may contradict the views of the CosmicNootropic team and are given for informational purposes only.

What is Phenibut Dosage?

The most common dosages indicated by the official manufacturer are 250–500 mg, 2-3 times a day. The maximum single dosage is 750 mg. The usual course duration is 2-3 weeks. One pack of Phenibut capsules 250mg contains 20 pills.

It is advisable to refrain from Phenibut high dosages. Consider choosing the low dose to minimize any negative side effects. Besides it is not always necessary to take Phenibut as a course treatment. Please consult your doctor prior to use.

What are Phenibut Side Effects?

The most common adverse reactions to the drug are an increase in irritability, lethargy, dizziness, and nausea.

If Phenibut is used for a long time at high doses, a hepatotoxic effect, including fatty liver dystrophy, and eosinophilia may occur because of the Phenibut liver toxicity.

For more information on Phenibut dosages and side effects, please refer to the translated official drug sheets linked below.

OFFICIAL INSTRUCTION OF PHENIBUT

  1. I Lapin (2001) Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug https://www.ncbi.nlm.nih.gov/pubmed/11830761
  2. G Shul’gina, E Ziablitseva (2005) Effect of the GABA derivative phenibut on learning https://www.ncbi.nlm.nih.gov/pubmed/15776965
  3. E Ziablitseva, I Pavlova (2007) Effect of GABA receptor agonist phenibut on behavior and respiration of rabbits in the negative emotional situation https://www.ncbi.nlm.nih.gov/pubmed/17944107
  4. E Zyablitseva, I Pavlova (2008) Effects of the GABA receptor agonist phenibut on behavior and respiration in rabbits in emotionally negative situations https://www.ncbi.nlm.nih.gov/pubmed/18607733
  5. Dambrova et al (2008) Comparative pharmacological activity of optical isomers of phenibut https://www.ncbi.nlm.nih.gov/pubmed/18275958
  6. Ziablitseva et al (2009) The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning https://www.ncbi.nlm.nih.gov/pubmed/19476215
  7. E Ziablitseva, I Pavlova (2009) Influence of GABA agonist phenibut on the neuronal activity and interaction in hippocampus and neocortex in emotionally negative situations https://www.ncbi.nlm.nih.gov/pubmed/19899708
  8. Borodkina et al (2009) Effect of phenibut on the content of monoamines, their metabolites, and neurotransmitter amino acids in rat brain structures https://www.ncbi.nlm.nih.gov/pubmed/19334514
  9. Tiurenkov et al (2012) Fenibut and its citrate prevent psychoneurological disorders caused by chronic stress (paradoxical sleep deprivation) https://www.ncbi.nlm.nih.gov/pubmed/22891435
  10. Samokhvalov et al (2013) Phenibut dependence https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604470/
  11. Owen et al (2016) Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects and acute toxicity https://www.ncbi.nlm.nih.gov/pubmed/26693960
  12. Volotova et al (2016) Neuroprotective action of phenibut and neuroglutam in experimental cerebral ischemia on the background of altered immunoreactivity https://www.ncbi.nlm.nih.gov/pubmed/29949699
  13. Vavers et al (2016) The neuroprotective effects of R-phenibut after focal cerebral ischemia https://www.ncbi.nlm.nih.gov/pubmed/26621244
  14. Ahuja et al (2018) Phenibut (β-Phenyl-γ-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952553/
  15. Joshi et al (2018) Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662439/
  16. Kupats et al (2020) Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports https://pubmed.ncbi.nlm.nih.gov/32340063/ 
  17. Kupats et al (2020) Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury https://pubmed.ncbi.nlm.nih.gov/33274011/
  18. C Doyno, C White (2021) Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank https://pubmed.ncbi.nlm.nih.gov/34396551/

4.5

Based on 139 Reviews

(114)

(7)

(3)

(3)

(12)

 

01/25/2025

David M.

David M.

 Verified Buyer
US

US

Phenibut

I’ve used Phenibut for years, and as another reviewer stated, this is legitimate Phenibut HCL; it is an excellent product to help ease anxiety and boost self-confidence and mood. In addition, it always seems to help me with my sleep quality. Do your research. Onset is 2-4 hours, peaks about 4-6 hours afterward, and can stay in your system for about 24 hours. Respect this product, follow recommended dosages, and USE SPARINGLY to maintain efficacy and to avoid tolerance and dependency (I use one dosage 1-2 times a week at most). Lastly, I would like to add that I’m very impressed with Cosmic Nootropics products and outstanding customer support. Thank you

02/05/2025

Cosmic Nootropic

Dear David, thank you for the thoughtful review! We're so glad to hear you're having a positive experience with our Phenibut and that it’s helping with anxiety, mood, and sleep. We also appreciate your responsible approach to usage. Thanks for choosing us! 💛

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01/24/2025

Laura P.

Laura P.

 Verified Buyer
US

US

Phenibut

Always satisfied with product and service. Thank ypu

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01/19/2025

Joanne W.

Joanne W.

 Verified Buyer
US

US

Phenibut is a big help

I only use occasionally. But it is a guarantee of a good night’s sleep.

01/19/2025

Cosmic Nootropic

Thanks for the great review, Joanne. We’re glad to hear that Phenibut is helping you get a good night’s sleep!

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01/14/2025

Justin C.

Justin C.

 Verified Buyer
US

US

Satisfied

There was some confusion with the payment. I was asked to dispute my charge and pay again. This seemed really sketchy. I hope you guys work something out with your payment options as I'm cautious about shopping with you again

01/15/2025

Cosmic Nootropic

Dear Justin, thank you for sharing your feedback! We're actively working to improve our payment system to ensure smoother transactions in the future. Your concerns are important to us, and we appreciate your patience and understanding. We hope to serve you again soon!

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12/21/2024

Thomas C.

Thomas C.

 Verified Buyer
US

US

Excellent

First time trying Phenibut and didn’t know what to expect. Really good quality and will be purchasing again.

12/22/2024

Cosmic Nootropic

Dear Thomas, Thank you for your review! We're delighted that you enjoyed the product and hope to see you as a customer again soon!

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12/07/2024

Kevin j.

Kevin j.

 Verified Buyer
US

US

Overpriced

Good until price went up. Much cheaper elsehere

12/07/2024

Cosmic Nootropic

Thank you for your feedback! We understand your concern about pricing. Unfortunately, the high costs of logistics, financial, and legal risks make price reductions unlikely at this time. We remain committed to keeping our products accessible and will reassess if circumstances improve. Feel free to reach out with any further questions!

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12/06/2024

Michael C.

Michael C.

 Verified Buyer
US

US

Phenibut works well.

I use 1-2 tabs of Phenibut about twice a week and it helps me relax for a good nights sleep. I save it for my nights when I have a busy, stressfull day coming up and can't afford a bad night's sleep. I don't over use it or abuse it and this way there's no dependency, tolerance, withdrawal, side effects, etc.

12/06/2024

Cosmic Nootropic

Hi Michael! Thank you for your thoughtful review! It’s great to hear that our product is helping you relax and prepare for restful nights when you need it most. We’re glad our product is meeting your needs, and we appreciate you sharing your experience! However, please note that it's essential to follow the manufacturer's instructions and your doctor's recommendations. If you ever have questions or need support, don’t hesitate to reach out!

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12/05/2024

P.S

P.S

US

US

This is pharmaceutical

Works fine and it\'s 100% , not 62% or 96% who knows what.You can by a kilo of that if you want?What are you getting?I will pay for pharmaceutical grade.

12/06/2024

Cosmic Nootropic

Hi! Thank you for your review! We're glad to hear you value the pharmaceutical-grade quality of our product :) We pride ourselves on offering reliable legitimate options that you can trust. Your commitment to quality speaks volumes, and we’re happy to provide exactly what you’re looking for. If you ever need assistance or have questions, feel free to reach out!

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11/28/2024

Seth R.

Seth R.

 Verified Buyer
US

US

Didn't Work

My review won't even make it to the website page, but I took larger and larger doses and felt nothing compared to other Phennibut manufacturers.

11/29/2024

Cosmic Nootropic

Hi Seth! We’re sorry to hear this product didn’t meet your expectations. 😔 We aim to provide high-quality items and take all feedback seriously. It's important to remember that everyone is different and the reactions to different products depend on many factors and can vary. Please feel free to reach out to us if you have any questions —we’d be happy to discuss your experience further and assist you! 🙏

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11/17/2024

Christopher H.

Christopher H.

 Verified Buyer
US

US

Damaged product apparently from usps

My. Package was damaged again I assume from USPS product unusable package was ripped and boxes had been torn pills had fell out in the bag very disappointed

11/17/2024

Cosmic Nootropic

Dear Christopher, We're sorry that you received a damaged product. Our support team has sent you a message, please check your inbox so we can resolve the issue quickly.

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11/14/2024

Kenneth O.

Kenneth O.

 Verified Buyer

Phenibut

The quality of the product is good. However, other vendors offer a product as good as yours in bulk powder containing a lot more for a MUCH lower price.

11/15/2024

Cosmic Nootropic

Hi Kenneth! Thank you for your feedback! We’re glad to hear you’re satisfied with the quality of our product. While we may not always compete with bulk pricing, we strive to provide high-quality certified pharmaceutical products with reliable service and fast shipping. We appreciate your input and hope to continue serving you!

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11/11/2024

Jacob G.

Jacob G.

 Verified Buyer
US

US

Never Recieved Item

I wish I could write a review for it, but I got charged and never received the item. USPS didn’t help and neither did cosmic nootropics

11/11/2024

Cosmic Nootropic

Hi Jacob! We're very sorry to hear about this experience. We’ve reached out to you via email to help resolve the issue, as your satisfaction is our priority. Shipping problems can be frustrating, and we're here to support you in getting this sorted out as quickly as possible. Thank you for your patience as we work on a solution together.

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11/10/2024

Ruth B.

Ruth B.

 Verified Buyer
US

US

Mastercard

I would like to place an order but you said you’re having a problem with Mastercard and that you are working on it. Has it been fixed yet?

11/11/2024

Cosmic Nootropic

Hi Ruth! Thank you for checking in! We’re still working on resolving the issue with card payments and apologize for the inconvenience. In the meantime, we offer other payment options to ensure you can place your order smoothly. If you need assistance with this, please don’t hesitate to reach out—we’re here to help!

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11/04/2024

Ian C.

Ian C.

 Verified Buyer
US

US

Great quality, fast shipping

Great quality product and is really a game changer for me. Cosmic has gone out of their way to make orders right for me in the past, they're a good company. You won't be let down.

11/05/2024

Cosmic Nootropic

Hi Ian! Thank you so much for your kind words! We're thrilled to hear the product has made a difference for you and that you’ve had a great experience with our team.

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11/03/2024

Charlotte N.

Charlotte N.

 Verified Buyer
US

US

Phenibut

This IS legitimately Phenibut HCl. Excellent customer service- highly recommended. I have ordered various nootropics from them for years. (Be aware of companies that are not selling actual Phenibut hydrochloride.) Please BE CAREFUL WITH THIS PHENIBUT AND ONLY USE AS COSMIC NOOTROPICS INSTRUCTS. I am impressed with how careful their instructions are for their customers. FOLLOW THEM! Do NOT overuse. Charlotte, RN BSN Ohio - United States

11/05/2024

Cosmic Nootropic

Hi Charlotte! Thank you so much for your thoughtful and detailed review. We're glad to hear you're satisfied with the quality of our product and our customer service. We truly appreciate your long-standing trust in us for your nootropic needs. Your message about using the product safely and following our instructions is so important, and we're grateful for you highlighting that. We take pride in providing clear, responsible guidance to help our customers use products safely. Thanks again for your recommendation, and we're honored to continue serving you! Stay safe and take care.

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11/03/2024

Ruth B.

Ruth B.

 Verified Buyer
US

US

Payment

You said you were working on the problem with Mastercard payment, has it been resolved? Can I pay with Mastercard?

11/05/2024

Cosmic Nootropic

Hi Ruth! We're working on it. Unfortunately, we can't say exactly when the card payment option will be available again, but we hope for the best. At the moment we have maximized our cryptocurrency payment discount up to 25% So we recommend considering this as a payment option. If you are not familiar with crypto, we have a step-by-step guide on how to set up a crypto wallet: https://cosmicnootropic.com/blog/crypto-wallet-a-step-by-step-guide/

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10/25/2024

Laura P.

Laura P.

 Verified Buyer
US

US

I still havent received it

10/27/2024

Cosmic Nootropic

Hi Laura! We're sorry to hear that! Please contact us at our support email ([email protected]) and we'll look into this situation.

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10/24/2024

Walter W.

Walter W.

 Verified Buyer
US

US

Found a Better Supplier

Found a supplier that offers the same product I was buying at more than -%70 the price that cosmic nootropics was selling for.

10/25/2024

Cosmic Nootropic

Hi Walter! Thank you for your feedback. We understand that pricing is an important factor for our customers. However, we want to emphasize that all of our products are original and come with manufacturer certificates, ensuring quality and authenticity. We believe in providing value through high-quality products that are backed by trusted sources. If you have any questions about our offerings or would like to discuss further, please don’t hesitate to reach out. We appreciate your support!

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10/15/2024

Akiko

Akiko

 Verified Buyer
US

US

Great company and products

Happy with the product, helps with anxiety and for some reason helps me have a better workout!

10/17/2024

Cosmic Nootropic

Hi Akiko! Thank you so much for your kind words! We’re thrilled to hear that our product is helping with your anxiety and enhancing your workouts. Your satisfaction means a lot to us, and we’re here to support you on your journey. If you have any questions or need further assistance, feel free to reach out!

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09/27/2024

Christie B.

Christie B.

 Verified Buyer
US

US

Dependable company and product!

I have now purchased Phenibut for the second time with Cosmic Nootropic. I have had nothing but a great experience so far, and I am satisfied with the product. Phenibut is one of the only things in the world that calms my anxiety. I normally take it a couple times a week. You do have to be careful with it. In the future, I might even try some of the other products. Thank you.

09/27/2024

Cosmic Nootropic

Hi Christie! Thank you for your thoughtful review! We’re so glad to hear that our product has been helpful for your anxiety and that you've had a great experience with us. It’s always important to use it carefully, so we appreciate your mindfulness. If you decide to try any of our other products in the future, we’re here to help with any questions you might have. Thank you for choosing CosmicNootropic, and we look forward to serving you again!

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3 months ago

Review

Christopher H. Verified Buyer

Damaged product apparently from usps

My. Package was damaged again I assume from USPS product unusable package was ripped and boxes had been torn pills had fell out in the bag very disappointed

Reply:

Dear Christopher, We're sorry that you received a damaged product. Our support team has sent you a message, please check your inbox so we can resolve the issue quickly.

Response

3 months ago

Review

Ruth B. Verified Buyer

Mastercard

I would like to place an order but you said you’re having a problem with Mastercard and that you are working on it. Has it been fixed yet?

Reply:

Hi Ruth! Thank you for checking in! We’re still working on resolving the issue with card payments and apologize for the inconvenience. In the meantime, we offer other payment options to ensure you can place your order smoothly. If you need assistance with this, please don’t hesitate to reach out—we’re here to help!

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