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Phenibut®
145 Reviews
Description
Dosage
Research
Reviews
| Other names: | Aminophenyl butyric hydrochloride acid, Phenibut HCL, Fenibut, Fenigam; Phenigam; Phenybut; Phenygam; Phenylgamma; Phenigama; PHG; PhGABA; β-Phenyl-γ-aminobutyric acid; β-Phenyl-GABA; Noophen/ Noofen; Anvifen |
| Form: | Pills (250mg) |
| Active ingredient: | Aminophenyl butyric acid hydrochloride |
| Excipients: | Lactose, potato starch, calcium stearate |
| Formula: | C10H13NO2 • HCl |
| Pharmacological classification: | Nootropic, anxiolytic |
| ATC code: | N06BX22 Other psychostimulants and nootropic agents |
| CAS Number: | 1078-21-3 |
| Pharmacological action: | Nootropic, tranquilizing, anxiolytic, neuroprotective, antioxidant, antiplatelet |
| Elimination half-life: | 5.3 hours (250 mg) |
| Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C. Keep out of reach of children. |
| Shelf life: | 5 years |
| Manufacturer: | Usolye Pharm |
Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter Gamma-Aminobutyric Acid, or GABA. An extra phenyl ring makes Phenibut cross the blood-brain barrier much better than the original compound.
Phenibut is not approved by the FDA and is not intended to diagnose, treat, cure, or prevent any disease. In the United States and many other countries, it is primarily used as a research chemical in pharmaceutical testing and scientific studies. For more details, please refer to the manufacturer’s instructions or peer-reviewed scientific literature.
Note: In accordance with the FDA’s rules, we do not provide information regarding medical indications or therapeutic uses of this compound on our website.
Due to FDA regulations, we cannot provide dosage recommendations for Phenibut. Note that it has known contraindications and can cause adverse reactions. In the USA it can be used for research purposes only. For more information on Phenibut, please refer to the translated official drug sheets in English.
- I Lapin (2001). Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.
- G. Shul’gina, E. Ziablitseva (2005). Effect of the GABA derivative Phenibut on learning.
- E. Ziablitseva and I. Pavlova (2007). Effect of GABA receptor agonist Phenibut on behavior and respiration of rabbits in the negative emotional situation.
- E. Zyablitseva and I. Pavlova (2008). Effects of the GABA receptor agonist Phenibut on behavior and respiration in rabbits in emotionally negative situations.
- Dambrova et al. (2008). Comparative pharmacological activity of optical isomers of Phenibut.
- Ziablitseva et al. (2009). The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning.
- E. Ziablitseva and I. Pavlova (2009). Influence of GABA agonist phenibut on the neuronal activity and interaction in hippocampus and neocortex in emotionally negative situations.
- Borodkina et al. (2009). Effect of phenibut on the content of monoamines, their metabolites, and neurotransmitter amino acids in rat brain structures.
- Tiurenkov et al. (2012). Phenibut and its citrate prevent psychoneurological disorders caused by chronic stress (paradoxical sleep deprivation).
- Samokhvalov et al. (2013). Phenibut dependence.
- Owen et al. (2016). Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity.
- Volotova et al. (2016). Neuroprotective action of phenibut and neuroglutam in experimental cerebral ischemia on the background of altered immunoreactivity.
- Vavers et al. (2016). The neuroprotective effects of R-phenibut after focal cerebral ischemia.
- Ahuja et al. (2018). Phenibut (β-Phenyl-γ-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse.
- Joshi et al. (2018). Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report.
- Kupats et al. (2020). Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports.
- Kupats et al. (2020). Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury.
- C. Doyno and C. White (2021), Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
4.5
Based on 145 Reviews
(119)
(7)
(3)
(4)
(12)
05/12/2025
Susan M.
Verified Buyer
US
Phenibut is a game changer
The phenibut I purchased from you guys was amazing. When I took one it was within 20 minutes that I felt good about everything. My anxiety disappeared. Thanks so much for a high quality item.
05/12/2025
CosmicNootropic
Hi Susan! Thank you for your feedback!
05/12/2025
Chad
Verified Buyer
JM
Still testing
Tbh I took 1 pill which is 250mg and felt literally nothing the whole day, also had gave my friend 1 and also the same experience for him, week later I tried 3 pills at once (750mg) and I did feel some effects 2-3 hours later, mainly elevated mood and motivation but nothing that met my expectations based off what I heard this drug can do, however it might be important to note I only spent like 30mins outside when that feeling kicked in then went back home to do some work. I think next time I\'ll try 4 pills (1G) to see what I feel before I determine whether this drug is for me or not, because I like what it sounds like on paper.
05/12/2025
CosmicNootropic
Hi Chad! Thank you for taking the time to share your experience! We really appreciate your detailed feedback. Everyone’s response to nootropics can vary depending on factors like individual neurochemistry, sensitivity, and even external circumstances like sleep, nutrition, or time spent outdoors—as you pointed out.
05/06/2025
Julie M.
Verified Buyer
US
Y’all are amazing
I got my item right away. Right away. I haven’t used my stuff as of yet. I was prompted by an email to tell how I liked using it. I trust these guys. A lot of
05/07/2025
CosmicNootropic
Hi Julie! Thank you for your kind words!
04/22/2025
Nicholas H.
Verified Buyer
US
Phenibut 250mg #20
Cosmic Nootropic only vendor with legitimate product as far as I have gathered. I have been a customer for ~12 months and have placed numerous orders and have received products and service always, always as stated. These people are reliable, professional, and are true to their word.
04/23/2025
CosmicNootropic
Dear Nicholas, thank you so much for the kind words — it truly means a lot to us! We’re honored to have earned your trust over the past year. Consistency, transparency, and quality are at the core of what we do, and it’s incredibly rewarding to hear that it’s made a difference for you. 🙏
04/11/2025
BARBARA V.
Verified Buyer
US
Couldn't tell the difference
I really couldn't tell the difference from a regular anxiety ridden day.
04/18/2025
CosmicNootropic
Dear Barbara, thank you for sharing your experience — we’re really sorry to hear the product didn’t meet your expectations. Everyone’s body reacts differently, especially when it comes to nootropics and mood support. This is why we always recommend consulting your doctor before taking any medication.
04/05/2025
Joshua B.
Verified Buyer
US
Amazing products with trusted seller
Excellent experience. Exactly like what I read and researched and was looking for. Have tried everything non prescription for anxiety and this is the only thing I can promise you will cut that edge off social anxiety.. Josh from Indiana USA
04/06/2025
CosmicNootropic
Thank you for the great review, Josh! We’re really glad to hear the product worked well for you and helped with social anxiety. Your trust means a lot to us!
03/20/2025
Joshua B.
Verified Buyer
US
Absolutely best noorotropic ever!
Such a relaxing calm with no hangover feeling after use. Totally recommend for anyone struggling with anxiety.
03/20/2025
CosmicNootropic
Dear Joshua, thank you for your great review! We're so glad our nootropic helped with relaxation and anxiety. Your recommendation means a lot to us!
03/08/2025
Cody D.
Verified Buyer
US
Amazing
This is by far the best Phenibut I have used!
03/08/2025
CosmicNootropic
Dear Cody, thank you for your feedback! 🤗
02/16/2025
Joanne W.
Verified Buyer
US
Great resource
I truly love getting a solid nights sleep with Phenibut.
02/18/2025
CosmicNootropic
Dear Joanne, thank you for sharing your experience, we really appreciate your feedback! 🙌
01/25/2025
David M.
Verified Buyer
US
Phenibut
I’ve used Phenibut for years, and as another reviewer stated, this is legitimate Phenibut HCL; it is an excellent product to help ease anxiety and boost self-confidence and mood. In addition, it always seems to help me with my sleep quality. Do your research. Onset is 2-4 hours, peaks about 4-6 hours afterward, and can stay in your system for about 24 hours. Respect this product, follow recommended dosages, and USE SPARINGLY to maintain efficacy and to avoid tolerance and dependency (I use one dosage 1-2 times a week at most). Lastly, I would like to add that I’m very impressed with Cosmic Nootropics products and outstanding customer support. Thank you
02/05/2025
CosmicNootropic
Dear David, thank you for the thoughtful review! We're so glad to hear you're having a positive experience with our Phenibut and that it’s helping with anxiety, mood, and sleep. We also appreciate your responsible approach to usage. Thanks for choosing us! 💛
01/24/2025
Laura P.
Verified Buyer
US
Phenibut
Always satisfied with product and service. Thank ypu
01/19/2025
Joanne W.
Verified Buyer
US
Phenibut is a big help
I only use occasionally. But it is a guarantee of a good night’s sleep.
01/19/2025
CosmicNootropic
Thanks for the great review, Joanne. We’re glad to hear that Phenibut is helping you get a good night’s sleep!
01/15/2025
Justin C.
Verified Buyer
US
Satisfied
There was some confusion with the payment. I was asked to dispute my charge and pay again. This seemed really sketchy. I hope you guys work something out with your payment options as I'm cautious about shopping with you again
01/15/2025
CosmicNootropic
Dear Justin, thank you for sharing your feedback! We're actively working to improve our payment system to ensure smoother transactions in the future. Your concerns are important to us, and we appreciate your patience and understanding. We hope to serve you again soon!
12/21/2024
Thomas C.
Verified Buyer
US
Excellent
First time trying Phenibut and didn’t know what to expect. Really good quality and will be purchasing again.
12/22/2024
CosmicNootropic
Dear Thomas, Thank you for your review! We're delighted that you enjoyed the product and hope to see you as a customer again soon!
12/07/2024
Kevin j.
Verified Buyer
US
Overpriced
Good until price went up. Much cheaper elsehere
12/07/2024
CosmicNootropic
Thank you for your feedback! We understand your concern about pricing. Unfortunately, the high costs of logistics, financial, and legal risks make price reductions unlikely at this time. We remain committed to keeping our products accessible and will reassess if circumstances improve. Feel free to reach out with any further questions!
12/06/2024
Michael C.
Verified Buyer
US
Phenibut works well.
I use 1-2 tabs of Phenibut about twice a week and it helps me relax for a good nights sleep. I save it for my nights when I have a busy, stressfull day coming up and can't afford a bad night's sleep. I don't over use it or abuse it and this way there's no dependency, tolerance, withdrawal, side effects, etc.
12/06/2024
CosmicNootropic
Hi Michael! Thank you for your thoughtful review! It’s great to hear that our product is helping you relax and prepare for restful nights when you need it most. We’re glad our product is meeting your needs, and we appreciate you sharing your experience! However, please note that it's essential to follow the manufacturer's instructions and your doctor's recommendations. If you ever have questions or need support, don’t hesitate to reach out!
12/05/2024
P.S
Verified Buyer
US
This is pharmaceutical
Works fine and it\'s 100% , not 62% or 96% who knows what.You can by a kilo of that if you want?What are you getting?I will pay for pharmaceutical grade.
12/06/2024
CosmicNootropic
Hi! Thank you for your review! We're glad to hear you value the pharmaceutical-grade quality of our product :) We pride ourselves on offering reliable legitimate options that you can trust. Your commitment to quality speaks volumes, and we’re happy to provide exactly what you’re looking for. If you ever need assistance or have questions, feel free to reach out!
11/28/2024
Seth R.
Verified Buyer
US
Didn't Work
My review won't even make it to the website page, but I took larger and larger doses and felt nothing compared to other Phennibut manufacturers.
11/29/2024
CosmicNootropic
Hi Seth! We’re sorry to hear this product didn’t meet your expectations. 😔 We aim to provide high-quality items and take all feedback seriously. It's important to remember that everyone is different and the reactions to different products depend on many factors and can vary. Please feel free to reach out to us if you have any questions —we’d be happy to discuss your experience further and assist you! 🙏
11/17/2024
Christopher H.
Verified Buyer
US
Damaged product apparently from usps
My. Package was damaged again I assume from USPS product unusable package was ripped and boxes had been torn pills had fell out in the bag very disappointed
11/17/2024
CosmicNootropic
Dear Christopher, We're sorry that you received a damaged product. Our support team has sent you a message, please check your inbox so we can resolve the issue quickly.
11/14/2024
Kenneth O.
Verified BuyerPhenibut
The quality of the product is good. However, other vendors offer a product as good as yours in bulk powder containing a lot more for a MUCH lower price.
11/15/2024
CosmicNootropic
Hi Kenneth! Thank you for your feedback! We’re glad to hear you’re satisfied with the quality of our product. While we may not always compete with bulk pricing, we strive to provide high-quality certified pharmaceutical products with reliable service and fast shipping. We appreciate your input and hope to continue serving you!
Joshua B. Verified Buyer
Christopher H. Verified Buyer
Ruth B. Verified Buyer
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