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Phenibut
144 Reviews
Description
Dosage
Research
Reviews
| Other names: | Aminophenyl butyric hydrochloride acid, Phenibut HCL, Fenibut, Fenigam; Phenigam; Phenybut; Phenygam; Phenylgamma; Phenigama; PHG; PhGABA; β-Phenyl-γ-aminobutyric acid; β-Phenyl-GABA; Noophen/ Noofen; Anvifen |
| Form: | Pills (250mg) |
| Active ingredient: | Aminophenyl butyric acid hydrochloride |
| Excipients: | Lactose, potato starch, calcium stearate |
| Formula: | C10H13NO2 • HCl |
| Pharmacological classification: | Nootropic, anxiolytic |
| ATC code: | N06BX22 Other psychostimulants and nootropic agents |
| CAS Number: | 1078-21-3 |
| Pharmacological action: | Nootropic, tranquilizing, anxiolytic, neuroprotective, antioxidant, antiplatelet |
| Elimination half-life: | 5.3 hours (250 mg) |
| Storage conditions: | Store in a dry dark place at temperatures no higher than 25°C. Keep out of reach of children. |
| Shelf life: | 5 years |
| Manufacturer: | Usolye Pharm |
Phenibut is a derivative of the naturally occurring inhibitory neurotransmitter Gamma-Aminobutyric Acid, or GABA. An extra phenyl ring makes Phenibut cross the blood-brain barrier much better than the original compound.
Phenibut is not intended to diagnose, treat, cure, or prevent any disease. In the United States and many other countries, it is primarily used as a research chemical in pharmaceutical testing and scientific studies. For more details, refer to the manufacturer’s instructions or peer-reviewed scientific literature.
Please note: In accordance with the FDA’s rules, we are unable to provide information regarding indications for use on our website.
Due to FDA regulations, we cannot provide dosage recommendations for Phenibut. For more information on Phenibut, please refer to the translated official drug sheets in English.
- I Lapin (2001). Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug.
- G. Shul’gina, E. Ziablitseva (2005). Effect of the GABA derivative Phenibut on learning.
- E. Ziablitseva and I. Pavlova (2007). Effect of GABA receptor agonist Phenibut on behavior and respiration of rabbits in the negative emotional situation.
- E. Zyablitseva and I. Pavlova (2008). Effects of the GABA receptor agonist Phenibut on behavior and respiration in rabbits in emotionally negative situations.
- Dambrova et al. (2008). Comparative pharmacological activity of optical isomers of Phenibut.
- Ziablitseva et al. (2009). The effects of agonists of ionotropic GABA(A) and metabotropic GABA(B) receptors on learning.
- E. Ziablitseva and I. Pavlova (2009). Influence of GABA agonist phenibut on the neuronal activity and interaction in hippocampus and neocortex in emotionally negative situations.
- Borodkina et al. (2009). Effect of phenibut on the content of monoamines, their metabolites, and neurotransmitter amino acids in rat brain structures.
- Tiurenkov et al. (2012). Phenibut and its citrate prevent psychoneurological disorders caused by chronic stress (paradoxical sleep deprivation).
- Samokhvalov et al. (2013). Phenibut dependence.
- Owen et al. (2016). Phenibut (4-amino-3-phenyl-butyric acid): Availability, prevalence of use, desired effects, and acute toxicity.
- Volotova et al. (2016). Neuroprotective action of phenibut and neuroglutam in experimental cerebral ischemia on the background of altered immunoreactivity.
- Vavers et al. (2016). The neuroprotective effects of R-phenibut after focal cerebral ischemia.
- Ahuja et al. (2018). Phenibut (β-Phenyl-γ-aminobutyric Acid) Dependence and Management of Withdrawal: Emerging Nootropics of Abuse.
- Joshi et al. (2018). Dissociative intoxication and prolonged withdrawal associated with phenibut: a case report.
- Kupats et al. (2020). Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports.
- Kupats et al. (2020). Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury.
- C. Doyno and C. White (2021), Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank.
4.5
Based on 144 Reviews
(118)
(7)
(3)
(4)
(12)
04/11/2025
BARBARA V.
Verified Buyer
US
Couldn't tell the difference
I really couldn't tell the difference from a regular anxiety ridden day.
01/01/1970
CosmicNootropic
Dear Barbara, thank you for sharing your experience — we’re really sorry to hear the product didn’t meet your expectations. Everyone’s body reacts differently, especially when it comes to nootropics and mood support. This is why we always recommend consulting your doctor before taking any medication.
04/05/2025
Joshua B.
Verified Buyer
US
Amazing products with trusted seller
Excellent experience. Exactly like what I read and researched and was looking for. Have tried everything non prescription for anxiety and this is the only thing I can promise you will cut that edge off social anxiety.. Josh from Indiana USA
01/01/1970
CosmicNootropic
Thank you for the great review, Josh! We’re really glad to hear the product worked well for you and helped with social anxiety. Your trust means a lot to us!
03/20/2025
Joshua B.
Verified Buyer
US
Absolutely best noorotropic ever!
Such a relaxing calm with no hangover feeling after use. Totally recommend for anyone struggling with anxiety.
01/01/1970
CosmicNootropic
Dear Joshua, thank you for your great review! We're so glad our nootropic helped with relaxation and anxiety. Your recommendation means a lot to us!
03/08/2025
Cody D.
Verified Buyer
US
Amazing
This is by far the best Phenibut I have used!
01/01/1970
CosmicNootropic
Dear Cody, thank you for your feedback! 🤗
02/16/2025
Joanne W.
Verified Buyer
US
Great resource
I truly love getting a solid nights sleep with Phenibut.
01/01/1970
CosmicNootropic
Dear Joanne, thank you for sharing your experience, we really appreciate your feedback! 🙌
01/25/2025
David M.
Verified Buyer
US
Phenibut
I’ve used Phenibut for years, and as another reviewer stated, this is legitimate Phenibut HCL; it is an excellent product to help ease anxiety and boost self-confidence and mood. In addition, it always seems to help me with my sleep quality. Do your research. Onset is 2-4 hours, peaks about 4-6 hours afterward, and can stay in your system for about 24 hours. Respect this product, follow recommended dosages, and USE SPARINGLY to maintain efficacy and to avoid tolerance and dependency (I use one dosage 1-2 times a week at most). Lastly, I would like to add that I’m very impressed with Cosmic Nootropics products and outstanding customer support.
01/25/2025
David M.
Verified Buyer
US
Phenibut
I’ve used Phenibut for years, and as another reviewer stated, this is legitimate Phenibut HCL; it is an excellent product to help ease anxiety and boost self-confidence and mood. In addition, it always seems to help me with my sleep quality. Do your research. Onset is 2-4 hours, peaks about 4-6 hours afterward, and can stay in your system for about 24 hours. Respect this product, follow recommended dosages, and USE SPARINGLY to maintain efficacy and to avoid tolerance and dependency (I use one dosage 1-2 times a week at most). Lastly, I would like to add that I’m very impressed with Cosmic Nootropics products and outstanding customer support. Thank you
01/01/1970
CosmicNootropic
Dear David, thank you for the thoughtful review! We're so glad to hear you're having a positive experience with our Phenibut and that it’s helping with anxiety, mood, and sleep. We also appreciate your responsible approach to usage. Thanks for choosing us! 💛
01/24/2025
Laura P.
Verified Buyer
US
Phenibut
Always satisfied with product and service. Thank ypu
01/19/2025
Joanne W.
Verified Buyer
US
Phenibut is a big help
I only use occasionally. But it is a guarantee of a good night’s sleep.
01/01/1970
CosmicNootropic
Thanks for the great review, Joanne. We’re glad to hear that Phenibut is helping you get a good night’s sleep!
01/15/2025
Justin C.
Verified Buyer
US
Satisfied
There was some confusion with the payment. I was asked to dispute my charge and pay again. This seemed really sketchy. I hope you guys work something out with your payment options as I'm cautious about shopping with you again
01/01/1970
CosmicNootropic
Dear Justin, thank you for sharing your feedback! We're actively working to improve our payment system to ensure smoother transactions in the future. Your concerns are important to us, and we appreciate your patience and understanding. We hope to serve you again soon!
12/21/2024
Thomas C.
Verified Buyer
US
Excellent
First time trying Phenibut and didn’t know what to expect. Really good quality and will be purchasing again.
01/01/1970
CosmicNootropic
Dear Thomas, Thank you for your review! We're delighted that you enjoyed the product and hope to see you as a customer again soon!
12/07/2024
Kevin j.
Verified Buyer
US
Overpriced
Good until price went up. Much cheaper elsehere
01/01/1970
CosmicNootropic
Thank you for your feedback! We understand your concern about pricing. Unfortunately, the high costs of logistics, financial, and legal risks make price reductions unlikely at this time. We remain committed to keeping our products accessible and will reassess if circumstances improve. Feel free to reach out with any further questions!
12/06/2024
Michael C.
Verified Buyer
US
Phenibut works well.
I use 1-2 tabs of Phenibut about twice a week and it helps me relax for a good nights sleep. I save it for my nights when I have a busy, stressfull day coming up and can't afford a bad night's sleep. I don't over use it or abuse it and this way there's no dependency, tolerance, withdrawal, side effects, etc.
01/01/1970
CosmicNootropic
Hi Michael! Thank you for your thoughtful review! It’s great to hear that our product is helping you relax and prepare for restful nights when you need it most. We’re glad our product is meeting your needs, and we appreciate you sharing your experience! However, please note that it's essential to follow the manufacturer's instructions and your doctor's recommendations. If you ever have questions or need support, don’t hesitate to reach out!
12/05/2024
P.S
Verified Buyer
US
This is pharmaceutical
Works fine and it\'s 100% , not 62% or 96% who knows what.You can by a kilo of that if you want?What are you getting?I will pay for pharmaceutical grade.
01/01/1970
CosmicNootropic
Hi! Thank you for your review! We're glad to hear you value the pharmaceutical-grade quality of our product :) We pride ourselves on offering reliable legitimate options that you can trust. Your commitment to quality speaks volumes, and we’re happy to provide exactly what you’re looking for. If you ever need assistance or have questions, feel free to reach out!
11/28/2024
Seth R.
Verified Buyer
US
Didn't Work
My review won't even make it to the website page, but I took larger and larger doses and felt nothing compared to other Phennibut manufacturers.
01/01/1970
CosmicNootropic
Hi Seth! We’re sorry to hear this product didn’t meet your expectations. 😔 We aim to provide high-quality items and take all feedback seriously. It's important to remember that everyone is different and the reactions to different products depend on many factors and can vary. Please feel free to reach out to us if you have any questions —we’d be happy to discuss your experience further and assist you! 🙏
11/17/2024
Christopher H.
Verified Buyer
US
Damaged product apparently from usps
My. Package was damaged again I assume from USPS product unusable package was ripped and boxes had been torn pills had fell out in the bag very disappointed
01/01/1970
CosmicNootropic
Dear Christopher, We're sorry that you received a damaged product. Our support team has sent you a message, please check your inbox so we can resolve the issue quickly.
11/14/2024
Kenneth O.
Verified BuyerPhenibut
The quality of the product is good. However, other vendors offer a product as good as yours in bulk powder containing a lot more for a MUCH lower price.
01/01/1970
CosmicNootropic
Hi Kenneth! Thank you for your feedback! We’re glad to hear you’re satisfied with the quality of our product. While we may not always compete with bulk pricing, we strive to provide high-quality certified pharmaceutical products with reliable service and fast shipping. We appreciate your input and hope to continue serving you!
11/11/2024
Jacob G.
Verified Buyer
US
Never Recieved Item
I wish I could write a review for it, but I got charged and never received the item. USPS didn’t help and neither did cosmic nootropics
01/01/1970
CosmicNootropic
Hi Jacob! We're very sorry to hear about this experience. We’ve reached out to you via email to help resolve the issue, as your satisfaction is our priority. Shipping problems can be frustrating, and we're here to support you in getting this sorted out as quickly as possible. Thank you for your patience as we work on a solution together.
11/10/2024
Ruth B.
Verified Buyer
US
Mastercard
I would like to place an order but you said you’re having a problem with Mastercard and that you are working on it. Has it been fixed yet?
01/01/1970
CosmicNootropic
Hi Ruth! Thank you for checking in! We’re still working on resolving the issue with card payments and apologize for the inconvenience. In the meantime, we offer other payment options to ensure you can place your order smoothly. If you need assistance with this, please don’t hesitate to reach out—we’re here to help!
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