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Picamilon® (Nicotinoyl-GABA)
69 Reviews
INN: | N-nicotinoyl-gamma-aminobutyric acid |
Chemical name of Picamilon: | Sodium salt of N-nicotinoyl-g-aminobutyric acid |
Form: | Pills (20 mg and 50 mg) |
Active ingredient: | Picamilon or N-nicotinoyl-GABA – 20mg or 50 mg |
Excipients: | Potato starch, magnesium hydroxycarbonate hydrate, talc, sucrose, stearic acid or calcium stearate. |
CAS Number: | 34562-97-5 |
Molecular formula: | C10H12N2O3 |
ATC code: | N06BX Nootropic |
Pharmacological action: | Tranquilizing, psycho-stimulating, antiaggregant, antioxidant |
Bioavailability: | From 50 to 88% |
Half-life: | 30 min |
Shelf life: | 3 years. Do not use beyond the expiration date printed on the package. |
Storage conditions: | Store in a dry, dark place at temperatures no higher than 25 °C (77 °F). Keep out of reach of children. |
Manufacturer: | PharmStandard |
What is Picamilon?
Picamilon is a synthetic compound made by combining gamma-aminobutyric acid (GABA) and niacin, where GABA reduces neuronal excitability and niacin functions as a vasodilator.
What is Picamilon Used For?
Picamilon, according to the manufacturer, can be applied for the following conditions:
- Cerebrovascular diseases;
- Anxiety;
- Migraine;
- Asthenic disorders (lack of energy);
- Mild depressions;
- Alcohol withdrawal syndrome.
What are the Benefits and Effects of Picamilon?
Picamilon dilates blood vessels in the brain, as the official instruction claims. It also has tranquilizing, psychostimulating, antiaggregant, and antioxidant effects. It can improve the functional state of the brain due to the normalization of tissue metabolism and its influence on cerebral circulation. The listed effects include increased volume and linear speed of cerebral blood flow, reduced resistance of cerebral vessels, suppressed platelet aggregation, and better microcirculation.
After a full treatment course under the doctor’s supervision, Picamilon is said to increase physical and mental efficiency, reduce headaches, and normalize sleep.
Is Picamilon Safe To Take?
Picamilon is generally considered safe for human consumption under medical supervision and normal dosages, although users should consult a healthcare professional before starting it.
FAQ:
Where to Order Picamilon?
You may purchase Picamilon at CosmicNootropic. It’s a reliable vendor that offers high-quality nootropics and supplements to improve brain function, reduce anxiety and enhance general well-being.
How does Picamilon differ from Phenibut?
Picamilon is an “older brother” of Phenibut. They have similar properties, but they are not the same. Both drugs reduce anxiety and improve mood. However, unlike Phenibut, Picamilon is said to have a much stronger impact on energy metabolism in the brain because it stimulates the consumption of oxygen and glucose by the neuronal tissue.
Does Picamilon Lower Blood Pressure?
Picamilon may help lower blood pressure and in some cases the risk of hypertension.
Can Picamilon Be Taken At Night?
Picamilon can be taken at night because it doesn’t interfere with sleep and doesn’t directly increase energy.
What Is the Dosage of Picamilon?
Dosages of Picamilon and course duration depend on the patient’s condition and doctor’s recommendations. The typical daily dose for pills is 30–50 mg, once or twice a day. Picamilon injection dosage varies from 100 to 200 mg once a day.
What Are the Side Effects of Picamilon?
Picamilon causes side effects in approximately 12% of users, including decreased blood pressure, dizziness, headache, mild nausea, irritability, agitation, anxiety, and allergic reactions such as skin rash or itching.
For more information on Picamilon dosages and side effects, please refer to the translated official drug sheets linked below.
Picamilon Injections Official Instruction
Picamilon Pills Official Instruction
- Voznesenskii et al (1989) Comparative study of the effect of picamilone and piracetam on learning in rats in a radial maze
- I Sapegin, A Beketov (1993) The effect of pikamilon and fenibut on the blood supply of the brain at rest and under gravitational exposures
- Shyman’kyi et al (2002) Oxidative stress correction by nicotinamide and nicotynol-GABA in diabetic neuropathy
- Kuchmerovs’ka et al (2003) State of GABA-benzodiazepine receptor complex in diabetic neuropathy: effect of nicotinamide and nicotinoyl-GABA
- Silkina et al (2005) Gabaergic mechanism of cerebrovascular and neuroprotective effects of afobazole and picamilon
- Likhodeev et al (2009) Effects of aminalon, fenibut, and picamilon on the typological parameters of cerebral hemodynamics in swimmers with dysadaptation syndrome
- Avula et al (2016) Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States
- Zakharov et al (2022) Treatment of patients with chronic cerebral ischemia: experience of using the combined neuroprotective drug Picamilon Ginkgo
- M Santillo, R Sprando (2023) Picamilon, a γ-aminobutyric acid (GABA) analogue and marketed nootropic, is inactive against 50 biological targets
4.4
Based on 69 Reviews
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(5)
03/18/2025
Amir N.
Verified BuyerUS
Works as advertised.
I appreciated the relaxing feeling the product provided, I am still experimenting with your other products, Grandaxin seems similar, I would like to know what the difference is between the two of them, be. Either way. They seem to have some effect on my anxiety which is nice.
01/01/1970
CosmicNootropic
Dear Amir, thank you for your review! We're glad our product is helping with your anxiety. Picamilon improves focus and relaxation, while Grandaxin is more focused on reducing anxiety without sedation. We hope this helps with your experimentations! Let us know if you have more questions.
03/15/2025
Lesya S.
Verified BuyerUS
Highly recommend
I used Picamilon as suggested for two months; the benefits were incredible! It regulated my sleep, and within a week, I noticed a difference in my sports performance and willingness to exercise more. This led to better stamina and overall health, including muscle growth and a leaner body. My focus improved, and I'm retaining learned information more easily. I'm 54, a 54-year-old female with untreated ADHD. Picamilon works, and you don't depend on it
01/01/1970
CosmicNootropic
Dear Lesya, thank you for your wonderful review! We’re thrilled that Picamilon has had such a positive impact on your sleep, sports performance, and overall health. Your experience is inspiring, and we appreciate you sharing it with others.
01/16/2025
Justin F.
Verified BuyerUS
Effective, and is great supplemental to..
Wonderful swell product, I take usually 100 mg 3x a day and as my title says supplemental to.. I guess that niacin molecule attached to the GABA really what was needed, another vitamin or amino acid sounds like could be vitamin B6 I believe, this is almost neck and neck with the Pantogam Active n-pantoyl-gaba I believe? Pantogam active subjectively from my personal experience the Pantogam Active being superior. Yes indeed though..GABA alone as we know very little to none crosses the blood brain barrier and unfortunately is not real effective, unless it is supplemented with and what I find to be real effective your L-Theanine, Valerian Root and Vitamin B6. Give it a try I think you will be very impressed absolutely blows the “NOW” brand and most all the other form of GABA you see sold in most retail stores and health food stores across the United States out of the water, there is one that is supposed to be pretty good too, though although it’s not actually manufacturing United States, I believe in Japan called PharmaGABA. Hope this review helps anyone reading and seek of any traumatic brain injuries, strokes, or anxiety🙏 Thank you Cosmic Nootropics!
01/01/1970
CosmicNootropic
Thank you so much for your thoughtful and informative review, Justin! We are very pleased to hear that you have found our product to be effective and that it complements your routine so well. We also really appreciate you sharing your experience with others, thank you for your support! 🙌
01/07/2025
Nick
Verified BuyerUS
Sketchy. Not sure about cosmicnootropic anymore.
First experience on this website I tried Grandaxin. No effects were felt/observed at min-max dosage. Was thinking maybe it was just me, or maybe just sugar pills. After receiving this product with NO SEAL and the literal taste of sugar, I am now convinced they sell BS sugar pills. There is absolutely NO reason they can’t put a seal on the bottle. Look elsewhere for similar products, they are easy to find. One last note, the picture of the pill on the bottle is a blue oval shaped pill, the pills in the bottle are white circles. Unacceptable.
01/01/1970
CosmicNootropic
Dear Nick, thank you for your review! We are sorry to hear that you were disappointed with your experience with our products. If we understand correctly, you are writing a review about Picamilon, not Grandaxin. And it's important to note that the pharmaceutical company that manufactures Picamilon does not put a seal on the bottles, so this is perfectly normal. As for the pictures of the tablets, usually the packaging shows white round tablets, but we would be happy for you to email us a picture of the packaging so we can check what is wrong and help you.
12/06/2024
Nazar
Verified BuyerAU
Don\'t bother
they have no control on their delivery company they use. you can\'t chase it. they won\'t contact the shipping company. and the shipping company only receives complains from inside USA. so if you outside USA they won\'t bother solve your problem. all they will do and say we understand your frustration and sorry.
11/11/2024
Heather W.
Verified BuyerUS
Love it!
1 pill is perfect for mild relaxation. 2 are perfect for unwinding before bed. I have amazing sleep and wake up energized.
01/01/1970
CosmicNootropic
Dear Heather, thank you for sharing your experience! We're so happy to hear that you’re enjoying the effects—relaxation, great sleep, and waking up energized sound like the perfect combo. We appreciate your feedback and are glad our product is helping you unwind!
09/26/2024
Benjamin P.
Verified BuyerUS
Very helpful
Very helpful for getting off Kratom!
01/01/1970
CosmicNootropic
Dear Benjamin, Thank you for your kind words! We’re so glad to hear that our product have been helpful for you in your journey.
09/20/2024
Alan Y.
Verified BuyerSG
Solid company and products
**Company Opinion** CosmicNootropic has truly impressed me with its exceptional customer service. Unlike many companies that provide generic responses, their team actively listens to my concerns and works diligently to resolve them. This personalized approach sets them apart in a crowded market. My overall experience with the brand has been outstanding; they prioritize customer satisfaction and demonstrate a genuine commitment to helping their clients. **Product Review** I purchased **Picamilon** and **Mexidol**, and I am delighted with both products. - **Picamilon** is known for its ability to enhance focus and calmness, making it an excellent choice for navigating the stresses of my work environment in procurement. It effectively boosts mental clarity while reducing anxiety, allowing me to maintain productivity without feeling overwhelmed. Users have reported improvements in mood, cognitive function, and even physical working capacity after stressful tasks, which resonates with my experience. - **Mexidol**, on the other hand, has been a game-changer for managing stress levels. It acts as an antioxidant that protects brain cells from damage while improving cognitive processes such as attention and memory. The product has helped me feel more resilient in high-pressure situations, aligning perfectly with its reputation for enhancing mental performance and emotional well-being. Both products have exceeded my expectations, providing me with the mental focus I need while keeping me calm under pressure. **Personal Experience** The ordering process with CosmicNootropic was seamless. The website is user-friendly, making it easy to navigate through product options and information. I encountered some technical issues during my purchase, but the customer service team was prompt and reassuring, ensuring that my concerns were addressed quickly. Upon delivery, I was satisfied with the packaging; everything arrived intact and well-protected. The delivery time was also impressive, as my order arrived within the expected timeframe. Overall, my experience with CosmicNootropic has been overwhelmingly positive, making them a reliable source for nootropic products.
01/01/1970
CosmicNootropic
Thank you so much for sharing your detailed experience, Alan! We're thrilled to hear that both Picamilon and Mexidol have been working so well for you, and that our customer service was able to resolve any issues promptly. We're always here to help and appreciate your trust in us!
09/19/2024
ALAN Y.
Verified BuyerSG
Effective Stuff
I recently started taking Picamilon, and I must say, it has been a game-changer for me. As someone who often deals with anxiety and occasional stress, I was looking for a natural supplement that could help me manage my symptoms without the side effects associated with traditional medications. Picamilon has exceeded my expectations in several ways. First and foremost, I noticed a significant reduction in my anxiety levels shortly after starting the supplement. It provides a calming effect that allows me to tackle daily tasks with a clearer mind. Unlike some other anxiety relief options that can leave you feeling drowsy or lethargic, Picamilon offers a “calm focus”, which is perfect for maintaining productivity throughout the day. Additionally, I\'ve experienced improvements in my cognitive performance. My memory and concentration have noticeably enhanced, making it easier to stay engaged during long work sessions. I feel more alert and motivated, which has positively impacted my overall mood. The combination of GABA and niacin in Picamilon seems to work wonders for boosting brain function while also promoting relaxation. Another aspect I appreciate is how quickly the effects kick in. Within an hour of taking it, I can feel the benefits starting to take hold, which is incredibly helpful during stressful situations or when I need to perform well, such as before meetings or presentations. Moreover, I’ve found that Picamilon helps improve my sleep quality. Since incorporating it into my routine, I\'ve been sleeping more soundly and waking up feeling refreshed. This has contributed to my overall well-being and energy levels throughout the day. Overall, I highly recommend Picamilon to anyone looking for a natural way to enhance their mental clarity, reduce anxiety, and improve their mood. It’s affordable, effective, and has worked wonders for me without any noticeable side effects. If you\'re considering trying it out, I encourage you to give it a shot—you might just find it as beneficial as I have!
01/01/1970
CosmicNootropic
Hi Alan! Thank you for such an in-depth and thoughtful review! We’re thrilled to hear that Picamilon has been a game-changer for you. It’s wonderful to know that it’s helping you manage anxiety while enhancing your cognitive performance and overall mood. We appreciate you sharing your experience with how quickly the effects kick in and the benefits for your sleep quality. It sounds like Picamilon has truly become an integral part of your routine! Your recommendation means a lot to us, and we’re here to support you as you continue your journey. If you have any questions or need further assistance, don’t hesitate to reach out.
09/19/2024
Joe
Verified BuyerUS
My favorite nootropic so far
Picamilon really helps take the edge off and keep me positive! Was a little afraid my second order wouldn\'t be delivered because cosmicnootropic was not accepting visa at the time but placed order with wise transfer and everything came. Great customer service! Highly recommend and will be buying more.
01/01/1970
CosmicNootropic
Hi Joe! Thank you for your fantastic review! We’re so glad to hear that Picamilon is helping you stay positive and take the edge off. It’s also great to know our customer service met your expectations during your ordering process.
08/21/2024
Julie V.
Verified BuyerUS
Amazing supplement for me
This picamilon is exactly what my brain seems to need for clearing brain fog, as well as efficient problem solving and articulating. Very thankful!
01/01/1970
CosmicNootropic
Hi Julie! Thank you so much for your wonderful review! We're thrilled to hear that our Picamilon supplement is helping you with brain fog, problem solving, and articulation. Your satisfaction means a lot to us, and we’re grateful for your feedback.
08/06/2024
Nick B.
Verified BuyerUS
Great service, great products
Everything I’ve ordered arrived promptly. Quality is always top notch!
01/01/1970
CosmicNootropic
Hi Nick! Thank you so much for your kind words! We're thrilled to hear that you're pleased with both our service and products. We always strive to deliver the best, so it's great to know we're hitting the mark :)
08/02/2024
Marko R.
Verified BuyerAU
I didnt recieve my item - item got seized at customs
Item never received as it was seized at customs
01/01/1970
CosmicNootropic
Hi Marko. We're so sorry to hear that your order was seized at customs. It looks like we have already started working on your problem and have emailed you about it. We have reached out to you again in case you've missed our previous email. We're looking forward to resolving this issue!
07/28/2024
Aaron T.
Verified BuyerUS
This is good
This stuff is good I really really like it. It works.
01/01/1970
CosmicNootropic
Dear Aaron, Thanks for the awesome feedback! We're so glad to hear that you like Picamilon and that it's working for you. If you have any questions or need anything else, feel free to reach out!
07/21/2024
Aaron T.
Verified BuyerUS
It be the good good use of great
So goodly good. Like bigly good. It’s the gooder of goodest and I love good.
01/01/1970
CosmicNootropic
Dear Aaron, Sounds like Picamilon is hitting all the “good” notes :) We're happy to hear that you like it! Thanks for the fun and fantastic review.
07/18/2024
Beomtaek L.
Verified BuyerUS
Great experiece with Cosmic Nootropic
I am a long term user and I am always happy with the product and Cosmis Nootropic.
01/01/1970
CosmicNootropic
Hi Beomtaek! Thank you very much for your loyal support and fantastic feedback! We're delighted to hear that you've had a consistently great experience with CosmicNootropic.
06/28/2024
Sherry F.
Verified BuyerUS
Picamilon is great
I love picamilon. So many anti-anxiety treatments I have tried create so much fatigue that I can't focus. Not picamilon! It relaxes me during the day without having side effects. I use them at night when I am stressed and can't calm down. Love them!!!!
01/01/1970
CosmicNootropic
Hi Sherry! Thank you for your positive feedback on Picamilon! We're thrilled to hear it's helping you manage anxiety effectively without causing fatigue. Your satisfaction is important to us.
06/20/2024
MICHAEL S.
Verified BuyerUS
Will order more soon
Picamilon works well for me. I will get more shortly
01/01/1970
CosmicNootropic
Hi Michael! Thank you so much for your positive feedback! We're thrilled to hear that Picamilon is working effectively for you. Whenever you're ready to reorder, we'll be here to assist you. If you have any questions or need further assistance in the future, please don't hesitate to reach out. Your satisfaction is our priority.
06/02/2024
Zachary B.
Verified BuyerUS
Great for leveling me out.
I’ve been taking 1.5 of these daily and occasionally a little more for about 3 months. I’ve noticed my anxiety has gone way down and emotions seem much more leveled out than in a long time. I’ve always been very socially anxious and this has helped tremendously. At first in the bedroom it seemed to have a very negative effect. Very non-intense orgasm but after a couple weeks it’s been the opposite. Sex has been so much more intense and best in my life… even at 42 male.
01/01/1970
CosmicNootropic
Dear Zachary, Thank you for sharing your experience with our product! We're glad to hear it has helped reduce your anxiety and improve your social interactions. It's great to know that you've also seen positive changes in your intimate life.
05/02/2024
Catherine W.
Verified BuyerUS
PICAMILON: Helped then hurt
I took Picamilon to avert depression and anxiety I experienced prior to having post menopausal hot flashing. And during the first 6 weeks it worked just fine. Then I started to have the sensation that I was going to faint, and had to sit down quickly. This happened several times until I quit taking Picamilon. It took about 4 days to have these effects clear my system. I am afraid to take more of this product because of these near fainting spells.
01/01/1970
CosmicNootropic
Hi Catherine! We are sorry to hear about this. While some individuals may find certain nootropics helpful in managing specific symptoms, it’s essential to consult with a healthcare professional for a proper diagnosis and treatment plan tailored to your specific needs. The effect of most nootropics varies from person to person, depending on the personal conditions, so you should definitely consult a doctor on this matter.
A well-known biohacker Lucas Aoun reviews Picamilon on YouTube
This video gives an overview of how Picamilon works in the brain, its benefits and dosage. Lucas also ranks Picamilon alongside other popular nootropic compounds in terms of potency. Whether you're considering adding Picamilon to your supplement regimen or simply curious about its effects, this video will provide you with all the information you need.
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