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PINEAMIN (Polypeptides of Pineal Gland)

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Option	10 vials x 10 mg
Ships from	3-6 business days US delivery for $12.50 20-30 business days international delivery for $25.00

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All statements on this page are for informational purposes only and have not been evaluated by the US FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Before using this product consulting a qualified MD is mandatory. See more

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Pineamin is an injectable preparation containing Polypeptides of Pineal Gland (PPG) used in the treatment of menopausal syndrome. It is also claimed to have the Anti-age effect.

Generic name:	Pineamin, polypeptides of epiphysis (pineal gland)
Form:	Lyophilisate for solution for intramuscular and intravenous injections in ampoules/vials
Pharmacological group:	Anti-climacteric agent
Indications:	Neurovegetative disorders in menopausal women
Pharmacodynamics:	The drug can optimize epiphyseal-hypothalamic interaction, and normalize the function of the anterior lobe of the pituitary gland and the balance of gonadotropic hormones
Form description:	A powder or porous mass of white or white with a yellowish tint
Active ingredient:	A complex of water-soluble polypeptide fractions of epiphysis (pineal gland) of horned cattle not older than 12 months old, isolated from dried Pineamin extracts
Excipients:	Glycine as a stabilizer
ATC code:	G02CX Other gynecologicals
Shelf life:	3 years. Do not use it beyond the expiration date printed on the package.
Storage:	Store at temperatures from 2°C to 20°C (35.6-68°F)
Manufacturer:	GeroPharm

What Is Pineamin?

Pineamin is a complex containing Polypeptides of Pineal Gland (PPG) studied for the treatment of menopausal syndrome and for its anti-age effect. PPG-peptides stimulate the synthesis of endogenous melatonin and serotonin by the epiphysis. [3] Endogenous melatonin has a positive anti-aging effect on age-related skin changes.

Pineamin is anecdotally used by women in menopause who struggle with neurovegetative disorders, in case they have contraindications to the hormone replacement therapy (HRT) or refuse to undergo it.

What Is Pineamin Used For?

This compound is used by women for alleviating hot flashes, sweating, insomnia, depression, irritability and other aging symptoms. These symptoms can occur both in perimenopause (menopausal transition and menopause) and in postmenopause.

What are Pineamin Benefits and Effects?

The manufacturer claims that the compound can boast several key advantages, namely:

High tolerability and a safety profile,
Absence of contraindications and limitations common for traditional therapy, such as varicose veins, gallstones, obesity, etc
Convenient treatment mode of 2-3 short courses per year,
Long-lasting effects (up to 180 days).

Is Pineamin Safe To Take?

According to the manufacturer, Pineamin has a high safety profile with almost no side effects. Although allergic reactions may still occur in cases of individual hypersensitivity to the drug components. Other side effects of Pineamin inclde rare cases of infiltrate at the site of injection, as well as bloody discharge from the vagina and increased blood estradiol concentration.

For information on contraindications, please refer to the FAQ section below.

FAQ:

What Are Pineamin Contraindications?

• hypersensitivity or intolerance to any of the components, • age below 18 y.o., • pregnancy and breastfeeding, • metrorrhagia (bloody discharge from the genital tract of unclear genesis), • hyperestrogenism, • patients with estrogen-dependent tumors. The compound has no effect on the concentration of sex hormones in blood plasma. However, caution must be taken when testing Pineamin in case of uterine leiomyoma and endometriosis.

What Is Menopause?

Menopause is a natural process for many women which usually starts after 45-50 y.o. It is a milestone period when the reproductive system, primarily the ovaries, gradually begins to decline, the hormonal background changes and monthly cycles eventually stop. This period is referred to as menopause or menopausal syndrome.

What Are the Symptoms of Menopause?

Unpleasant sensations of menopause inlcude: • wrinkles, dark spots and uneven skin tone • headaches • mood swings, nervousness • depressive states • sleep deprivation • weight loss • excessive bleeding, etc.

How To Treat Menopause?

Hormonal therapy is viewed as a traditional approach to combating the symptoms of menopause. However, despite its effectiveness, many female patients opt not to undergo this treatment because of a number of restrictions, contraindications and side effects.

The product is not used for cure, mitigation, treatment, or prevention of any disease. Always consult a healthcare professional before using this product to determine if it is appropriate for you. For informational purposes, you may also refer to the official instructions provided by the manufacturer.

What Is Pineamin Dosage?

Pineamin is administered in a course of 10 days through intramuscular injections. Before injection, the contents of the vial are dissolved in 1-2 ml of 0.5% procaine (novocaine) solution, water for injection, or 0.9% sodium chloride solution. The compound is injected once daily at a dose of 10 mg for 10 days.

If an injection is missed, it is not recommended to administer the double dose. Instead, the next injection shall be made on schedule.

The courses can be repeated 2-3 times a year.

Note:

Before self-testing Pineamin, it’s crucial to undergo a standardized examination to ensure that the symptoms are not mistaken for menopause or false menopause, where similar symptoms may be due to other diseases.

Pineamin Research

Yureneva SV et al (2020). The results of an open-label comparative randomized controlled clinical trial of the use of combined treatment including Pineamin in postmenopausal women. https://geropharm.ru/uploads/multimedia/gerofarmyurenevaakush2202.pdf
Burova NA, Selezneva TA, Abolonina OV (2019). Novel treatment approach to the premature ovarian failure in women of reproductive age with pelvic inflammatory disease. https://cyberleninka.ru/article/n/klimaktericheskiy-sindrom-innovatsii-v-menopauzalnoy-terapii
Trofimova SV, Khavinson VKh et al (2017). Pineamin increased pineal melatonin synthesis in elderly people. https://pubmed.ncbi.nlm.nih.gov/28849889/
Prilepskaya V.N. (2017). Climacteric syndrome: novel modalities for menopausal therapy. https://geropharm.ru/uploads/multimedia/parsed/pdf/88c305449c44b4ce96769e1c35d09455.pdf
Korkushko OV, Lapin BA et al (2007). Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people. https://pubmed.ncbi.nlm.nih.gov/17969590/
Labunets IF, Butenko GM et al (2004). Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people. https://pubmed.ncbi.nlm.nih.gov/15455130/
Official Pineamin website: https://pineamin.ru/#about

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