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Pineamin is an injectable preparation containing Polypeptides of Pineal Gland (PPG) used in the treatment of menopausal syndrome. It is also claimed to have the Anti-age effect.

This drug is prescribed to women struggling with hot flashes, sweating, insomnia, depression, irritability and other aging symptoms.

Buy Pineamin for its short course and long-lasting effects.

Generic name: Pineamin, polypeptides of epiphysis (pineal gland) 
Form: Lyophilisate for solution for intramuscular and intravenous injections in ampoules/vials
Pharmacological group: Anti-climacteric agent
Indications: Neurovegetative disorders in menopausal women
Pharmacodynamics: The drug can optimize epiphyseal-hypothalamic interaction, and normalize the function of the anterior lobe of the pituitary gland and the balance of gonadotropic hormones
Form description: A powder or porous mass of white or white with a yellowish tint
Active ingredient: A complex of water-soluble polypeptide fractions of epiphysis (pineal gland) of horned cattle not older than 12 months old, isolated from dried Pineamin extracts
Excipients: Glycine as a stabilizer
ATC code: G02CX Other gynecologicals
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage: Store at temperatures from 2°C to 20°C (35.6-68°F)
Manufacturer: GeroPharm, Russia

How to anti-age?

For many women, the age after 45-50 y.o. is a milestone period when the reproductive system, primarily the ovaries, gradually begins to decline, the hormonal background changes and monthly cycles eventually stop. This period is referred to as menopause or menopausal syndrome.

This is a natural process that may still cause unpleasant sensations such as:

  • wrinkles, dark spots and uneven skin tone
  • headaches
  • mood swings, nervousness
  • depressive states
  • sleep deprivation
  • weight loss
  • excessive bleeding, etc. 

Hormonal therapy is viewed as a traditional approach to combating the symptoms of menopause. However, despite its effectiveness, many female patients opt not to undergo this treatment because of a number of restrictions, contraindications and side effects.

What are the benefits of Pineamin?

PPG-peptides in Pineamin stimulate the synthesis of endogenous melatonin and serotonin by the epiphysis. [3] Endogenous melatonin has a positive anti-aging effect on age-related skin changes. The producer asserts that the positive effect of Pineamin can last up to 180 days.

The manufacturer claims that the drug can boast several key advantages, namely:

  • High tolerability and a safety profile,
  • Absence of contraindications and limitations common for traditional therapy, such as varicose veins, gallstones, obesity, etc. For more information on contraindications, please refer to the dosage section.
  • Convenient treatment mode of 2-3 short courses per year.

What are the side effects of Pineamin?

According to the manufacturer, the mechanism of action and intramuscular route administration of Pineamin ensure a high safety profile with almost no side effects. Although allergic reactions may still occur in cases of individual hypersensitivity to the drug components.

Other side effects of Pineamin include rare cases of infiltrate at the site of injection, as well as not frequent bloody discharge from the vagina and increased blood estradiol concentration. If you experience these side effects, please consult the doctor

How to Use Pineamin?

Pineamin is administered in a short course of 10 days through intramuscular injections. Before injection, the contents of the vial are dissolved in 1-2 ml of 0.5% procaine (novocaine) solution, water for injection, or 0.9% sodium chloride solution. The drug is injected once daily at a dose of 10 mg for 10 days.

If an injection is missed, it is not recommended to administer the double dose. Instead, the next injection shall be made on schedule.

The treatment courses can be repeated 2-3 times a year.


  • hypersensitivity or intolerance to any of the drug components, 
  • age below 18 y.o., 
  • pregnancy and breastfeeding, 
  • metrorrhagia (bloody discharge from the genital tract of unclear genesis), 
  • hyperestrogenism, 
  • patients with estrogen-dependent tumors.

Caution: The drug has no effect on the concentration of sex hormones in blood plasma. However, caution must be taken when using Pineamin in case of uterine leiomyoma and endometriosis.


Before self-prescribing Pineamin, it’s crucial to undergo a standardized examination to ensure that the symptoms are not mistaken for menopause or false menopause, where similar symptoms may be due to other diseases.

Pineamin Research

  1. Yureneva SV et al (2020). The results of an open-label comparative randomized controlled clinical trial of the use of combined treatment including Pineamin in postmenopausal women.
  2. Burova NA, Selezneva TA, Abolonina OV (2019). Novel treatment approach to the premature ovarian failure in women of reproductive age with pelvic inflammatory disease.
  3. Trofimova SV, Khavinson VKh et al (2017). Pineamin increased pineal melatonin synthesis in elderly people.
  4. Prilepskaya V.N. (2017). Climacteric syndrome: novel modalities for menopausal therapy.
  5. Korkushko OV, Lapin BA et al (2007). Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people.
  6. Labunets IF, Butenko GM et al (2004). Effect of epithalamin on circadian relationship between the endocrine function of the thymus and melatonin-producing function of the pineal gland in elderly people.
  7. Official Pineamin website:


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