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Selank®
57 Reviews
Pharmacological Profile
| International Non-Proprietary Name (INN): | Threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate |
| Form: | Nasal drops 0.15% (3 ml) |
| Form description: | The colorless transparent liquid in a 3 ml dropper bottle |
| Active ingredient: | Selank in terms of 100% substance (threonyl-lysyl-prolyl-arginyl-prolyl-glycyl-proline diacetate) – 1.5 mg; |
| Excipients: | Methyl parahydroxybenzoate (nipagin) – 1 mg, purified water – up to 1 ml |
| СAS Number: | 129954-34-3 |
| ATC code: | N06BX |
| Pharmacological action: | Antianxiety, antiasthenic, nootropic |
| Bioavailability: | 92.8% |
| Shelf life: | 2 years. Do not use beyond the expiration date printed on the package. |
| Storage conditions: | Store at temperatures not exceeding 10°C (50°F), do not freeze, protect from light. |
| Manufacturer: | CJSC ‘Innovation Research and Production Center Peptogen’. |
What Is Selank?
Selank 0.15% is an anxiolytic peptide with nootropic properties. The main effects include antianxiety, and antiasthenic. By its structure, Selank is based on endogenous tetrapeptide Tuftsin which plays an important role in the immune system.
Selank usually goes in the form of nasal spray or drops.
What is Selank Used For?
Primary Uses of Selank 0.15% nasal drops listed by the manufacturer include:
- Anxiety and adjustment disorders;
- Neurasthenia, emotional lability;
- Stress-related disorders, including GAD, PTSD, etc.
More detailed information about the studies on the application can be found in the Research tab.
What Are the Benefits and Effects of Selank?
Selank is a popular anti-anxiety compound that combines mechanisms of antidepressants and psychostimulants. It also has the capacity to enhance memory and cognitive functions.
Is Selank Safe to Take?
Selank does not form dependence, and long-term use has not been associated with withdrawal or tolerance. As nasal drops, Selank absorbs quickly and is said to integrate naturally into metabolism without harming organs or causing addiction.
Selank has no effect on depressants or stimulants. Thus, it can be combined with neuro- and psychotherapy, upon your doctor’s prescription.
Certificate of Analysis
Third-party tested. View Certificate of Analysis: COA Selank nasal drops 0.15%
FAQ
How Long does Selank Last?
Selank’s effects typically last up to 6–10 hours after administration. However, the duration and intensity can vary depending on the individual’s metabolism, dosage, and frequency of use.
Does Selank Help Anxiety?
Selank is best known for its anxiolytic (anti-anxiety) effects. It has been shown to reduce symptoms of anxiety without causing sedation, dependence, or withdrawal.
Does Selank Increase Serotonin?
While Selank doesn’t directly increase serotonin levels, studies suggest it modulates the balance of neurotransmitters, including serotonin, contributing to improved mood and reduced anxiety.
Does Selank Improve Sleep?
Selank may help improve sleep quality by reducing stress and anxiety, which are common causes of insomnia. According to the official instructions, one of its intended uses includes supporting sleep disorders.
How Fast does Selank work?
Selank typically starts working within 15 to 30 minutes after intranasal administration. While some feel immediate relief, others may experience cumulative benefits over several days of consistent use, especially for anxiety, cognitive enhancement, or sleep support.
How do Selank and Semax Differ?
Semax and Selank are two different products. Even though they are both peptides administered nasally, they produce different effects. While Semax is a nootropic and has pronounced stimulating effects, Selank is an anxiolytic. In short, if you are looking for improved focus, mild stimulation, and faster learning, Semax is your choice. Selank will be useful for those looking to release stress, relax, and improve their mood.
What is the Dosage of Selank?
The average dose is 2-3 drops in each nostril. Selank should be taken up to 3 times per day. The treatment course is 14 days.
One bottle of Selank contains 60 drops, each having 75 mcg of the active ingredient.
What Are the Side Effects of Selank?
Selank is generally well-tolerated. The side effects listed in the instructions are very rare and include irritation of the nasal mucosa and mild allergic reactions. No cases of overdose were recorded.
For more information on Selank dosages and side effects, please refer to the translated official drug sheets linked below.
Selank Instruction 0.15% Nasal Drops
- Zozulya et al (2001) The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity
- Kost et al (2001) Semax and selank inhibit the enkephalin-degrading enzymes from human serum
- Sokolov et al (2002) Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions
- Kozlovskaya et al (2003) Selank and short peptides of the tuftsin family in the regulation of adaptive behavior in stress
- I. Kozlovkii, N. Danchev (2003) The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats
- T. Ganshina, I. Kozlovskii (2005) Effects of the new peptide anxiolytic drug selank on the cardiovascular system functioning and respiration in cats
- Semenova et al (2007) Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny
- Sarkisova et al (2008) Effects of heptapeptide selank on genetically-based and situation-provoked symptoms of depression in behavior in WAG/Rij and Wistar rats, and in BALB/c mice
- Zozulia et al (2008) Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia
- Uchakina et al (2008) Immunomodulatory effects of selank in patients with anxiety-asthenic disorders
- Medvedev et al (2014) A comparison of the anxiolytic effect and tolerability of selank and phenazepam in the treatment of anxiety disorders
- Kolomin et al (2014) The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action
- Medvedev et al (2015) Optimization of the treatment of anxiety disorders with selank
- Volkova et al (2016) Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission
- Kaisan et al (2017) Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats
- Filatova et al (2017) GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells
- Fomenko et al (2017) Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress
- Slominsky et al (2017) Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism
- Vyunova et al (2018) Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity
- C Doyno, C White (2021) Sedative-Hypnotic Agents That Impact Gamma-Aminobutyric Acid Receptors: Focus on Flunitrazepam, Gamma-Hydroxybutyric Acid, Phenibut, and Selank
- Yasenyavskaya et al (2021) The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress
4.1
Based on 57 Reviews
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(9)
08/29/2025
john r.
Verified BuyerUS
it works
selank needs to come to usa for OTC. its works. the amount in the vial is so small however. not worth if you want to keep buying since it is such a small amount. also, not sure if the product is 100% shelflife by the time we receive since these peptides degrade. no instructions on how to store the peptide either
08/29/2025
CosmicNootropic
Hi John! Thank you for your feedback and for sharing your experience with Selank! We understand your concerns regarding storage and shelf life. Please note that the storage instructions can be found on the product page. Peptides are relatively stable during shipping, and when stored as recommended, they maintain their quality throughout the shelf life.
08/19/2025
Whitney v.
Verified BuyerUS
Disappointed
I thought there would be more. It’s a very small amount. And I thought it would be a nasal spray
08/19/2025
CosmicNootropic
Hi Whitney! Thank you for your feedback! We’re sorry for any confusion. The information about the amount and form of Selank is available on the product page, but we appreciate you pointing this out.
07/27/2025
Tahnee N.
Verified BuyerAU
Selank for improving Mood lability
Effects were mild, I wasn't really sure if I could notice much and for the small amount you get for the price I probably won't buy that one again. The postage and ordering process was smooth and customer service was good though.
07/31/2025
CosmicNootropic
Hi Tahnee! Thank you for your honest feedback! We’re sorry to hear that Selank didn’t meet your expectations, effects can vary quite a bit from person to person, and we understand that it’s disappointing when results aren’t as noticeable as hoped. We appreciate your kind words about our service and shipping process.
06/13/2025
Can K.
Verified BuyerFR
Good but pricey
Is calming as advertised. A bit pricey if you want to use regularly. Mebicar would be more bang for your buck for the same kind of effect
06/13/2025
CosmicNootropic
Hi Can! Thank you for sharing your feedback! We're glad to hear you found it calming as expected.
05/28/2025
Dan W.
Verified BuyerUS
HiQuality Selank
Love the product, had a positive experience, did not enjoy the eye-dropper delivery mechanism, would have preferred the spray method.
05/12/2025
Shawn L.
Verified BuyerUS
Like a squeegee for my brain
I tried Selank with Mebicar as well as solo and can definitely tell when I've not applied it. To be alert without being wired; to be focused without being mechanical... Definitely a keeper for me!
05/12/2025
CosmicNootropic
Hi Shawn! Thank you for the wonderful review!
04/29/2025
Diane M.
Verified BuyerUS
Better than Rx alternatives
I’ve recommended this to several patients who only thought that benzodiazepines would work for their anxiety. I’m glad to say that many made the switch and had improvement in mood without the downsides of dependence and tolerance of the Rx meds. Success!
04/29/2025
CosmicNootropic
Dear Diane, thank you for your wonderful feedback! We're thrilled to hear that our nootropics have helped your patients find a better alternative for managing anxiety—naturally and effectively. Your support means the world to us!
04/22/2025
Murray A.
Verified BuyerUS
Selank
I was disappointed. I guess I didn’t read it carefully enough, but I thought it would be a spray as that seems to be the more typical way to administer Selank. It’s very difficult to use properly in the form of a dropper, and it ends up not going very far.
04/23/2025
CosmicNootropic
Dear Murray, thanks so much for your feedback. We’re sorry to hear the dropper format wasn’t what you expected. Selank is supplied in its original manufacturer packaging, and unfortunately, we’re not able to alter that. We completely understand that the spray format can be more convenient, and we’ll make sure to clarify this more clearly on the product page.
03/23/2025
Amanda C.
Verified BuyerUS
Amazing!
I feel so focused
03/26/2025
CosmicNootropic
Dear Amanda, thank you for your feedback! 🙌
03/06/2025
Taylor
Verified BuyerUS
waste
received two empty bottles of Semax and two nearly-empty bottles of Selank. I ordered Selank once before and the bottle came half full (i used for a week and put in the photo on the end with the dropper for reference). i want to return these for a refund but customer service is adamant on store credit or reshipment— they also said the two nearly-empty bottles of Selank are “probably fine” to use. I don’t appreciate the idea of using a medical product that is “probably fine” to use per a customer service rep. seriously disappointed in Cosmic Nootropic when i was excited to try an alternative to prescription meds. would rather be anxious in general than anxious over these products (or should i say lack there of). what a waste of time and money.
03/08/2025
CosmicNootropic
Dear Taylor, thank you for sharing your experience. We are very sorry that you had such an unpleasant experience and apologize on behalf of our company. We have already contacted you by email to resolve the issue. Please check it out.
02/28/2025
Justin F.
Verified BuyerUS
Hands down my favorite Neuroprotective peptide Nootropic
Hands down my favorite Neuroprotective nootropic as I suffer from moderate/severe PTSD, anxiety and treatment, resistant depression, the first one I purchased directly from Cosmic and came in the brand name form directly from the manufacturer and I felt immediate relief within second after applying the first few drops in both my left and right nostrils, peaceful, gentle serene, feeling of calmness stillness, as well as focus, now the drawbacks with anything that modulates and is agonistic on GABA receptors, come the short lifved relief Do you too tolerance buildup, which can happen very quickly that is why I try to use it as needed sparingly and even take breaks at times if needed, The price is great you can’t be $20 .00 And the only other drawback is the vials are only half full, which is not a mistake or error. That is exactly how much is supposed to be in them. It’s just a shame they’re not filled all the way.and being the reason so nant graduate on the NA Amidate form of it, and the only other drawback, surely not just the formula from cosmic tropics, but just the nature of the peptide in general is dryness irritation, and sometimes scabbing around the tip of the nostril area that’s why you have some then there who have made it into a Diacetate form to reduce that nasal mucosa, dryness, redness, and irritation but overall, I absolutely love this anxiolytic/anti-depressive and antithetic peptide!! Thank you Cosmic Nootropicd and this of course is a subjective review. Always do your own research and or control with your primary care physician or general practitioner first is recommended. Thank you to the fabulous, always quick, kind, courteous, and friendly staff and support at Cosmic and Cosmic Nootroics For not only going above and beyond will even help try to source and locate a product for you, and that really made me a truly dedicated loyal, grateful and appreciative customer for life and Their ultra reliable and fast shipping and delivering speeds What can I say, Cosmic Nootropics is simply just Excellent in all areas thank you and live healthy and live well Kind Regards, Justin
03/02/2025
CosmicNootropic
Wow, thank you for such an in-depth and thoughtful review! We really appreciate you sharing your experience and insights — it means a lot to us. We’re glad to hear that Selank has been helpful for you and that you’ve had a great experience with our team and service. Noted on the nasal irritation and tolerance buildup — it’s always good to use these products mindfully. And yes, the vial fill level is as intended, but we totally get how it might seem surprising at first!
12/26/2024
Justin F
Verified BuyerUS
Relief!
I wanted to say thank you guys again not only for your amazingly fast delivery times and low prices but for being a a rare gem as far I’m concerned and glimmer of hope for someone who suffers from horrible PTSD and panic disorder this has been truly amazing even if the relief is only temporary or is always there I still am very grateful and do what I can to get the word out about you guys, thank you again and look forward to placing more orders soon!
12/27/2024
CosmicNootropic
Hi Justin! Thank you so much for sharing your experience with us. It truly means the world to know that we've been able to bring you some relief and positivity. We're deeply grateful for your kind words and your trust in us. Your support and willingness to spread the word about us are incredibly appreciated. Please know we're here for you, and we look forward to continuing to provide the service and products you need. Thank you again, and we wish you all the best on your journey to healing and comfort! ❤️
12/02/2024
Morgan H.
Verified BuyerUS
Doesn’t work
Didn’t do anything
12/03/2024
CosmicNootropic
Hi Morgan! Thank you for sharing your feedback! We understand that everyone's experience with products can vary, as each person’s body may respond differently. That’s why we always recommend consulting with a medical professional before starting any new medication or supplement. Your health and safety are our top priority, and a healthcare provider can offer personalized advice based on your specific needs.
11/15/2024
shah
Verified BuyerUS
selank droppers
used selank droppers with a protocol of 2 drops per nostril, once in the morning and again before bed for a total of 3 weeks. felt restorative sleep after long days of studying. highly recommend for those looking for long term benefits after putting in crazy hours for studying!
12/05/2024
CosmicNootropic
Hi Shah! Thank you for sharing your experience with Selank! We're glad to hear it made a positive difference, especially by supporting restorative sleep after intense study sessions. Your detailed feedback and recommendation are much appreciated—wishing you continued success!
11/05/2024
Yeras R.
Verified BuyerUS
Selank
Excellent service, fast delivery and excellent quality of the product, strongly recommended.
11/06/2024
CosmicNootropic
Hi Yeras! Thank you so much for your positive feedback! We're thrilled to hear that you were pleased with our service, delivery speed, and product quality. It means a lot to us that you'd recommend us!
10/29/2024
Jim B.
Verified BuyerCA
Great Product
I felt Selank was a good fit for my condition. However it must continually be pointed out that as good a company that Cosmic Nootropics is with products and services..... Delivery to Canada absolutely sucks!!!! I love Cosmic Nootropics BUT I'm not sure I'll order from them anymore because the shipping is completely unreliable. You just can't keep blaming customs!!! Figure it out please.
10/29/2024
CosmicNootropic
Dear Jim, thank you for your review and for your kind words about our products! We’re glad to hear that Selank has been a good fit for you. We truly value your feedback regarding the shipping issues to Canada. We understand how frustrating unreliable delivery can be, and we will certainly look into this issue. Your support means a lot to us, and we hope to provide you with a better experience in the future. If you have any other concerns or suggestions, please feel free to reach out.
10/17/2024
Aman I.
Verified BuyerGB
Review
Pleasent and surprising
10/17/2024
CosmicNootropic
Hi Aman! Thank you for your thoughtful review! We’re glad to hear you had a pleasant experience and that our product surprised you in a positive way. If you have any specific feedback or suggestions that could help us earn that fifth star, we’d love to hear it!
10/09/2024
Connor G.
Verified BuyerUS
Very beneficial
Very effective for stress relief and mental calmness. Enjoyed stacked with Semax
10/10/2024
CosmicNootropic
Hi Connor! Thank you for your review! We’re so glad to hear that you found our product beneficial for stress relief and mental calmness. It’s great to know you enjoyed stacking it with Semax! If you have any more tips or feedback, feel free to share. We're here to help!
09/29/2024
Cecil K.
Verified BuyerUS
Works for me
It’s been great I adjusted the instructions and take only on the weekends or when feel very anxious n stressed.
09/30/2024
CosmicNootropic
Hi Cecil! Thank you for your feedback! We’re glad to hear that you found a routine that works for you. Adjusting the dosage to fit your needs is a smart approach. We appreciate your trust in us!
09/13/2024
Josh
Verified BuyerUS
Love it!
I have very high anxiety. Sometimes it can make me nearly un functional. It completely removes anxiety from me without making me feel tired or strange. I have never taken anything like this that actually really and truly removes all anxiety and allows me get on with a clear head.
09/16/2024
CosmicNootropic
Thanks so much for the feedback! We're really happy to hear that Selank has made such a difference for your anxiety without any weird side effects.
