Semax is a synthetic peptide nootropic derived from a fragment of the endogenous adrenocorticotropic hormone (ACTH). Studies have shown its potential to improve cognitive function and support recovery in various brain-related conditions.

Semax is generally used to support brain health and mental function. According to the manufacturer, it may also be used in the following conditions, depending on the dosage:

Semax 0.1%:

• Increase of attention and memory during repetitive and monotonous tasks;
• Improvement of adaptive capacity of the human body in extreme conditions;
• Cognitive impairments caused by cerebrovascular disorders, traumatic brain injuries, and neurosurgery;
• ADHD.

Semax 1%:

• Prevention and treatment of circulatory disorders and cognitive impairment, including after ischemic stroke;
• Transient ischemic attacks;
• Acute period of traumatic brain injury.

Please note that despite manufacturer recommendations, consultation with your attending physician is a must before taking any substances, including Semax neuropeptide.

More detailed information about the studies on the application can be found in the Research tab.

The main benefits and effects of Semax include:

Rapid Onset and Prolonged Effects

Semax delivers fast-acting results thanks to its intranasal delivery system. By bypassing the blood-brain barrier through perineural transport along the olfactory nerves, Semax reaches brain cells in under five minutes. Peak concentrations are typically achieved within 30 minutes, and its cognitive and neuroprotective effects can last for up to 24 hours.

Safety Profile

One of Semax’s most notable advantages is its tolerability. Clinical data from the manufacturer and user reports indicate that it has no known adverse interactions with other medications, making it a safe option.

User-Friendly Administration

Semax is available as a nasal spray, offering a non-invasive, painless, and highly convenient method of administration. This ease of use makes it a practical choice for individuals seeking consistent cognitive enhancement and neuroprotection without the need for injections or oral supplements.

According to research published on the official website of the manufacturer, Semax is claimed to be safe. Still, there are several officially recorded Semax side effects, which are the possible irritation of the nasal mucosa and very rare allergic reactions. 

Reddit users have reported hair loss and thinning issues linked to Semax administration, though there’s no official data supporting this correlation. Potentially taking higher doses and employing administration routes other than authentic drops may also lead to hair loss. Additionally, concurrent use of other nootropics can contribute to elevated BDNF levels, causing hair issues over prolonged periods.

Watch the Semax video review on YouTube

Third-party tested. View Certificate of Analysis: COA Semax nasal drops 0.1%

How does Semax Affect the Brain?

Semax influences several brain systems. It increases levels of BDNF (brain-derived neurotrophic factor), supporting neuroplasticity, and improves attention, memory, and resilience to stress in both animal and some human studies.

Does Semax Increase Dopamine Levels?

Semax may increase dopamine and other neurotransmitters, helping regulate mood, motivation, and cognitive performance.

Is Semax Legal in the US, UK, and Australia?

Semax is not FDA-approved and isn’t sold in pharmacies in the US, UK, or Australia. However, it can be legally imported for personal use in small amounts. In most cases, there are no issues with customs when shipping nootropics like Semax.

How Long does Semax Last?

Semax can take effect within 15–30 minutes and may last up to 24 hours. The exact duration varies by individual and dose.

How Does Semax Differ from Selank?

Semax and Selank are both peptides administered nasally, but their effects are quite different. Semax acts as a nootropic with mild stimulating properties, while Selank is primarily known for its anxiolytic (anti-anxiety) effects. If your goal is to improve focus and support faster learning, Semax may be the better choice. Selank, on the other hand, could be more suitable for those seeking stress relief, relaxation, and mood enhancement.

Can Semax be kept at Room Temperature? 

Semax can be kept at room temperatures below 30°C (86°F) for up to 30 days due to the inclusion of a safe preservative in its composition. However, exposure to direct sunlight is not recommended. For long-term storage, Semax should be kept in the refrigerator.

Biohackers about Semax

The standard Semax dosage is 2 drops in each nostril, administered 1–2 times per day depending on the regimen.

Course Duration:

Use for 3 to 14 days depending on the regimen.

Bottle Yield:

One bottle contains 70–75 drops (each drop delivers 50 mcg of Semax), which is typically enough for 3–10 days of use.

Note:

For a faster onset and a more pronounced effect, a second dose can be taken 15 minutes after the first one.
Using a higher-concentration Semax does not always enhance results.

Officially recorded side effects include possible irritation of the nasal mucosa and, in very rare cases, allergic reactions. Some users on platforms like Reddit have reported hair thinning or hair loss associated with Semax use, although there is no clinical data confirming this link. These effects might be influenced by prolonged usage, high dosages, using forms other than the authentic nasal drops, or combining Semax with other nootropics, which could elevate BDNF levels and potentially affect hair health over extended periods.

For more information on Semax dosages and side effects, please refer to the translated official drug sheets linked below.