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SEMAX ® Nasal Drops
133 Reviews
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Semax is a peptide nootropic that may be used to support brain health and mental function.
INN | Methionyl-glutamyl-histidyl-phenylalanil-prolyl-glycyl-proline |
Form: | Nasal drops 0.1% and 1% |
Form description: | Colorless transparent liquid in a 3 ml dropper bottle. One bottle of Semax contains 60 drops, each having 50 mcg of the active ingredient. |
Active ingredient: | Semax as per 100% substance (1l): 0.1% – 1 g; 1% – 10g. |
Excipients: | Methyl parahydroxybenzoate (nipagin) – 1 g, purified water – up to 1 l. |
СAS Number: | 80714-61-0 |
ATC code: | N06ВХ Other psychostimulants and nootropics |
Pharmacological action: | Nootropic, antioxidant, anti-hypoxic, cerebroprotective |
Bioavailability: | 60-70% |
Shelf life: | 2 years. Do not use it beyond the expiration date printed on the package. |
Storage conditions: | Store at temperatures not exceeding 10°C (50°F). Do not freeze. Protect from light. |
Legal Status: | Unscheduled |
Manufacturer: | CJSC Peptogen https://semax.ru/ |
What is Semax?
Semax is a peptide nootropic. Certain studies showed its effectiveness in improving cognitive functions [1] and helping in case of various brain conditions [2].
By its structure, Semax is a fragment of endogenous neuropeptide ACTH. The drug was shown to increase BDNF [3, 4] which is responsible for the growth and differentiation of new neurons and synapses.
What is Semax Used for?
Semax nootropic is manufactured in two dosage forms: Semax 0.1% and Semax 1%. What are they used for? – According to the manufacturer, Semax can be used in the following conditions in complex treatment with other medications prescribed by your doctor. Please note that despite manufacturer recommendations, consultation with your attending physician is a must before taking any substances including Semax neuropeptide.
Semax 0.1% Uses:
- Increase of attention and memory during repetitive and monotonous tasks;
- Improvement of adaptive capacity of the human body in extreme conditions;
- Cognitive impairments caused by cerebrovascular disorders, traumatic brain injuries, and neurosurgery;
- ADHD.
Semax 1% Uses:
- Prevention and treatment of circulatory disorders and cognitive impairment including after ischemic stroke;
- Transient ischemic attacks;
- Acute period of traumatic brain injury.
It may also help with brain fog. For more information from the manufacturer visit Semax drug sheet pages | Semax 0.1% | Semax 1%
What are Semax Benefits and Effects?
- Semax directly enters the brain cells from the cerebral mucosa using perineural transport along the sensory (olfactory) nerves, bypassing the blood-brain barrier (BBB);
- High speed of action – Semax is found in brain cells no later than 5 minutes after an administration, the maximum concentration is reached after 30 minutes;
- Long-term action – the active concentration of Semax in the brain remains stable high for 20-24 hours;
- No side effects from interactions with other drugs;
- Convenient and painless introduction.
Is Semax Safe to Take?
According to research published on the official website of the manufacturer, Semax is claimed to be a safe peptide. [5] Still there are several officially recorded Semax side effects which are the possible irritation of the nasal mucosa and very rare allergic reactions.
Reddit users have reported hair-loss and thinning issues linked to Semax administration, though there’s no official data supporting this correlation. Potentially taking higher doses and employing administration routes other than authentic drops may also lead to hair-loss. Additionally, concurrent use of other nootropics can contribute to elevated BDNF levels, causing hair issues over prolonged periods.
For more information from the manufacturer visit Semax drug sheet pages | Semax 0.1% | Semax 1%
Watch Semax video review on YouTube
Biohackers about Semax
FAQ:
Where to Buy Semax?
You can obtain authentic Semax nasal drops of the highest quality at CosmicNootropic. We offer worldwide shipping.
There are other forms of Semax available for purchase. You might have heard about Semax nasal spray, N-Acetyl Semax, N-Acetyl Semax Amidate, or Adamax. But these forms of Semax peptide are unconventional. So if you are looking for a product with reliable safety-effectiveness ratio – choose authentic nootropics and follow your doctor’s recommendations!
How many packs of Semax are needed for a course?
2-Week Course of Semax 0.1% is 2 Bottles
Semax vs. Selank: What’s the Difference?
Semax and Selank are two very different products. Even though they are both peptides administered nasally, they produce different effects. While Semax is a nootropic with mild stimulating effects, Selank is an anxiolytic.
In short, if you are looking for improved focus, and faster learning – consider Semax potential. On the other hand Selank might be of interest for those looking to release stress, relax, and improve mood.
Semax Storage Conditions: How to Store it Properly?
Keep Semax drops in a dark place at temperatures less than 10°C (50°F). Do not freeze it.
An open bottle of Semax can be stored for as long as six months without losing its properties if stored properly. The shelf-life of the new product is 2 years.
Can I keep Semax at Room Temperature?
There is a safe preservative in the composition of Semax. That is why you can keep it at room temperatures below 30°C (86°F) for a period of up to 30 days. Exposure to direct sunlight is not recommended. For longer periods of time, Semax should be stored in the refrigerator.
Read more in our in-depth review of Semax nasal drops
What is Semax Dosage?
Semax is to be taken 1-2 times a day, 2 drops into each nostril, for a period of 3 to 14 days.
One bottle of Semax contains 70–75 drops, each having 50 mcg of the active ingredient. Depending on the chosen regimen, one bottle of the drug is sufficient for a course of 3–10 days.
Note
For faster onset and more pronounced effect, a second dose can be taken 15 minutes after the first one. Using a stronger version of Semax does not necessarily result in a stronger effect of the therapy.
What are Semax Side Effects?
According to research published on the official website of the manufacturer, Semax is claimed to be a safe peptide. [5] Still there are several officially recorded Semax side effects which are the possible irritation of the nasal mucosa and very rare allergic reactions.
Reddit users have reported hair-loss and thinning issues linked to Semax administration, though there’s no official data supporting this correlation. Potentially taking higher doses and employing administration routes other than authentic drops may also lead to hair-loss. Additionally, concurrent use of other nootropics can contribute to elevated BDNF levels, causing hair issues over prolonged periods.
For more information on Semax dosages and side effects, please refer to the translated official drug sheets linked below.
OFFICIAL INSTRUCTION – Semax 0.1%
OFFICIAL INSTRUCTION – Semax 1%
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- Asmarin et al (1997) A nootropic adrenocorticotropin analog 4-10-semax (l5 years experience in its design and study https://www.ncbi.nlm.nih.gov/pubmed/9173745
- Miasoedova et al (1999) Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/10358912
- Gusev et al (2005) Semax in prevention of disease progress and development of exacerbations in patients with cerebrovascular insufficiency https://www.ncbi.nlm.nih.gov/pubmed/15792140
- Eremin et al (2005) Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents https://www.ncbi.nlm.nih.gov/pubmed/16362768
- Dolotov et al (2006) Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus https://www.ncbi.nlm.nih.gov/pubmed/16996037
- SJ Tsai (2007) Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome https://www.ncbi.nlm.nih.gov/pubmed/16996699
- Agapova et al (2008) Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex https://www.ncbi.nlm.nih.gov/pubmed/18756821
- Grivennikov et al (2008) Effects of behaviorally active ACTH (4-10) analogue – Semax on rat basal forebrain cholinergic neurons https://www.ncbi.nlm.nih.gov/pubmed/18431004
- Shadrina et al (2010) Comparison of the temporary dynamics of NGF and BDNF gene expression in rat hippocampus, frontal cortex, and retina under Semax action https://www.ncbi.nlm.nih.gov/pubmed/19662538
- Manchenko et al (2010) Nootropic and analgesic effects of Semax following different routes of administration https://www.ncbi.nlm.nih.gov/pubmed/21268834
- Medvedeva et al (2014) The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987924/
- Shypshyna et al (2015) Effect of peptide semax on synaptic activity and short-term plasticity of glutamatergic synapses of co-cultured dorsal root ganglion and dorsal horn neurons https://www.ncbi.nlm.nih.gov/pubmed/26552305
- Medvedeva et al (2017) Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats https://www.ncbi.nlm.nih.gov/pubmed/28255762
- Gusev et al (2018) The efficacy of semax in the tretament of patients at different stages of ischemic stroke https://www.ncbi.nlm.nih.gov/pubmed/29798983
- Lebedeva et al (2018) Effects of Semax on the Default Mode Network of the Brain https://www.ncbi.nlm.nih.gov/pubmed/30225715
- Samotrueva et al (2019) Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress https://pubmed.ncbi.nlm.nih.gov/31028579/
- Elagina et al (2020) Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide Drugs https://pubmed.ncbi.nlm.nih.gov/32246363/
4.3
Based on 133 Reviews
(101)
(5)
(6)
(4)
(17)
02/01/2025
Jimmy
Verified BuyerMX
Worked for me. Turns my Brain on.
I was surprised how well it worked. I’m new to nootropics and peptides. But I’ll say it definitely turned my brain on!! Absolutely worth a try for ADHD or running a business
02/05/2025
Cosmic Nootropic
Dear Jimmy, Thanks so much for the awesome review! We’re so glad to hear it worked well for you. It’s great to know you’re feeling the benefits, especially for focus and mental clarity.
01/29/2025
Tony R.
US
Ineffective
Zero effect, money wasted. Garbage product. Wont be using again.
01/29/2025
Cosmic Nootropic
Dear Tony, thank you for your feedback. We’re sorry to hear that the product didn’t meet your expectations. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.
12/02/2024
Morgan H.
Verified BuyerUS
Didn’t work
Didn’t do anything
12/03/2024
Cosmic Nootropic
Dear Morgan, it's heartbreaking for us to hear that Semax as well didn’t have the desired effect for you. We once again recommend consulting with a healthcare professional to determine the best approach for your specific needs.
11/23/2024
Joseph S.
Verified BuyerUS
Long time in transit/ no good
I bought this product because it was on sale do to being at the USA border too long according to the website, but when the tracking number was provided it was coming from Russia instead of the USA as advertised. The product smelled like fried bacon and yet I used it and little to no effects took place. I will not order it again if it sits to long again. The stuff I ordered from Russsianmeds was amazing and will Oder more from them again. Don’t buy it if it’s expired. My loss this time Take care
11/25/2024
Cosmic Nootropic
Thank you for your feedback. We would like to clarify that we do offer a choice of warehouses at checkout and upon reviewing your order, we see that you have selected our CIS warehouse. Our customer support team has already emailed you to resolve this issue and address your concerns about the product. We take quality very seriously and we're here to make sure you have a better experience in the future. Please don't hesitate to reply to our email if you have any further questions or concerns.
11/15/2024
Shah
Verified BuyerUS
selank drops
I want start off by saying I really appreciate you guys for having the items I needed, always in stock, and discrete packaging. I got the semax drops, using this protocol: 2 drops per nostril, once in the morning, and again in the evening. I felt a noticeable difference by week two. Felt less foggy in the morning and I really like the calmness factor it provided me, especially during my long study hours. I didnt like the dropper because of the tip shape, but overall great product. Definitely met my expectation for increasing mental endurance. Ordered both the semax and selank nasal drops and they arrived within the week! 100% satisfaction on the first few purchases. Will be checking out other neutropics.
12/05/2024
Cosmic Nootropic
Hi Shah! Thank you for your detailed review! We're thrilled the Semax drops met your expectations and helped with mental endurance and focus. Glad to hear your order arrived quickly—looking forward to helping with your future nootropic needs! 🚀✨
11/14/2024
Shah
Verified BuyerUS
semax
tried the dropper version of semax. didnt notice a difference until week 2. my protocol was 2 drops in each nostril, once in morning and again before bed. sleep was restorative, felt more relaxed when putting in long hours studying. highly recommend for someone who need long term benefits while studying like crazy!
11/15/2024
Cosmic Nootropic
H Shah! Thank you for sharing your experience with Semax, and we’re sorry to see a 1-star rating despite your positive results. We're glad it helped with restorative sleep and focus during intense study sessions. If there’s anything we can do to improve your experience further, please don’t hesitate to let us know!
11/03/2024
katrin z.
Verified BuyerUS
semax amazing product
fast shipping and amazing product and product information, I am reordering.
11/05/2024
Cosmic Nootropic
Hi Katrin! Thank you for the great feedback! We're thrilled to hear you're happy with both the product and the fast shipping. We truly appreciate your trust and are excited to serve you again with your reorder!
10/09/2024
Connor G.
Verified BuyerUS
Very beneficial
Great for motivation
10/10/2024
Cosmic Nootropic
Dear Connor, thank you for your review! We're thrilled to hear that you find our product great for motivation. Your feedback means a lot to us!
09/28/2024
Alex
Verified BuyerUS
Semax - Fantastic Product from Terrific Company!
I\'ve been using the majority of classical nootropics for over 15 years. Most racetams, especially pramiracetam and phenotropil, as well as modafinil and its analogues and metabolites, other substances like Bromantane, PRL 8-53, oxazolidinones, you name it. All of them to some degree help to focus, provide additional mental energy, improve multitasking, auditory and visual perception and working memory. I have tried an american-made N-Acetyl-Semax some years ago, but it (or perhaps that particular batch) didn\'t have much effect on me. I kept on reading about development of newer peptides which boosted BDNF, and finally I decided to turn to Semax in its original form. There is Semax made in US that you could buy online, but since Semax was originally developed in Soviet Union, I decided to buy it from Cosmic Nootropic, which sells a version manufactured in one of the countries that used to be a part of USSR. The process of ordering online with a credit card was straightforward. I had some additional questions about my account and sent Cosmic Nootropic an email. It was promptly answered the next day. It was the warmest, most personal email I have ever received from a vendor\'s customer support. I pay attention to such things and its tone genuinely touched and delighted me. The next day I received an order tracking number and my order arrived in about 4 days, which was great. Everything was professionally packaged. Each bottle of Semax was inside original packaging, which also contained a rather unique super precise dropper in its own ziplocked packet and the original manufacturer printout describing the medication. My only misgiving was that there is no plastic seal covering the bottle cap, which is a common practice in US for liquid medication. But this is probably how the original manufacturer packages it and is outside of Cosmic Nootropic control. Now about Semax effect. As a senior professional software developer, I have to study new information on daily basis. Normally I have to reread explanations of complex functionality or re-watch parts of the videos, before the information is fully absorbed. While other nootropics made that somewhat easier, nothing could prepare me for what Semax did. When I was in school, up to a certain point in time, when a teacher was deriving an equation on a black board, most of the other kids were copying his results to their notebooks, but I could simply kind of follow along, deriving the equation myself without looking at the black board. I didn\'t think much about it. Much later, when I lost that ability, probably due to alcohol consumption, I realized that in those moments I was in a kind of an extremely quiet, comfortable happy place, in a total state of relaxation and the answers would come to me effortlessly. Note that it was a happy place and not a \"Zone\" or state of Zen that one can get into with Modafinil or Adderall. And that\'s what Semax did after 3 weeks! No stimulation whatsoever, no push, but some sort of quiet pseudo time dilation which gives me time to absorb the information without stressing out from trying to focus. Note that this is not the kind of time dilation that occurs with psychedelics. I am aware of time passing in a normal way, its just as if my brain was somehow given more time to process information internally. The overload is gone as if I gained multiple brains. It also affects the senses, the world feels closer, quiet sounds are more distinct, I almost feel them with my skin. The state of NOW, fully living in the present. This is how I perceived the world when I was a child and I assume that this is exactly what scientists mean when they speak gain plasticity! By the way if anybody wonders, I was never diagnosed with ADHD, but I can understand now how this agent could help anyone with diminished executive function, derealization, etc. Having had this tremendous success with Semax, it is temping to try other newer BDNF substances that Cosmic Nootropic carries, but there is a significant risk experimenting with new substances. And Semax has been around for a long time. Yes, you might have to use topical minoxidil and finasteride, if you are one of those who is subjected to enhanced hair loss from Semax, but I think its worth it. It is medically accepted that all BDNF agents might cause hair loss, but the enhanced brain function theoretically should bring extra income to deal mediate it. Back to Cosmic Nootropic. The company goes out its way to help its customers. They have published the most complete guide on Semax on the web. Kudos to them for all that they have done!
10/06/2024
Cosmic Nootropic
Hi Alex! Thank you for your thoughtful review! We’re thrilled to hear how Semax has positively impacted your focus and cognitive function. It’s great to know our customer support and ordering process met your expectations. We appreciate your feedback on the packaging, and we’re glad you found our resources helpful. If you have any questions or want to explore more products, we’re here for you. Thanks for choosing CosmicNootropic, and we look forward to serving you again!
09/13/2024
Josh
Verified BuyerUS
Great Stuff
My Wife Loves it. She gets more talkative. Her mood and overall wellbeing improve dramatically she says. I myself use it to help with my ADHD and focus. It does a great job. I would recommend this to anyone really. Its all around a great peptide.
09/15/2024
Cosmic Nootropic
Thank you so much for your feedback, Josh! We’re thrilled to hear that both you and your wife are experiencing such positive effects with Semax. We appreciate your recommendation and support!
07/30/2024
Sandra L.
Verified BuyerUS
Excellent nootropic
I work in a fast paced medical environment. Semax enhances my focus, information processing and productivity. Love this nootropic! I highly recommend.
07/30/2024
Cosmic Nootropic
Hi Sandra! Thank you so much for your enthusiastic review! We're delighted to hear that Semax is enhancing your focus, information processing, and productivity, especially in such a demanding medical environment. It's wonderful to know that our product is making a positive impact on your work.
07/14/2024
Robert F.
Verified BuyerUS
semax
I did my first cycle 2 weeks ago. No noticeable difference yet.
07/15/2024
Cosmic Nootropic
Hi Robert! Thanks for sharing your experience with us. It's common for effects from supplements like Semax to vary among individuals, and sometimes it can take a few cycles to notice significant changes. Factors like dosage, frequency, and individual response can all play a role. If you have any concerns or questions about your experience, feel free to reach out to us. We're here to help and provide support as you explore the benefits of Semax.
07/07/2024
Ron R.
Verified BuyerUS
Not enough
There was not enough of the product to adequately determine any benefit.
07/08/2024
Cosmic Nootropic
Hi Ron! Thank you for your feedback. We're sorry to hear that you felt there wasn't enough product in the package. One bottle of Semax contains 60 drops, each having 50 mcg of the active ingredient. Depending on the chosen regimen, one bottle of the drug is sufficient for a course of 3–10 days.
06/08/2024
Nick D.
Verified BuyerUS
I wish there was a bigger bottle with more liquid, or if it was a tad cheaper, but it’s a great product!
06/09/2024
Cosmic Nootropic
We appreciate your feedback and are pleased to hear that you like the product overall. We also wish the manufacturer would make a bigger bottle :)
06/07/2024
Liam H.
Verified BuyerUS
Works well, fast shipping
Semax works as advertised. Increased mental clarity and also useful to attenuate brain damage from MMA sparring. Also, I ordered and got it literally two days later which is awesome
06/07/2024
Cosmic Nootropic
Hi Liam! We're thrilled to hear that Semax delivered the results you were looking for! Your satisfaction and well-being are our top priorities, and we're delighted that our product and shipping exceeded your expectations.
06/03/2024
Nathan p.
Verified BuyerRO
Works great!!
Nice awake feeling with boost in visuals colors seemed to pop. But must be administered correctly. Overall it was really cool to try and let others try! Thanks cosmic!
06/03/2024
Cosmic Nootropic
Hi Nathan! Thank you for sharing your positive experience! We're delighted to hear that our product provided you with a nice awake feeling and enhanced visual perception. Your support means a lot to us!
06/03/2024
Nick D.
Verified BuyerUS
I feel the same way about the selank, but I wish a bigger bottle was available. It feels like I go through it really quick. Other than that it’s a great product 👍
06/03/2024
Cosmic Nootropic
Hi Nick! Thank you for your feedback! We're glad to hear you find Selank to be a great product. Unfortunately, the 3 ml bottle is the standard one that the manufacturer offers and we are not able to affect this in any way, although we would definitely take this into consideration!
06/02/2024
Anton I.
Verified BuyerUS
Nice thing
It improve concentration and focus and works very soft.
06/03/2024
Cosmic Nootropic
Hi Anton! Thank you for your positive feedback! We're glad our product helped improve your concentration and focus smoothly. Your satisfaction is important to us, and we appreciate your support!
04/03/2024
Zahirul I.
Verified BuyerGB
Did not receive the item
Hi, I did not receive the item and the tracking is showing it has been returned to the sender. Please refund.
04/04/2024
Cosmic Nootropic
Hi Zahirul! We are so sorry to hear that you have not received your order! We have contacted you via email.
03/03/2024
Vincent B.
Verified BuyerUS
Worked as advertised
Would echo the caution some have previously stated regarding using SEMAX too close to bedtime. Incredible product.
04/04/2024
Cosmic Nootropic
Dear Vincent, Appreciate your feedback on Semax and the caution about bedtime use. We're here for any more insights or questions you may have!
02/15/2023
Dan
So the 0.1% is 50mcg per drop. And the 1% will be 500mcg per drop correct? I believe only the 0.1% dosing is shown in the items description.
02/17/2023
Cosmic Nootropic
Yes, these calculations are correct. Please note that these are only approximate values.
Was this helpful?
0 001/31/2023
Adrienne
Hi why are there two options for locations to ship FROM? Is the one out of the US more legit? Serious question
01/31/2023
Cosmic Nootropic
Hi, It is just a warehouse that it will be shipped from. The product is exactly the same
Was this helpful?
0 02 years ago
Sterling, C. Verified Buyer
Great company
After so many changes in the nootropic company finding these guys has been amazing! Super good communication and great products plus very fast shipping! I would definitely do business again!
Thank you so much for your kind words! 😊
6 years ago
Shane S. Verified Buyer
A fantastic nootropic. A amazing company.
Selank for me has been a great experience. It calms down my thoughts, and makes it easier to digest information. The substance itself feels very subtle, but has profound positive mental effects. I would suggest that anyone who has trouble studying to give it a try. It is also great after a rough day to relax. Dealing Cosmic Nootropic has been nothing but pleasurable. Very fast delivery to the united states, and discounts for using bit coin. On top of that they provide almost near instant updates on the status of your package. Going even further. Will notify you, and confirm the delivery of it. They go even further by making sure you are totally satisfied with the products once delivered. I have never had a more positive, and detailed experience ordering anything.
6 years ago
Shane S. Verified Buyer
A fantastic nootropic. A amazing company.
Selank for me has been a great experience. It calms down my thoughts, and makes it easier to digest information. The substance itself feels very subtle, but has profound positive mental effects. I would suggest that anyone who has trouble studying to give it a try. It is also great after a rough day to relax. Dealing Cosmic Nootropic has been nothing but pleasurable. Very fast delivery to the united states, and discounts for using bit coin. On top of that they provide almost near instant updates on the status of your package. Going even further. Will notify you, and confirm the delivery of it. They go even further by making sure you are totally satisfied with the products once delivered. I have never had a more positive, and detailed experience ordering anything.
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