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SERMION ® (Nicergoline)

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Nicergoline is an ergot derivative used primarily to treat senile dementia and other disorders which are known to have a vascular origin. It is known to decrease vascular resistance and increase arterial blood flow within the brain, thus improving the utilization of oxygen and glucose uptake by brain cells.

Indications

  • Cerebral atherosclerosis;
  • Thrombosis and embolism of cerebral vessels;
  • Transient cerebrovascular disorders of the ischemic type;
  • Obliterating endarteritis;
  • Raynaud syndrome;
  • Migraine;
  • Hypertensive crisis (parenteral administration of the drug as an adjuvant);
  • Arterial hypertension (as part of combination therapy).

 

Produced by Pfizer, USA / Italy.

Check the other products from the Nootropics & Brain Health category!

Dosage and administration

The drug is taken orally.

Chronic cerebral circulatory disorders, vascular cognitive impairment, post-stroke states: 10 mg 3 times/day. The therapeutic effect of the drug is developing gradually and the treatment course should be at least 3 months.

Vascular dementia: 30 mg 2 times/day. In this case, the patient is recommended every 6 months to consult with the doctor about whether to continue therapy.

Peripheral blood flow disorders: 10 mg 3 times/day for a long time (several months).

Contraindications

Hypersensitivity to nicergoline, heavy bleeding, acute myocardial infarction, orthostatic [postural] hypotension, expressed bradycardia, pregnancy, lactation period, and children under 18 years old.

Side effects

In very rare cases, clinically irrelevant side effects were noted: Hypotension and dizziness, very slight gastric distress, flushing, sleepiness, and insomnia.

Overdose

Symptoms: hypotension.

Treatment: You should take the horizontal position for a few minutes.

Drug interaction

Potentiate action of antihypertensive drugs.

Precautions

Caution should be used in administering Sermion in patients with hyperuricemia or with a history of gout and/or under treatment with drugs that might be able to interfere with the metabolism and excretion of uric acid. Sermion may potentiate the effect of antihypertensive drugs.

Manufacturer

Pfizer, USA / Italy.

OFFICIAL INSTRUCTION

  1. Saletu et al (2014) Safety of Nicergoline as an Agent for Management of Cognitive Function Disorders https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163411/
  2. Winblad et al (2008) Therapeutic use of nicergoline https://www.ncbi.nlm.nih.gov/pubmed/18666801
  3. M Fioravanti, L Flicker (2001) Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment https://www.ncbi.nlm.nih.gov/pubmed/11687175
  4. J Kugler, H Heidrich (1984) Nicergoline and cerebral performance insufficiency. Observations in 1 year treatment controls https://www.ncbi.nlm.nih.gov/pubmed/6392047
  5. Fioravanti et al (2014) A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4120366/
  6. Saletu et al (2014) Safety of nicergoline as an agent for management of cognitive function disorders https://www.ncbi.nlm.nih.gov/pubmed/25243157
  7. Popova et al (2017) The use nicergoline in the treatment of diabetes mellitus https://www.ncbi.nlm.nih.gov/pubmed/28902812
  8. Felisati et al (2004) Nicergoline in the treatment of dizziness in elderly patients. A review https://www.ncbi.nlm.nih.gov/pubmed/15207410
  9. Voronina et al (1988) Effect of nicergoline on learning and memory https://www.ncbi.nlm.nih.gov/pubmed/3419247
  10. K Shintomi (1991) Pharmacological study of nicergoline. Effects on regional cerebral blood flows and arterial carbon dioxide and oxygen pressure and pH in rats under cyanide-induced histotoxic anoxia https://www.ncbi.nlm.nih.gov/pubmed/1796914
  11. Nakashima et al (2011) Nicergoline improves dysphagia by upregulating substance P in the elderly https://www.ncbi.nlm.nih.gov/pubmed/21694649
  12. Dikova et al (1990) Rheoencephalographic and electroencephalographic studies on nicergoline https://www.ncbi.nlm.nih.gov/pubmed/2232965
  13. Walford et al (2016) Nicergoline inhibits human platelet Ca2+signalling through triggering a microtubule‐dependent reorganization of the platelet ultrastructure https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813371/
  14. Bottiger et al (1996) Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans https://www.ncbi.nlm.nih.gov/pubmed/8971425
  15. Mizuno et al (2005) Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes https://www.ncbi.nlm.nih.gov/pubmed/16325157

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