buy etifoxine

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STRESAM ® (Etifoxine)

40 Reviews

Etifoxine is not approved for clinical use by the U.S. Food and Drug Administration (FDA). Etifoxine has been marketed in over 40 countries including France, Morocco, Ukraine, Russia and some others. On 27 January 2022, the European Medicines Agency finalized its review of Stresam (etifoxine) and concluded that the medicine can continue to be used for the treatment of anxiety disorders, but it must not be used in patients who previously had severe skin reactions or severe liver problems.

Buy Stresam® Online!

Etifoxine (trade name Stresam) is an anxiolytic and anticonvulsant medication developed in the 1960s and used ever since. Its benefits are similar to those of benzodiazepines, but Stresam is considered to be much safer.

Chemical name Etifoxine / Etafenoxine
Form: 24 pills of 50mg / 60 pills of 50mg
Form description: Smooth, shiny gelatin capsules with a white body and a blue cap, the content is a powder of white or white with a slight yellowish tint color
Active ingredient: Etifoxine hydrochloride, 50 mg
Excipients: Lactose monohydrate, Talc, Microcrystalline cellulose, Anhydrous colloidal silicon dioxide, Magnesium stearate.
Capsule shell composition: titanium dioxide, gelatin, indigo carmine.
СAS Number: 21715-46-8
ATC code: N05BX03
Pharmacological action: Anxiolytic (tranquilizer)
Bioavailability: 90%
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store at temperatures of 15-25°C (59-77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Biocodex, France https://www.biocodex.com/

What is Stresam?

Stresam is an anxiolytic drug manufactured by the French company Biocodex. The drug is approved in more than 40 countries. Its active substance is etifoxine. It is a benzoxazine derivative. It is characterized by maximum selectivity and physiological action.

The active substance was developed back in the 1960s by the German pharmaceutical company. Back then benzodiazepines (diazepam, oxazepam, phenazepam), which are psychoactive substances with sedative effects, dominated the market. However, it is a well-known fact that tranquilizers of the benzodiazepine structure have significant side effects. Etifoxine was one of several anxiolytics with enough potential to replace benzodiazepine drugs.

The compound produces neurosteroids in the brain that can indirectly modulate the activity of the GABAA response. Enhancing neurosteroids in the brain has a lot of potential in keeping the functional yet calm state of body and mind.

What is Stresam used for?

Stresam is used for the treatment of psychosomatic signs of anxiety, fear, inner tension, increased irritability, and decreased mood (including associated with somatic diseases and especially diseases of cardiovascular nature).

What are Stresam Benefits and Effects?

  • The drug effectively eliminates manifestations of anxiety: fear, stress, discomfort, insomnia, inner tension, etc.
  • Etifoxine does not have a withdrawal syndrome and does not cause dependence. Hence it can be of interest to narcologists. Stresam has shown its effectiveness in the reduction of manifestations of alcohol withdrawal, tremors, and paroxysmal sweating. Also, Stresam helps to reduce the pathological craving for alcohol, improving the quality of life in the post-withdrawal period.
  • Some state that Stresam may also exhibit nootropic benefits like improvement in concentration and memory functions. This is attributed to the fact that Stresam is said to stimulate mitochondrial benzodiazepine receptors, thereby enhancing the synthesis of neurosteroids.
  • Another property of Stresam that has been recently discovered is neuroprotection. Stresam was shown to promote neuron growth; in particular, it accelerates axonal regeneration and may serve as a treatment for polyneuropathy.
  • Stresam was also proven to have the ability to alleviate mild depression. However, Stresam is not an antidepressant.
  • Stresam has an indirect effect on the course of cardiovascular, pulmonary, gastroenterological, and other psychosomatic diseases.

Is Stresam Safe to Take?

Contraindications:

Hypersensitivity to the active ingredient or other components of the drug, shock state, myasthenia, and severe disorders of the liver and/or kidney function. Due to the presence of lactose in the drug, it should not be used if the patient suffers from galactosemia, glucose-galactose malabsorption syndrome, and lactase deficiency.

It is not recommended to use the drug at the age below 18 years old as well as during pregnancy or lactation.

FAQ

Can Stresam (Etifoxine) cause weight gain?

Indeed many anxiolytics may cause weight increase. But the good news is that etifoxine does not cause weight gain. A recent study on mice even showed that it may actually have the opposite effect (see Ibrahim et al., 2020).

Where Can I Order Stresam Online?

You can order Stresam (Etifoxine) online at different vendors. CosmicNootropic offers Stresam in packs of 60x50mg pills with worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
You can order Etifoxine and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.

Can I Overdose with Stresam?

Overdose is noted only in doses many times higher than the recommended ones. The treatment is symptomatic.
Stresam is devoid of a significant number of side effects of its precursors (benzodiazepines). Rare side effects include drowsiness, insomnia, and the development of skin allergic reactions.

 

 

 

What is Stresam Dosage?

The usual course of treatment is 1-2 capsules 2-3 times a day from 1 week to 2 months. To choose a dose and duration of treatment, please refer to the official instructions and consult with your doctor.

What are Stresam Side Effects?

Central nervous system disorders
Rare: Insignificant drowsiness during the first days of taking the drug. It usually disappears on its own in the process of treatment.

Skin and subcutaneous tissue disorders
Rare: Maculopapular rash, erythema multiform, itching, facial edema; (very rare) urticaria, Quincke’s edema; (frequency unidentified) anaphylactic shock, drug-induced hypersensitivity syndrome with eosinophilia, Stevens-Johnson syndrome, leukocytoclastic vasculitis.

Hepatobiliary disorders
Frequency unidentified: Hepatitis, cytolytic hepatitis.

Reproductive system and breast disorders
Frequency unidentified: Metrorrhagia among women who take oral contraceptives.

Gastrointestinal tract disorders
Frequency unidentified: Lymphocytic colitis.

For more information on Stresam dosages and side effects, please refer to the translated official drug sheets linked below.

OFFICIAL INSTRUCTION

  1. Micallef et al (2001) A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected] https://www.ncbi.nlm.nih.gov/pubmed/11468032
  2. Hamon et al (2003) The modulatory effects of the anxiolytic etifoxine on GABA(A) receptors are mediated by the beta subunit https://www.ncbi.nlm.nih.gov/pubmed/12871647
  3. Nhuyen et al (2006) Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice https://www.ncbi.nlm.nih.gov/pubmed/16625522
  4. Ugale et al (2007) Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats https://www.ncbi.nlm.nih.gov/pubmed/17950705
  5. Girard et al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2629330/
  6. Verleye et al (2011) Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits? https://www.ncbi.nlm.nih.gov/pubmed/20943351
  7. Zhou et al (2013) Etifoxine promotes glial derived neurotrophic factor induced neurite outgrowth in PC12 cells https://www.spandidos-publications.com/10.3892/mmr.2013.1474
  8. Aouad et al (2014) Etifoxine stimulates allopregnanolone synthesis in the spinal cord to produce analgesia in experimental mononeuropathy https://www.ncbi.nlm.nih.gov/pubmed/23881562
  9. Choi et al (2015) Etifoxine for pain patients with anxiety https://www.ncbi.nlm.nih.gov/pubmed/25589941
  10. Y Choi, K Kim (2015) Etifoxine for Pain Patients with Anxiety https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293506/
  11. Rego et al (2015) The Non-Benzodiazepine Anxiolytic Drug Etifoxine Causes a Rapid, Receptor-Independent Stimulation of Neurosteroid Biosynthesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364751/
  12. D Stein (2015) Etifoxine Versus Alprazolam for the Treatment of Adjustment Disorder with Anxiety: a Randomized Controlled Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311065/
  13. Simon-O’Brien et al (2016) Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002207/
  14. Ravikumar et al (2016) Differential efficacy of the TSPO ligands etifoxine and XBD-173 in two rodent models of Multiple Sclerosis https://europepmc.org/abstract/med/27039042
  15. Bouillot et al (2016) A microPET comparison of the effects of etifoxine and diazepam on [(11)C]flumazenil uptake in rat brains https://www.ncbi.nlm.nih.gov/pubmed/26644334
  16. Costa et al (2017) The Anxiolytic Etifoxine Binds to TSPO Ro5-4864 Binding Site with Long Residence Time Showing a High Neurosteroidogenic Activity https://www.ncbi.nlm.nih.gov/pubmed/28362078
  17. Poisbeau et al (2018) Anxiolytics targeting GABAA receptors: Insights on etifoxine https://www.ncbi.nlm.nih.gov/pubmed/30204559
  18. Deplanque et al (2018) Etifoxine impairs neither alertness nor cognitive functions of the elderly: A randomized, double-blind, placebo-controlled crossover study https://www.ncbi.nlm.nih.gov/pubmed/30135030
  19. Nuss et al (2019) An update on the anxiolytic and neuroprotective properties of etifoxine: from brain GABA modulation to a whole-body mode of action https://pubmed.ncbi.nlm.nih.gov/31308671/
  20. Shehadeh et al (2019) Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine https://pubmed.ncbi.nlm.nih.gov/31146356/
  21. Ibrahim et al (2020) Etifoxine reverses weight gain and alters the colonic bacterial community in a mouse model of obesity https://pubmed.ncbi.nlm.nih.gov/32679124/
  22. Palzur et al (2021) Etifoxine Restores Mitochondrial Oxidative Phosphorylation and Improves Cognitive Recovery Following Traumatic Brain Injury https://pubmed.ncbi.nlm.nih.gov/34884686/

4.5

Based on 40 Reviews

(30)

(4)

(3)

(1)

(2)

 

02/06/2025

Justin F.

Justin F.

 Verified Buyer
US

US

Interesting novel anxiolytic that is worth a try

My experience with this non-benzodiazepine anxiolytic medication that I am still somewhere in the middle with with, some articles claim it’s not much more than a placebo, which just simply is not possible or true it just has. It’s very on unique mechanism of action, Several mechanisms of actions actually from what the literature shows and I believe it certainly does have some value in relieving manifestations or deep, internalized “foreboding and possibly existential, dread or thoughts “seems effective for mild or general social anxiety, agoraphobia perhaps even effective in treating both anxiety and depression, it reminds me a little bit of life what we have in the United States the medication Buspar/Buspirone only I would say 100 times more effective than that. This is one of those medication is much like Buspar I’ve seen people all too many times in despair frustration simply say, shaking their heads “It don’t work” understandable because I still very much independent on my rescue medication’s for me being the Clonazepam 0.5mg 3x a day what I know considered to be a God send the Selank I truly have never felt relief of both anxiety and depression, almost simultaneously at the same time as I did with the heavenly Selank, take it short term/take it long-term. Why can’t we just take what makes our quality of life just a little better and a little gentler everything is subjective and different to each patient despite contrary to what doctors and providers going by just really DEA laws at the end of the DEA laws at the end of the day as how I see it but I have been taking the advised recommended daily dosage 100mg (2 50mg capsules 3x a day) I also am intrigued by the literature out on the Grandaxin/Tofisopam it soft being the mildest of mild, but indeed a benzodiazepine, interesting articles and literature out there using that medication as well for the treatment of schizophrenia that is genetic in both me and my biological sisters case both prone to and suffer from seizures, and believe me some of the anti-convulsions out there that are recognized as a standard of treatment generally Depakote and Haldol neurological afflictions that I have have been on the as rough stuff! rough stuff talking about the Depakote/Valproic acid The stomach cramping ringing in the ears, just to name a couple, pretty dreadful side effects just could not tolerate They love to throw that one at you in a given chance I’ve noticed too.”Let’s just a little mood stabilization” Only the side effects with that we’re not so painful really so I gentle effective relief and who on earth could blame you I recognize also the Stresam Really must be taken regularly daily and can take a week or 2 before you begin to see notice results weeks before you begin noticing improvement in symptoms and results, And it’s a little on the costly side $80–$90 But I would say give this a try It has several different mechanisms of action, not only with GABA receptors, but serotonin and a few other different ones as well. Just be sure to do 2 things really your own research and if you have any concerns about drug interactions, you can easily enter in on medication that you are on into a simple CVS Walgreens and various other drug data and interaction banks on different websites and apps and 2 run it by your doctor or nurse practitioner if you are under the care of and 9 times don’t of 10 they are usually quite intrigued themselves and are all on board with it, I mentioned it to my provider just last month regarding the Neuroprotective Peptides and she seemed to have a general basic understanding of what thing are and what they do, This is my review on the Stresam/Etifoxine Best of regards to all and wishing you Peace Love Happiness and Health!! Kind Regards- Justin

02/07/2025

Cosmic Nootropic

Dear Justin, thank you for sharing such a detailed and thoughtful review! We’re glad to hear that you found the product effective in managing your anxiety and mood, especially in comparison to other treatments you've tried. Your insights on its mechanisms of action are very valuable, and we appreciate you taking the time to share your experience. As always, we encourage customers to consult with their healthcare providers, and it’s great to hear that your provider is open to learning more about these types of treatments. Wishing you continued peace, health, and happiness! 🤗

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09/25/2024

Benjamin P.

Benjamin P.

 Verified Buyer
US

US

Great anxiety reduction!

Love this for taking the edge off after a stressful day!

09/26/2024

Cosmic Nootropic

Hi Benjamin! Thank you for sharing your experience! Your well-being is our priority, and we’re here to support you.

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09/19/2024

Stephanie P.

Stephanie P.

 Verified Buyer
US

US

Huge fan

Aside from their customer service being wonderful, this product in particular has become mandatory to my nootropic stack. Still experimenting with others, but I’ve actually had some help from this one.

09/20/2024

Cosmic Nootropic

Hi Stephanie! Thank you for your wonderful review! We’re thrilled to hear that our product has become a key part of your nootropic stack. It’s great to know it’s making a positive impact for you!

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08/02/2024

Bonnie B.

Bonnie B.

 Verified Buyer
US

US

Strezam works!

I had never heard of Strezam before, but was looking for anti-anxiety help. I was pleasantly surprised that just one capsule did the trick but didn't make me sleepy. Will definitely repurchase from Cosmic Nootropics!

08/05/2024

Cosmic Nootropic

Hi Bonnie! Thank you for sharing your experience! We're delighted to hear that Strezam is working well for you and that it didn’t cause any drowsiness. It’s great to know you’re finding relief with our product. We appreciate your support and look forward to serving you again at CosmicNootropic!

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03/22/2024

Helen M.

Helen M.

 Verified Buyer
CA

CA

Etifoxine

I’ve been using this off and on for a few months. It’s not as effective as a true benzo but is still helpful to quell anxiety. I’d say it’s about 75% as effective as a benzo. On the other hand, it’s much less addictive according to everything I’ve read about it. That’s why I’m using it.

03/24/2024

Cosmic Nootropic

Thank you for sharing your experience, Helen! It's great to hear that Stresam has been helpful in managing your anxiety, even if it's not as potent as a traditional benzodiazepine. The fact that it's less addictive is definitely a positive aspect and makes it a valuable option for many. We appreciate your feedback!

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02/09/2024

Shelbyll M.

Shelbyll M.

 Verified Buyer
US

US

Strezam

This is a good product. It was well received from my body and it worked without any side effects.

02/15/2024

Cosmic Nootropic

Thanks for your positive review, Shelbyll! Great to know that Stresam is working well for you.

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09/02/2023

Richard F.

Richard F.

 Verified Buyer
US

US

Fast and Effective for Anxiety!

No side effects at all. Why take anything else? Just wish it was one a day.

09/03/2023

Cosmic Nootropic

Thanks for the review! We're happy to know that Stresam has helped you!

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09/02/2023

Michael F.

Michael F.

 Verified Buyer
US

US

Stresam

It is consistent on how it helped me relax.

09/03/2023

Cosmic Nootropic

We're happy to know it has worked for you, Michael!

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08/23/2023

R J.

R J.

 Verified Buyer
US

US

Nice Anxiolytic

Stresam 50 mg seemed to provide roughly equivalent anxiolysis of about 7.5–10 mg diazepam, but minus the hypnotic effects. Hence, I can’t recommend Stresam for sleep (though it may well help; I don’t know). However, I CAN heartily recommend it as a moderately powerful anxiolytic (with less dependence liability than benzodiazepines).

08/23/2023

Cosmic Nootropic

Hi Jason! We're glad to hear that Stresam has had a positive impact on your life. Thank you for your detailed review and for sharing your experience with us!

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06/22/2023

Artur

Artur

 Verified Buyer
US

US

Did not work for me!

Unfortunately Strezam did not work for me. Any doses any situation- no effects what so ever. 5 stars to the company! Other products are great 👍

06/23/2023

Cosmic Nootropic

Dear Artur, we're sorry the product didn't work for you. For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication. We're glad to hear that you had a positive experience shopping with us!

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03/30/2023

John A.

John A.

 Verified Buyer
US

US

Works for others but it does not work for me

I don't think I felt anything. My liver did hurt for a bit when I first took the recommended dose, but it stopped hurting after the 2nd one. Honestly, it did nothing for me. Fortunately, there's other things that do work for me. It wasn't really worth 90$.

03/31/2023

Cosmic Nootropic

Dear John, we are sorry that the product didn't work for you properly.😓 For most nootropics, the effect can be varied for different people. It strongly depends on the personal conditions, so we always recommend consulting a specialist before taking any medication.

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02/27/2023

David P.

David P.

 Verified Buyer
US

US

Working Great

Working great for anxiety and haven't noticed any side effects. I was also able to go off of my Zoloft prescription and hopefully can go off of Klonopin prescription as well.

03/01/2023

Cosmic Nootropic

Hi David, thank you for your feedback! We're happy to hear that you found the product effective. :)

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0

12/19/2022

Joe

Joe

US

US

Etifoxine is great!

First, these guys are great. Always very responsive during business hours and helpful with orders. Thank you! Second, the Etifoxine is exactly what I needed. I suffer from Post-Finasteride Syndrome, which results in a depletion of Allopregnanolone in the brain. Etifoxine is one of very few compounds in the world that agonize the TSPO receptors, the rate limiting step in the synthesis of Allopregnanolone, to start that natural production of Allopregnanolone again. Allopregnanolone, for context, is the body's natural Xanax/Benzodiazepine that is potent to the GABAA receptors for potentiality the action of tranquility, euphoria, and relaxation in the nervous system and stimulates the release of the neurotransmitter, GABA. It works well. Thank you!

12/21/2022

Cosmic Nootropic

Hi Joe! We're so happy that Etifoxine helps you! And thank you for your kind words! 💙

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12/13/2022

Elaine T.

Elaine T.

 Verified Buyer
AU

AU

Where is my order

I have not received my order of which I paid a large amount

12/14/2022

Cosmic Nootropic

Hi Elaine! We replied to you regarding this issue via email. Please check your inbox.

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11/22/2022

Dominic B.

Dominic B.

 Verified Buyer
AU

AU

Gave me liver pain/

It caused a moderate sedation the first time I used this medication. I continued at the recommended dose and then developed pale stools and right upper quadrant pain. I threw them in the trash. $200 gone

11/23/2022

Cosmic Nootropic

Hi Dominic, I'm sorry that Stresam didn't suit you. :( I hope you're ok now! Please note that we always recommend consulting a doctor before taking any medication. It can help you to avoid possible side effects.

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11/10/2022

Tamryn K.

Tamryn K.

 Verified Buyer
GB

GB

Great product

Both my husband and I have used this product for anxiety. I works wonders! I have not experienced any side effects using this medication.

11/16/2022

Cosmic Nootropic

Hi Tamryn, we're glad that Stresam helps you and your husband! Thank you for your feedback. :)

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07/01/2022

pettclan

pettclan

 Verified Buyer
US

US

Power

Heard that this was going off the market. Sad. For my daughter who has high anxiety, this has worked better than anything. If you have to take normal prescription anxiolytics, this would be the closest one. It could help you get off regular benzos as it gives you a close feeling. Anxiety sucks, but having something like this really does help.

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06/18/2022

Shaun S.

Shaun S.

 Verified Buyer
US

US

A valuable and effective alternative to traditional benzodiazapines

I found Strezam to be particularly effective for coping with reduction of or discontinuation of mainline benzodiazepines. In fact, I haven’t found a better recourse for withdrawal symptoms, or even PAWS, then this nootropic. Very grateful for the minds that have made this available to the Western world, where such pharmacological antidotes have not been seriously considered by the FDA. Thank you cosmic once again!

08/01/2022

Cosmic Nootropic

Hi Shaun, You're always welcome! We're so glad that Stresam works great for you. :)

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12/04/2021

Jason L.

Jason L.

 Verified Buyer
US

US

Fast Shipping! Genuine Product!

I have not used this medication yet as I am currently on pain medication and cannot take both, but I was happy that it came quickly and safely in sealed blister packs and was the genuine product. :)

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10/31/2021

ANTONY D.

ANTONY D.

 Verified Buyer
CH

CH

Awesome

Great customer service and products, thanks a lot!

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