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Tenoten ® is an anxiolytic and antidepressant based on antibodies to brain-specific protein S-100B. The preparation is said to affect mechanisms of neuronal plasticity and manifestations of higher nervous activity. It is used to treat anxiety and stress-induced disorders.

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Form: 40 pills of 3mg
Form description: Flat cylindrical pills with a facet of white or almost white color and a break line. “MATERIA MEDICA” inscription is on the side with a break line. “TENOTEN” inscription is on the other side.
Active ingredient: Affinity-purified antibodies to the brain-specific protein S-100 – 3 mg
Excipients: Microcrystalline cellulose, magnesium stearate, lactose monohydrate (lactose).
ATC code: N05BX
Pharmacological action: Antidepressive, anti-asthenic, anxiolytic, nootropic, neuroprotective, antihypoxic, anti-stress, anti-amnestic
Shelf life: 3 years. Do not use it beyond the expiration date printed on the package.
Storage conditions: Store in a dry dark place at temperatures no higher than 25°C (77°F). Keep out of reach of children.
Terms of release: Over-the-counter
Manufacturer: Materia Medica Holding, Russia

What is Tenoten?

Tenoten is a homeopathic drug that is claimed to produce anxiolytic and nootropic effects.

The manufacturer claims that the mechanisms of these effects are attributed to the antibodies against S-100 protein: at ultra-low doses, they exert GABA-mimetic and neurotrophic actions, up-regulate stress-limiting systems and contribute to the restoration of neuroplasticity. However, many people say that the effect of this drug is mostly attributed to a placebo effect because the amount of the active ingredient is too small to have any effect.

What is the Mechanism of Action of Tenoten?

The drug modifies the functional activity of the S-100 protein, which conjugates the synaptic and metabolic processes in the brain. Due to its GABA-mimetic and neurotrophic action, the drug increases the activity of stress-limiting systems and contributes to the restoration of neuronal plasticity.

What are the Benefits and Effects of Tenoten?

  • Tenoten has a calming, anxiolytic action without causing undesirable hypnogenic and muscle relaxant effects.
  • Tenoten improves the tolerance to psychoemotional loads.
  • Tenoten has a stress-protective, nootropic, anti-amnestic, antihypoxic, neuroprotective, anti-asthenic, antidepressant action.
  • In case of intoxication, hypoxia, or after an acute disturbance of cerebral blood circulation, Tenoten has a neuroprotective effect, limits the damage zone, and normalizes learning and memory processes in CNS.
  • Tenoten inhibits the processes of lipid peroxidation.

What is Tenoten Used For?

Tenoten is used to treat the following functional disorders:

  • Neurotic and neurosis-like disorders;
  • Psychosomatic diseases;
  • Stress-induced disorders with increased tensions;
  • Irritability, anxiety, and autonomic reactions;
  • Mild to moderate organic CNS disorders.

Where Can I Order Tenoten Online?

You can buy Tenoten online at different vendors. CosmicNootropic offers Tenoten in packs of 40x3mg pills. We offer fast US delivery and worldwide shipping with volume discounts! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.

You can order Tenoten and get it delivered to the USA, Europe, the UK, Asia, and many other regions and countries via CosmicNootropic.


Legal Disclaimer
This product has not been approved by the US FDA. All statements on this page are for informational purposes only and have not been evaluated by the US FDA.
This product is not intended to diagnose, treat, cure, or prevent any disease. See more

What is Tenoten Dosage, How to Use It?

It is recommended to administer one or two tablets at a time. Keep tablets in the mouth until complete dissolution. Do not take the preparation with food.

In mild to moderate conditions, the drug is taken twice daily.

When the symptoms are more intense, up to 4 times daily.

The drug is usually prescribed for 1-3 months but can also be taken 2-3 days before a stressful event (e.g. presentation, important meeting, etc.). Depending on the chosen regimen, one pack is sufficient for a course of 5-15 days.

What are the Side Effects of Tenoten?

When the drug was taken according to the indications and at the recommended dosage, no side effects have been detected. Reactions to the drug ingredients are possible in case of increased individual sensitivity.


No cases of overdose have been reported so far.


When not treated, emotional stress tends to have physical manifestations. Dosage and frequency regimens are chosen based on the intensity and duration of clinical symptoms.



  1. S Duma, S Shishkin (2009) Tenoten in the therapy of patients with moderate cognitive impairment
  2. N Vanchakova, A Popov (2009) Tenoten in the therapy of anxious disturbances in patients with essential hypertension and coronary heart disease
  3. L Serova (2009) Tenoten in complex therapy for cerebrovascular insufficiency in elderly patients
  4. E Dyakonova, V Shalimov (2016) The efficacy of tenoten for children in the treatment of motor and speech disorders in children with perinatal damage of the central nervous system
  5. Keshishyan et al (2019) [Therapy of perinatal brain injury outcomes: results of a multicenter double-blind placebo-controlled randomized study of tenoten for children (liquid dosage form)] 
  6. Zavadenko et al (2020) [Developmental disorders of academic skills in children: the efficacy and safety of Tenoten for children in the multicenter double-blind placebo-controlled randomized study] 

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