Thymogen

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Thymogen (int. Glutamyl-Tryptophan) is a peptide immunomodulator containing chemically synthesised dipeptide Glu-Trp (glutamyl-tryptophan) equal to a natural compound of thymus extract.

Thymogen was developed by a team of Leningrad and Moscow scientists as a drug for the treatment of immunodeficiency. In 1990, it was approved for medical use.

Thymogen is a versatile preparation that has several dosage forms available: ampoules, spray and cream. Its spray form is usually used as a prophylactic and treatment of acute and chronic non-specific lung diseases. The injection form is used for the treatment of various acute and chronic viral and bacterial infections that are accompanied by weakened immunity. The cream form is used for the treatment of dermatitis and as a regeneration aid for the treatment of wounds and scars.

Indications

Thymogen is used as part of complex therapy of acute and chronic viral and bacterial infections that are accompanied by weakened immunity such as:

  • viral hepatitis;
  • acute and chronic non-specific lung diseases (CNSLD): chronic bronchitis, acute and chronic pneumonia;
  • dermal and subcutaneous tissue diseases (pyoderma, furunculosis, erysipelas);
  • as part of complex therapy of diffuse atopic dermatitis;
  • as part of complex therapy of severe mechanical, chemical, radiation and thermal injuries (burns);
  • in combination treatment of wound and surgical infections, including purulent-septic complications in the post-operative period;
  • during the preoperative procedures before elective surgery in order to prevent infectious complications and stimulate regeneration;
  • after radiotherapy or chemotherapy treatment, as well as long-term antibiotic therapy in massive doses.

Thymogen has been shown to be an effective immunomodulator, restoring the immune reactivity as part of complex therapy of viral hepatitis, tuberculosis, pseudotuberculosis, influenza and acute respiratory viral infection (ARVI), papillomatosis and sepsis.

Thymogen improves patients’ general condition and ensures a faster biochemical and immune restoration, when used in the acute period of intestinal amebiasis, typhoid fever, acute dysentery, erysipelas, diphtheria, brucellosis and hemorrhagic fever with renal syndrome. As a result of the use of the preparation, the incidence of prolonged recurrent and chronic disease is reduced.

Buy Thymogen nasal spray to treat infectious, inflammatory and allergic bronchopulmonary diseases, it helps reduce the disease duration, restore the immune system and significantly reduce the likelihood of developing complications.

According to clinical studies, Thymogen is used as part of complex therapy of bacterial, viral and fungal skin infections, as well as atopic dermatitis.

Medical research contains recorded cases of Thymogen being used as part of complex therapy of acute pancreatitis, peritonitis, mechanical trauma, compartment syndrome and burns, as well as for treatment and rehabilitation after major abdominal surgery.

Pharmacological effect

Pharmacodynamic properties:

Thymogen prevents the suppression of regeneration and enhances cell metabolism. It also promotes the expression of differentiation receptors on lymphocytes, normalises the number and ratio of T-helper cells and cytotoxic T lymphocytes in patients with various immunodeficiency disorders.

Pharmacokinetic properties:

The preparation quickly enters the systemic circulation after the injection or infusion. Peptidases cleave sodium alpha-glutamyl-tryptophan into L-glutamic acid and L-tryptophan, which are used in peptide synthesis.

Ingredients:

Solution for intramuscular injection, 100 µg / ml. 1 ml of the drug contains:

  • active ingredient: sodium alpha-glutamyl-tryptophan (Thymogen® sodium) 100 µg (expressed as alpha-glutamyl-tryptophan)
  • inactive ingredients: sodium chloride 9,000 µg and water for injections up to 1 ml.

One dose of nasal spray contains:

  • active ingredient: Thymogen (glutamyl-tryptophan monosodium salt) 25 µg;
  • inactive ingredient: benzalkonium chloride and normal saline.

One spray bottle contains 100 doses, which last 25 days or 2.5 treatment courses. In case of prolonged storage, the spray should be stored in the fridge.

Application and dosage

Injections: intramuscularly, once a day. Dosage for adults and children from 14 years of age is 100 µg (300–1,000 µg per course). Duration of treatment course is from 3 to 10 days.

Spray: intranasally – 1 dose in each nasal passage twice a day. Duration of the treatment is 10 days for therapeutic purposes and 3–5 days for preventive purposes. The treatment can be repeated after 1 month at the soonest.

Side effects

Side effects are rare and usually include allergic reactions such as rhinitis.

The medication is very safe: in experiments an increase in the dose over 100-fold did not result in any side effects.

  1. Furgal et al (1993) The clinico-epidemiological efficacy of thymogen in acute respiratory viral infections in a military collective https://wwww.unboundmedicine.com/medline/citation/8498021/[The_clinico_epidemiological_efficacy_of_thymogen_in_acute_respiratory_viral_infections_in_a_military_collective]

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