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TRIAZAVIRIN ®

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The antiviral drug Triazavirin is the first medicine in the azoloazine group and the pioneer of this class of drugs. It was created in the bowels of Soviet military medicine. It took scientists about 30 years to develop Triazavirin. The drug is an innovation that was created in collaboration with the Institute of Military Medicine and the Institute of Influenza of St. Petersburg, then other organizations joined: the Virology Center of the Ministry of Defense of Russia, the Ural Federal University, etc. A large group of people including chemists, biologists, physicians, technologists, economists, and other specialists, took part in the creation of this drug.

In 2014, Triazavirin was registered and has since been used as a treatment of influenza. It is effective against over 15 strains of influenza and fevers, including swine and avian ones. Buy Triazavirin to fight a number of dangerous pathogenic viruses like Dengue and West Nile fever, tick-borne encephalitis, and other dangerous infections. Recently, they started using Triazavirin in case of exacerbations of bronchial asthma caused by viral infections.

In 2017, Triazavirin was included in the Federal Clinical Recommendations of the Ministry of Health of Russia as one of the four antiviral drugs with a direct antiviral effect. It has low toxicity, which is confirmed by many years of practice.

Chemically, it is a synthetic analog of guanine – an integral part of DNA with the help of which hereditary information is recorded. The instructions say that the drug inhibits the synthesis of the RNA virus and the replication of fragments of its genome. Simply put, it does not allow the virus to produce its copies in the affected cell. The drug is not aimed at eliminating the symptoms but acts directly on the contagious matron of the infection.

According to the results of clinical trials, Triazavirin can help even in case of a delayed start of the treatment of ARVI and influenza. It improves the general condition during the first days of the treatment, reduces the likelihood of complications; quickly inhibits clinical signs of rotavirus infection, and may prevent the worsening of the disease. It can reduce the time to recover and the duration of clinical symptoms (intoxication, fever, catarrhal phenomena), regardless of the treatment initiation. According to Dr. Chupakhin, PhD in Chemistry and Academician of the Russian Academy of Sciences, the virus is not spotted in the blood as soon as on the second day of the treatment with Triazavirin.

In 2016, this antiviral drug received a prestigious international pharmaceutical award the Prix Galien in the nomination “The Best Research in Russia”.

 

Intended uses

  • Outpatient treatment of mild and moderate uncomplicated forms of influenza;
  • Inpatient treatment of severe/complicated forms of influenza.

 

Produced by Medsintez Plant, Russia.

Dosage and administration

Method of application: per os, regardless of meals.

One 250 mg capsule 3 times a day, during 5–7 days. The daily dose is 750 mg.

Side effects

The treatment with Triazavirin is well tolerated by patients and is rarely accompanied by the development of adverse reactions. It is important that the drug does not cause cardiovascular complications and does not interact with other agents.

Manufacturer

Medsintez Plant, Russia.

OFFICIAL INSTRUCTION

References:

  1. Karpenko I et al (2010). Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza A and B virus replication. https://www.ncbi.nlm.nih.gov/pubmed/20194696
  2. Borisevich SV et al (2011). Therapeutic efficacy of Triazavirin, a novel Russian chemotherapeutic, against influenza virus A (H5N1). https://www.ncbi.nlm.nih.gov/pubmed/21780665
  3. Kiselev OI et al (2012). A new antiviral drug Triazavirin: results of phase II clinical trial. https://www.ncbi.nlm.nih.gov/pubmed/23477247
  4. Loginova SIa et al (2012). Toxicity of triazavirin, a novel Russian antiinfluenza chemotherapeutic. https://www.ncbi.nlm.nih.gov/pubmed/23700930
  5. Shvetsov AV et al (2018). Triazavirine supramolecular complexes as modifiers of the peptide oligomeric structure. https://www.ncbi.nlm.nih.gov/pubmed/28828928

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