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VISOMITIN ® (SkQ1 / Skulachev Ions)
Buy Visomitin® SKQ1 Online!
Visomitin® (SkQ1) is a Russian medication with a mitochondria-targeted antioxidant SkQ1 as the active ingredient. It proved to be effective for a wide range of age-related disorders such as cardiovascular diseases, neurodegenerative disorders, and ophthalmic conditions. Visomitin eye drops are used to treat age-related vision degeneration, dry eye syndrome, non-infectious uveitis, cataract and glaucoma.
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|Form description:||Transparent or slightly opalescent, colorless or slightly colored liquid.|
|Active ingredient:||In 1 ml: plastohinonildetsiltriphenylphosphonium bromide (PDTP) 0.155 mcg.|
|Excipients:||In 1 ml: benzalkonium chloride – 0.1 mg, hypromellose – 2 mg, sodium chloride – 9 mg, sodium dihydrogen phosphate dihydrate – 0.81 mg, sodium hydrogen phosphate dodecahydrate – 1.16 mg, sodium hydroxide 1M solution – up to pH 6–8, purified water – up to 1 ml.|
|Shelf life:||2 years. Do not use it beyond the expiration date printed on the package.|
|Storage conditions:||Store in a dry dark place at temperatures no higher than 2-8°C (35.6-46.4°F). Use the opened bottle within 1 month. Keep in a safe place out of reach of children.|
|Terms of release:||Over-the-counter|
|Manufacturer:||Mitotech, Russia https://sk-q.com/|
What is Visomitin?
The active substance of Visomitin is SkQ1. It is a small molecule synthesized by professor V. Skulachev at his team at the Moscow State University. One part of SkQ1 acts as a molecular “tow truck” carrying the other part of the molecule – an extremely active antioxidant plastoquinone – into mitochondria. The physics of the mitochondrial membrane and unique properties of SkQ1 direct it into the inner leaflet of the inner mitochondrial membrane with high accuracy.
The presence of SkQ1 in the mitochondrial membrane enables mitochondria to protect themselves from reactive oxygen species (ROS) by breaking the chain reaction of lipid destruction. This ability of the lead molecule to protect cells against oxidative stress is the key to treating patients with various age-related disorders such as cardiovascular diseases, neurodegenerative disorders, and ophthalmic conditions.
What Does Visomitin Do?
It has been hypothesized that age-dependent accumulation of oxidative damages in living organisms may be the main cause of the aging process. It is possible to control this damage accumulation by controlling the level of ROS production in mitochondria. It is important to stress that ROS production shall only be controlled but not stopped, so that ROS can still fulfill a number of crucial biological functions, for instance, fighting bacteria and viruses.
According to Dr Skulachev, a “perfect” antioxidant shall be specifically targeted to mitochondria where ROS are produced. And it shall effectively remove excessive ROS. The antioxidant must be non-toxic and it must not be recognized and eliminated by cell enzymes. If these criteria is fulfilled, the “perfect” antioxidant compound can prevent/repair oxidative damage and prevent/treat many age-related disorders across various therapeutic areas.
The mechanism of action of SkQ1 involves at least two extremely complex and novel concepts: 1) delivering a compound inside mitochondria and 2) reducing ROS production inside mitochondria in a controlled and sustainable manner. SkQ1 molecule successfully addresses these two aspects as experiments show.
What are Intended Uses of Visomitin?
More than a dozen studies have been conducted and showed SkQ1 effectiveness in such critical therapeutic areas as:
- Age-related macular degeneration (AMD);
- Dry eye syndrome (DES);
- Non-infectious uveitis;
Where Can I Order Visomitin (SkQ1) Online?
You can order Visomitin online at different vendors. CosmicNootropic offers Visomitin in the form of eye drops with fast US delivery and worldwide shipping! Always be sure to do your research before purchasing any nootropic supplement to ensure you are getting a quality product.
You can order Visomitin and get it delivered to the USA, Europe, the UK, Asia, and many other destinations via CosmicNootropic.
Also, try other SkQ1 revolutionary products!
What is Visomitin Dosage, Administration?Dosage is 1-2 drops 3 times a day. Duration of treatment is determined by the ophthalmologist individually, depending on the severity of symptoms and the dynamics of the pathological process in the eyes. The average treatment period is two to six months. During complex treatment of senile cataract it is recommended to hold regular medical examinations by ophthalmologist.
Visomitin ContraindicationsUsing Visomitin eye drops is contraindicated in case of individual intolerance or hypersensitivity to the active ingredient and auxiliary ingredients. Also, the drug cannot be used by children under 18 years old.
What are the Side Effects of Visomitin?Local adverse reactions in the eye can develop in the form of a burning sensation, cramps, redness of the conjunctiva, etc. Rare side effects: systemic allergic reactions such as skin rashes, itching, urticaria (a characteristic rash and swelling which in appearance resemble the sting). Cases of severe allergic reactions in the form of angioedema, or anaphylactic shock have not been reported. Note: The product shall be kept in the fridge.
- Krementsova et al (2012) Reproducible effects of the mitochondria-targeted plastoquinone derivative SkQ1 on Drosophila melanogaster lifespan under different experimental scenarios https://www.ncbi.nlm.nih.gov/pubmed/23073710
- Kolosova et al (2012) The mitochondria-targeted antioxidant SkQ1 but not N-acetylcysteine reverses aging-related biomarkers in rats https://www.ncbi.nlm.nih.gov/pubmed/23104863
- Ilyasova et al (2012) Substitution of ether linkage for ester bond in phospholipids increases permeability of bilayer lipid membrane for SkQ1-type penetrating cations https://www.ncbi.nlm.nih.gov/pubmed/23157264
- Chistyakov et al (2012) Effect of plastoquinone derivative 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats https://www.ncbi.nlm.nih.gov/pubmed/23244734
- Snytnikova et al (2012) The therapeutic effect of mitochondria-targeted antioxidant SkQ1 and Cistanche deserticola is associated with increased levels of tryptophan and kynurenine in the rat lens https://www.ncbi.nlm.nih.gov/pubmed/23288574
- Solovieva et al (2013) Effect of mitochondria-targeted antioxidant SkQ1 on programmed cell death induced by viral proteins in tobacco plants https://www.ncbi.nlm.nih.gov/pubmed/24228922
- Kapay et al (2013) Mitochondria-targeted plastoquinone antioxidant SkQ1 prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices https://www.ncbi.nlm.nih.gov/pubmed/23735258
- Stefanova et al (2014) Alzheimer's disease-like pathology in senescence-accelerated OXYS rats can be partially retarded with mitochondria-targeted antioxidant SkQ1 https://www.ncbi.nlm.nih.gov/pubmed/24047616
- Vays et al (2014) Antioxidant SkQ1 delays sarcopenia-associated damage of mitochondrial ultrastructure https://www.ncbi.nlm.nih.gov/pubmed/24519884
- Perepechaeva et al (2014) The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy https://www.ncbi.nlm.nih.gov/pubmed/25132985
- Muraleva et al (2014) The mitochondria-targeted antioxidant SkQ1 restores αB-crystallin expression and protects against AMD-like retinopathy in OXYS rats https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614531/
- Novikova et al (2014) Preventive and therapeutic effects of SkQ1-containing Visomitin eye drops against light-induced retinal degeneration https://www.ncbi.nlm.nih.gov/pubmed/25519068
- Rogovin et al (2014) Mitochondria-Targeted Antioxidant SkQ1 Accelerates Maturation in Campbell Dwarf Hamsters (Phodopus campbelli) https://www.researchgate.net/publication/266980940_Mitochondria-Targeted_Antioxidant_SkQ1_Accelerates_Maturation_in_Campbell_Dwarf_Hamsters_Phodopus_campbelli
- Rogovin et al (2014) Effects of mitochondria-targeted plastoquinone derivative antioxidant (SkQ1) on demography of free-breeding Campbell dwarf hamsters (Phodopus campbelli) kept in outdoor conditions. reproduction and lifespan: explanation in the framework of ultimate loads https://www.ncbi.nlm.nih.gov/pubmed/25519070
- Myasoedova et al (2014) Therapeutic Doses of SkQ1 Do Not Induce Cytochromes P450 in Rat Liver https://www.researchgate.net/publication/269771479_Therapeutic_Doses_of_SkQ1_Do_Not_Induce_Cytochromes_P450_in_Rat_Liver
- Manskikh et al (2014) Effect of the mitochondria-targeted antioxidant SkQ1 on development of spontaneous tumors in BALB/c mice https://www.ncbi.nlm.nih.gov/pubmed/25519073
- Iomdina et al (2015) Mitochondria-targeted antioxidant SkQ1 reverses glaucomatous lesions in rabbits https://www.ncbi.nlm.nih.gov/pubmed/25553485
- V Samuilov, D Kiselevsky (2015) Effect of cationic plastoquinone SkQ1 on electron transfer reactions in chloroplasts and mitochondria from pea seedlings https://www.ncbi.nlm.nih.gov/pubmed/25869358
- Rumyantseva et al (2015) Ameliorative effects of SkQ1 eye drops on cataractogenesis in senescence-accelerated OXYS rats https://www.ncbi.nlm.nih.gov/pubmed/25267419
- Manskikh et al (2015) Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antioxidant SkQ1 https://www.ncbi.nlm.nih.gov/pubmed/25323729
- Weniger et al (2016) The Analgesic Effect of the Mitochondria-Targeted Antioxidant SkQ1 in Pancreatic Inflammation https://wwww.unboundmedicine.com/medline/citation/27274778/The_Analgesic_Effect_of_the_Mitochondria_Targeted_Antioxidant_SkQ1_in_Pancreatic_Inflammation
- Bazhin et al (2016) The novel mitochondria-targeted antioxidant SkQ1 modulates angiogenesis and inflammatory micromilieu in a murine orthotopic model of pancreatic cancer https://www.ncbi.nlm.nih.gov/pubmed/26914404
- Bakeeva et al (2016) Mitochondria-targeted antioxidant SkQ1 reduces age-related alterations in the ultrastructure of the lacrimal gland https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5348314/
- Petrov et al (2016) SkQ1 Ophthalmic Solution for Dry Eye Treatment: Results of a Phase 2 Safety and Efficacy Clinical Study in the Environment and During Challenge in the Controlled Adverse Environment Model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735228/
- Tsybulko et al (2016) The Mitochondria-Targeted Plastoquinone–Derivative SkQ1 Promotes Health and Increases Drosophila melanogaster Longevity in Various Environments https://academic.oup.com/biomedgerontology/article/72/4/499/2630002
- Zernii et al (2017) Mitochondria-Targeted Antioxidant SkQ1 Prevents Anesthesia-Induced Dry Eye Syndrome https://www.researchgate.net/publication/320369542_Mitochondria-Targeted_Antioxidant_SkQ1_Prevents_Anesthesia-Induced_Dry_Eye_Syndrome
- Rademann et al (2017) Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5625755/
- Titova et al (2018) Mitochondria-targeted antioxidant SkQ1 suppresses fibrosarcoma and rhabdomyosarcoma tumour cell growth https://www.ncbi.nlm.nih.gov/pubmed/29995559
- Jiang et al (2018) Mitochondria-targeted antioxidant SkQ1 improves spermatogenesis in Immp2l mutant mice https://www.ncbi.nlm.nih.gov/pubmed/28703400
- Rogov et al (2018) New Data on Effects of SkQ1 and SkQT1 on Rat Liver Mitochondria and Yeast Cells https://www.ncbi.nlm.nih.gov/pubmed/29738689
- Zernii et al (2018) Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-018-0996-7
- Wei et al (2019) The Role of SKQ1 (Visomitin) in Inflammation and Wound Healing of the Ocular Surface https://pubmed.ncbi.nlm.nih.gov/30565203/
- Dvoretskaya et al (2021) Mitochondrial Antioxidant SkQ1 Has a Beneficial Effect in Experimental Diabetes as Based on the Analysis of Expression of microRNAs and mRNAs for the Oxidative Metabolism Regulators https://pubmed.ncbi.nlm.nih.gov/34829620/
- Rudnitskaya et al (2022) Changes in Glial Support of the Hippocampus during the Development of an Alzheimer's Disease-like Pathology and Their Correction by Mitochondria-Targeted Antioxidant SkQ1 https://pubmed.ncbi.nlm.nih.gov/35163053/
- Song et al (2022) Mitochondrial Targeted Antioxidant SKQ1 Ameliorates Acute Kidney Injury by Inhibiting Ferroptosis https://pubmed.ncbi.nlm.nih.gov/36193064/
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