Effect of Thymalin on adaptive immunity in patients with Covid-19

When we were preparing the post about the peptides of thymus gland we found a research of a group of Russian scientists led by Dr. Khavinson (PhD) who conducted a study of Thymalin polypeptide that may stimulate immune response, including antibody production in COVID-19 patients. It is said to regulate the number and ratio of T- and B-lymphocytes, enhance phagocytosis, and stimulate the processes of regeneration and hematopoiesis in case of their suppression.

The single-center open-label prospective randomized controlled study included patients hospitalized in Russia with the COVID-19 diagnosis. All patients (75 people, aged 64.70 ± 7.20 y.o.) received standard treatment, according to the “Temporary guidelines in prevention, diagnosis and treatment of COVID-19 by the Ministry of Health of the Russian Federation“.

The concentration of antibodies has a tendency to decrease in patients who recover after COVID-19. Hence the opportunity to increase the level of IgG antibodies after the completion of treatment or slow down the decrease in their concentration in patients is of interest. This might increase the duration of the body resistance to potential re-infection.

The patients were divided into 2 groups: the control group included 37 people who received the treatment according to the standard scheme; the main group consisted of 38 patients who additionally received thymalin. The drug was used starting from the day of admission to the hospital at the dose of 10 mg in 2 ml of saline (0.9% sodium chloride solution) once daily IM for 5 days.

The level of IgG antibodies to SARSCoV-2 was studied after the therapy at various times. The indicator in the thymalin group was 2.04 times higher than in the control group. It was concluded that this polypeptide has the ability to increase the level of antibody production and maintain a sufficient concentration of antibodies in the blood of COVID-19 patients. The discovered properties of thymalin in regards to COVID-19 were explained by its ability:

  • to optimize the process of antibody production,
  • to induce the formation of immunological memory.

You can read the full translation of the research following the Reddit link below:

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