Melarena is an adaptogen, sedative and hypnotic drug based on a synthetic analogue of pineal hormone melatonin. It is used in case of jet lag, adjusts sleep-wake cycles in people whose daily work schedule changes (shift-work disorder), and helps blind people establish a day and night cycle. It stabilises circadian rhythms.

It increases levels of gamma-Aminobutyric acid and serotonin in the midbrain and hypothalamus as it regulates the pyridoxal kinase which influences the synthesis of these compounds. The drug inhibits the secretion of gonadotropins and other pituitary gland hormones (corticotropin, thyroid stimulating hormone and somatotropin). It normalizes daily changes in body activity and temperature, improves brain activity and reduces irritability. Melarena has a positive effect on night sleep. It helps fall asleep, reduces night time awakenings and facilitates morning awakening.

The drug has also been proven effective in adapting to rapid change of time zones while travelling. It reduces stress and weather sensitivity and stabilises the neuroendocrine system. Melarena has immunomodulating and antioxidant properties. The drug is non-addictive. It has been shown that the natural production of melatonin declines with age, so it is better to use melatonin at an older age.


Prevention and treatment of:

• desynchronosis (alterations to the body’s circadian rhythms caused by rapid long-distance trans-meridian (east–west or west–east) travel or working shifts and jet lag);
• weather sensitivity;
• fatigue and sleep disorders;
• depression